-
1
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Comprehensive molecular portraits of human breast tumours. Nature 2012, 490:61-70. 10.1038/nature11412.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
2
-
-
78649711427
-
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
-
21127244
-
Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 2010, 330:1340-1344. 10.1126/science.1193494, 21127244.
-
(2010)
Science
, vol.330
, pp. 1340-1344
-
-
Levine, A.J.1
Puzio-Kuter, A.M.2
-
3
-
-
79952741730
-
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
-
21289278
-
Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci U S A 2011, 108:3270-3275. 10.1073/pnas.1019393108, 21289278.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3270-3275
-
-
Reitman, Z.J.1
Jin, G.2
Karoly, E.D.3
Spasojevic, I.4
Yang, J.5
Kinzler, K.W.6
He, Y.7
Bigner, D.D.8
Vogelstein, B.9
Yan, H.10
-
4
-
-
84863011452
-
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
-
22326218
-
Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Mates JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab 2012, 15:157-170. 10.1016/j.cmet.2011.12.015, 22326218.
-
(2012)
Cell Metab
, vol.15
, pp. 157-170
-
-
Yuneva, M.O.1
Fan, T.W.2
Allen, T.D.3
Higashi, R.M.4
Ferraris, D.V.5
Tsukamoto, T.6
Mates, J.M.7
Alonso, F.J.8
Wang, C.9
Seo, Y.10
Chen, X.11
Bishop, J.M.12
-
5
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
23242140
-
Maddocks OD, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, Vousden KH. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 2013, 493:542-546. 10.1038/nature11743, 23242140.
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
6
-
-
84859215796
-
Systemic elevation of PTEN induces a tumor-suppressive metabolic state
-
22401813
-
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell 2012, 149:49-62. 10.1016/j.cell.2012.02.030, 22401813.
-
(2012)
Cell
, vol.149
, pp. 49-62
-
-
Garcia-Cao, I.1
Song, M.S.2
Hobbs, R.M.3
Laurent, G.4
Giorgi, C.5
de Boer, V.C.6
Anastasiou, D.7
Ito, K.8
Sasaki, A.T.9
Rameh, L.10
Carracedo, A.11
Vander Heiden, M.G.12
Cantley, L.C.13
Pinton, P.14
Haigis, M.C.15
Pandolfi, P.P.16
-
7
-
-
84860390004
-
Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes
-
21672245
-
Gatza ML, Kung HN, Blackwell KL, Dewhirst MW, Marks JR, Chi JT. Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes. Breast Cancer Res 2011, 13:R62. 10.1186/bcr2899, 21672245.
-
(2011)
Breast Cancer Res
, vol.13
, pp. R62
-
-
Gatza, M.L.1
Kung, H.N.2
Blackwell, K.L.3
Dewhirst, M.W.4
Marks, J.R.5
Chi, J.T.6
-
8
-
-
79960954452
-
18 F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers
-
21646475
-
Palaskas N, Larson SM, Schultz N, Komisopoulou E, Wong J, Rohle D, Campos C, Yannuzzi N, Osborne JR, Linkov I, Kastenhuber ER, Taschereau R, Plaisier SB, Tran C, Heguy A, Wu H, Sander C, Phelps ME, Brennan C, Port E, Huse JT, Graeber TG, Mellinghoff IK. 18 F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer Res 2011, 71:5164-5174. 10.1158/0008-5472.CAN-10-4633, 21646475.
-
(2011)
Cancer Res
, vol.71
, pp. 5164-5174
-
-
Palaskas, N.1
Larson, S.M.2
Schultz, N.3
Komisopoulou, E.4
Wong, J.5
Rohle, D.6
Campos, C.7
Yannuzzi, N.8
Osborne, J.R.9
Linkov, I.10
Kastenhuber, E.R.11
Taschereau, R.12
Plaisier, S.B.13
Tran, C.14
Heguy, A.15
Wu, H.16
Sander, C.17
Phelps, M.E.18
Brennan, C.19
Port, E.20
Huse, J.T.21
Graeber, T.G.22
Mellinghoff, I.K.23
more..
-
9
-
-
84873390490
-
Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
-
23236214
-
Brauer HA, Makowski L, Hoadley KA, Casbas-Hernandez P, Lang LJ, Roman-Perez E, D'Arcy M, Freemerman AJ, Perou CM, Troester MA. Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res 2013, 19:571-585. 10.1158/1078-0432.CCR-12-2123, 23236214.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 571-585
-
-
Brauer, H.A.1
Makowski, L.2
Hoadley, K.A.3
Casbas-Hernandez, P.4
Lang, L.J.5
Roman-Perez, E.6
D'Arcy, M.7
Freemerman, A.J.8
Perou, C.M.9
Troester, M.A.10
-
10
-
-
84867527044
-
Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer
-
22986741
-
Jerby L, Wolf L, Denkert C, Stein GY, Hilvo M, Oresic M, Geiger T, Ruppin E. Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer. Cancer Res 2012, 72:5712-5720. 10.1158/0008-5472.CAN-12-2215, 22986741.
-
(2012)
Cancer Res
, vol.72
, pp. 5712-5720
-
-
Jerby, L.1
Wolf, L.2
Denkert, C.3
Stein, G.Y.4
Hilvo, M.5
Oresic, M.6
Geiger, T.7
Ruppin, E.8
-
11
-
-
80052338863
-
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia
-
21852960
-
Kung HN, Marks JR, Chi JT. Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. PLoS Genet 2011, 7:e1002229. 10.1371/journal.pgen.1002229, 21852960.
-
(2011)
PLoS Genet
, vol.7
, pp. e1002229
-
-
Kung, H.N.1
Marks, J.R.2
Chi, J.T.3
-
12
-
-
0034680102
-
Molecular portraits of human breast tumours
-
10963602
-
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Aksien LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature 2000, 406:747-752. 10.1038/35021093, 10963602.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
van de Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
Pollack, J.R.7
Ross, D.T.8
Johnsen, H.9
Aksien, L.A.10
Fluge, O.11
Pergamenschikov, A.12
Williams, C.13
Zhu, S.X.14
Lonning, P.E.15
Borresen-Dale, A.L.16
Brown, P.O.17
Botstein, D.18
-
13
-
-
68349130357
-
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
-
19648928
-
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009, 15:907-913. 10.1038/nm.2000, 19648928.
-
(2009)
Nat Med
, vol.15
, pp. 907-913
-
-
Lim, E.1
Vaillant, F.2
Wu, D.3
Forrest, N.C.4
Pal, B.5
Hart, A.H.6
Asselin-Labat, M.L.7
Gyorki, D.E.8
Ward, T.9
Partanen, A.10
Feleppa, F.11
Huschtscha, L.I.12
Thorne, H.J.13
Fox, S.B.14
Yan, M.15
French, J.D.16
Brown, M.A.17
Smyth, G.K.18
Visvader, J.E.19
Lindeman, G.J.20
more..
-
14
-
-
33847419142
-
Molecular definition of breast tumor heterogeneity
-
17349583
-
Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak K. Molecular definition of breast tumor heterogeneity. Cancer Cell 2007, 11:259-273. 10.1016/j.ccr.2007.01.013, 17349583.
-
(2007)
Cancer Cell
, vol.11
, pp. 259-273
-
-
Shipitsin, M.1
Campbell, L.L.2
Argani, P.3
Weremowicz, S.4
Bloushtain-Qimron, N.5
Yao, J.6
Nikolskaya, T.7
Serebryiskaya, T.8
Beroukhim, R.9
Hu, M.10
Halushka, M.K.11
Sukumar, S.12
Parker, L.M.13
Anderson, K.S.14
Harris, L.N.15
Garber, J.E.16
Richardson, A.L.17
Schnitt, S.J.18
Nikolsky, Y.19
Gelman, R.S.20
Polyak, K.21
more..
-
15
-
-
32844456226
-
Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters
-
16229059
-
Sitter B, Lundgren S, Bathen TF, Halgunset J, Fjosne HE, Gribbestad IS. Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters. NMR Biomed 2006, 19:30-40. 10.1002/nbm.992, 16229059.
-
(2006)
NMR Biomed
, vol.19
, pp. 30-40
-
-
Sitter, B.1
Lundgren, S.2
Bathen, T.F.3
Halgunset, J.4
Fjosne, H.E.5
Gribbestad, I.S.6
-
16
-
-
84865602043
-
Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study
-
22823888
-
Budczies J, Denkert C, Muller BM, Brockmoller SF, Klauschen F, Gyorffy B, Dietel M, Richter-Ehrenstein C, Marten U, Salek RM, Griffin JL, Hilvo M, Oresic M, Wohlgemuth G, Fiehn O. Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study. BMC Genomics 2012, 13:334. 10.1186/1471-2164-13-334, 22823888.
-
(2012)
BMC Genomics
, vol.13
, pp. 334
-
-
Budczies, J.1
Denkert, C.2
Muller, B.M.3
Brockmoller, S.F.4
Klauschen, F.5
Gyorffy, B.6
Dietel, M.7
Richter-Ehrenstein, C.8
Marten, U.9
Salek, R.M.10
Griffin, J.L.11
Hilvo, M.12
Oresic, M.13
Wohlgemuth, G.14
Fiehn, O.15
-
17
-
-
78649681933
-
Merging transcriptomics and metabolomics-advances in breast cancer profiling
-
21080935
-
Borgan E, Sitter B, Lingjaerde OC, Johnsen H, Lundgren S, Bathen TF, Sorlie T, Borresen-Dale AL, Gribbestad IS. Merging transcriptomics and metabolomics-advances in breast cancer profiling. BMC Cancer 2010, 10:628. 10.1186/1471-2407-10-628, 21080935.
-
(2010)
BMC Cancer
, vol.10
, pp. 628
-
-
Borgan, E.1
Sitter, B.2
Lingjaerde, O.C.3
Johnsen, H.4
Lundgren, S.5
Bathen, T.F.6
Sorlie, T.7
Borresen-Dale, A.L.8
Gribbestad, I.S.9
-
18
-
-
79955518028
-
Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression
-
21415164
-
Hilvo M, Denkert C, Lehtinen L, Muller B, Brockmoller S, Seppanen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S, Berg E, Nygren H, Sysi-Aho M, Griffin JL, Fiehn O, Loibl S, Richter-Ehrenstein C, Radke C, Hyotylainen T, Kallioniemi O, Iljin K, Oresic M. Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res 2011, 71:3236-3245. 10.1158/0008-5472.CAN-10-3894, 21415164.
-
(2011)
Cancer Res
, vol.71
, pp. 3236-3245
-
-
Hilvo, M.1
Denkert, C.2
Lehtinen, L.3
Muller, B.4
Brockmoller, S.5
Seppanen-Laakso, T.6
Budczies, J.7
Bucher, E.8
Yetukuri, L.9
Castillo, S.10
Berg, E.11
Nygren, H.12
Sysi-Aho, M.13
Griffin, J.L.14
Fiehn, O.15
Loibl, S.16
Richter-Ehrenstein, C.17
Radke, C.18
Hyotylainen, T.19
Kallioniemi, O.20
Iljin, K.21
Oresic, M.22
more..
-
19
-
-
3242798206
-
Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride
-
15166110
-
Struys EA, Jansen EE, Verhoeven NM, Jakobs C. Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride. Clin Chem 2004, 50:1391-1395. 10.1373/clinchem.2004.033399, 15166110.
-
(2004)
Clin Chem
, vol.50
, pp. 1391-1395
-
-
Struys, E.A.1
Jansen, E.E.2
Verhoeven, N.M.3
Jakobs, C.4
-
20
-
-
0042424602
-
Statistical significance for genomewide studies
-
12883005
-
Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003, 100:9440-9445. 10.1073/pnas.1530509100, 12883005.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9440-9445
-
-
Storey, J.D.1
Tibshirani, R.2
-
21
-
-
0032441150
-
Cluster analysis and display of genome-wide expression patterns
-
9843981
-
Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998, 95:14863-14868. 10.1073/pnas.95.25.14863, 9843981.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14863-14868
-
-
Eisen, M.B.1
Spellman, P.T.2
Brown, P.O.3
Botstein, D.4
-
22
-
-
0035942271
-
Significance analysis of microarrays applied to the ionizing radiation response
-
11309499
-
Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001, 98:5116-5121. 10.1073/pnas.091062498, 11309499.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 5116-5121
-
-
Tusher, V.G.1
Tibshirani, R.2
Chu, G.3
-
23
-
-
84906828740
-
-
The Cancer Genome Atlas - data portal
-
The Cancer Genome Atlas - data portal. https://tcga-data.nci.nih.gov/tcga/
-
-
-
-
24
-
-
84906833827
-
-
cBioPortal for Cancer Genomics
-
cBioPortal for Cancer Genomics. http://www.cbioportal.org/public-portal/
-
-
-
-
25
-
-
84865100704
-
A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen
-
22711706
-
Chia SK, Bramwell VH, Tu D, Shepherd LE, Jiang S, Vickery T, Mardis E, Leung S, Ung K, Pritchard KI, Parker JS, Bernard PS, Perou CM, Ellis MJ, Nielsen TO. A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen. Clin Cancer Res 2012, 18:4465-4472. 10.1158/1078-0432.CCR-12-0286, 22711706.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4465-4472
-
-
Chia, S.K.1
Bramwell, V.H.2
Tu, D.3
Shepherd, L.E.4
Jiang, S.5
Vickery, T.6
Mardis, E.7
Leung, S.8
Ung, K.9
Pritchard, K.I.10
Parker, J.S.11
Bernard, P.S.12
Perou, C.M.13
Ellis, M.J.14
Nielsen, T.O.15
-
26
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
11553815
-
Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lonning P, Borresen-Dale AL. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001, 98:10869-10874. 10.1073/pnas.191367098, 11553815.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
Aas, T.4
Geisler, S.5
Johnsen, H.6
Hastie, T.7
Eisen, M.B.8
van de Rijn, M.9
Jeffrey, S.S.10
Thorsen, T.11
Quist, H.12
Matese, J.C.13
Brown, P.O.14
Botstein, D.15
Eystein Lonning, P.16
Borresen-Dale, A.L.17
-
27
-
-
84892939615
-
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
-
24316975
-
Terunuma A, Putluri N, Mishra P, Mathe EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, et al. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest 2014, 124:398-412. 10.1172/JCI71180, 24316975.
-
(2014)
J Clin Invest
, vol.124
, pp. 398-412
-
-
Terunuma, A.1
Putluri, N.2
Mishra, P.3
Mathe, E.A.4
Dorsey, T.H.5
Yi, M.6
Wallace, T.A.7
Issaq, H.J.8
Zhou, M.9
Killian, J.K.10
Stevenson, H.S.11
Karoly, E.D.12
Chan, K.13
Samanta, S.14
Prieto, D.15
Hsu, T.Y.16
Kurley, S.J.17
Putluri, V.18
Sonavane, R.19
Edelman, D.C.20
Wulff, J.21
Starks, A.M.22
Yang, Y.23
Kittles, R.A.24
Yfantis, H.G.25
Lee, D.H.26
Ioffe, O.B.27
Schiff, R.28
Stephens, R.M.29
Meltzer, P.S.30
more..
-
28
-
-
0018594336
-
Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase
-
42913
-
Griffith OW, Bridges RJ, Meister A. Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A 1979, 76:6319-6322. 10.1073/pnas.76.12.6319, 42913.
-
(1979)
Proc Natl Acad Sci U S A
, vol.76
, pp. 6319-6322
-
-
Griffith, O.W.1
Bridges, R.J.2
Meister, A.3
-
29
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
19935646
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009, 462:739-744. 10.1038/nature08617, 19935646.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinowitz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
30
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
23558169
-
Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C, Tsoi J, Clark O, Oldrini B, Komisopoulou E, Kunii K, Pedraza A, Schalm S, Silverman L, Miller A, Wang F, Yang H, Chen Y, Kernytsky A, Rosenblum MK, Liu W, Biller SA, Su SM, Brennan CW, Chan TA, Graeber TG, Yen KE, Mellinghoff IK. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013, 340:626-630. 10.1126/science.1236062, 23558169.
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
Turcan, S.4
Grommes, C.5
Campos, C.6
Tsoi, J.7
Clark, O.8
Oldrini, B.9
Komisopoulou, E.10
Kunii, K.11
Pedraza, A.12
Schalm, S.13
Silverman, L.14
Miller, A.15
Wang, F.16
Yang, H.17
Chen, Y.18
Kernytsky, A.19
Rosenblum, M.K.20
Liu, W.21
Biller, S.A.22
Su, S.M.23
Brennan, C.W.24
Chan, T.A.25
Graeber, T.G.26
Yen, K.E.27
Mellinghoff, I.K.28
more..
-
31
-
-
33645646867
-
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase
-
16326698
-
Moreau K, Dizin E, Ray H, Luquain C, Lefai E, Foufelle F, Billaud M, Lenoir GM, Venezia ND. BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. J Biol Chem 2006, 281:3172-3181. 10.1074/jbc.M504652200, 16326698.
-
(2006)
J Biol Chem
, vol.281
, pp. 3172-3181
-
-
Moreau, K.1
Dizin, E.2
Ray, H.3
Luquain, C.4
Lefai, E.5
Foufelle, F.6
Billaud, M.7
Lenoir, G.M.8
Venezia, N.D.9
-
32
-
-
84881609139
-
Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1
-
23317938
-
Singh KK, Shukla PC, Yanagawa B, Quan A, Lovren F, Pan Y, Wagg CS, Teoh H, Lopaschuk GD, Verma S. Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1. J Thorac Cardiovasc Surg 2013, 146:702-709. 10.1016/j.jtcvs.2012.12.046, 23317938.
-
(2013)
J Thorac Cardiovasc Surg
, vol.146
, pp. 702-709
-
-
Singh, K.K.1
Shukla, P.C.2
Yanagawa, B.3
Quan, A.4
Lovren, F.5
Pan, Y.6
Wagg, C.S.7
Teoh, H.8
Lopaschuk, G.D.9
Verma, S.10
-
33
-
-
7444271583
-
BRCA1 induces antioxidant gene expression and resistance to oxidative stress
-
15520196
-
Bae I, Fan S, Meng Q, Rih JK, Kim HJ, Kang HJ, Xu J, Goldberg ID, Jaiswal AK, Rosen EM. BRCA1 induces antioxidant gene expression and resistance to oxidative stress. Cancer Res 2004, 64:7893-7909. 10.1158/0008-5472.CAN-04-1119, 15520196.
-
(2004)
Cancer Res
, vol.64
, pp. 7893-7909
-
-
Bae, I.1
Fan, S.2
Meng, Q.3
Rih, J.K.4
Kim, H.J.5
Kang, H.J.6
Xu, J.7
Goldberg, I.D.8
Jaiswal, A.K.9
Rosen, E.M.10
-
34
-
-
68049137923
-
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner
-
19622773
-
Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM. Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res 2009, 69:6083-6091. 10.1158/0008-5472.CAN-08-3309, 19622773.
-
(2009)
Cancer Res
, vol.69
, pp. 6083-6091
-
-
Fan, S.1
Meng, Q.2
Saha, T.3
Sarkar, F.H.4
Rosen, E.M.5
-
35
-
-
84884215156
-
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
-
23857982
-
Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med 2013, 210:1529-1544. 10.1084/jem.20121337, 23857982.
-
(2013)
J Exp Med
, vol.210
, pp. 1529-1544
-
-
Gorrini, C.1
Baniasadi, P.S.2
Harris, I.S.3
Silvester, J.4
Inoue, S.5
Snow, B.6
Joshi, P.A.7
Wakeham, A.8
Molyneux, S.D.9
Martin, B.10
Bouwman, P.11
Cescon, D.W.12
Elia, A.J.13
Winterton-Perks, Z.14
Cruickshank, J.15
Brenner, D.16
Tseng, A.17
Musgrave, M.18
Berman, H.K.19
Khokha, R.20
Jonkers, J.21
Mak, T.W.22
Gauthier, M.L.23
more..
-
36
-
-
0031969566
-
Mutational inactivation of aminoacylase-I in a small cell lung cancer cell line
-
9559343
-
Cook RM, Franklin WA, Moore MD, Johnson BE, Miller YE. Mutational inactivation of aminoacylase-I in a small cell lung cancer cell line. Genes Chromosomes Cancer 1998, 21:320-325. 10.1002/(SICI)1098-2264(199804)21:4<320::AID-GCC5>3.0.CO;2-0, 9559343.
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 320-325
-
-
Cook, R.M.1
Franklin, W.A.2
Moore, M.D.3
Johnson, B.E.4
Miller, Y.E.5
-
37
-
-
58949085533
-
Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma
-
19028700
-
Zhong Y, Onuki J, Yamasaki T, Ogawa O, Akatsuka S, Toyokuni S. Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma. Carcinogenesis 2009, 30:158-164. 10.1093/carcin/bgn255, 19028700.
-
(2009)
Carcinogenesis
, vol.30
, pp. 158-164
-
-
Zhong, Y.1
Onuki, J.2
Yamasaki, T.3
Ogawa, O.4
Akatsuka, S.5
Toyokuni, S.6
-
38
-
-
40849097298
-
Miscoding properties of 2′-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases
-
18304575
-
Yasui M, Suenaga E, Koyama N, Masutani C, Hanaoka F, Gruz P, Shibutani S, Nohmi T, Hayashi M, Honma M. Miscoding properties of 2′-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. J Mol Biol 2008, 377:1015-1023. 10.1016/j.jmb.2008.01.033, 18304575.
-
(2008)
J Mol Biol
, vol.377
, pp. 1015-1023
-
-
Yasui, M.1
Suenaga, E.2
Koyama, N.3
Masutani, C.4
Hanaoka, F.5
Gruz, P.6
Shibutani, S.7
Nohmi, T.8
Hayashi, M.9
Honma, M.10
-
39
-
-
60149091657
-
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
-
19212411
-
Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009, 457:910-914. 10.1038/nature07762, 19212411.
-
(2009)
Nature
, vol.457
, pp. 910-914
-
-
Sreekumar, A.1
Poisson, L.M.2
Rajendiran, T.M.3
Khan, A.P.4
Cao, Q.5
Yu, J.6
Laxman, B.7
Mehra, R.8
Lonigro, R.J.9
Li, Y.10
Nyati, M.K.11
Ahsan, A.12
Kalyana-Sundaram, S.13
Han, B.14
Cao, X.15
Byun, J.16
Omenn, G.S.17
Ghosh, D.18
Pennathur, S.19
Alexander, D.C.20
Berger, A.21
Shuster, J.R.22
Wei, J.T.23
Varambally, S.24
Beecher, C.25
Chinnaiyan, A.M.26
more..
-
40
-
-
84869209736
-
The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism
-
23026133
-
Chinnaiyan P, Kensicki E, Bloom G, Prabhu A, Sarcar B, Kahali S, Eschrich S, Qu X, Forsyth P, Gillies R. The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res 2012, 72:5878-5888. 10.1158/0008-5472.CAN-12-1572-T, 23026133.
-
(2012)
Cancer Res
, vol.72
, pp. 5878-5888
-
-
Chinnaiyan, P.1
Kensicki, E.2
Bloom, G.3
Prabhu, A.4
Sarcar, B.5
Kahali, S.6
Eschrich, S.7
Qu, X.8
Forsyth, P.9
Gillies, R.10
-
41
-
-
84869077946
-
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
-
23153533
-
Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Aleckovic M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 2012, 22:585-600. 10.1016/j.ccr.2012.09.020, 23153533.
-
(2012)
Cancer Cell
, vol.22
, pp. 585-600
-
-
Hitosugi, T.1
Zhou, L.2
Elf, S.3
Fan, J.4
Kang, H.B.5
Seo, J.H.6
Shan, C.7
Dai, Q.8
Zhang, L.9
Xie, J.10
Gu, T.L.11
Jin, P.12
Aleckovic, M.13
LeRoy, G.14
Kang, Y.15
Sudderth, J.A.16
DeBerardinis, R.J.17
Luan, C.H.18
Chen, G.Z.19
Muller, S.20
Shin, D.M.21
Owonikoko, T.K.22
Lonial, S.23
Arellano, M.L.24
Khoury, H.J.25
Khuri, F.R.26
Lee, B.H.27
Ye, K.28
Boggon, T.J.29
Kang, S.30
more..
-
42
-
-
84868220730
-
Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion
-
23090118
-
Platten M, Wick W, Van den Eynde BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res 2012, 72:5435-5440. 10.1158/0008-5472.CAN-12-0569, 23090118.
-
(2012)
Cancer Res
, vol.72
, pp. 5435-5440
-
-
Platten, M.1
Wick, W.2
Van den Eynde, B.J.3
-
43
-
-
75749113671
-
Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
-
19487045
-
Suzuki Y, Suda T, Furuhashi K, Suzuki M, Fujie M, Hahimoto D, Nakamura Y, Inui N, Nakamura H, Chida K. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. Lung Cancer 2010, 67:361-365. 10.1016/j.lungcan.2009.05.001, 19487045.
-
(2010)
Lung Cancer
, vol.67
, pp. 361-365
-
-
Suzuki, Y.1
Suda, T.2
Furuhashi, K.3
Suzuki, M.4
Fujie, M.5
Hahimoto, D.6
Nakamura, Y.7
Inui, N.8
Nakamura, H.9
Chida, K.10
-
44
-
-
79957467461
-
Tryptophan degradation in women with breast cancer: a pilot study
-
21615916
-
Lyon DE, Walter JM, Starkweather AR, Schubert CM, McCain NL. Tryptophan degradation in women with breast cancer: a pilot study. BMC Res Notes 2011, 4:156. 10.1186/1756-0500-4-156, 21615916.
-
(2011)
BMC Res Notes
, vol.4
, pp. 156
-
-
Lyon, D.E.1
Walter, J.M.2
Starkweather, A.R.3
Schubert, C.M.4
McCain, N.L.5
-
45
-
-
84860197918
-
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons
-
22044881
-
Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. J Mol Cell Biol 2012, 4:79-87. 10.1093/jmcb/mjr030, 22044881.
-
(2012)
J Mol Cell Biol
, vol.4
, pp. 79-87
-
-
Wang, Z.1
Chatterjee, D.2
Jeon, H.Y.3
Akerman, M.4
Vander Heiden, M.G.5
Cantley, L.C.6
Krainer, A.R.7
-
46
-
-
84878740749
-
Metabolic phenotypes in triple-negative breast cancer
-
23443971
-
Kim S, Kim Do H, Jung WH, Koo JS. Metabolic phenotypes in triple-negative breast cancer. Tumour Biol 2013, 34:1699-1712. 10.1007/s13277-013-0707-1, 23443971.
-
(2013)
Tumour Biol
, vol.34
, pp. 1699-1712
-
-
Kim, S.1
Kim Do, H.2
Jung, W.H.3
Koo, J.S.4
-
47
-
-
84881056831
-
MYC, metabolism, cell growth, and tumorigenesis
-
Dang CV. MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb Perspect Med 2013, 3:1-15.
-
(2013)
Cold Spring Harb Perspect Med
, vol.3
, pp. 1-15
-
-
Dang, C.V.1
-
48
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
22265415
-
Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Borresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 2012, 148:244-258. 10.1016/j.cell.2011.12.017, 22265415.
-
(2012)
Cell
, vol.148
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerod, A.4
Moon, S.H.5
Rodriguez-Barrueco, R.6
Barsotti, A.7
Chicas, A.8
Li, W.9
Polotskaia, A.10
Bissell, M.J.11
Osborne, T.F.12
Tian, B.13
Lowe, S.W.14
Silva, J.M.15
Borresen-Dale, A.L.16
Levine, A.J.17
Bargonetti, J.18
Prives, C.19
-
49
-
-
84866381970
-
Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source
-
23028762
-
Foster R, Griffin S, Grooby S, Feltell R, Christopherson C, Chang M, Sninsky J, Kwok S, Torrance C. Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source. PLoS One 2012, 7:e45061. 10.1371/journal.pone.0045061, 23028762.
-
(2012)
PLoS One
, vol.7
, pp. e45061
-
-
Foster, R.1
Griffin, S.2
Grooby, S.3
Feltell, R.4
Christopherson, C.5
Chang, M.6
Sninsky, J.7
Kwok, S.8
Torrance, C.9
-
50
-
-
0032893756
-
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
-
9892190
-
Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999, 59:80-84. 9892190.
-
(1999)
Cancer Res
, vol.59
, pp. 80-84
-
-
Aboagye, E.O.1
Bhujwalla, Z.M.2
-
51
-
-
27144444683
-
Alterations of choline phospholipid metabolism in ovarian tumor progression
-
16230400
-
Iorio E, Mezzanzanica D, Alberti P, Spadaro F, Ramoni C, D'Ascenzo S, Millimaggi D, Pavan A, Dolo V, Canevari S, Podo F. Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer Res 2005, 65:9369-9376. 10.1158/0008-5472.CAN-05-1146, 16230400.
-
(2005)
Cancer Res
, vol.65
, pp. 9369-9376
-
-
Iorio, E.1
Mezzanzanica, D.2
Alberti, P.3
Spadaro, F.4
Ramoni, C.5
D'Ascenzo, S.6
Millimaggi, D.7
Pavan, A.8
Dolo, V.9
Canevari, S.10
Podo, F.11
-
52
-
-
33645742041
-
Disruption of G1-phase phospholipid turnover by inhibition of Ca2 + -independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase
-
16492706
-
Zhang XH, Zhao C, Seleznev K, Song K, Manfredi JJ, Ma ZA. Disruption of G1-phase phospholipid turnover by inhibition of Ca2 + -independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase. J Cell Sci 2006, 119:1005-1015. 10.1242/jcs.02821, 16492706.
-
(2006)
J Cell Sci
, vol.119
, pp. 1005-1015
-
-
Zhang, X.H.1
Zhao, C.2
Seleznev, K.3
Song, K.4
Manfredi, J.J.5
Ma, Z.A.6
-
53
-
-
84867142011
-
Regulation of lipid metabolism by p53 - fighting two villains with one sword
-
22819212
-
Goldstein I, Rotter V. Regulation of lipid metabolism by p53 - fighting two villains with one sword. Trends Endocrinol Metab 2012, 23:567-575. 10.1016/j.tem.2012.06.007, 22819212.
-
(2012)
Trends Endocrinol Metab
, vol.23
, pp. 567-575
-
-
Goldstein, I.1
Rotter, V.2
-
54
-
-
76749114291
-
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control
-
20126473
-
Li CH, Cheng YW, Liao PL, Kang JJ. Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control. Neoplasia 2010, 12:150-160. 20126473.
-
(2010)
Neoplasia
, vol.12
, pp. 150-160
-
-
Li, C.H.1
Cheng, Y.W.2
Liao, P.L.3
Kang, J.J.4
-
55
-
-
36448939111
-
Method for lipidomic analysis: p53 expression modulation of sulfatide, ganglioside, and phospholipid composition of U87 MG glioblastoma cells
-
17929901
-
He H, Conrad CA, Nilsson CL, Ji Y, Schaub TM, Marshall AG, Emmett MR. Method for lipidomic analysis: p53 expression modulation of sulfatide, ganglioside, and phospholipid composition of U87 MG glioblastoma cells. Anal Chem 2007, 79:8423-8430. 10.1021/ac071413m, 17929901.
-
(2007)
Anal Chem
, vol.79
, pp. 8423-8430
-
-
He, H.1
Conrad, C.A.2
Nilsson, C.L.3
Ji, Y.4
Schaub, T.M.5
Marshall, A.G.6
Emmett, M.R.7
-
56
-
-
80051717722
-
The emerging importance of alpha-L-fucose in human breast cancer: a review
-
21904652
-
Listinsky JJ, Siegal GP, Listinsky CM. The emerging importance of alpha-L-fucose in human breast cancer: a review. Am J Transl Res 2011, 3:292-322. 21904652.
-
(2011)
Am J Transl Res
, vol.3
, pp. 292-322
-
-
Listinsky, J.J.1
Siegal, G.P.2
Listinsky, C.M.3
-
57
-
-
84865171628
-
Ki-67: level of evidence and methodological considerations for its role in the clinical management of breast cancer: analytical and critical review
-
22048814
-
Luporsi E, Andre F, Spyratos F, Martin PM, Jacquemier J, Penault-Llorca F, Tubiana-Mathieu N, Sigal-Zafrani B, Arnould L, Gompel A, Egele C, Poulet B, Clough KB, Crouet H, Fourquet A, Lefranc JP, Mathelin C, Rouyer N, Serin D, Spielmann M, Haugh M, Chenard MP, Brain E, de Cremoux P, Bellocq JP. Ki-67: level of evidence and methodological considerations for its role in the clinical management of breast cancer: analytical and critical review. Breast Cancer Res Treat 2012, 132:895-915. 10.1007/s10549-011-1837-z, 22048814.
-
(2012)
Breast Cancer Res Treat
, vol.132
, pp. 895-915
-
-
Luporsi, E.1
Andre, F.2
Spyratos, F.3
Martin, P.M.4
Jacquemier, J.5
Penault-Llorca, F.6
Tubiana-Mathieu, N.7
Sigal-Zafrani, B.8
Arnould, L.9
Gompel, A.10
Egele, C.11
Poulet, B.12
Clough, K.B.13
Crouet, H.14
Fourquet, A.15
Lefranc, J.P.16
Mathelin, C.17
Rouyer, N.18
Serin, D.19
Spielmann, M.20
Haugh, M.21
Chenard, M.P.22
Brain, E.23
de Cremoux, P.24
Bellocq, J.P.25
more..
-
58
-
-
19944422061
-
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
-
15591335
-
Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004, 351:2817-2826. 10.1056/NEJMoa041588, 15591335.
-
(2004)
N Engl J Med
, vol.351
, pp. 2817-2826
-
-
Paik, S.1
Shak, S.2
Tang, G.3
Kim, C.4
Baker, J.5
Cronin, M.6
Baehner, F.L.7
Walker, M.G.8
Watson, D.9
Park, T.10
Hiller, W.11
Fisher, E.R.12
Wickerham, D.L.13
Bryant, J.14
Wolmark, N.15
|