Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Science

Volumn 357, Issue 6351, 2017, Pages 570-575

  Byndloss, Mariana X ^a   Olsan, Erin E ^a   Rivera Chávez, Fabian ^a   Tiffany, Connor R ^a   Cevallos, Stephanie A ^a   Lokken, Kristen L ^a   Torres, Teresa P ^a   Byndloss, Austin J ^a   Faber, Franziska ^a   Gao, Yandong ^b   Litvak, Yael ^a   Lopez, Christopher A ^a   Xu, Gege ^c   Napoli, Eleonora ^c   Giulivi, Cecilia ^c   Tsolis, Renée M ^a   Revzin, Alexander ^b   Lebrilla, Carlito B ^c   Bäumler, Andreas J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; NITRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STREPTOMYCIN; 2-CHLORO-5-NITROBENZANILIDE; ANGIOPOIETIN RELATED PROTEIN 4; ANILIDE; ANTIINFECTIVE AGENT; BUTYRIC ACID DERIVATIVE; NITRIC ACID DERIVATIVE;

BIOAVAILABILITY; CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM; GENE; GENE EXPRESSION; HOMEOSTASIS; MICROBIAL COMMUNITY; MICROORGANISM; NITRIC OXIDE; OXIDATION; PROTEIN;

ARTICLE; BIOAVAILABILITY; CELL HYPOXIA; COLITIS; COLON CELL; COLON EPITHELIUM; DYSBIOSIS; ENTEROBACTERIACEAE; ESCHERICHIA; GENE EXPRESSION; INTESTINE FLORA; OXYGENATION; PRIORITY JOURNAL; PROTEIN DEPLETION; REGULATORY T LYMPHOCYTE; SALMONELLA; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CACO-2 CELL LINE; CHEMICALLY INDUCED; CLOSTRIDIUM; COLON; DRUG EFFECTS; EPITHELIUM CELL; FEMALE; GENETICS; HOMEOSTASIS; HUMAN; MALE; METABOLISM; MICROBIOLOGY; MOUSE; OXIDATION REDUCTION REACTION; PATHOGENICITY;

ENTEROBACTERIACEAE; ESCHERICHIA; SALMONELLA;

ANGIOPOIETIN-LIKE 4 PROTEIN; ANILIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BUTYRATES; CACO-2 CELLS; CLOSTRIDIUM; COLITIS; COLON; DYSBIOSIS; ENTEROBACTERIACEAE; EPITHELIAL CELLS; FEMALE; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION; HOMEOSTASIS; HUMANS; MALE; MICE; MICE, INBRED C57BL; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; PPAR GAMMA; SIGNAL TRANSDUCTION; STREPTOMYCIN;

EID: 85027175538     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aam9949     Document Type: Article

References (25)

1. N. R. Shin, T. W. Whon, J. W. Bae, Trends Biotechnol. 33, 496–503 (2015).
2. A. M. Spees et al., mBio 4, e00430-13 (2013).
3. F. Rivera-Chávez et al., Cell Host Microbe 19, 443–454 (2016).
4. S. E. Winter et al., Science 339, 708–711 (2013).
5. D. R. Donohoe et al., Cell Metab. 13, 517–526 (2011).
6. R. Marion-Letellier, M. Butler, P. Déchelotte, R. J. Playford, S. Ghosh, Am. J. Clin. Nutr. 87, 939–948 (2008).
7. M. Lefebvre et al., J. Endocrinol. 162, 331–340 (1999).
8. S. Alex et al., Mol. Cell. Biol. 33, 1303–1316 (2013).
9. M. Vital, A. C. Howe, J. M. Tiedje, mBio 5, e00889-14 (2014).
10. K. Atarashi et al., Nature 500, 232–236 (2013).
11. C. J. Kelly et al., Cell Host Microbe 17, 662–671 (2015).
12. G. T. Furuta et al., J. Exp. Med. 193, 1027–1034 (2001).
13. M. N. Xavier et al., Cell Host Microbe 14, 159–170 (2013).
14. N. Terada, N. Ohno, S. Saitoh, S. Ohno, Histochem. Cell Biol. 128, 253–261 (2007).
15. S. Kizaka-Kondoh, H. Konse-Nagasawa, Cancer Sci. 100, 1366–1373 (2009).
16. K. M. Maslowski et al., Nature 461, 1282–1286 (2009).
17. A. L. Millard et al., Clin. Exp. Immunol. 130, 245–255 (2002).
18. B. Wang, A. Morinobu, M. Horiuchi, J. Liu, S. Kumagai, Cell. Immunol. 253, 54–58 (2008).
19. P. V. Chang, L. Hao, S. Offermanns, R. Medzhitov, Proc. Natl. Acad. Sci. U.S.A. 111, 2247–2252 (2014).
20. K. Atarashi et al., Science 331, 337–341 (2011).
21. N. Arpaia et al., Nature 504, 451–455 (2013).
22. Y. Furusawa et al., Nature 504, 446–450 (2013).
23. P. M. Smith et al., Science 341, 569–573 (2013).
24. N. Singh et al., Immunity 40, 128–139 (2014).
25. L. Peyrin-Biroulet et al., Proc. Natl. Acad. Sci. U.S.A. 107, 8772–8777 (2010).