A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Science

Volumn 352, Issue 6293, 2016, Pages 1535-1542

  Birchenough, George M H ^a   Nystrom, Elisabeth E L ^a   Johansson, Malin E V ^a   Hansson, Gunnar C ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; BACTERIAL DNA; CASPASE 11; DYNASORE; FLAGELLIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; IONOMYCIN; LIGAND; LIPID A; MUCIN 2; MURAMYL DIPEPTIDE; MYELOID DIFFERENTIATION FACTOR 88; NICOTINAMIDE ADENINE DINUCLEOTIDE; NLRP6 PROTEIN; PEPTIDOGLYCAN; PROTEIN; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG; CALCIUM; CELL SURFACE RECEPTOR; MUC2 PROTEIN, MOUSE; MYD88 PROTEIN, MOUSE; NOD-LIKE RECEPTOR PYRIN DOMAIN-CONTAINING PROTEIN 6, MOUSE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

BACTERIUM; CALCIUM; CELLS AND CELL COMPONENTS; IMMUNE SYSTEM; MUCUS; OXYGEN; RODENT; SECRETION;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL ACTIVATION; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; EX VIVO STUDY; FLUORESCENCE; GAP JUNCTION; GENE DOSAGE; GOBLET CELL; INTESTINAL STEM CELL; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SYNTHESIS; ANIMAL; BACTERIUM; C57BL MOUSE; COLON; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY;

BACTERIA (MICROORGANISMS);

ANIMALS; BACTERIA; CALCIUM; COLON; ENDOCYTOSIS; GASTROINTESTINAL MICROBIOME; GOBLET CELLS; IMMUNITY, INNATE; INFLAMMASOMES; INTESTINAL MUCOSA; LIGANDS; MICE; MICE, INBRED C57BL; MUCIN-2; MYELOID DIFFERENTIATION FACTOR 88; REACTIVE OXYGEN SPECIES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 5;

EID: 84976310851     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf7419     Document Type: Article

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