메뉴 건너뛰기




Volumn 19, Issue 5, 2019, Pages 305-323

Mining the microbiota for microbial and metabolite-based immunotherapies

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL ACTIVITY; DENDRITIC CELL; EFFECTOR CELL; FECES MICROFLORA; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; INTRAEPITHELIAL LYMPHOCYTE; LIVER CANCER; MICROBIOME; MICROFLORA; MUCOSAL-ASSOCIATED INVARIANT T CELL; NATURAL KILLER T CELL; NERVE CELL; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; TH1 CELL; TH17 CELL; ANIMAL; BACTERIUM; IMMUNOLOGY; IMMUNOTHERAPY; INTESTINE FLORA; MAMMAL; PROCEDURES;

EID: 85062881986     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/s41577-019-0144-5     Document Type: Review
Times cited : (230)

References (284)
  • 1
    • 85019737857 scopus 로고    scopus 로고
    • Colonization and succession within the human gut microbiome by archaea, bacteria, and microeukaryotes during the first year of life
    • PID: 28512451
    • Wampach, L. et al. Colonization and succession within the human gut microbiome by archaea, bacteria, and microeukaryotes during the first year of life. Front. Microbiol. 8, 738 (2017).
    • (2017) Front. Microbiol. , vol.8 , pp. 738
    • Wampach, L.1
  • 2
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • COI: 1:CAS:528:DC%2BC38Xos1ejurs%3D, This study shows the enormous heterogeneity of phylogenetic composition the healthy human microbiota, as well as the relative stability of metabolic pathways
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214 (2012). Shows the enormous heterogeneity in phylogenetic composition of healthy human microbiota and relative stability of metabolic pathways.
    • (2012) Nature , vol.486 , pp. 207-214
  • 3
    • 85053167207 scopus 로고    scopus 로고
    • Causal effects of the microbiota on immune-mediated diseases
    • PID: 29440265
    • Round, J. L. & Palm, N. W. Causal effects of the microbiota on immune-mediated diseases. Sci. Immunol. 3, eaao1603 (2018).
    • (2018) Sci. Immunol. , vol.3
    • Round, J.L.1    Palm, N.W.2
  • 4
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • COI: 1:CAS:528:DC%2BC3cXislahsLc%3D, PID: 20203603
    • Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65 (2010).
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1
  • 5
    • 85005965070 scopus 로고    scopus 로고
    • The human intestinal microbiome in health and disease
    • COI: 1:CAS:528:DC%2BC2sXhvVSnsQ%3D%3D
    • Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369–2379 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 2369-2379
    • Lynch, S.V.1    Pedersen, O.2
  • 7
    • 84999041258 scopus 로고    scopus 로고
    • Dysbiosis is not an answer
    • COI: 1:CAS:528:DC%2BC2sXkvFyqsr0%3D, PID: 27886190
    • Olesen, S. W. & Alm, E. J. Dysbiosis is not an answer. Nat. Microbiol. 1, 16228 (2016).
    • (2016) Nat. Microbiol. , vol.1 , pp. 16228
    • Olesen, S.W.1    Alm, E.J.2
  • 8
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BD2sXpvVGjsbg%3D, PID: 17699621
    • Frank, D. N. et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl Acad. Sci. USA 104, 13780–13785 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1
  • 9
    • 84863022950 scopus 로고    scopus 로고
    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
    • COI: 1:CAS:528:DC%2BC38XhsFygtrg%3D, PID: 22009990
    • Kostic, A. D. et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22, 292–298 (2012).
    • (2012) Genome Res. , vol.22 , pp. 292-298
    • Kostic, A.D.1
  • 10
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • COI: 1:CAS:528:DC%2BC3sXhvFGiurbF, PID: 3897394
    • Hsiao, E. Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451–1463 (2013).
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 11
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • COI: 1:CAS:528:DC%2BD1cXht1yju7%2FK, PID: 18806780
    • Wen, L. et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 455, 1109–1113 (2008).
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1
  • 12
    • 84871814687 scopus 로고    scopus 로고
    • Symptomatic atherosclerosis is associated with an altered gut metagenome
    • PID: 23212374, COI: 1:CAS:528:DC%2BC3sXhsVCisrs%3D
    • Karlsson, F. H. et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat. Commun. 3, 1245 (2012).
    • (2012) Nat. Commun. , vol.3
    • Karlsson, F.H.1
  • 13
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • COI: 1:CAS:528:DC%2BD28XhtlemtLvM, PID: 17183309
    • Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022–1023 (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 14
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • PID: 17183312
    • Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031 (2006).
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 15
    • 52649090774 scopus 로고    scopus 로고
    • An Invitation to the marriage of metagenomics and metabolomics
    • COI: 1:CAS:528:DC%2BD1cXhtFCqs7jL, PID: 18775300
    • Turnbaugh, P. J. & Gordon, J. I. An Invitation to the marriage of metagenomics and metabolomics. Cell 134, 708–713 (2008).
    • (2008) Cell , vol.134 , pp. 708-713
    • Turnbaugh, P.J.1    Gordon, J.I.2
  • 16
    • 84978134353 scopus 로고    scopus 로고
    • Microbiome-wide association studies link dynamic microbial consortia to disease
    • COI: 1:CAS:528:DC%2BC28XhtFensLzF, PID: 27383984
    • Gilbert, J. A. et al. Microbiome-wide association studies link dynamic microbial consortia to disease. Nature 535, 94–103 (2016).
    • (2016) Nature , vol.535 , pp. 94-103
    • Gilbert, J.A.1
  • 17
    • 84861988021 scopus 로고    scopus 로고
    • Microbiota, disease, and back to health: a metastable journey
    • PID: 22674557, COI: 1:CAS:528:DC%2BC3sXptVeltA%3D%3D
    • Blumberg, R. & Powrie, F. Microbiota, disease, and back to health: a metastable journey. Sci. Transl Med. 4, 137rv7 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 137rv7
    • Blumberg, R.1    Powrie, F.2
  • 18
    • 84866174523 scopus 로고    scopus 로고
    • Genomic approaches to studying the human microbiota
    • COI: 1:CAS:528:DC%2BC38XhtleqsrzO, PID: 22972298
    • Weinstock, G. M. Genomic approaches to studying the human microbiota. Nature 489, 250–256 (2012).
    • (2012) Nature , vol.489 , pp. 250-256
    • Weinstock, G.M.1
  • 19
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • COI: 1:CAS:528:DC%2BC38Xhtleru7jO, PID: 22972295
    • Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. & Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489, 220–230 (2012).
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3    Jansson, J.K.4    Knight, R.5
  • 20
    • 85038231037 scopus 로고    scopus 로고
    • Moving beyond microbiome-wide associations to causal microbe identification
    • COI: 1:CAS:528:DC%2BC2sXhvFGlsbzI, PID: 29211710
    • Surana, N. K. & Kasper, D. L. Moving beyond microbiome-wide associations to causal microbe identification. Nature 552, 244 (2017).
    • (2017) Nature , vol.552 , pp. 244
    • Surana, N.K.1    Kasper, D.L.2
  • 21
    • 85050885001 scopus 로고    scopus 로고
    • Microbiome: focus on causation and mechanism
    • COI: 1:CAS:528:DC%2BC1cXhsVyltrjM, PID: 30096310
    • Fischbach, M. A. Microbiome: focus on causation and mechanism. Cell 174, 785–790 (2018).
    • (2018) Cell , vol.174 , pp. 785-790
    • Fischbach, M.A.1
  • 22
    • 85020788732 scopus 로고    scopus 로고
    • Understanding the holobiont: how microbial metabolites affect human health and shape the immune system
    • COI: 1:CAS:528:DC%2BC2sXhtVWrur3J, PID: 28625867
    • Postler, T. S. & Ghosh, S. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metab. 26, 110–130 (2017).
    • (2017) Cell Metab. , vol.26 , pp. 110-130
    • Postler, T.S.1    Ghosh, S.2
  • 23
    • 84969704060 scopus 로고    scopus 로고
    • Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
    • COI: 1:CAS:528:DC%2BC28Xnt1Ogsrg%3D, PID: 4890681
    • Browne, H. P. et al. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature 533, 543–546 (2016).
    • (2016) Nature , vol.533 , pp. 543-546
    • Browne, H.P.1
  • 24
    • 84994399678 scopus 로고    scopus 로고
    • Culture of previously uncultured members of the human gut microbiota by culturomics
    • COI: 1:CAS:528:DC%2BC2sXkvFyruro%3D
    • Lagier, J.-C. et al. Culture of previously uncultured members of the human gut microbiota by culturomics. Nat. Microbiol. 1, 16203 (2016).
    • (2016) Nat. Microbiol. , vol.1 , pp. 16203
    • Lagier, J.-C.1
  • 25
    • 85048972988 scopus 로고    scopus 로고
    • Culturing the human microbiota and culturomics
    • COI: 1:CAS:528:DC%2BC1cXht1Smt7vI
    • Lagier, J.-C. et al. Culturing the human microbiota and culturomics. Nat. Rev. Microbiol. 16, 540–550 (2018).
    • (2018) Nat. Rev. Microbiol. , vol.16 , pp. 540-550
    • Lagier, J.-C.1
  • 26
    • 62649151803 scopus 로고    scopus 로고
    • Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
    • COI: 1:CAS:528:DC%2BD1MXjt1Gksrk%3D, PID: 19234110
    • Wikoff, W. R. et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc. Natl Acad. Sci. USA 106, 3698–3703 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3698-3703
    • Wikoff, W.R.1
  • 27
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • COI: 1:CAS:528:DC%2BC2cXhtFOls78%3D
    • David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559–563 (2014).
    • (2014) Nature , vol.505 , pp. 559-563
    • David, L.A.1
  • 28
    • 84905968786 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for the treatment of clostridium difficile infection: a systematic review
    • PID: 24440934
    • Cammarota, G., Ianiro, G. & Gasbarrini, A. Fecal microbiota transplantation for the treatment of clostridium difficile infection: a systematic review. J. Clin. Gastroenterol. 48, 693–702 (2014).
    • (2014) J. Clin. Gastroenterol. , vol.48 , pp. 693-702
    • Cammarota, G.1    Ianiro, G.2    Gasbarrini, A.3
  • 29
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • PID: 23323867, COI: 1:CAS:528:DC%2BC3sXitVelsbs%3D, This study highlights the striking efficacy of FMT for treating CDI
    • van Nood, E. et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407–415 (2013). This study highlights the striking efficacy of FMT for treating CDI.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 407-415
    • van Nood, E.1
  • 30
    • 85044337697 scopus 로고    scopus 로고
    • Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation
    • COI: 1:CAS:528:DC%2BC1cXivVSlsr0%3D, PID: 29447696
    • Smillie, C. S. et al. Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation. Cell Host Microbe 23, 229–240 (2018).
    • (2018) Cell Host Microbe , vol.23 , pp. 229-240
    • Smillie, C.S.1
  • 31
    • 84968880438 scopus 로고    scopus 로고
    • Durable coexistence of donor and recipient strains after fecal microbiota transplantation
    • COI: 1:CAS:528:DC%2BC28Xms1KisLg%3D, PID: 27126044
    • Li, S. S. et al. Durable coexistence of donor and recipient strains after fecal microbiota transplantation. Science 352, 586–589 (2016).
    • (2016) Science , vol.352 , pp. 586-589
    • Li, S.S.1
  • 32
    • 84982822142 scopus 로고    scopus 로고
    • Fecal transplants: what is being transferred?
    • PID: 27404502, COI: 1:CAS:528:DC%2BC2sXovVyht7g%3D
    • Bojanova, D. P. & Bordenstein, S. R. Fecal transplants: what is being transferred? PLOS Biol. 14, e1002503 (2016).
    • (2016) PLOS Biol. , vol.14
    • Bojanova, D.P.1    Bordenstein, S.R.2
  • 33
    • 85014315210 scopus 로고    scopus 로고
    • Efficacy of sterile fecal filtrate transfer for treating patients with Clostridium difficile infection
    • PID: 27866880
    • Ott, S. J. et al. Efficacy of sterile fecal filtrate transfer for treating patients with Clostridium difficile infection. Gastroenterology 152, 799–811 (2017).
    • (2017) Gastroenterology , vol.152 , pp. 799-811
    • Ott, S.J.1
  • 34
    • 84929148131 scopus 로고    scopus 로고
    • Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C difficile infection: a randomized clinical trial
    • PID: 25942722
    • Gerding, D. N. et al. Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C difficile infection: a randomized clinical trial. JAMA 313, 1719–1727 (2015).
    • (2015) JAMA , vol.313 , pp. 1719-1727
    • Gerding, D.N.1
  • 35
    • 84884908772 scopus 로고    scopus 로고
    • Systematic review: the efficacy of herbal therapy in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3sXhsFGgsLnJ, PID: 23981095
    • Ng, S. C. et al. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Aliment. Pharmacol. Ther. 38, 854–863 (2013).
    • (2013) Aliment. Pharmacol. Ther. , vol.38 , pp. 854-863
    • Ng, S.C.1
  • 36
    • 84931423571 scopus 로고    scopus 로고
    • Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis
    • PID: 25836986
    • Rossen, N. G. et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 149, 110–118 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 110-118
    • Rossen, N.G.1
  • 37
    • 84931469899 scopus 로고    scopus 로고
    • Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial
    • PID: 25857665
    • Moayyedi, P. et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149, 102–109 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 102-109
    • Moayyedi, P.1
  • 38
    • 85012869662 scopus 로고    scopus 로고
    • Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial
    • PID: 28214091
    • Paramsothy, S. et al. Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 389, 1218–1228 (2017).
    • (2017) Lancet , vol.389 , pp. 1218-1228
    • Paramsothy, S.1
  • 39
    • 84992074418 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut
    • COI: 1:CAS:528:DC%2BC2sXhtlSit7k%3D, PID: 27461930
    • Kakihana, K. et al. Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut. Blood 128, 2083–2088 (2016).
    • (2016) Blood , vol.128 , pp. 2083-2088
    • Kakihana, K.1
  • 40
    • 85058106303 scopus 로고    scopus 로고
    • Fecal microbiota transplantation as safe and successful therapy for intestinal graft-versus-host disease
    • Van Lier, Y. F. et al. Fecal microbiota transplantation as safe and successful therapy for intestinal graft-versus-host disease. Blood 130, 1986 (2017).
    • (2017) Blood , vol.130 , pp. 1986
    • Van Lier, Y.F.1
  • 41
    • 85025454802 scopus 로고    scopus 로고
    • Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation
    • COI: 1:CAS:528:DC%2BC2sXht1Wgu7vE, PID: 28733895
    • Doki, N. et al. Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation. Ann. Hematol. 96, 1517–1523 (2017).
    • (2017) Ann. Hematol. , vol.96 , pp. 1517-1523
    • Doki, N.1
  • 42
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • COI: 1:CAS:528:DC%2BC38Xht1GlurzE, PID: 22728514
    • Vrieze, A. et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143, 913–916 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 913-916
    • Vrieze, A.1
  • 43
    • 85016009015 scopus 로고    scopus 로고
    • Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study
    • PID: 28122648
    • Kang, D. W. et al. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome 5, 10 (2017).
    • (2017) Microbiome , vol.5
    • Kang, D.W.1
  • 44
    • 84977079273 scopus 로고    scopus 로고
    • A novel microbiome therapeutic increases gut microbial diversity and prevents recurrent Clostridium difficile infection
    • PID: 26908752
    • Khanna, S. et al. A novel microbiome therapeutic increases gut microbial diversity and prevents recurrent Clostridium difficile infection. J. Infect. Dis. 214, 173–181 (2016).
    • (2016) J. Infect. Dis. , vol.214 , pp. 173-181
    • Khanna, S.1
  • 45
    • 84887412695 scopus 로고    scopus 로고
    • Expediting drug development — the FDA’s new “breakthrough therapy” designation
    • COI: 1:CAS:528:DC%2BC3sXhvVams73J, PID: 24224621
    • Sherman, R. E., Li, J., Shapley, S., Robb, M. & Woodcock, J. Expediting drug development — the FDA’s new “breakthrough therapy” designation. N. Engl. J. Med. 369, 1877–1880 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1877-1880
    • Sherman, R.E.1    Li, J.2    Shapley, S.3    Robb, M.4    Woodcock, J.5
  • 46
    • 85013740268 scopus 로고    scopus 로고
    • Leading microbiome-based therapeutic falters in phase II trial
    • PID: 27573225
    • Mullard, A. Leading microbiome-based therapeutic falters in phase II trial. Nat. Rev. Drug Discov. 15, 595 (2016).
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 595
    • Mullard, A.1
  • 47
    • 85036645553 scopus 로고    scopus 로고
    • Probiotics for prevention of Clostridium difficile infection
    • COI: 1:CAS:528:DC%2BC1MXhvFyksrk%3D, PID: 29189354
    • Mills, J. P., Rao, K. & Young, V. B. Probiotics for prevention of Clostridium difficile infection. Curr. Opin. Gastroenterol. 34, 3–10 (2018).
    • (2018) Curr. Opin. Gastroenterol. , vol.34 , pp. 3-10
    • Mills, J.P.1    Rao, K.2    Young, V.B.3
  • 48
    • 85031298377 scopus 로고    scopus 로고
    • Critical microbiological view of SER-109
    • PID: 28077591
    • Lagier, J.-C., Cadoret, F. & Raoult, D. Critical microbiological view of SER-109. J. Infect. Dis. 215, 161–162 (2017).
    • (2017) J. Infect. Dis. , vol.215 , pp. 161-162
    • Lagier, J.-C.1    Cadoret, F.2    Raoult, D.3
  • 49
    • 85020615240 scopus 로고    scopus 로고
    • Seres’s pioneering microbiome drug fails mid-stage trial
    • COI: 1:CAS:528:DC%2BC28Xhs1KlsrfO, PID: 27727226
    • Ratner, M. Seres’s pioneering microbiome drug fails mid-stage trial. Nat. Biotechnol. 34, 1004–1005 (2016).
    • (2016) Nat. Biotechnol. , vol.34 , pp. 1004-1005
    • Ratner, M.1
  • 50
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • COI: 1:CAS:528:DC%2BC2cXhvVemtrvE, PID: 25337874, This study shows that C. scindens protects against CDI via production of secondary bile acids
    • Buffie, C. G. et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517, 205–208 (2015). This study shows that C. scindens protects against CDI via production of secondary bile acids.
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1
  • 51
    • 41549142775 scopus 로고    scopus 로고
    • Bile salts and glycine as cogerminants for Clostridium difficile spores
    • COI: 1:CAS:528:DC%2BD1cXktVymu7c%3D, PID: 18245298
    • Sorg, J. A. & Sonenshein, A. L. Bile salts and glycine as cogerminants for Clostridium difficile spores. J. Bacteriol. 190, 2505–2512 (2008).
    • (2008) J. Bacteriol. , vol.190 , pp. 2505-2512
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 52
    • 77957337708 scopus 로고    scopus 로고
    • Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid
    • COI: 1:CAS:528:DC%2BC3cXhsFCitbrN, PID: 20675492
    • Sorg, J. A. & Sonenshein, A. L. Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J. Bacteriol. 192, 4983–4990 (2010).
    • (2010) J. Bacteriol. , vol.192 , pp. 4983-4990
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 53
    • 85015286846 scopus 로고    scopus 로고
    • Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids
    • COI: 1:CAS:528:DC%2BC2sXksV2qt7k%3D, PID: 28279860
    • Thanissery, R., Winston, J. A. & Theriot, C. M. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. Anaerobe 45, 86–100 (2017).
    • (2017) Anaerobe , vol.45 , pp. 86-100
    • Thanissery, R.1    Winston, J.A.2    Theriot, C.M.3
  • 54
    • 85048309356 scopus 로고    scopus 로고
    • Mechanistic insights in the success of fecal microbiota transplants for the treatment of Clostridium difficile infections
    • PID: 29946308
    • Baktash, A. et al. Mechanistic insights in the success of fecal microbiota transplants for the treatment of Clostridium difficile infections. Front. Microbiol. 9, 1242 (2018).
    • (2018) Front. Microbiol. , vol.9 , pp. 1242
    • Baktash, A.1
  • 55
    • 84945295917 scopus 로고    scopus 로고
    • Interactions between the gastrointestinal microbiome and Clostridium difficile
    • COI: 1:CAS:528:DC%2BC2MXhslSru7vO, PID: 26488281
    • Theriot, C. M. & Young, V. B. Interactions between the gastrointestinal microbiome and Clostridium difficile. Annu. Rev. Microbiol. 69, 445–461 (2015).
    • (2015) Annu. Rev. Microbiol. , vol.69 , pp. 445-461
    • Theriot, C.M.1    Young, V.B.2
  • 56
    • 84944754899 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pouchitis associated with the infection
    • COI: 1:CAS:528:DC%2BC28XhtlCju7bI, PID: 26485102
    • Weingarden, A. R. et al. Ursodeoxycholic acid inhibits clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pouchitis associated with the infection. J. Clin. Gastroenterol. 50, 624–630 (2016).
    • (2016) J. Clin. Gastroenterol. , vol.50 , pp. 624-630
    • Weingarden, A.R.1
  • 57
    • 85055508325 scopus 로고    scopus 로고
    • Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea
    • PID: 30355801, COI: 1:CAS:528:DC%2BC1MXjvFaiu7o%3D
    • Battaglioli, E. J. et al. Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea. Sci. Transl Med. 10, eaam7019 (2018).
    • (2018) Sci. Transl Med. , vol.10
    • Battaglioli, E.J.1
  • 58
    • 84885573828 scopus 로고    scopus 로고
    • Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
    • COI: 1:CAS:528:DC%2BC3sXhtlGltL7N, PID: 23995682
    • Ng, K. M. et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature 502, 96–99 (2013).
    • (2013) Nature , vol.502 , pp. 96-99
    • Ng, K.M.1
  • 59
    • 84943570990 scopus 로고    scopus 로고
    • Distinct but spatially overlapping intestinal niches for vancomycin-resistant Enterococcus faecium and carbapenem-resistant klebsiella pneumoniae
    • PID: 26334306, COI: 1:CAS:528:DC%2BC28XitFSlt74%3D
    • Caballero, S. et al. Distinct but spatially overlapping intestinal niches for vancomycin-resistant Enterococcus faecium and carbapenem-resistant Klebsiella pneumoniae. PLOS Pathog. 11, e1005132 (2015).
    • (2015) PLOS Pathog. , vol.11
    • Caballero, S.1
  • 60
    • 85019136323 scopus 로고    scopus 로고
    • Cooperating commensals restore colonization resistance to vancomycin-resistant Enterococcus faecium
    • COI: 1:CAS:528:DC%2BC2sXns1amsLc%3D, PID: 28494240
    • Caballero, S. et al. Cooperating commensals restore colonization resistance to vancomycin-resistant Enterococcus faecium. Cell Host Microbe 21, 592–602 (2017).
    • (2017) Cell Host Microbe , vol.21 , pp. 592-602
    • Caballero, S.1
  • 61
    • 85059927753 scopus 로고    scopus 로고
    • Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification
    • PID: 30563917, COI: 1:CAS:528:DC%2BC1MXkvFSnsr8%3D
    • Sorbara, M. T. et al. Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification. J. Exp. Med. 216, 84–98 (2018).
    • (2018) J. Exp. Med. , vol.216 , pp. 84-98
    • Sorbara, M.T.1
  • 62
    • 84930442353 scopus 로고    scopus 로고
    • The human mycobiome
    • PID: 25384764, COI: 1:CAS:528:DC%2BC1cXmtFOitrs%3D
    • Seed, P. C. The human mycobiome. Cold Spring Harb. Perspect. Med. 5, a019810 (2014).
    • (2014) Cold Spring Harb. Perspect. Med. , vol.5 , pp. a019810
    • Seed, P.C.1
  • 63
    • 85044251101 scopus 로고    scopus 로고
    • The gut mycobiome of the Human Microbiome Project healthy cohort
    • PID: 29178920
    • Nash, A. K. et al. The gut mycobiome of the Human Microbiome Project healthy cohort. Microbiome 5, 153 (2017).
    • (2017) Microbiome , vol.5
    • Nash, A.K.1
  • 64
    • 84920929686 scopus 로고    scopus 로고
    • An enteric virus can replace the beneficial function of commensal bacteria
    • COI: 1:CAS:528:DC%2BC2cXhvFGltLvP, PID: 25409145
    • Kernbauer, E., Ding, Y. & Cadwell, K. An enteric virus can replace the beneficial function of commensal bacteria. Nature 516, 94–98 (2014).
    • (2014) Nature , vol.516 , pp. 94-98
    • Kernbauer, E.1    Ding, Y.2    Cadwell, K.3
  • 65
    • 84929676980 scopus 로고    scopus 로고
    • The virome in host health and disease
    • COI: 1:CAS:528:DC%2BC2MXoslCnsLw%3D, PID: 25992857
    • Cadwell, K. The virome in host health and disease. Immunity 42, 805–813 (2015).
    • (2015) Immunity , vol.42 , pp. 805-813
    • Cadwell, K.1
  • 66
    • 84987654794 scopus 로고    scopus 로고
    • Healthy human gut phageome
    • COI: 1:CAS:528:DC%2BC28XhsVWks7bE, PID: 27573828
    • Manrique, P. et al. Healthy human gut phageome. Proc. Natl Acad. Sci. USA 113, 10400–10405 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 10400-10405
    • Manrique, P.1
  • 67
    • 84990846993 scopus 로고    scopus 로고
    • Host-protozoan interactions protect from mucosal infections through activation of the inflammasome
    • COI: 1:CAS:528:DC%2BC28Xhs1CltrzF, PID: 27716507
    • Chudnovskiy, A. et al. Host-protozoan interactions protect from mucosal infections through activation of the inflammasome. Cell 167, 444–456 (2016).
    • (2016) Cell , vol.167 , pp. 444-456
    • Chudnovskiy, A.1
  • 69
    • 84963860997 scopus 로고    scopus 로고
    • Helminth infection promotes colonization resistance via type 2 immunity
    • COI: 1:CAS:528:DC%2BC28Xms1Kisb8%3D, PID: 27080105
    • Ramanan, D. et al. Helminth infection promotes colonization resistance via type 2 immunity. Science 352, 608–612 (2016).
    • (2016) Science , vol.352 , pp. 608-612
    • Ramanan, D.1
  • 70
    • 84963934432 scopus 로고    scopus 로고
    • Macrobiota - helminths as active participants and partners of the microbiota in host intestinal homeostasis
    • PID: 27116368
    • Gause, W. C. & Maizels, R. M. Macrobiota - helminths as active participants and partners of the microbiota in host intestinal homeostasis. Curr. Opin. Microbiol. 32, 14–18 (2016).
    • (2016) Curr. Opin. Microbiol. , vol.32 , pp. 14-18
    • Gause, W.C.1    Maizels, R.M.2
  • 71
    • 80053025965 scopus 로고    scopus 로고
    • The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment
    • COI: 1:CAS:528:DC%2BC3MXhtFymt7bJ, PID: 21925113
    • Sczesnak, A. et al. The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe 10, 260–272 (2011).
    • (2011) Cell Host Microbe , vol.10 , pp. 260-272
    • Sczesnak, A.1
  • 72
    • 80053045987 scopus 로고    scopus 로고
    • Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation
    • COI: 1:CAS:528:DC%2BC3MXhtFymt7bK, PID: 21925114
    • Prakash, T. et al. Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation. Cell Host Microbe 10, 273–284 (2011).
    • (2011) Cell Host Microbe , vol.10 , pp. 273-284
    • Prakash, T.1
  • 73
    • 84926360580 scopus 로고    scopus 로고
    • Growth and host interaction of mouse segmented filamentous bacteria in vitro
    • COI: 1:CAS:528:DC%2BC2MXjt1Sntbw%3D, PID: 25600271
    • Schnupf, P. et al. Growth and host interaction of mouse segmented filamentous bacteria in vitro. Nature 520, 99–103 (2015).
    • (2015) Nature , vol.520 , pp. 99-103
    • Schnupf, P.1
  • 74
    • 0021363628 scopus 로고
    • Host specificity of filamentous, segmental microorganisms adherent to the small bowel epithelium in mice and rats
    • COI: 1:STN:280:DyaL2c7nslequw%3D%3D, PID: 6712214
    • Tannock, G. W., Miller, J. R. & Savage, D. C. Host specificity of filamentous, segmental microorganisms adherent to the small bowel epithelium in mice and rats. Appl. Environ. Microbiol. 47, 441–442 (1984).
    • (1984) Appl. Environ. Microbiol. , vol.47 , pp. 441-442
    • Tannock, G.W.1    Miller, J.R.2    Savage, D.C.3
  • 75
    • 0027411385 scopus 로고
    • Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species
    • COI: 1:STN:280:DyaK3s3nsVymsg%3D%3D, PID: 8501895
    • Klaasen, H. L. B. M. et al. Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species. Lab. Anim. 27, 141–150 (1993).
    • (1993) Lab. Anim. , vol.27 , pp. 141-150
    • Klaasen, H.L.B.M.1
  • 76
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • H17 cells
    • H 17 cells.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 77
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • COI: 1:CAS:528:DC%2BD1MXhsVChtLrF, PID: 19833089
    • Gaboriau-Routhiau, V. et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31, 677–689 (2009).
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1
  • 78
    • 0033004028 scopus 로고    scopus 로고
    • Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system
    • COI: 1:CAS:528:DyaK1MXitFCrt7w%3D, PID: 10085047
    • Talham, G. L., Jiang, H. Q., Bos, N. A. & Cebra, J. J. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect. Immun. 67, 1992–2000 (1999).
    • (1999) Infect. Immun. , vol.67 , pp. 1992-2000
    • Talham, G.L.1    Jiang, H.Q.2    Bos, N.A.3    Cebra, J.J.4
  • 79
    • 84898685253 scopus 로고    scopus 로고
    • Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses
    • COI: 1:CAS:528:DC%2BC2cXmsVKksLw%3D
    • Lécuyer, E. et al. Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity 40, 608–620 (2014).
    • (2014) Immunity , vol.40 , pp. 608-620
    • Lécuyer, E.1
  • 80
    • 0029093082 scopus 로고
    • Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse
    • COI: 1:CAS:528:DyaK2MXnvV2jtbw%3D, PID: 7494493
    • Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A. & Setoyama, H. Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse. Microbiol. Immunol. 39, 555–562 (1995).
    • (1995) Microbiol. Immunol. , vol.39 , pp. 555-562
    • Umesaki, Y.1    Okada, Y.2    Matsumoto, S.3    Imaoka, A.4    Setoyama, H.5
  • 81
    • 84881477044 scopus 로고    scopus 로고
    • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
    • regcells
    • reg cells.
    • (2013) Nature , vol.500 , pp. 232-236
    • Atarashi, K.1
  • 82
    • 85060753155 scopus 로고    scopus 로고
    • A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
    • +T cells
    • + T cells.
    • (2019) Nature , vol.565 , pp. 565-605
    • Tanoue, T.1
  • 83
    • 84907300008 scopus 로고    scopus 로고
    • Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC2cXhsV2jtLfJ, PID: 4174347
    • Palm, N. W. et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158, 1000–1010 (2014).
    • (2014) Cell , vol.158 , pp. 1000-1010
    • Palm, N.W.1
  • 84
    • 84991929179 scopus 로고    scopus 로고
    • Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy
    • COI: 1:CAS:528:DC%2BC2MXktF2is70%3D, PID: 25717097, Together with Palm et al. (2014), this study describes IgA-seq and its application to identifying microorganisms associated with health and disease
    • Kau, A. L. et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl Med. 7, 276ra24 (2015). References 83 and 84 described IgA-seq and its use in identifying microorganisms associated with health and disease.
    • (2015) Sci. Transl Med. , vol.7 , pp. 276ra24
    • Kau, A.L.1
  • 85
    • 84890675911 scopus 로고    scopus 로고
    • Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core
    • PID: 24343271
    • D’Auria, G. et al. Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core. Sci. Rep. 3, 3515 (2013).
    • (2013) Sci. Rep. , vol.3
    • D’Auria, G.1
  • 86
    • 85043299252 scopus 로고    scopus 로고
    • Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis
    • COI: 1:CAS:528:DC%2BC1cXjt1Sgsbk%3D, PID: 29478774
    • Wilmore, J. R. et al. Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis. Cell Host Microbe 23, 302–311 (2018).
    • (2018) Cell Host Microbe , vol.23 , pp. 302-311
    • Wilmore, J.R.1
  • 87
    • 85036500288 scopus 로고    scopus 로고
    • A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
    • COI: 1:CAS:528:DC%2BC2sXhvVynsLnJ, PID: 29168502, This study uses bacterial genetic engineering conjunction with gnotobiotic studies to elucidate the effects of aC. sporogenesmetabolic pathway on host physiology
    • Dodd, D. et al. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature 551, 648–652 (2017). This study elucidated the effects of a C. sporogenes metabolic pathway on host physiology.
    • (2017) Nature , vol.551 , pp. 648-652
    • Dodd, D.1
  • 88
    • 85062874308 scopus 로고    scopus 로고
    • Depletion of microbiome-derived molecules in the host using Clostridium genetics
    • Preprint at
    • Guo, C. J. et al. Depletion of microbiome-derived molecules in the host using Clostridium genetics. Preprint at bioRxiv. 10.1101/401489 (2018).
    • (2018) bioRxiv
    • Guo, C.-J.1
  • 89
    • 85018499853 scopus 로고    scopus 로고
    • Engineered regulatory systems modulate gene expression of human commensals in the gut
    • COI: 1:CAS:528:DC%2BC2sXmsVamur4%3D, PID: 28431252
    • Lim, B., Zimmermann, M., Barry, N. A. & Goodman, A. L. Engineered regulatory systems modulate gene expression of human commensals in the gut. Cell 169, 547–558 (2017).
    • (2017) Cell , vol.169 , pp. 547-558
    • Lim, B.1    Zimmermann, M.2    Barry, N.A.3    Goodman, A.L.4
  • 90
    • 84997701899 scopus 로고    scopus 로고
    • A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
    • COI: 1:CAS:528:DC%2BC28XhvFShtrnK, PID: 27892954
    • Plovier, H. et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat. Med. 23, 107–113 (2017).
    • (2017) Nat. Med. , vol.23 , pp. 107-113
    • Plovier, H.1
  • 91
    • 84943639694 scopus 로고    scopus 로고
    • Th17 cell induction by adhesion of microbes to intestinal epithelial cells
    • H17 cells
    • H 17 cells.
    • (2015) Cell , vol.163 , pp. 367-380
    • Atarashi, K.1
  • 92
  • 93
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • COI: 1:CAS:528:DC%2BD1MXotlOlsw%3D%3D, This study highlights the stability of metabolic pathways across individuals’ microbiotas, despite phylogenetic differences
    • Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480–484 (2009). Highlights the stability of metabolic pathways across phylogenetically diverse microbiotas.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 94
    • 85030771846 scopus 로고    scopus 로고
    • Strains, functions and dynamics in the expanded Human Microbiome Project
    • COI: 1:CAS:528:DC%2BC2sXhsFehtrzE, PID: 28953883
    • Lloyd-Price, J. et al. Strains, functions and dynamics in the expanded Human Microbiome Project. Nature 550, 61–66 (2017).
    • (2017) Nature , vol.550 , pp. 61-66
    • Lloyd-Price, J.1
  • 95
    • 84864037467 scopus 로고    scopus 로고
    • Metabolic reconstruction for metagenomic data and its application to the human microbiome
    • COI: 1:CAS:528:DC%2BC38Xpt1Gnu7k%3D
    • Abubucker, S. et al. Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLOS Comput. Biol. 8, 1002358 (2012).
    • (2012) PLOS Comput. Biol. , vol.8 , pp. 1002358
    • Abubucker, S.1
  • 96
    • 84872281329 scopus 로고    scopus 로고
    • Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells
    • COI: 1:CAS:528:DC%2BC38XhvVWis7zN, PID: 23201429
    • Shimizu, H., Yisireyili, M., Higashiyama, Y., Nishijima, F. & Niwa, T. Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells. Life Sci. 92, 143–148 (2013).
    • (2013) Life Sci. , vol.92 , pp. 143-148
    • Shimizu, H.1    Yisireyili, M.2    Higashiyama, Y.3    Nishijima, F.4    Niwa, T.5
  • 97
    • 84859111301 scopus 로고    scopus 로고
    • Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells
    • COI: 1:CAS:528:DC%2BC38XisFKhs7s%3D, PID: 22326498
    • Shimizu, H. et al. Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells. Life Sci. 90, 525–530 (2012).
    • (2012) Life Sci. , vol.90 , pp. 525-530
    • Shimizu, H.1
  • 98
    • 85006117379 scopus 로고    scopus 로고
    • Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota
    • COI: 1:CAS:528:DC%2BC28XhvF2gtrzL, PID: 27916477
    • Devlin, A. S. et al. Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota. Cell Host Microbe 20, 709–715 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 709-715
    • Devlin, A.S.1
  • 99
    • 84908072394 scopus 로고    scopus 로고
    • Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine
    • COI: 1:CAS:528:DC%2BC2cXhs1agt7zI, PID: 25263219
    • Williams, B. B. et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe 16, 495–503 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 495-503
    • Williams, B.B.1
  • 100
    • 85048206165 scopus 로고    scopus 로고
    • Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion
    • COI: 1:CAS:528:DC%2BC1cXhtFCqtrrF, PID: 29902441
    • Bhattarai, Y. et al. Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion. Cell Host Microbe 23, 775–785 (2018).
    • (2018) Cell Host Microbe , vol.23 , pp. 775-785
    • Bhattarai, Y.1
  • 101
    • 84977620054 scopus 로고    scopus 로고
    • Interactions between the microbiota and pathogenic bacteria in the gut
    • PID: 27383983, COI: 1:CAS:528:DC%2BC28XhtFensL%2FF
    • Bäumler, A. J. & Sperandio, V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature 535, 85–93 (2016).
    • (2016) Nature , vol.535 , pp. 85-93
    • Bäumler, A.J.1    Sperandio, V.2
  • 102
    • 85028085286 scopus 로고    scopus 로고
    • An oxidative central metabolism enables Salmonella to utilize microbiota-derived succinate
    • COI: 1:CAS:528:DC%2BC2sXhtlylsbrL, PID: 28844888
    • Spiga, L. et al. An oxidative central metabolism enables Salmonella to utilize microbiota-derived succinate. Cell Host Microbe 22, 291–301 (2017).
    • (2017) Cell Host Microbe , vol.22 , pp. 291-301
    • Spiga, L.1
  • 103
    • 84920621547 scopus 로고    scopus 로고
    • Gut microbiota-produced succinate promotes C. Difficile infection after antibiotic treatment or motility disturbance
    • COI: 1:CAS:528:DC%2BC2cXhvFOgsb%2FO, PID: 25498344
    • Ferreyra, J. A. et al. Gut microbiota-produced succinate promotes C. Difficile infection after antibiotic treatment or motility disturbance. Cell Host Microbe 16, 770–777 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 770-777
    • Ferreyra, J.A.1
  • 104
    • 84920613211 scopus 로고    scopus 로고
    • The gut commensal bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape
    • COI: 1:CAS:528:DC%2BC2cXitFOrtLzP, PID: 4269104
    • Curtis, M. M. et al. The gut commensal bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape. Cell Host Microbe 16, 759–769 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 759-769
    • Curtis, M.M.1
  • 105
    • 79251584066 scopus 로고    scopus 로고
    • Bifidobacteria can protect from enteropathogenic infection through production of acetate
    • COI: 1:CAS:528:DC%2BC3MXhtFShtLs%3D
    • Fukuda, S. et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469, 543–549 (2011).
    • (2011) Nature , vol.469 , pp. 543-549
    • Fukuda, S.1
  • 106
    • 84861972274 scopus 로고    scopus 로고
    • Regulated virulence controls the ability of a pathogen to compete with the gut microbiota
    • COI: 1:CAS:528:DC%2BC38XnvFekt70%3D, PID: 3439148, Together with Ng et al. (Nature, 2013) and Fukuda et al. (2011), this study shows that the microbiota can contribute to susceptibility to enteropathogenic infection by producing or consuming certain metabolites
    • Kamada, N. et al. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336, 1325–1329 (2012). References 58, 105 and 106 show that the microbiota can affect susceptibility to enteropathogenic infections by producing or consuming metabolites.
    • (2012) Science , vol.336 , pp. 1325-1329
    • Kamada, N.1
  • 107
    • 84873333650 scopus 로고    scopus 로고
    • Transepithelial antigen delivery in the small intestine: different paths, different outcomes
    • COI: 1:CAS:528:DC%2BC3sXit1ejt7Y%3D, PID: 23380572
    • Knoop, K. A., Miller, M. J. & Newberry, R. D. Transepithelial antigen delivery in the small intestine: different paths, different outcomes. Curr. Opin. Gastroenterol. 29, 112–118 (2013).
    • (2013) Curr. Opin. Gastroenterol. , vol.29 , pp. 112-118
    • Knoop, K.A.1    Miller, M.J.2    Newberry, R.D.3
  • 108
    • 84940984328 scopus 로고    scopus 로고
    • In vivo imaging and tracking of host–microbiota interactions via metabolic labeling of gut anaerobic bacteria
    • COI: 1:CAS:528:DC%2BC2MXhtlCksL7P, PID: 26280120
    • Geva-Zatorsky, N. et al. In vivo imaging and tracking of host–microbiota interactions via metabolic labeling of gut anaerobic bacteria. Nat. Med. 21, 1091–1100 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1091-1100
    • Geva-Zatorsky, N.1
  • 109
    • 85021399783 scopus 로고    scopus 로고
    • Illuminating vital surface molecules of symbionts in health and disease
    • COI: 1:CAS:528:DC%2BC2sXhtVOjt7rM, PID: 28650431, Together with Geva-Zatorsky et al. (2015), this study uses a metabolic-labelling platform to fluorescently tag and track surface molecules on a variety of commensal bacteria vivo
    • Hudak, J. E., Alvarez, D., Skelly, A., von Andrian, U. H. & Kasper, D. L. Illuminating vital surface molecules of symbionts in health and disease. Nat. Microbiol. 2, 17099 (2017). References 108 and 109 used a metabolic-labelling platform to tag and track surface molecules on commensal bacteria in vivo.
    • (2017) Nat. Microbiol. , vol.2 , pp. 17099
    • Hudak, J.E.1    Alvarez, D.2    Skelly, A.3    von Andrian, U.H.4    Kasper, D.L.5
  • 110
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • COI: 1:CAS:528:DC%2BD2MXmsFeiurw%3D, PID: 16009137
    • Mazmanian, S. K., Cui, H. L., Tzianabos, A. O. & Kasper, D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122, 107–118 (2005).
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Cui, H.L.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 111
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • regcell differentiation and production of IL-10
    • reg cells and IL-10.
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 112
    • 85062818668 scopus 로고    scopus 로고
    • Inducible Foxp3+regulatory T cell development by a commensal bacterium of the intestinal microbiota
    • Round, J. L. & Mazmanian, S. K. Inducible Foxp3+regulatory T cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl Acad. Sci. USA 11, 79–80 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.11 , pp. 79-80
    • Round, J.L.1    Mazmanian, S.K.2
  • 113
    • 84898647980 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
    • COI: 1:CAS:528:DC%2BC2cXmtVGiu78%3D, PID: 24721570
    • Dasgupta, S., Erturk-Hasdemir, D., Ochoa-Reparaz, J., Reinecker, H. C. & Kasper, D. L. Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe 15, 413–423 (2014).
    • (2014) Cell Host Microbe , vol.15 , pp. 413-423
    • Dasgupta, S.1    Erturk-Hasdemir, D.2    Ochoa-Reparaz, J.3    Reinecker, H.C.4    Kasper, D.L.5
  • 114
    • 79956311926 scopus 로고    scopus 로고
    • The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • COI: 1:CAS:528:DC%2BC3MXmtFSgurY%3D, PID: 21512004
    • Round, J. L. et al. The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332, 974–977 (2011).
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1
  • 115
    • 84867656021 scopus 로고    scopus 로고
    • Outer membrane vesicles of a human commensal mediate immune regulation and disease protection
    • COI: 1:CAS:528:DC%2BC38Xhtl2rsr3F, PID: 3895402
    • Shen, Y. et al. Outer membrane vesicles of a human commensal mediate immune regulation and disease protection. Cell Host Microbe 12, 509–520 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 509-520
    • Shen, Y.1
  • 116
    • 84966293351 scopus 로고    scopus 로고
    • Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC28XosValsLo%3D, PID: 27230380
    • Chu, H. et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science 352, 1116–1120 (2016).
    • (2016) Science , vol.352 , pp. 1116-1120
    • Chu, H.1
  • 117
    • 85055076579 scopus 로고    scopus 로고
    • Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+regulatory T cells
    • PID: 30341145
    • Verma, R. et al. Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+regulatory T cells. Sci. Immunol. 3, eaat6975 (2018).
    • (2018) Sci. Immunol. , vol.3
    • Verma, R.1
  • 118
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • COI: 1:CAS:528:DC%2BC3MXmsVCjsw%3D%3D, PID: 21205640
    • Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337–341 (2011).
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1
  • 119
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
    • COI: 1:CAS:528:DC%2BC3sXhvFOmtrrJ, PID: 24226773
    • Arpaia, N. et al. Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation. Nature 504, 451–455 (2013).
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 120
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • COI: 1:CAS:528:DC%2BC3sXhvFOltr3F, PID: 24226770
    • Furusawa, Y. et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504, 446–450 (2013).
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1
  • 121
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • COI: 1:CAS:528:DC%2BC3sXhtFyjsr3P, PID: 23828891, Together with Arpaia et al. (2013) and Furusawa et al. (2013), this study provides mechanistic insight into the various ways that commensal-derived SCFAs can affect the host immune system
    • Smith, P. M. et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341, 569–573 (2013). References 119–121 provide mechanistic insight into how commensal-derived SCFAs affect host immunity.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 122
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • COI: 1:CAS:528:DC%2BD1MXhtlOjt7vI, PID: 19865172
    • Maslowski, K. M. et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461, 1282–1286 (2009).
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1
  • 123
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • COI: 1:CAS:528:DC%2BC2MXosFemtrs%3D, PID: 25828455
    • Macia, L. et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015).
    • (2015) Nat. Commun. , vol.6
    • Macia, L.1
  • 124
    • 85053208491 scopus 로고    scopus 로고
    • Microbial metabolite sensor GPR43 controls severity of experimental GVHD
    • PID: 30201970, COI: 1:CAS:528:DC%2BC1cXhslWju7nK
    • Fujiwara, H. et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat. Commun. 9, 3674 (2018).
    • (2018) Nat. Commun. , vol.9
    • Fujiwara, H.1
  • 125
    • 43449135305 scopus 로고    scopus 로고
    • TGF-Β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
    • COI: 1:CAS:528:DC%2BD1cXls12msL4%3D, PID: 18368049
    • Zhou, L. et al. TGF-Β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function. Nature 453, 236–240 (2008).
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1
  • 126
    • 84940077758 scopus 로고    scopus 로고
    • Individual intestinal symbionts induce a distinct population of ROR+regulatory T cells
    • COI: 1:CAS:528:DC%2BC2MXhsVSlsr3E, PID: 26272906
    • Sefik, E. et al. Individual intestinal symbionts induce a distinct population of ROR+regulatory T cells. Science 349, 993–997 (2015).
    • (2015) Science , vol.349 , pp. 993-997
    • Sefik, E.1
  • 127
    • 84940547063 scopus 로고    scopus 로고
    • The microbiota regulates type 2 immunity through RORγt+T cells
    • regcells the intestine
    • reg cells.
    • (2015) Science , vol.349 , pp. 989-993
    • Ohnmacht, C.1
  • 128
    • 85042146013 scopus 로고    scopus 로고
    • C-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
    • COI: 1:CAS:528:DC%2BC1cXisVKjsrY%3D, PID: 29414937
    • Xu, M. et al. C-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature 554, 373–377 (2018).
    • (2018) Nature , vol.554 , pp. 373-377
    • Xu, M.1
  • 129
    • 85038580888 scopus 로고    scopus 로고
    • Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation
    • PID: 28733471
    • Chai, J. N. et al. Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation. Sci. Immunol. 2, eaal5068 (2017).
    • (2017) Sci. Immunol. , vol.2
    • Chai, J.N.1
  • 130
    • 84943638660 scopus 로고    scopus 로고
    • An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses
    • COI: 1:CAS:528:DC%2BC2MXhsFKqsb7F, PID: 26411290
    • Sano, T. et al. An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. Cell 163, 381–393 (2015).
    • (2015) Cell , vol.163 , pp. 381-393
    • Sano, T.1
  • 131
    • 85003426944 scopus 로고    scopus 로고
    • Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
    • COI: 1:CAS:528:DC%2BC28XhvFelsLrI, PID: 27911839
    • Tan, T. G. et al. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc. Natl Acad. Sci. USA 113, E8141–E8150 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E8141-E8150
    • Tan, T.G.1
  • 132
    • 84901979873 scopus 로고    scopus 로고
    • Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
    • COI: 1:CAS:528:DC%2BC2cXhtFygsrfL, PID: 24739972
    • Yang, Y. et al. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature 510, 152–156 (2014).
    • (2014) Nature , vol.510 , pp. 152-156
    • Yang, Y.1
  • 133
    • 85035359870 scopus 로고    scopus 로고
    • A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients
    • PID: 29183332, COI: 1:CAS:528:DC%2BC1cXit1Wrs7bI
    • Hall, A. B. et al. A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients. Genome Med. 9, 103 (2017).
    • (2017) Genome Med. , vol.9
    • Hall, A.B.1
  • 134
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • COI: 1:CAS:528:DC%2BC3cXovVahur8%3D, PID: 20620945
    • Wu, H. J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815–827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1
  • 135
    • 84887323708 scopus 로고    scopus 로고
    • Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    • PID: 24192039, COI: 1:CAS:528:DC%2BC2cXmvVymtrY%3D
    • Scher, J. U. et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2, e01202 (2013).
    • (2013) eLife , vol.2
    • Scher, J.U.1
  • 137
    • 84992549184 scopus 로고    scopus 로고
    • Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine
    • COI: 1:CAS:528:DC%2BC28XhslGgs77O, PID: 27333153
    • Maeda, Y. et al. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol. 68, 2646–2661 (2016).
    • (2016) Arthritis Rheumatol. , vol.68 , pp. 2646-2661
    • Maeda, Y.1
  • 138
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BC3MXjvVCku74%3D, PID: 20660719
    • Lee, Y. K., Menezes, J. S., Umesaki, Y. & Mazmanian, S. K. Proinflammatory T cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 108, 4615–4622 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 139
    • 85036551713 scopus 로고    scopus 로고
    • Salt-responsive gut commensal modulates TH17 axis and disease
    • COI: 1:CAS:528:DC%2BC2sXhvVynsLfL, PID: 29143823
    • Wilck, N. et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551, 585–589 (2017).
    • (2017) Nature , vol.551 , pp. 585-589
    • Wilck, N.1
  • 140
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-β induces development of the TH17 lineage
    • COI: 1:CAS:528:DC%2BD28XksVGns7k%3D, PID: 16648837
    • Mangan, P. R. et al. Transforming growth factor-β induces development of the TH17 lineage. Nature 441, 231–234 (2006).
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1
  • 141
    • 58449115208 scopus 로고    scopus 로고
    • Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype typhimurium in the intestine
    • COI: 1:CAS:528:DC%2BD1MXhs1SisLc%3D, PID: 18955477
    • Godinez, I. et al. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype typhimurium in the intestine. Infect. Immun. 77, 387–398 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 387-398
    • Godinez, I.1
  • 142
    • 25144515561 scopus 로고    scopus 로고
    • Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    • COI: 1:CAS:528:DC%2BD2MXhtVegsLjI, PID: 16157683
    • Happel, K. I. et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J. Exp. Med. 202, 761–769 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 761-769
    • Happel, K.I.1
  • 143
    • 85032492045 scopus 로고    scopus 로고
    • Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation
    • H1 cells, thereby contributing to intestinal inflammation
    • Atarashi, K. et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science 358, 162–169 (2017). Shows that members of the oral microbiota can colonize the gut and cause intestinal inflammation.
    • (2017) Science , vol.358 , pp. 162-169
    • Atarashi, K.1
  • 144
    • 62749195559 scopus 로고    scopus 로고
    • The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    • COI: 1:CAS:528:DC%2BD1MXkvVSisbg%3D, PID: 19324295
    • Nordmann, P., Cuzon, G. & Naas, T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect. Dis. 9, 228–236 (2009).
    • (2009) Lancet Infect. Dis. , vol.9 , pp. 228-236
    • Nordmann, P.1    Cuzon, G.2    Naas, T.3
  • 146
    • 84886260592 scopus 로고    scopus 로고
    • Report reveals scope of US antibiotic resistance threat
    • COI: 1:CAS:528:DC%2BC3sXhvVahs7vP, PID: 24150445
    • Hampton, T. Report reveals scope of US antibiotic resistance threat. JAMA 310, 1661–1663 (2013).
    • (2013) JAMA , vol.310 , pp. 1661-1663
    • Hampton, T.1
  • 147
    • 84902281269 scopus 로고    scopus 로고
    • AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition
    • COI: 1:CAS:528:DC%2BC2cXhtlaitrnN, PID: 23896971
    • Chassaing, B., Koren, O., Carvalho, F. A., Ley, R. E. & Gewirtz, A. T. AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition. Gut 63, 1069–1080 (2014).
    • (2014) Gut , vol.63 , pp. 1069-1080
    • Chassaing, B.1    Koren, O.2    Carvalho, F.A.3    Ley, R.E.4    Gewirtz, A.T.5
  • 148
    • 4143069158 scopus 로고    scopus 로고
    • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
    • PID: 15300573
    • Darfeuille-Michaud, A. et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease. Gastroenterology 127, 412–421 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 412-421
    • Darfeuille-Michaud, A.1
  • 149
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer
    • COI: 1:CAS:528:DC%2BD2cXmsVShsrs%3D, PID: 15236175
    • Martin, H. M. et al. Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer. Gastroenterology 127, 80–93 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 80-93
    • Martin, H.M.1
  • 150
    • 84863436944 scopus 로고    scopus 로고
    • −/−mice
    • COI: 1:CAS:528:DC%2BC38XpvVSmsLc%3D, PID: 22722865
    • −/− mice. Nature 487, 104–108 (2012).
    • (2012) Nature , vol.487 , pp. 104-108
    • Devkota, S.1
  • 151
    • 85037035475 scopus 로고    scopus 로고
    • Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier
    • PID: 29221933, COI: 1:CAS:528:DC%2BC2sXhvV2it7jL
    • Olivares-Villagómez, D. & Van Kaer, L. Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier. Trends Immunol. 39, 264–275 (2018).
    • (2018) Trends Immunol. , vol.39 , pp. 264-275
    • Olivares-Villagómez, D.1    Van Kaer, L.2
  • 152
    • 85044303941 scopus 로고    scopus 로고
    • Regulation of the immune response by the aryl hydrocarbon receptor
    • PID: 29343438, COI: 1:CAS:528:DC%2BC1cXhtVOis7w%3D
    • Gutiérrez-Vázquez, C. & Quintana, F. J. Regulation of the immune response by the aryl hydrocarbon receptor. Immunity 48, 19–33 (2018).
    • (2018) Immunity , vol.48 , pp. 19-33
    • Gutiérrez-Vázquez, C.1    Quintana, F.J.2
  • 153
    • 80155164160 scopus 로고    scopus 로고
    • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    • COI: 1:CAS:528:DC%2BC3MXhtl2ntrrK, PID: 21999944
    • Li, Y. et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147, 629–640 (2011).
    • (2011) Cell , vol.147 , pp. 629-640
    • Li, Y.1
  • 154
    • 85027063083 scopus 로고    scopus 로고
    • Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+T cells
    • COI: 1:CAS:528:DC%2BC2sXhtlKntrrM, PID: 28775213
    • Cervantes-Barragan, L. et al. Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+T cells. Science 357, 806–810 (2017).
    • (2017) Science , vol.357 , pp. 806-810
    • Cervantes-Barragan, L.1
  • 155
    • 84974536519 scopus 로고    scopus 로고
    • Tissue adaptation of regulatory and intraepithelial CD4+T cells controls gut inflammation
    • COI: 1:CAS:528:DC%2BC28XhtVaitLzE, PID: 27256884
    • Sujino, T. et al. Tissue adaptation of regulatory and intraepithelial CD4+T cells controls gut inflammation. Science 352, 1581–1586 (2016).
    • (2016) Science , vol.352 , pp. 1581-1586
    • Sujino, T.1
  • 156
    • 85027952412 scopus 로고    scopus 로고
    • Transcriptional reprogramming of mature CD4+helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
    • COI: 1:CAS:528:DC%2BC3sXhtFShtbc%3D, PID: 23334788
    • Mucida, D. et al. Transcriptional reprogramming of mature CD4+helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat. Immunol. 14, 281–289 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 281-289
    • Mucida, D.1
  • 157
    • 85027933013 scopus 로고    scopus 로고
    • Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+T cell immunity
    • COI: 1:CAS:528:DC%2BC3sXhtFSitb4%3D, PID: 23334789
    • Reis, B. S., Rogoz, A., Costa-Pinto, F. A., Taniuchi, I. & Mucida, D. Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity. Nat. Immunol. 14, 271–280 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 271-280
    • Reis, B.S.1    Rogoz, A.2    Costa-Pinto, F.A.3    Taniuchi, I.4    Mucida, D.5
  • 158
    • 84907367131 scopus 로고    scopus 로고
    • Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation
    • COI: 1:CAS:528:DC%2BC2cXhsVygsr7M, PID: 25148025
    • Reis, B. S., Hoytema van Konijnenburg, D. P., Grivennikov, S. I. & Mucida, D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity 41, 244–256 (2014).
    • (2014) Immunity , vol.41 , pp. 244-256
    • Reis, B.S.1    Hoytema van Konijnenburg, D.P.2    Grivennikov, S.I.3    Mucida, D.4
  • 159
    • 85011706119 scopus 로고    scopus 로고
    • The composition of T cell subtypes in duodenal biopsies are altered in coeliac disease patients
    • PID: 28166225, COI: 1:CAS:528:DC%2BC2sXpvF2rt7g%3D
    • Steenholt, J. V. et al. The composition of T cell subtypes in duodenal biopsies are altered in coeliac disease patients. PLOS ONE 12, e0170270 (2017).
    • (2017) PLOS ONE , vol.12
    • Steenholt, J.V.1
  • 160
    • 6944232241 scopus 로고    scopus 로고
    • CD4+CD8+human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease
    • PID: 15371918
    • Carton, J., Byrne, B., Madrigal-Estebas, L., O’Donoghue, D. P. & O’Farrelly, C. CD4+CD8+human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease. Eur. J. Gastroenterol. Hepatol. 16, 961–968 (2004).
    • (2004) Eur. J. Gastroenterol. Hepatol. , vol.16 , pp. 961-968
    • Carton, J.1    Byrne, B.2    Madrigal-Estebas, L.3    O’Donoghue, D.P.4    O’Farrelly, C.5
  • 161
    • 76949100372 scopus 로고    scopus 로고
    • Raising the NKT cell family
    • COI: 1:CAS:528:DC%2BC3cXhs1Onsbo%3D, PID: 20139988
    • Godfrey, D. I., Stankovic, S. & Baxter, A. G. Raising the NKT cell family. Nat. Immunol. 11, 197–206 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 197-206
    • Godfrey, D.I.1    Stankovic, S.2    Baxter, A.G.3
  • 162
    • 84860216630 scopus 로고    scopus 로고
    • Microbial exposure during early life has persistent effects on natural killer T cell function
    • COI: 1:CAS:528:DC%2BC38XlvFGqtro%3D, PID: 22442383
    • Olszak, T. et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336, 489–493 (2012).
    • (2012) Science , vol.336 , pp. 489-493
    • Olszak, T.1
  • 163
    • 84892774558 scopus 로고    scopus 로고
    • Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells
    • COI: 1:CAS:528:DC%2BC2cXhtF2mtLY%3D, PID: 24439373
    • An, D. et al. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 156, 123–133 (2014).
    • (2014) Cell , vol.156 , pp. 123-133
    • An, D.1
  • 164
    • 84880941717 scopus 로고    scopus 로고
    • Production of α-galactosylceramide by a prominent member of the human gut microbiota
    • PID: 23874157, COI: 1:CAS:528:DC%2BC3sXht1ygu7vL
    • Wieland Brown, L. C. et al. Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLOS Biol. 11, e1001610 (2013).
    • (2013) PLOS Biol. , vol.11
    • Wieland Brown, L.C.1
  • 165
    • 85047415625 scopus 로고    scopus 로고
    • Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
    • PID: 29798856, COI: 1:CAS:528:DC%2BC1cXpvFGjsb0%3D
    • Ma, C. et al. Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells. Science 360, eaan5931 (2018).
    • (2018) Science , vol.360
    • Ma, C.1
  • 166
    • 85047110060 scopus 로고    scopus 로고
    • Dietary and microbial oxazoles induce intestinal inflammation by modulating aryl hydrocarbon receptor responses
    • COI: 1:CAS:528:DC%2BC1cXpvVemurc%3D, PID: 29775592
    • Iyer, S. S. et al. Dietary and microbial oxazoles induce intestinal inflammation by modulating aryl hydrocarbon receptor responses. Cell 173, 1123–1134 (2018).
    • (2018) Cell , vol.173 , pp. 1123-1134
    • Iyer, S.S.1
  • 167
    • 84894610824 scopus 로고    scopus 로고
    • Structure, function, and biosynthesis of thiazole/oxazole-modified microcins
    • COI: 1:CAS:528:DC%2BC2cXjtlWjtLs%3D
    • Metelev, M. V. & Ghilarov, D. A. Structure, function, and biosynthesis of thiazole/oxazole-modified microcins. Mol. Biol. 48, 29–45 (2014).
    • (2014) Mol. Biol. , vol.48 , pp. 29-45
    • Metelev, M.V.1    Ghilarov, D.A.2
  • 168
    • 85034088916 scopus 로고    scopus 로고
    • Mucosal-associated invariant T cells: New insights into antigen recognition and activation
    • PID: 29176983, COI: 1:CAS:528:DC%2BC1cXitFemsL7F
    • Xiao, X. & Cai, J. Mucosal-associated invariant T cells: New insights into antigen recognition and activation. Front. Immunol. 8, 1540 (2017).
    • (2017) Front. Immunol. , vol.8 , pp. 1540
    • Xiao, X.1    Cai, J.2
  • 169
    • 77954701928 scopus 로고    scopus 로고
    • Human mucosal associated invariant T cells detect bacterially infected cells
    • PID: 20613858, COI: 1:CAS:528:DC%2BC3cXos1altLc%3D
    • Gold, M. C. et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLOS Biol. 8, e1000407 (2010).
    • (2010) PLOS Biol. , vol.8
    • Gold, M.C.1
  • 170
    • 78751575411 scopus 로고    scopus 로고
    • The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice
    • COI: 1:CAS:528:DC%2BC3MXovVarsA%3D%3D, PID: 21190736
    • Georgel, P., Radosavljevic, M., Macquin, C. & Bahram, S. The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice. Mol. Immunol. 48, 769–775 (2011).
    • (2011) Mol. Immunol. , vol.48 , pp. 769-775
    • Georgel, P.1    Radosavljevic, M.2    Macquin, C.3    Bahram, S.4
  • 171
    • 0037434974 scopus 로고    scopus 로고
    • Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
    • COI: 1:CAS:528:DC%2BD3sXhvFKgsr8%3D, PID: 12634786
    • Treiner, E. et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422, 164–169 (2003).
    • (2003) Nature , vol.422 , pp. 164-169
    • Treiner, E.1
  • 172
    • 84877044428 scopus 로고    scopus 로고
    • MAIT cells, surveyors of a new class of antigen: development and functions
    • PID: 23422835, COI: 1:CAS:528:DC%2BC3sXisl2is7Y%3D
    • Le Bourhis, L., Mburu, Y. K. & Lantz, O. MAIT cells, surveyors of a new class of antigen: development and functions. Curr. Opin. Immunol. 25, 174–180 (2013).
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 174-180
    • Le Bourhis, L.1    Mburu, Y.K.2    Lantz, O.3
  • 173
    • 84870284140 scopus 로고    scopus 로고
    • MR1 presents microbial vitamin B metabolites to MAIT cells
    • COI: 1:CAS:528:DC%2BC38XhsVykurvO, PID: 23051753
    • Kjer-Nielsen, L. et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491, 717–723 (2012).
    • (2012) Nature , vol.491 , pp. 717-723
    • Kjer-Nielsen, L.1
  • 174
    • 84900551126 scopus 로고    scopus 로고
    • T cell activation by transitory neo-antigens derived from distinct microbial pathways
    • COI: 1:CAS:528:DC%2BC2cXotV2iu78%3D, PID: 24695216
    • Corbett, A. J. et al. T cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature 509, 361–365 (2014).
    • (2014) Nature , vol.509 , pp. 361-365
    • Corbett, A.J.1
  • 175
    • 85011110731 scopus 로고    scopus 로고
    • Mucosal-associated invariant T cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals
    • COI: 1:CAS:528:DC%2BC28XntFyls7Y%3D, PID: 27143301
    • Chen, Z. et al. Mucosal-associated invariant T cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals. Mucosal Immunol. 10, 58–68 (2017).
    • (2017) Mucosal Immunol. , vol.10 , pp. 58-68
    • Chen, Z.1
  • 176
    • 85033576428 scopus 로고    scopus 로고
    • Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
    • COI: 1:CAS:528:DC%2BC1cXjslOrsw%3D%3D, PID: 29097494
    • Routy, B. et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359, 91–97 (2018).
    • (2018) Science , vol.359 , pp. 91-97
    • Routy, B.1
  • 177
    • 85040119520 scopus 로고    scopus 로고
    • The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
    • COI: 1:CAS:528:DC%2BC1cXjslOksg%3D%3D, PID: 29302014
    • Matson, V. et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science 359, 104–108 (2018).
    • (2018) Science , vol.359 , pp. 104-108
    • Matson, V.1
  • 178
    • 85033587326 scopus 로고    scopus 로고
    • Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
    • COI: 1:CAS:528:DC%2BC1cXjslOrsA%3D%3D, PID: 29097493, Together with Routy et al. (2018) and Matson et al. (2018), this study uses human microbiota-transplanted mice to show that certain commensals causally affect the responsiveness of patients with cancer to immune checkpoint blockade therapies
    • Gopalakrishnan, V. et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359, 97–103 (2018). References 176–178 show that gut commensals affect responses to immune checkpoint blockade therapy in patients with cancer.
    • (2018) Science , vol.359 , pp. 97-103
    • Gopalakrishnan, V.1
  • 179
    • 85053066099 scopus 로고    scopus 로고
    • Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response
    • COI: 1:CAS:528:DC%2BC1cXhs1Cgur3J, PID: 30193848
    • Uchimura, Y. et al. Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response. Immunity 49, 545–559 (2018).
    • (2018) Immunity , vol.49 , pp. 545-559
    • Uchimura, Y.1
  • 180
    • 85046534759 scopus 로고    scopus 로고
    • Gut microbiota utilize immunoglobulin A for mucosal colonization
    • COI: 1:CAS:528:DC%2BC1cXpsVCgsL8%3D, PID: 29724905
    • Donaldson, G. P. et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science 360, 795–800 (2018).
    • (2018) Science , vol.360 , pp. 795-800
    • Donaldson, G.P.1
  • 181
    • 85030571807 scopus 로고    scopus 로고
    • Natural polyreactive IgA antibodies coat the intestinal microbiota
    • PID: 28971969, COI: 1:CAS:528:DC%2BC2sXhs1Kns73F
    • Bunker, J. J. et al. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science 358, eaan6619 (2017).
    • (2017) Science , vol.358
    • Bunker, J.J.1
  • 182
    • 84979735744 scopus 로고    scopus 로고
    • Gut microbial metabolites fuel host antibody responses
    • COI: 1:CAS:528:DC%2BC28Xht1Ghu7nO, PID: 27476413
    • Kim, M., Qie, Y., Park, J. & Kim, C. H. Gut microbial metabolites fuel host antibody responses. Cell Host Microbe 20, 202–214 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 202-214
    • Kim, M.1    Qie, Y.2    Park, J.3    Kim, C.H.4
  • 184
    • 44349167059 scopus 로고    scopus 로고
    • Dendritic cells in intestinal immune regulation
    • COI: 1:CAS:528:DC%2BD1cXmt1Ojt7w%3D, PID: 18500229
    • Coombes, J. L. & Powrie, F. Dendritic cells in intestinal immune regulation. Nat. Rev. Immunol. 8, 435–446 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 435-446
    • Coombes, J.L.1    Powrie, F.2
  • 185
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+DCs induces Foxp3+regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
    • COI: 1:CAS:528:DC%2BD2sXptVyjs7k%3D, PID: 17620361
    • Coombes, J. L. et al. A functionally specialized population of mucosal CD103+DCs induces Foxp3+regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism. J. Exp. Med. 204, 1757–1764 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1
  • 186
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • COI: 1:CAS:528:DC%2BD2sXptVyjs7c%3D, PID: 17620362
    • Sun, C.-M. et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204, 1775–1785 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.-M.1
  • 187
    • 34548208943 scopus 로고    scopus 로고
    • Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
    • COI: 1:CAS:528:DC%2BD2sXhtVKiu7jL, PID: 17694047
    • Travis, M. A. et al. Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449, 361–365 (2007).
    • (2007) Nature , vol.449 , pp. 361-365
    • Travis, M.A.1
  • 188
    • 79959396339 scopus 로고    scopus 로고
    • Bile retinoids imprint intestinal CD103 + dendritic cells with the ability to generate gut-tropic T cells
    • PID: 21289617, COI: 1:CAS:528:DC%2BC3MXns12kt7o%3D
    • Jaensson-Gyllenbäck, E. et al. Bile retinoids imprint intestinal CD103 + dendritic cells with the ability to generate gut-tropic T cells. Mucosal Immunol. 4, 438–447 (2011).
    • (2011) Mucosal Immunol. , vol.4 , pp. 438-447
    • Jaensson-Gyllenbäck, E.1
  • 189
    • 63649135273 scopus 로고    scopus 로고
    • GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity
    • COI: 1:CAS:528:DC%2BD1MXjslOksLk%3D, PID: 19190084
    • Yokota, A. et al. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int. Immunol. 21, 361–377 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 361-377
    • Yokota, A.1
  • 190
    • 5644300399 scopus 로고    scopus 로고
    • Retinoic acid imprints gut-homing specificity on T cells
    • COI: 1:CAS:528:DC%2BD2cXpvVygtLw%3D, PID: 15485630
    • Iwata, M. et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 21, 527–538 (2004).
    • (2004) Immunity , vol.21 , pp. 527-538
    • Iwata, M.1
  • 191
    • 84964403670 scopus 로고    scopus 로고
    • Development and maintenance of intestinal regulatory T cells
    • COI: 1:CAS:528:DC%2BC28XmtFens7c%3D, PID: 27087661
    • Tanoue, T., Atarashi, K. & Honda, K. Development and maintenance of intestinal regulatory T cells. Nat. Rev. Immunol. 16, 295–309 (2016).
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 295-309
    • Tanoue, T.1    Atarashi, K.2    Honda, K.3
  • 192
    • 77957025756 scopus 로고    scopus 로고
    • Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
    • COI: 1:CAS:528:DC%2BC3cXht1SntLvN, PID: 20870174
    • Xu, L. et al. Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity 33, 313–325 (2010).
    • (2010) Immunity , vol.33 , pp. 313-325
    • Xu, L.1
  • 193
    • 84876812029 scopus 로고    scopus 로고
    • Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells
    • COI: 1:CAS:528:DC%2BC38XhvVajurfF, PID: 23235743
    • Zeng, R. et al. Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal Immunol. 6, 847–856 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 847-856
    • Zeng, R.1
  • 194
    • 84953341448 scopus 로고    scopus 로고
    • Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid
    • COI: 1:CAS:528:DC%2BC28XhvFKmtA%3D%3D, PID: 26129652
    • Zeng, R., Bscheider, M., Lahl, K., Lee, M. & Butcher, E. C. Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid. Mucosal Immunol. 9, 183–193 (2016).
    • (2016) Mucosal Immunol. , vol.9 , pp. 183-193
    • Zeng, R.1    Bscheider, M.2    Lahl, K.3    Lee, M.4    Butcher, E.C.5
  • 195
    • 84877954998 scopus 로고    scopus 로고
    • Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms
    • COI: 1:CAS:528:DC%2BC3sXovVKgt70%3D, PID: 23704880
    • Konieczna, P. et al. Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms. PLOS ONE 8, e62617 (2013).
    • (2013) PLOS ONE , vol.8
    • Konieczna, P.1
  • 196
    • 84949491459 scopus 로고    scopus 로고
    • Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of prevotella
    • COI: 1:CAS:528:DC%2BC2MXhsl2mtr%2FM, PID: 26552345
    • Kovatcheva-Datchary, P. et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of prevotella. Cell Metab. 22, 971–982 (2015).
    • (2015) Cell Metab. , vol.22 , pp. 971-982
    • Kovatcheva-Datchary, P.1
  • 197
    • 54549089749 scopus 로고    scopus 로고
    • Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
    • COI: 1:CAS:528:DC%2BD1cXht1KrtbrF
    • Rubic, T. et al. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat. Immunol. 9, 1261–1269 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1261-1269
    • Rubic, T.1
  • 198
    • 85020848232 scopus 로고    scopus 로고
    • Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43
    • PID: 27966553, COI: 1:CAS:528:DC%2BC28XitFSnt7%2FF
    • Wu, W. et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunol. 10, 946–956 (2016).
    • (2016) Mucosal Immunol. , vol.10 , pp. 946-956
    • Wu, W.1
  • 199
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • COI: 1:CAS:528:DC%2BC3cXhtFSntL7F, PID: 20720200
    • Mezrich, J. D. et al. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J. Immunol. 185, 3190–3198 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 3190-3198
    • Mezrich, J.D.1
  • 200
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: tolerance and tryptophan catabolism
    • COI: 1:CAS:528:DC%2BD2cXotVSlsLg%3D, PID: 15459668
    • Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat. Rev. Immunol. 4, 762–774 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 201
    • 34748835898 scopus 로고    scopus 로고
    • IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation
    • COI: 1:CAS:528:DC%2BD2sXhtVOrtbnN, PID: 17767193
    • Puccetti, P. & Grohmann, U. IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation. Nat. Rev. Immunol. 7, 817–823 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 817-823
    • Puccetti, P.1    Grohmann, U.2
  • 202
    • 85048755356 scopus 로고    scopus 로고
    • Critical role for the microbiota in CX3CR1+intestinal mononuclear phagocyte regulation of intestinal T cell responses
    • COI: 1:CAS:528:DC%2BC1cXht1GjsLbL, PID: 29980437
    • Kim, M. et al. Critical role for the microbiota in CX3CR1+intestinal mononuclear phagocyte regulation of intestinal T cell responses. Immunity 49, 151–163 (2018).
    • (2018) Immunity , vol.49 , pp. 151-163
    • Kim, M.1
  • 203
    • 84874688283 scopus 로고    scopus 로고
    • Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1-hi cells
    • COI: 1:CAS:528:DC%2BC3sXhtV2rsLY%3D, PID: 23334413
    • Diehl, G. E. et al. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1-hi cells. Nature 494, 116–120 (2013).
    • (2013) Nature , vol.494 , pp. 116-120
    • Diehl, G.E.1
  • 204
    • 84939793511 scopus 로고    scopus 로고
    • Intestinal monocyte-derived macrophages control commensal-specific Th17 responses
    • COI: 1:CAS:528:DC%2BC2MXhtlCis7rF, PID: 26279572
    • Panea, C. et al. Intestinal monocyte-derived macrophages control commensal-specific Th17 responses. Cell Rep. 12, 1314–1324 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 1314-1324
    • Panea, C.1
  • 205
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • COI: 1:CAS:528:DC%2BC2cXisFyisL4%3D, PID: 24390544
    • Chang, P. V., Hao, L., Offermanns, S. & Medzhitov, R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl Acad. Sci. USA 111, 2247–2252 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 206
    • 85055538084 scopus 로고    scopus 로고
    • Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis
    • COI: 1:CAS:528:DC%2BC1MXjvFaiu7s%3D
    • Mann, E. R. et al. Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Sci. Transl Med. 10, 4755 (2018).
    • (2018) Sci. Transl Med. , vol.10 , pp. 4755
    • Mann, E.R.1
  • 207
    • 84964577698 scopus 로고    scopus 로고
    • Microbial metabolite butyrate facilitates M2 macrophage polarization and function
    • COI: 1:CAS:528:DC%2BC28XmsFyktLg%3D, PID: 27094081
    • Ji, J. et al. Microbial metabolite butyrate facilitates M2 macrophage polarization and function. Sci. Rep. 6, 24838 (2016).
    • (2016) Sci. Rep. , vol.6
    • Ji, J.1
  • 208
    • 85026755340 scopus 로고    scopus 로고
    • The microbial metabolite desaminotyrosine protects from influenza through type I interferon
    • COI: 1:CAS:528:DC%2BC2sXht1GgsrfM, PID: 28774928
    • Steed, A. L. et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science 357, 498–502 (2017).
    • (2017) Science , vol.357 , pp. 498-502
    • Steed, A.L.1
  • 209
    • 84961052700 scopus 로고    scopus 로고
    • The influence of commensal bacteria on infection with enteric viruses
    • COI: 1:CAS:528:DC%2BC28Xit1Wktr0%3D, PID: 26853118
    • Karst, S. M. The influence of commensal bacteria on infection with enteric viruses. Nat. Rev. Microbiol. 14, 197–204 (2016).
    • (2016) Nat. Rev. Microbiol. , vol.14 , pp. 197-204
    • Karst, S.M.1
  • 210
    • 80054091498 scopus 로고    scopus 로고
    • Intestinal microbiota promote enteric virus replication and systemic pathogenesis
    • COI: 1:CAS:528:DC%2BC3MXht1yktr%2FI, PID: 21998395
    • Kuss, S. K. et al. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science 334, 249–252 (2011).
    • (2011) Science , vol.334 , pp. 249-252
    • Kuss, S.K.1
  • 211
    • 84928112296 scopus 로고    scopus 로고
    • Synthetic microbes as drug delivery systems
    • COI: 1:CAS:528:DC%2BC2cXht1ClsbbP, PID: 25079685
    • Claesen, J. & Fischbach, M. A. Synthetic microbes as drug delivery systems. ACS Synth. Biol. 4, 358–364 (2015).
    • (2015) ACS Synth. Biol. , vol.4 , pp. 358-364
    • Claesen, J.1    Fischbach, M.A.2
  • 212
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • COI: 1:CAS:528:DC%2BC3MXmtVCltw%3D%3D, PID: 21235323
    • Kumar, H., Kawai, T. & Akira, S. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30, 16–34 (2011).
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 213
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • COI: 1:CAS:528:DC%2BC3cXotlahtLY%3D, PID: 20351312
    • Krawczyk, C. M. et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115, 4742–4749 (2010).
    • (2010) Blood , vol.115 , pp. 4742-4749
    • Krawczyk, C.M.1
  • 214
    • 84942982260 scopus 로고    scopus 로고
    • Metabolic reprogramming in macrophages and dendritic cells in innate immunity
    • PID: 26045163, COI: 1:CAS:528:DC%2BC2MXhtFOjtr%2FI
    • Kelly, B. & O’Neill, L. A. J. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 25, 771–784 (2015).
    • (2015) Cell Res. , vol.25 , pp. 771-784
    • Kelly, B.1    O’Neill, L.A.J.2
  • 215
    • 85065108716 scopus 로고    scopus 로고
    • Pipeline. symbiotix-bio
    • Symbiotix Biotherapies. Pipeline. symbiotix-bio http://symbiotix-bio.com/research-and-development/pipeline/ (2019).
    • (2019) Symbiotix Biotherapies
  • 216
    • 84977622019 scopus 로고    scopus 로고
    • Diet-microbiota interactions as moderators of human metabolism
    • COI: 1:CAS:528:DC%2BC28XhtFensLzI, PID: 5991619
    • Sonnenburg, J. L. & Bäckhed, F. Diet-microbiota interactions as moderators of human metabolism. Nature 535, 56–64 (2016).
    • (2016) Nature , vol.535 , pp. 56-64
    • Sonnenburg, J.L.1    Bäckhed, F.2
  • 217
    • 85019662341 scopus 로고    scopus 로고
    • The path towards microbiome-based metabolite treatment
    • COI: 1:CAS:528:DC%2BC2sXosVWns7c%3D, PID: 28540921
    • Suez, J. & Elinav, E. The path towards microbiome-based metabolite treatment. Nat. Microbiol. 2, 17075 (2017).
    • (2017) Nat. Microbiol. , vol.2 , pp. 17075
    • Suez, J.1    Elinav, E.2
  • 218
    • 85051856613 scopus 로고    scopus 로고
    • Computer-guided design of optimal microbial consortia for immune system modulation
    • PID: 29664397
    • Stein, R. R. et al. Computer-guided design of optimal microbial consortia for immune system modulation. eLife 7, e30916 (2018).
    • (2018) eLife , vol.7
    • Stein, R.R.1
  • 219
    • 85043340868 scopus 로고    scopus 로고
    • Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies
    • COI: 1:CAS:528:DC%2BC1cXlt1Okt7o%3D, PID: 29556107
    • Tramontano, M. et al. Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies. Nat. Microbiol. 3, 514–522 (2018).
    • (2018) Nat. Microbiol. , vol.3 , pp. 514-522
    • Tramontano, M.1
  • 220
    • 84992363298 scopus 로고    scopus 로고
    • Stable engraftment of bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome
    • PID: 27693307, COI: 1:CAS:528:DC%2BC28XhsF2qtbzN
    • Maldonado-Gómez, M. X. et al. Stable engraftment of bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host Microbe 20, 515–526 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 515-526
    • Maldonado-Gómez, M.X.1
  • 221
    • 85047558885 scopus 로고    scopus 로고
    • An exclusive metabolic niche enables strain engraftment in the gut microbiota
    • COI: 1:CAS:528:DC%2BC1cXptlarsrc%3D, PID: 29743671
    • Shepherd, E. S., Deloache, W. C., Pruss, K. M., Whitaker, W. R. & Sonnenburg, J. L. An exclusive metabolic niche enables strain engraftment in the gut microbiota. Nature 557, 434–438 (2018).
    • (2018) Nature , vol.557 , pp. 434-438
    • Shepherd, E.S.1    Deloache, W.C.2    Pruss, K.M.3    Whitaker, W.R.4    Sonnenburg, J.L.5
  • 222
    • 85052211052 scopus 로고    scopus 로고
    • Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort
    • COI: 1:CAS:528:DC%2BC1MXkt1OnsQ%3D%3D
    • Gurry, T. et al. Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort. Sci. Rep. 8, 12699 (2017).
    • (2017) Sci. Rep. , vol.8
    • Gurry, T.1
  • 223
    • 85028348393 scopus 로고    scopus 로고
    • A randomized synbiotic trial to prevent sepsis among infants in rural India
    • COI: 1:CAS:528:DC%2BC2sXhtlGktrrE, PID: 28813414, This study shows that a synbiotic consisting ofL. plantarumand fructo-oligosaccharide protects infants against sepsis
    • Panigrahi, P. et al. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature 548, 407–412 (2017). This study shows that a synbiotic consisting of L. plantarum and fructo-oligosaccharide protects infants against sepsis.
    • (2017) Nature , vol.548 , pp. 407-412
    • Panigrahi, P.1
  • 224
    • 55549145803 scopus 로고    scopus 로고
    • Long-term colonization of a lactobacillus plantarum synbiotic preparation in the neonatal gut
    • PID: 18607268
    • Panigrahi, P. et al. Long-term colonization of a lactobacillus plantarum synbiotic preparation in the neonatal gut. J. Pediatr. Gastroenterol. Nutr. 47, 45–53 (2008).
    • (2008) J. Pediatr. Gastroenterol. Nutr. , vol.47 , pp. 45-53
    • Panigrahi, P.1
  • 225
    • 79955025122 scopus 로고    scopus 로고
    • Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
    • COI: 1:CAS:528:DC%2BC3MXltVOqurc%3D
    • Goodman, A. L. et al. Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc. Natl Acad. Sci. USA 108, 6252–6257 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 6252-6257
    • Goodman, A.L.1
  • 226
    • 85057537429 scopus 로고    scopus 로고
    • Colonocyte metabolism shapes the gut microbiota
    • PID: 30498100, COI: 1:CAS:528:DC%2BC1cXitlWhtLbP
    • Litvak, Y., Byndloss, M. X. & Bäumler, A. J. Colonocyte metabolism shapes the gut microbiota. Science 362, eaat9076 (2018).
    • (2018) Science , vol.362
    • Litvak, Y.1    Byndloss, M.X.2    Bäumler, A.J.3
  • 227
    • 85046668698 scopus 로고    scopus 로고
    • Healthy hosts rule within: ecological forces shaping the gut microbiota
    • COI: 1:CAS:528:DC%2BC1cXhtFKltbrI, PID: 29743614
    • Byndloss, M. X., Pernitzsch, S. R. & Bäumler, A. J. Healthy hosts rule within: ecological forces shaping the gut microbiota. Mucosal Immunol. 11, 1299–1305 (2018).
    • (2018) Mucosal Immunol. , vol.11 , pp. 1299-1305
    • Byndloss, M.X.1    Pernitzsch, S.R.2    Bäumler, A.J.3
  • 228
    • 85027175538 scopus 로고    scopus 로고
    • Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
    • COI: 1:CAS:528:DC%2BC2sXhtlehur%2FN, PID: 28798125
    • Byndloss, M. X. et al. Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. Science 357, 570–575 (2017).
    • (2017) Science , vol.357 , pp. 570-575
    • Byndloss, M.X.1
  • 229
    • 85026756258 scopus 로고    scopus 로고
    • Dysbiotic proteobacteria expansion: a microbial signature of epithelial dysfunction
    • COI: 1:CAS:528:DC%2BC2sXht1Cku7bE, PID: 28783509
    • Litvak, Y., Byndloss, M. X., Tsolis, R. M. & Bäumler, A. J. Dysbiotic proteobacteria expansion: a microbial signature of epithelial dysfunction. Curr. Opin. Microbiol. 39, 1–6 (2017).
    • (2017) Curr. Opin. Microbiol. , vol.39 , pp. 1-6
    • Litvak, Y.1    Byndloss, M.X.2    Tsolis, R.M.3    Bäumler, A.J.4
  • 230
    • 85048696117 scopus 로고    scopus 로고
    • Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota
    • COI: 1:CAS:528:DC%2BC1cXhtFGns73E, PID: 29915298
    • Tang, C. et al. Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota. Nat. Immunol. 19, 755–765 (2018).
    • (2018) Nat. Immunol. , vol.19 , pp. 755-765
    • Tang, C.1
  • 231
    • 84923273687 scopus 로고    scopus 로고
    • Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation
    • COI: 1:CAS:528:DC%2BC2MXitFemtQ%3D%3D, PID: 25574022
    • Cullen, T. W. et al. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation. Science 347, 170–175 (2015).
    • (2015) Science , vol.347 , pp. 170-175
    • Cullen, T.W.1
  • 232
    • 85018672799 scopus 로고    scopus 로고
    • NLRP6 protects Il10−/−mice from colitis by limiting colonization of akkermansia muciniphila
    • COI: 1:CAS:528:DC%2BC2sXmslSjsb0%3D, PID: 28445725
    • Seregin, S. S. et al. NLRP6 protects Il10−/−mice from colitis by limiting colonization of akkermansia muciniphila. Cell Rep. 19, 733–745 (2017).
    • (2017) Cell Rep. , vol.19 , pp. 733-745
    • Seregin, S.S.1
  • 233
    • 78149283854 scopus 로고    scopus 로고
    • Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
    • COI: 1:CAS:528:DC%2BC3cXhtlOhsb7J, PID: 20648002
    • Png, C. W. et al. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am. J. Gastroenterol. 105, 2420–2428 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 2420-2428
    • Png, C.W.1
  • 234
    • 85047009337 scopus 로고    scopus 로고
    • Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
    • COI: 1:CAS:528:DC%2BC1cXjtFOht78%3D, PID: 29472701
    • Chelakkot, C. et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp. Mol. Med. 50, e450 (2018).
    • (2018) Exp. Mol. Med. , vol.50
    • Chelakkot, C.1
  • 235
    • 84947460237 scopus 로고    scopus 로고
    • Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
    • COI: 1:CAS:528:DC%2BC2MXhvVOru7vM, PID: 26563823
    • Schneeberger, M. et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Sci. Rep. 5, 16643 (2015).
    • (2015) Sci. Rep. , vol.5
    • Schneeberger, M.1
  • 236
    • 85045856132 scopus 로고    scopus 로고
    • Microbiota-accessible carbohydrates suppress Clostridium difficile infection in a murine model
    • COI: 1:CAS:528:DC%2BC1cXotF2ktrw%3D, PID: 29686297
    • Hryckowian, A. J. et al. Microbiota-accessible carbohydrates suppress Clostridium difficile infection in a murine model. Nat. Microbiol. 3, 662–669 (2018).
    • (2018) Nat. Microbiol. , vol.3 , pp. 662-669
    • Hryckowian, A.J.1
  • 237
    • 0034714188 scopus 로고    scopus 로고
    • Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
    • COI: 1:CAS:528:DC%2BD3cXmt1amsLw%3D, PID: 10958782
    • Steidler, L. et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289, 1352–1355 (2000).
    • (2000) Science , vol.289 , pp. 1352-1355
    • Steidler, L.1
  • 238
    • 33744933432 scopus 로고    scopus 로고
    • A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn’s disease
    • COI: 1:CAS:528:DC%2BD28XmvVylsr0%3D, PID: 16716759
    • Braat, H. et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn’s disease. Clin. Gastroenterol. Hepatol. 4, 754–759 (2006).
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 754-759
    • Braat, H.1
  • 239
    • 85023177674 scopus 로고    scopus 로고
    • Sustainable therapies by engineered bacteria
    • PID: 28696008, COI: 1:CAS:528:DC%2BC2sXhsFOntLnP
    • Álvarez, B. & Fernández, L. Á. Sustainable therapies by engineered bacteria. Microb. Biotechnol. 10, 1057–1061 (2017).
    • (2017) Microb. Biotechnol. , vol.10 , pp. 1057-1061
    • Álvarez, B.1    Fernández, L.Á.2
  • 240
    • 77954920911 scopus 로고    scopus 로고
    • Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model
    • COI: 1:CAS:528:DC%2BC3cXot1eksLo%3D, PID: 20534565
    • Duan, F. & March, J. C. Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model. Proc. Natl Acad. Sci. USA 107, 11260–11264 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 11260-11264
    • Duan, F.1    March, J.C.2
  • 241
    • 84959284597 scopus 로고    scopus 로고
    • Vibrio cholerae biofilms and cholera pathogenesis
    • PID: 26845681, COI: 1:CAS:528:DC%2BC1cXmtlSqtLY%3D
    • Silva, A. J. & Benitez, J. A. Vibrio cholerae biofilms and cholera pathogenesis. PLOS Negl. Trop. Dis. 10, e0004330 (2016).
    • (2016) PLOS Negl. Trop. Dis. , vol.10
    • Silva, A.J.1    Benitez, J.A.2
  • 242
    • 84911468185 scopus 로고    scopus 로고
    • Members of the human gut microbiota involved in recovery from Vibrio cholerae infection
    • COI: 1:CAS:528:DC%2BC2cXhvVemtr3M, PID: 25231861
    • Hsiao, A. et al. Members of the human gut microbiota involved in recovery from Vibrio cholerae infection. Nature 515, 423–426 (2014).
    • (2014) Nature , vol.515 , pp. 423-426
    • Hsiao, A.1
  • 243
    • 80051910411 scopus 로고    scopus 로고
    • Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
    • PID: 21847113, COI: 1:CAS:528:DC%2BC3MXht12nsbfO
    • Saeidi, N. et al. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Mol. Syst. Biol. 7, 521 (2011).
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 521
    • Saeidi, N.1
  • 244
    • 85017396256 scopus 로고    scopus 로고
    • Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
    • COI: 1:CAS:528:DC%2BC2sXmtFGmt7w%3D, PID: 28398304
    • Hwang, I. Y. et al. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nat. Commun. 8, 15028 (2017).
    • (2017) Nat. Commun. , vol.8
    • Hwang, I.Y.1
  • 245
    • 84991053856 scopus 로고    scopus 로고
    • Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
    • PID: 27320064, COI: 1:CAS:528:DC%2BC28XhtVWnsbzP
    • Wahlström, A., Sayin, S. I., Marschall, H. U. & Bäckhed, F. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24, 41–50 (2016).
    • (2016) Cell Metab. , vol.24 , pp. 41-50
    • Wahlström, A.1    Sayin, S.I.2    Marschall, H.U.3    Bäckhed, F.4
  • 246
    • 51649086648 scopus 로고    scopus 로고
    • Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
    • COI: 1:CAS:528:DC%2BD1cXhtFeqs7fK, PID: 18757757
    • Jones, B. V., Begley, M., Hill, C., Gahan, C. G. M. & Marchesi, J. R. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc. Natl Acad. Sci. USA 105, 13580–13585 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13580-13585
    • Jones, B.V.1    Begley, M.2    Hill, C.3    Gahan, C.G.M.4    Marchesi, J.R.5
  • 247
    • 0034034841 scopus 로고    scopus 로고
    • Assignment of eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces
    • COI: 1:CAS:528:DC%2BD3cXktF2gs74%3D, PID: 10843034
    • Kitahara, M., Takamine, F., Imamura, T. & Benno, Y. Assignment of eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces. Int. J. Syst. Evol. Microbiol. 50, 971–978 (2000).
    • (2000) Int. J. Syst. Evol. Microbiol. , vol.50 , pp. 971-978
    • Kitahara, M.1    Takamine, F.2    Imamura, T.3    Benno, Y.4
  • 248
    • 0035155058 scopus 로고    scopus 로고
    • Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity
    • COI: 1:CAS:528:DC%2BD3MXhtlaksr8%3D, PID: 11211270
    • Kitahara, M., Takamine, F., Imamura, T. & Benno, Y. Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity. Int. J. Syst. Evol. Microbiol. 51, 39–44 (2001).
    • (2001) Int. J. Syst. Evol. Microbiol. , vol.51 , pp. 39-44
    • Kitahara, M.1    Takamine, F.2    Imamura, T.3    Benno, Y.4
  • 249
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • COI: 1:CAS:528:DC%2BD28XhtlaitL8%3D, PID: 16299351
    • Ridlon, J. M., Kang, D.-J. & Hylemon, P. B. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47, 241–259 (2006).
    • (2006) J. Lipid Res. , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.-J.2    Hylemon, P.B.3
  • 251
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • COI: 1:CAS:528:DC%2BD1MXit1Cqtro%3D, PID: 19126757
    • Lefebvre, P., Cariou, B., Lien, F., Kuipers, F. & Staels, B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89, 147–191 (2009).
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 252
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • COI: 1:CAS:528:DC%2BD3cXmvFShtr8%3D, PID: 11030617
    • Sinal, C. J. et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102, 731–744 (2000).
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1
  • 253
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • COI: 1:CAS:528:DC%2BD1MXhtlKhsbnJ, PID: 19864602
    • Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E. & Fiorucci, S. The bile acid receptor FXR is a modulator of intestinal innate immunity. J. Immunol. 183, 6251–6261 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 6251-6261
    • Vavassori, P.1    Mencarelli, A.2    Renga, B.3    Distrutti, E.4    Fiorucci, S.5
  • 254
    • 80052720863 scopus 로고    scopus 로고
    • TGR5: a novel target for weight maintenance and glucose metabolism
    • PID: 21754919
    • Chen, X., Lou, G., Meng, Z. & Huang, W. TGR5: a novel target for weight maintenance and glucose metabolism. Exp. Diabetes Res. 2011, 853501 (2011).
    • (2011) Exp. Diabetes Res. , vol.2011 , pp. 853501
    • Chen, X.1    Lou, G.2    Meng, Z.3    Huang, W.4
  • 255
    • 0036432845 scopus 로고    scopus 로고
    • Identification of membrane-type receptor for bile acids (M-BAR)
    • COI: 1:CAS:528:DC%2BD38Xot12kt78%3D, PID: 12419312
    • Maruyama, T. et al. Identification of membrane-type receptor for bile acids (M-BAR). Biochem. Biophys. Res. Commun. 298, 714–719 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.298 , pp. 714-719
    • Maruyama, T.1
  • 256
    • 84888798215 scopus 로고    scopus 로고
    • Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages
    • PID: 23990628, COI: 1:CAS:528:DC%2BC2cXhvFOlsr4%3D
    • Haselow, K. et al. Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages. J. Leukoc. Biol. 94, 1253–1264 (2013).
    • (2013) J. Leukoc. Biol. , vol.94 , pp. 1253-1264
    • Haselow, K.1
  • 257
    • 44649092024 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor TGR5 in Kupffer cells
    • COI: 1:CAS:528:DC%2BD1cXmvFeku7Y%3D, PID: 18468513
    • Keitel, V., Donner, M., Winandy, S., Kubitz, R. & Häussinger, D. Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem. Biophys. Res. Commun. 372, 78–84 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 78-84
    • Keitel, V.1    Donner, M.2    Winandy, S.3    Kubitz, R.4    Häussinger, D.5
  • 258
    • 84915748816 scopus 로고    scopus 로고
    • TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation
    • PID: 25365223
    • Perino, A. et al. TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation. J. Clin. Invest. 124, 5424–5436 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 5424-5436
    • Perino, A.1
  • 259
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • COI: 1:CAS:528:DC%2BC3MXhs1Sktr7M, PID: 22152303
    • Pols, T. W. H. et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab. 14, 747–757 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 747-757
    • Pols, T.W.H.1
  • 260
    • 85019134594 scopus 로고    scopus 로고
    • Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor
    • PID: 28493883, COI: 1:CAS:528:DC%2BC2sXhs12js7zO
    • Pols, T. W. H. et al. Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor. PLOS ONE 12, e0176715 (2017).
    • (2017) PLOS ONE , vol.12
    • Pols, T.W.H.1
  • 261
    • 34249284197 scopus 로고    scopus 로고
    • Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    • COI: 1:CAS:528:DC%2BD2sXmtVOksro%3D
    • Smith, K., McCoy, K. D. & Macpherson, A. J. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin. Immunol. 19, 59–69 (2007).
    • (2007) Semin. Immunol. , vol.19 , pp. 59-69
    • Smith, K.1    McCoy, K.D.2    Macpherson, A.J.3
  • 262
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • COI: 1:CAS:528:DC%2BD1MXjvF2gtbk%3D, PID: 19343057
    • Round, J. L. & Mazmanian, S. K. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol. 9, 313–323 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 263
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with a host-specific microbiota
    • COI: 1:CAS:528:DC%2BC38XptVKksb8%3D, PID: 22726443, This study shows that a host-specific microbiota is necessary for immunomaturation
    • Chung, H. et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149, 1578–1593 (2012). This study shows that a host-specific microbiota is necessary for immunomaturation.
    • (2012) Cell , vol.149 , pp. 1578-1593
    • Chung, H.1
  • 264
    • 84995744397 scopus 로고    scopus 로고
    • Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans
    • PID: 27858930
    • Zhang, L. et al. Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans. ISME J. 11, 676–690 (2017).
    • (2017) ISME J. , vol.11 , pp. 676-690
    • Zhang, L.1
  • 265
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • PID: 24009397, COI: 1:CAS:528:DC%2BC3sXhtlyjs77L
    • Ridaura, V. K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341, 1241214 (2013).
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1
  • 266
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
    • PID: 20368178, COI: 1:CAS:528:DC%2BC3cXhtVWkt7zI
    • Turnbaugh, P. J. et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci. Transl Med. 1, 6ra14 (2009).
    • (2009) Sci. Transl Med. , vol.1 , pp. 6ra14
    • Turnbaugh, P.J.1
  • 267
    • 85033501802 scopus 로고    scopus 로고
    • Mouse models for human intestinal microbiota research: a critical evaluation
    • COI: 1:CAS:528:DC%2BC2sXhsl2jt73K, PID: 29124307
    • Hugenholtz, F. & De Vos, W. M. Mouse models for human intestinal microbiota research: a critical evaluation. Cell. Mol. Life Sci. 75, 149–160 (2018).
    • (2018) Cell. Mol. Life Sci. , vol.75 , pp. 149-160
    • Hugenholtz, F.1    De Vos, W.M.2
  • 268
    • 85002556764 scopus 로고    scopus 로고
    • Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans
    • COI: 1:CAS:528:DC%2BC28XhvFyrtrzE, PID: 27638959
    • Takahashi, S. et al. Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. J. Lipid Res. 57, 2130–2137 (2016).
    • (2016) J. Lipid Res. , vol.57 , pp. 2130-2137
    • Takahashi, S.1
  • 269
    • 84920404296 scopus 로고    scopus 로고
    • How informative is the mouse for human gut microbiota research?
    • COI: 1:CAS:528:DC%2BC2MXosFSiu7k%3D, PID: 25561744
    • Nguyen, T. L. A., Vieira-Silva, S., Liston, A. & Raes, J. How informative is the mouse for human gut microbiota research? Dis. Model. Mech. 8, 1–16 (2015).
    • (2015) Dis. Model. Mech. , vol.8 , pp. 1-16
    • Nguyen, T.L.A.1    Vieira-Silva, S.2    Liston, A.3    Raes, J.4
  • 270
    • 84953273098 scopus 로고    scopus 로고
    • Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip
    • COI: 1:CAS:528:DC%2BC2MXitVWjtLbL, PID: 26668389
    • Kim, H. J., Li, H., Collins, J. J. & Ingber, D. E. Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip. Proc. Natl Acad. Sci. USA 113, E7–E15 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E7-E15
    • Kim, H.J.1    Li, H.2    Collins, J.J.3    Ingber, D.E.4
  • 271
    • 84968739591 scopus 로고    scopus 로고
    • A microfluidics-based in vitro model of the gastrointestinal human-microbe interface
    • COI: 1:CAS:528:DC%2BC28XnslegtbY%3D, PID: 27168102
    • Shah, P. et al. A microfluidics-based in vitro model of the gastrointestinal human-microbe interface. Nat. Commun. 7, 11535 (2016).
    • (2016) Nat. Commun. , vol.7
    • Shah, P.1
  • 272
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • COI: 1:CAS:528:DC%2BD1cXmtlejur0%3D, PID: 18407065
    • Turnbaugh, P. J., Bäckhed, F., Fulton, L. & Gordon, J. I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213–223 (2008).
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Bäckhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 273
    • 79956078164 scopus 로고    scopus 로고
    • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3MXmtFaisrw%3D, PID: 21575910
    • Bloom, S. M. et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 9, 390–403 (2011).
    • (2011) Cell Host Microbe , vol.9 , pp. 390-403
    • Bloom, S.M.1
  • 274
    • 84907000772 scopus 로고    scopus 로고
    • Commensal bacteria protect against food allergen sensitization
    • COI: 1:CAS:528:DC%2BC2cXhsVarsbzF, PID: 25157157
    • Stefka, A. T. et al. Commensal bacteria protect against food allergen sensitization. Proc. Natl Acad. Sci. USA 111, 13145–13150 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 13145-13150
    • Stefka, A.T.1
  • 275
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    • COI: 1:CAS:528:DC%2BC2MXhvFamtL3K, PID: 26541606
    • Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084–1089 (2015).
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 276
    • 5444248493 scopus 로고    scopus 로고
    • Akkermansia municiphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
    • COI: 1:CAS:528:DC%2BD2cXptVOls7s%3D, PID: 15388697
    • Derrien, M., Vaughan, E. E., Plugge, C. M. & de Vos, W. M. Akkermansia municiphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int. J. Syst. Evol. Microbiol. 54, 1469–1476 (2004).
    • (2004) Int. J. Syst. Evol. Microbiol. , vol.54 , pp. 1469-1476
    • Derrien, M.1    Vaughan, E.E.2    Plugge, C.M.3    de Vos, W.M.4
  • 277
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • COI: 1:CAS:528:DC%2BC3sXhtFait7rM, PID: 23671105
    • Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl Acad. Sci. USA 110, 9066–9071 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9066-9071
    • Everard, A.1
  • 278
    • 85014435525 scopus 로고    scopus 로고
    • Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function
    • PID: 28249045, COI: 1:CAS:528:DC%2BC2sXhtVGru73E
    • Ottman, N. et al. Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PLOS ONE 12, e0173004 (2017).
    • (2017) PLOS ONE , vol.12
    • Ottman, N.1
  • 279
    • 80053652303 scopus 로고    scopus 로고
    • Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats
    • PID: 21883787, COI: 1:CAS:528:DC%2BC3MXhsVKhtbbE
    • van den Abbeele, P. et al. Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats. Environ. Microbiol. 13, 2667–2680 (2011).
    • (2011) Environ. Microbiol. , vol.13 , pp. 2667-2680
    • van den Abbeele, P.1
  • 280
    • 85042191263 scopus 로고    scopus 로고
    • Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach
    • COI: 1:CAS:528:DC%2BC1cXjvFWntr8%3D, PID: 29460206
    • Chia, L. W. et al. Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach. Antonie Van Leeuwenhoek 111, 859–873 (2018).
    • (2018) Antonie Van Leeuwenhoek , vol.111 , pp. 859-873
    • Chia, L.W.1
  • 281
    • 84938917629 scopus 로고    scopus 로고
    • Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon
    • COI: 1:CAS:528:DC%2BC2MXht1Crt7rP, PID: 26216954
    • Ijssennagger, N. et al. Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon. Proc. Natl Acad. Sci. USA 112, 10038–10043 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 10038-10043
    • Ijssennagger, N.1
  • 282
    • 84883813272 scopus 로고    scopus 로고
    • Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella typhimurium-infected gnotobiotic mice
    • COI: 1:CAS:528:DC%2BC3sXhsVyrsbjL, PID: 24040367
    • Ganesh, B. P., Klopfleisch, R., Loh, G. & Blaut, M. Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella typhimurium-infected gnotobiotic mice. PLOS ONE 8, e74963 (2013).
    • (2013) PLOS ONE , vol.8
    • Ganesh, B.P.1    Klopfleisch, R.2    Loh, G.3    Blaut, M.4
  • 283
    • 84995739780 scopus 로고    scopus 로고
    • A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility
    • COI: 1:CAS:528:DC%2BC28XhvFWgu7nM, PID: 27863247
    • Desai, M. S. et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell 167, 1339–1353 (2016).
    • (2016) Cell , vol.167 , pp. 1339-1353
    • Desai, M.S.1
  • 284
    • 84975059616 scopus 로고    scopus 로고
    • Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors
    • COI: 1:CAS:528:DC%2BC28XhtVKhs7nL, PID: 27332730
    • Pitt, J. M. et al. Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors. Immunity 44, 1255–1269 (2016).
    • (2016) Immunity , vol.44 , pp. 1255-1269
    • Pitt, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.