메뉴 건너뛰기




Volumn 541, Issue 7637, 2017, Pages 321-330

Elements of cancer immunity and the cancer-immune set point

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

EID: 85016548232     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21349     Document Type: Review
Times cited : (3737)

References (118)
  • 1
    • 84928761118 scopus 로고    scopus 로고
    • Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A. et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1
  • 2
    • 84962301577 scopus 로고    scopus 로고
    • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
    • McGranahan, N. et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351, 1463-1469 (2016).
    • (2016) Science , vol.351 , pp. 1463-1469
    • McGranahan, N.1
  • 3
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189-2199 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2189-2199
    • Snyder, A.1
  • 4
    • 84871192340 scopus 로고    scopus 로고
    • Molecular pathways: Next-generation immunotherapy - inhibiting programmed death-ligand 1 and programmed death-1
    • Chen, D. S., Irving, B. A. & Hodi, F. S. Molecular pathways: next-generation immunotherapy - inhibiting programmed death-ligand 1 and programmed death-1. Clin. Cancer Res. 18, 6580-6587 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6580-6587
    • Chen, D.S.1    Irving, B.A.2    Hodi, F.S.3
  • 5
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • Topalian, S. L., Drake, C. G. & Pardoll, D. M. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 27, 450-461 (2015).
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 6
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman, I., Coukos, G. & Dranoff, G. Cancer immunotherapy comes of age. Nature 480, 480-489 (2011).
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 7
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • Sharma, P. & Allison, J. P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161, 205-214 (2015).
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 8
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 9
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong, H. et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nature Med. 8, 793-800 (2002).
    • (2002) Nature Med. , vol.8 , pp. 793-800
    • Dong, H.1
  • 10
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y. et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99, 12293-12297 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1
  • 11
    • 0842325739 scopus 로고    scopus 로고
    • PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells
    • Blank, C. et al. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res. 64, 1140-1145 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1140-1145
    • Blank, C.1
  • 12
    • 84959529731 scopus 로고    scopus 로고
    • PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
    • Zou, W., Wolchok, J. D. & Chen, L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations. Sci. Transl. Med. 8, 328rv4 (2016).
    • (2016) Sci. Transl. Med. , vol.8 , pp. 328rv4
    • Zou, W.1    Wolchok, J.D.2    Chen, L.3
  • 13
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen, D. S. & Mellman, I. Oncology meets immunology: The cancer-immunity cycle. Immunity 39, 1-10 (2013).
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 14
    • 84984973625 scopus 로고    scopus 로고
    • Immune escape to PD-L1/PD-1 blockade: Seven steps to success (or failure)
    • Kim, J. M. & Chen, D. S. Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure). Ann. Oncol. 27, 1492-1504 (2016).
    • (2016) Ann. Oncol. , vol.27 , pp. 1492-1504
    • Kim, J.M.1    Chen, D.S.2
  • 15
    • 0024121486 scopus 로고
    • Immunogenic (tum-) variants of mouse tumor P815: Cloning of the gene of tum-antigen P91A and identification of the tum-mutation
    • De Plaen, E. et al. Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum-antigen P91A and identification of the tum-mutation. Proc. Natl Acad. Sci. USA 85, 2274-2278 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 2274-2278
    • De Plaen, E.1
  • 16
    • 0023009267 scopus 로고
    • Identification of a unique tumor antigen as rejection antigen by molecular cloning and gene transfer
    • Stauss, H. J., Van Waes, C., Fink, M. A., Starr, B. & Schreiber, H. Identification of a unique tumor antigen as rejection antigen by molecular cloning and gene transfer. J. Exp. Med. 164, 1516-1530 (1986).
    • (1986) J. Exp. Med. , vol.164 , pp. 1516-1530
    • Stauss, H.J.1    Van Waes, C.2    Fink, M.A.3    Starr, B.4    Schreiber, H.5
  • 17
    • 84894559188 scopus 로고    scopus 로고
    • Tumour antigens recognized by T lymphocytes: At the core of cancer immunotherapy
    • Coulie, P. G., Van den Eynde, B. J., van der Bruggen, P. & Boon, T. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nature Rev. Cancer 14, 135-146 (2014).
    • (2014) Nature Rev. Cancer , vol.14 , pp. 135-146
    • Coulie, P.G.1    Van Den Eynde, B.J.2    Van Der Bruggen, P.3    Boon, T.4
  • 20
    • 0034695886 scopus 로고    scopus 로고
    • Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4∗0101-0103 and recognized by CD4+ T lymphocytes of patients with NY-ESO-1-expressing melanoma
    • Jäger, E. et al. Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4∗0101-0103 and recognized by CD4+ T lymphocytes of patients with NY-ESO-1-expressing melanoma. J. Exp. Med. 191, 625-630 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 625-630
    • Jäger, E.1
  • 21
    • 2642683198 scopus 로고    scopus 로고
    • Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: Definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes
    • Jäger, E. et al. Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J. Exp. Med. 187, 265-270 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 265-270
    • Jäger, E.1
  • 22
    • 0033151628 scopus 로고    scopus 로고
    • Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family
    • Tanzarella, S. et al. Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family. Cancer Res. 59, 2668-2674 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 2668-2674
    • Tanzarella, S.1
  • 23
    • 85047692172 scopus 로고    scopus 로고
    • Therapeutic vaccines for cancer: An overview of clinical trials
    • Melero, I. et al. Therapeutic vaccines for cancer: an overview of clinical trials. Nature Rev. Clin. Oncol. 11, 509-524 (2014).
    • (2014) Nature Rev. Clin. Oncol. , vol.11 , pp. 509-524
    • Melero, I.1
  • 24
    • 0030954442 scopus 로고    scopus 로고
    • Mutated mitogen-activated protein kinase: A tumor rejection antigen of mouse sarcoma
    • Ikeda, H. et al. Mutated mitogen-activated protein kinase: A tumor rejection antigen of mouse sarcoma. Proc. Natl Acad. Sci. USA 94, 6375-6379 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 6375-6379
    • Ikeda, H.1
  • 25
    • 84928811341 scopus 로고    scopus 로고
    • Mutant MHC class II epitopes drive therapeutic immune responses to cancer
    • Kreiter, S. et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature 520, 692-696 (2015).
    • (2015) Nature , vol.520 , pp. 692-696
    • Kreiter, S.1
  • 26
    • 84920921528 scopus 로고    scopus 로고
    • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
    • Gubin, M. M. et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, 577-581 (2014).
    • (2014) Nature , vol.515 , pp. 577-581
    • Gubin, M.M.1
  • 27
    • 84920956731 scopus 로고    scopus 로고
    • Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
    • Yadav, M. et al. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature 515, 572-576 (2014).
    • (2014) Nature , vol.515 , pp. 572-576
    • Yadav, M.1
  • 28
    • 84857725402 scopus 로고    scopus 로고
    • Exploiting the mutanome for tumor vaccination
    • Castle, J. C. et al. Exploiting the mutanome for tumor vaccination. Cancer Res. 72, 1081-1091 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 1081-1091
    • Castle, J.C.1
  • 29
    • 84900301377 scopus 로고    scopus 로고
    • Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
    • Tran, E. et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344, 641-645 (2014).
    • (2014) Science , vol.344 , pp. 641-645
    • Tran, E.1
  • 30
    • 84879101382 scopus 로고    scopus 로고
    • Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression
    • Lu, Y. C. et al. Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression. J. Immunol. 190, 6034-6042 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 6034-6042
    • Lu, Y.C.1
  • 31
    • 84872841412 scopus 로고    scopus 로고
    • Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
    • van Rooij, N. et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J. Clin. Oncol. 31, e439-e442 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. e439-e442
    • Van Rooij, N.1
  • 32
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • Robbins, P. F. et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nature Med. 19, 747-752 (2013).
    • (2013) Nature Med. , vol.19 , pp. 747-752
    • Robbins, P.F.1
  • 33
    • 84961323160 scopus 로고    scopus 로고
    • High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
    • Linnemann, C. et al. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma. Nature Med. 21, 81-85 (2015).
    • (2015) Nature Med. , vol.21 , pp. 81-85
    • Linnemann, C.1
  • 34
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley, M. E. et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298, 850-854 (2002).
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1
  • 35
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley, M. E. et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J. Clin. Oncol. 26, 5233-5239 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5233-5239
    • Dudley, M.E.1
  • 36
    • 77951714425 scopus 로고    scopus 로고
    • Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients
    • Besser, M. J. et al. Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients. Clin. Cancer Res. 16, 2646-2655 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2646-2655
    • Besser, M.J.1
  • 37
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg, S. A. et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin. Cancer Res. 17, 4550-4557 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1
  • 38
    • 84976406873 scopus 로고    scopus 로고
    • Neoantigen landscape dynamics during human melanoma-T cell interactions
    • Verdegaal, E. M. et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature 536, 91-95 (2016).
    • (2016) Nature , vol.536 , pp. 91-95
    • Verdegaal, E.M.1
  • 39
    • 54749102754 scopus 로고    scopus 로고
    • Cause and consequences of genetic and epigenetic alterations in human cancer
    • Sadikovic, B., Al-Romaih, K., Squire, J. A. & Zielenska, M. Cause and consequences of genetic and epigenetic alterations in human cancer. Curr. Genomics 9, 394-408 (2008).
    • (2008) Curr. Genomics , vol.9 , pp. 394-408
    • Sadikovic, B.1    Al-Romaih, K.2    Squire, J.A.3    Zielenska, M.4
  • 40
    • 0023818008 scopus 로고
    • Individually distinct transplantation antigens of chemically induced mouse tumors
    • Srivastava, P. K. & Old, L. J. Individually distinct transplantation antigens of chemically induced mouse tumors. Immunol. Today 9, 78-83 (1988).
    • (1988) Immunol. Today , vol.9 , pp. 78-83
    • Srivastava, P.K.1    Old, L.J.2
  • 41
    • 84963542411 scopus 로고    scopus 로고
    • Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers
    • Dieu-Nosjean, M. C. et al. Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers. Immunol. Rev. 271, 260-275 (2016).
    • (2016) Immunol. Rev. , vol.271 , pp. 260-275
    • Dieu-Nosjean, M.C.1
  • 42
    • 84864378851 scopus 로고    scopus 로고
    • Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection
    • Angelosanto, J. M., Blackburn, S. D., Crawford, A. & Wherry, E. J. Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection. J. Virol. 86, 8161-8170 (2012).
    • (2012) J. Virol. , vol.86 , pp. 8161-8170
    • Angelosanto, J.M.1    Blackburn, S.D.2    Crawford, A.3    Wherry, E.J.4
  • 43
    • 84870230232 scopus 로고    scopus 로고
    • Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
    • Paley, M. A. et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338, 1220-1225 (2012).
    • (2012) Science , vol.338 , pp. 1220-1225
    • Paley, M.A.1
  • 44
    • 84960450202 scopus 로고    scopus 로고
    • MAP kinase inhibition promotes T cell and anti-tumor activity in combination with PD-L1 checkpoint blockade
    • Ebert, P. J. et al. MAP kinase inhibition promotes T cell and anti-tumor activity in combination with PD-L1 checkpoint blockade. Immunity 44, 609-621 (2016).
    • (2016) Immunity , vol.44 , pp. 609-621
    • Ebert, P.J.1
  • 45
    • 84927666190 scopus 로고    scopus 로고
    • The BRAF and MEK inhibitors dabrafenib and trametinib: Effects on immune function and in combination with immunomodulatory antibodies targeting PD-1, PD-L1, and CTLA-4
    • Liu, L. et al. The BRAF and MEK inhibitors dabrafenib and trametinib: effects on immune function and in combination with immunomodulatory antibodies targeting PD-1, PD-L1, and CTLA-4. Clin. Cancer Res. 21, 1639-1651 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1639-1651
    • Liu, L.1
  • 46
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber, D. L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 47
    • 84988266244 scopus 로고    scopus 로고
    • Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
    • Im, S. J. et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537, 417-421 (2016).
    • (2016) Nature , vol.537 , pp. 417-421
    • Im, S.J.1
  • 48
    • 84981285538 scopus 로고    scopus 로고
    • CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
    • Leong, Y. A. et al. CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles. Nature Immunol. 17, 1187-1196 (2016).
    • (2016) Nature Immunol. , vol.17 , pp. 1187-1196
    • Leong, Y.A.1
  • 49
    • 84988410229 scopus 로고    scopus 로고
    • Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection
    • He, R. et al. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature 537, 412-428 (2016).
    • (2016) Nature , vol.537 , pp. 412-428
    • He, R.1
  • 50
    • 84983216790 scopus 로고    scopus 로고
    • Mutations associated with acquired resistance to PD-1 blockade in melanoma
    • Zaretsky, J. M. et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N. Engl. J. Med. 375, 819-829 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 819-829
    • Zaretsky, J.M.1
  • 51
    • 84967321420 scopus 로고    scopus 로고
    • The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition
    • Hegde, P. S., Karanikas, V. & Evers, S. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin. Cancer Res. 22, 1865-1874 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1865-1874
    • Hegde, P.S.1    Karanikas, V.2    Evers, S.3
  • 52
    • 84877330702 scopus 로고    scopus 로고
    • Cancer immunoediting: Antigens, mechanisms, and implications to cancer immunotherapy
    • Vesely, M. D. & Schreiber, R. D. Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy. Ann. NY Acad. Sci. 1284, 1-5 (2013).
    • (2013) Ann. NY Acad. Sci. , vol.1284 , pp. 1-5
    • Vesely, M.D.1    Schreiber, R.D.2
  • 53
    • 36849010167 scopus 로고    scopus 로고
    • Adaptive immunity maintains occult cancer in an equilibrium state
    • Koebel, C. M. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450, 903-907 (2007).
    • (2007) Nature , vol.450 , pp. 903-907
    • Koebel, C.M.1
  • 54
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23-34 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 23-34
    • Larkin, J.1
  • 55
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
    • Gros, A. et al. PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. J. Clin. Invest. 124, 2246-2259 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2246-2259
    • Gros, A.1
  • 56
    • 84891847993 scopus 로고    scopus 로고
    • The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
    • Fang, L. et al. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro. Oncol. 15, 1479-1490 (2013).
    • (2013) Neuro. Oncol. , vol.15 , pp. 1479-1490
    • Fang, L.1
  • 57
    • 84855165057 scopus 로고    scopus 로고
    • Characterization of T-cell memory phenotype after in vitro expansion of tumor-infiltrating lymphocytes from melanoma patients
    • Zhou, J., Nagarkatti, P., Zhong, Y. & Nagarkatti, M. Characterization of T-cell memory phenotype after in vitro expansion of tumor-infiltrating lymphocytes from melanoma patients. Anticancer Res. 31, 4099-4109 (2011).
    • (2011) Anticancer Res. , vol.31 , pp. 4099-4109
    • Zhou, J.1    Nagarkatti, P.2    Zhong, Y.3    Nagarkatti, M.4
  • 58
    • 84870352830 scopus 로고    scopus 로고
    • Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma
    • Wang, Q. J., Hanada, K., Robbins, P. F., Li, Y. F. & Yang, J. C. Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma. Cancer Res. 72, 6119-6129 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 6119-6129
    • Wang, Q.J.1    Hanada, K.2    Robbins, P.F.3    Li, Y.F.4    Yang, J.C.5
  • 59
    • 84890086459 scopus 로고    scopus 로고
    • Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments
    • Inoue, H. & Tani, K. Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments. Cell Death Differ. 21, 39-49 (2014).
    • (2014) Cell Death Differ. , vol.21 , pp. 39-49
    • Inoue, H.1    Tani, K.2
  • 60
    • 84945232013 scopus 로고    scopus 로고
    • RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells
    • Yatim, N. et al. RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells. Science 350, 328-334 (2015).
    • (2015) Science , vol.350 , pp. 328-334
    • Yatim, N.1
  • 61
    • 84956607773 scopus 로고    scopus 로고
    • Immunological effects of conventional chemotherapy and targeted anticancer agents
    • Galluzzi, L., Buque, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunological effects of conventional chemotherapy and targeted anticancer agents. Cancer Cell 28, 690-714 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 690-714
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 62
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst, R. S. et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515, 563-567 (2014).
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1
  • 63
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 64
    • 84902191817 scopus 로고    scopus 로고
    • IL-2: The first effective immunotherapy for human cancer
    • Rosenberg, S. A. IL-2: The first effective immunotherapy for human cancer. J. Immunol. 192, 5451-5458 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 5451-5458
    • Rosenberg, S.A.1
  • 65
    • 84877072174 scopus 로고    scopus 로고
    • Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
    • Gajewski, T. F. et al. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr. Opin. Immunol. 25, 268-276 (2013).
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 268-276
    • Gajewski, T.F.1
  • 66
    • 84940372582 scopus 로고    scopus 로고
    • The next hurdle in cancer immunotherapy: Overcoming the non-T-cell-inflamed tumor microenvironment
    • Gajewski, T. F. The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment. Semin. Oncol. 42, 663-671 (2015).
    • (2015) Semin. Oncol. , vol.42 , pp. 663-671
    • Gajewski, T.F.1
  • 67
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568-571 (2014).
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1
  • 68
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
    • Spranger, S. et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci. Transl. Med. 5, 200ra116 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 200ra116
    • Spranger, S.1
  • 69
    • 84962038946 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial
    • Fehrenbacher, L. et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial. Lancet 387, 1837-1846 (2016).
    • (2016) Lancet , vol.387 , pp. 1837-1846
    • Fehrenbacher, L.1
  • 70
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
    • Rosenberg, J. E. et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial. Lancet 387, 1909-1920 (2016).
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1
  • 71
    • 84962497081 scopus 로고    scopus 로고
    • Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: Long-term safety, clinical activity, and immune correlates from a phase Ia study
    • McDermott, D. F. et al. Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study. J. Clin. Oncol. 34, 833-842 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 833-842
    • McDermott, D.F.1
  • 72
    • 66149156276 scopus 로고    scopus 로고
    • Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
    • Harlin, H. et al. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res. 69, 3077-3085 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3077-3085
    • Harlin, H.1
  • 73
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube, J. M. et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin. Cancer Res. 20, 5064-5074 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 5064-5074
    • Taube, J.M.1
  • 74
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles, T. et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 515, 558-562 (2014).
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1
  • 75
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon, E. B. et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N. Engl. J. Med. 372, 2018-2028 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2018-2028
    • Garon, E.B.1
  • 76
    • 84928771999 scopus 로고    scopus 로고
    • T cell exclusion, immune privilege, and the tumor microenvironment
    • Joyce, J. A. & Fearon, D. T. T cell exclusion, immune privilege, and the tumor microenvironment. Science 348, 74-80 (2015).
    • (2015) Science , vol.348 , pp. 74-80
    • Joyce, J.A.1    Fearon, D.T.2
  • 77
    • 84857826513 scopus 로고    scopus 로고
    • Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
    • Salmon, H. et al. Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J. Clin. Invest. 122, 899-910 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 899-910
    • Salmon, H.1
  • 78
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski, T. F., Schreiber, H. & Fu, Y. X. Innate and adaptive immune cells in the tumor microenvironment. Nature Immunol. 14, 1014-1022 (2013).
    • (2013) Nature Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 80
    • 84871716970 scopus 로고    scopus 로고
    • Basic principles of tumor-associated regulatory T cell biology
    • Savage, P. A., Malchow, S. & Leventhal, D. S. Basic principles of tumor-associated regulatory T cell biology. Trends Immunol. 34, 33-40 (2013).
    • (2013) Trends Immunol. , vol.34 , pp. 33-40
    • Savage, P.A.1    Malchow, S.2    Leventhal, D.S.3
  • 81
    • 84954457746 scopus 로고    scopus 로고
    • Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade
    • Muller, P. et al. Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade. Sci. Transl. Med. 7, 315ra188 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 315ra188
    • Muller, P.1
  • 82
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nature Rev. Cancer 12, 252-264 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 83
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 84
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 85
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Le, D. T. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509-2520 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2509-2520
    • Le, D.T.1
  • 86
    • 84991204006 scopus 로고    scopus 로고
    • PD-L1 expression, Cancer Genome Atlas (TCGA) subtype, and mutational load as independent predictors of response to atezolizumab (atezo) in metastatic urothelial carcinoma (mUC; IMvigor210)
    • Rosenberg, J. et al. PD-L1 expression, Cancer Genome Atlas (TCGA) subtype, and mutational load as independent predictors of response to atezolizumab (atezo) in metastatic urothelial carcinoma (mUC; IMvigor210). J. Clin. Oncol. 34 (suppl.), 104 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 104
    • Rosenberg, J.1
  • 87
    • 84988566673 scopus 로고    scopus 로고
    • Spatiotemporal effects on programmed death ligand 1 (PD-L1) expression and immunophenotype of non-small cell lung cancer (NSCLC)
    • Kowanetz, M. et al. Spatiotemporal effects on programmed death ligand 1 (PD-L1) expression and immunophenotype of non-small cell lung cancer (NSCLC). J. Thorac. Oncol. 10 (suppl. 2), S199 (2015).
    • (2015) J. Thorac. Oncol. , vol.10 , pp. S199
    • Kowanetz, M.1
  • 88
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48-61 (2015).
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 89
    • 84953369260 scopus 로고    scopus 로고
    • Metastatic spread in patients with non-small cell lung cancer is associated with a reduced density of tumor-infiltrating T cells
    • Müller, P. et al. Metastatic spread in patients with non-small cell lung cancer is associated with a reduced density of tumor-infiltrating T cells. Cancer Immunol. Immunother. 65, 1-11 (2016).
    • (2016) Cancer Immunol. Immunother. , vol.65 , pp. 1-11
    • Müller, P.1
  • 90
    • 84944460024 scopus 로고    scopus 로고
    • Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens
    • Baine, M. K. et al. Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens. Oncotarget 6, 24990-25002 (2015).
    • (2015) Oncotarget , vol.6 , pp. 24990-25002
    • Baine, M.K.1
  • 91
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher, T. N. & Schreiber, R. D. Neoantigens in cancer immunotherapy. Science 348, 69-74 (2015).
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 92
    • 0029967963 scopus 로고    scopus 로고
    • Suppression of MHC class i antigens in oncogenic transformants: Association with decreased recognition by cytotoxic T lymphocytes
    • Seliger, B. et al. Suppression of MHC class I antigens in oncogenic transformants: association with decreased recognition by cytotoxic T lymphocytes. Exp. Hematol. 24, 1275-1279 (1996).
    • (1996) Exp. Hematol. , vol.24 , pp. 1275-1279
    • Seliger, B.1
  • 93
    • 0031964480 scopus 로고    scopus 로고
    • Down-regulation of the MHC class i antigen-processing machinery after oncogenic transformation of murine fibroblasts
    • Seliger, B. et al. Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts. Eur. J. Immunol. 28, 122-133 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 122-133
    • Seliger, B.1
  • 94
    • 1242319374 scopus 로고    scopus 로고
    • MHC class i antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma
    • Atkins, D. et al. MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma. Int. J. Cancer 109, 265-273 (2004).
    • (2004) Int. J. Cancer , vol.109 , pp. 265-273
    • Atkins, D.1
  • 95
    • 84961937792 scopus 로고    scopus 로고
    • BRAFV600E co-opts a conserved MHC class i internalization pathway to diminish antigen presentation and CD8+ T-cell recognition of melanoma
    • Bradley, S. D. et al. BRAFV600E co-opts a conserved MHC class I internalization pathway to diminish antigen presentation and CD8+ T-cell recognition of melanoma. Cancer. Immunol. Res. 3, 602-609 (2015).
    • (2015) Cancer. Immunol. Res. , vol.3 , pp. 602-609
    • Bradley, S.D.1
  • 96
    • 84911201387 scopus 로고    scopus 로고
    • Molecular regulation of effector and memory T cell differentiation
    • Chang, J. T., Wherry, E. J. & Goldrath, A. W. Molecular regulation of effector and memory T cell differentiation. Nature Immunol. 15, 1104-1115 (2014).
    • (2014) Nature Immunol. , vol.15 , pp. 1104-1115
    • Chang, J.T.1    Wherry, E.J.2    Goldrath, A.W.3
  • 97
    • 84874106288 scopus 로고    scopus 로고
    • DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer
    • Tekpli, X. et al. DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer. Cancer Immunol. Immunother. 62, 337-345 (2013).
    • (2013) Cancer Immunol. Immunother. , vol.62 , pp. 337-345
    • Tekpli, X.1
  • 98
    • 84923251407 scopus 로고    scopus 로고
    • Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    • Chen, L. et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nature Commun. 5, 5241 (2014).
    • (2014) Nature Commun. , vol.5 , pp. 5241
    • Chen, L.1
  • 99
    • 84964035466 scopus 로고    scopus 로고
    • Molecular, immune and histopathological characterization of NSCLC based on PDL1 expression on tumor and immune cells and assocation with response to the anti-PDL1 antibody MPDL3280A
    • Gettinger, S. N. et al. Molecular, immune and histopathological characterization of NSCLC based on PDL1 expression on tumor and immune cells and assocation with response to the anti-PDL1 antibody MPDL3280A. J. Clin. Oncol. 33 (suppl.), 3015 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 3015
    • Gettinger, S.N.1
  • 100
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
    • Calon, A. et al. Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell 22, 571-584 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 571-584
    • Calon, A.1
  • 101
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism
    • Coombes, J. L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J. Exp. Med. 204, 1757-1764 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1
  • 102
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    • Feig, C. et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc. Natl Acad. Sci. USA 110, 20212-20217 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 20212-20217
    • Feig, C.1
  • 103
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • Royal, R. E. et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J. Immunother. 33, 828-833 (2010).
    • (2010) J. Immunother. , vol.33 , pp. 828-833
    • Royal, R.E.1
  • 104
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer, J. R. et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28, 3167-3175 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1
  • 105
    • 84888086049 scopus 로고    scopus 로고
    • A phase i study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
    • Beatty, G. L. et al. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin. Cancer Res. 19, 6286-6295 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 6286-6295
    • Beatty, G.L.1
  • 106
    • 84936891410 scopus 로고    scopus 로고
    • Heterogeneity of autoimmune diseases: Pathophysiologic insights from genetics and implications for new therapies
    • Cho, J. H. & Feldman, M. Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies. Nature Med. 21, 730-738 (2015).
    • (2015) Nature Med. , vol.21 , pp. 730-738
    • Cho, J.H.1    Feldman, M.2
  • 107
    • 84882449068 scopus 로고    scopus 로고
    • Genetic insights into common pathways and complex relationships among immune-mediated diseases
    • Parkes, M., Cortes, A., van Heel, D. A. & Brown, M. A. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nature Rev. Genet. 14, 661-673 (2013).
    • (2013) Nature Rev. Genet. , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    Van Heel, D.A.3    Brown, M.A.4
  • 108
    • 84896344216 scopus 로고    scopus 로고
    • Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli
    • Duffy, D. et al. Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli. Immunity 40, 436-450 (2014).
    • (2014) Immunity , vol.40 , pp. 436-450
    • Duffy, D.1
  • 109
    • 85044695622 scopus 로고    scopus 로고
    • Cancer and the microbiota
    • Garrett, W. S. Cancer and the microbiota. Science 348, 80-86 (2015).
    • (2015) Science , vol.348 , pp. 80-86
    • Garrett, W.S.1
  • 110
    • 84888049920 scopus 로고    scopus 로고
    • Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    • Iida, N. et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342, 967-970 (2013).
    • (2013) Science , vol.342 , pp. 967-970
    • Iida, N.1
  • 111
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    • Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084-1089 (2015).
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 112
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • Vétizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vétizou, M.1
  • 113
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • Viaud, S. et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971-976 (2013).
    • (2013) Science , vol.342 , pp. 971-976
    • Viaud, S.1
  • 114
    • 84957565779 scopus 로고    scopus 로고
    • Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
    • Dubin, K. et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nature Commun. 7, 10391 (2016).
    • (2016) Nature Commun. , vol.7 , pp. 10391
    • Dubin, K.1
  • 115
    • 84965178537 scopus 로고    scopus 로고
    • Influence of statins on influenza vaccine response in elderly individuals
    • Black, S., Nicolay, U., Del Giudice, G. & Rappuoli, R. Influence of statins on influenza vaccine response in elderly individuals. J. Infect. Dis. 213, 1224-1228 (2016).
    • (2016) J. Infect. Dis. , vol.213 , pp. 1224-1228
    • Black, S.1    Nicolay, U.2    Del Giudice, G.3    Rappuoli, R.4
  • 116
    • 84964294900 scopus 로고    scopus 로고
    • Widespread seasonal gene expression reveals annual differences in human immunity and physiology
    • Dopico, X. C. et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nature Commun. 6, 7000 (2015).
    • (2015) Nature Commun. , vol.6 , pp. 7000
    • Dopico, X.C.1
  • 117
    • 84892778834 scopus 로고    scopus 로고
    • Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires
    • Wang, C. et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J. Immunol. 192, 603-611 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 603-611
    • Wang, C.1
  • 118
    • 79960997012 scopus 로고    scopus 로고
    • Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
    • Sasaki, S. et al. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J. Clin. Invest. 121, 3109-3119 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 3109-3119
    • Sasaki, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.