Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Science

Volumn 358, Issue 6361, 2017, Pages 359-365

  Atarashi, Koji ^a,b   Suda, Wataru ^a,c,d   Luo, Chengwei ^e,f   Kawaguchi, Takaaki ^a,b   Motoo, Iori ^b   Narushima, Seiko ^b   Kiguchi, Yuya ^c   Yasuma, Keiko ^a   Watanabe, Eiichiro ^b   Tanoue, Takeshi ^a,b   Thaiss, Christoph A ^g   Sato, Mayuko ^h   Toyooka, Kiminori ^h   Said, Heba S ^d,i   Yamagami, Hirokazu ^j   Rice, Scott A ^k   Gevers, Dirk ^e   Johnson, Ryan C ^l   Segre, Julia A ^l   Chen, Kong ^m   Kolls, Jay K ^m   Elinav, Eran ^g   Morita, Hidetoshi ⁿ   Xavier, Ramnik J ^e,f   Hattori, Masahira ^c,d   Honda, Kenya ^a,b   more..

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d WASEDA UNIVERSITY   (Japan)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^h RIKEN Center for Sustainable Resource Science   (Japan)

ⁱ MANSOURA UNIVERSITY   (Egypt)

^j OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^k NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^l NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^m UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

ⁿ OKAYAMA UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CXCL9 CHEMOKINE; DUAL OXIDASE 2; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; GUANINE NUCLEOTIDE BINDING PROTEIN; HERMES ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 18; METRONIDAZOLE; MYELOID DIFFERENTIATION FACTOR 88; OUTER MEMBRANE PROTEIN X; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RIBOSOME RNA; SPECTINOMYCIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TUMOR NECROSIS FACTOR; TYLOSIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT;

ANTIBIOTICS; BACTERIUM; CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISORDER; GENETIC ANALYSIS; HEALTH IMPACT;

ANAEROCOCCUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ISOLATION; BIFIDOBACTERIUM; CASE REPORT; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; DISEASE EXACERBATION; DYSBIOSIS; ESCHERICHIA; FUSOBACTERIUM; GEMELLA; GNOTOBIOTICS; HUMAN; INTESTINE FLORA; KLEBSIELLA PNEUMONIAE; MOUSE; MOUTH CAVITY; MOUTH FLORA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND; STREPTOCOCCUS; TH1 CELL; VEILLONELLA; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG EFFECTS; GERMFREE ANIMAL; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASE; INTESTINE; ISOLATION AND PURIFICATION; KLEBSIELLA; MICROBIOLOGY; MICROFLORA; MOUTH; PATHOGENICITY; SALIVA;

KLEBSIELLA;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; DYSBIOSIS; GERM-FREE LIFE; INFLAMMATORY BOWEL DISEASES; INTESTINES; KLEBSIELLA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROBIOTA; MOUTH; SALIVA; TH1 CELLS;

EID: 85032492045     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan4526     Document Type: Article

References (33)

1. I. Nasidze, J. Li, D. Quinque, K. Tang, M. Stoneking, Genome Res. 19, 636-643 (2009).
2. S. P. Humphrey, R. T. Williamson, J. Prosthet. Dent. 85, 162-169 (2001).
3. H. Seedorf et al., Cell 159, 253-266 (2014).
4. D. Gevers et al., Cell Host Microbe 15, 382-392 (2014).
5. C. A. Lozupone et al., Cell Host Microbe 14, 329-339 (2013).
6. I. Vujkovic-Cvijin et al., Sci. Transl. Med. 5, 193ra91 (2013).
7. N. Qin et al., Nature 513, 59-64 (2014).
8. Y. Chen et al., Sci. Rep. 6, 34055 (2016).
9. C. L. Sears, W. S. Garrett, Cell Host Microbe 15, 317-328 (2014).
10. E. S. Snitkin et al., Sci. Transl. Med. 4, 148ra116 (2012).
11. K. E. Holt et al., Proc. Natl. Acad. Sci. U.S.A. 112, E3574-E3581 (2015).
12. E. G. Pamer, Science 352, 535-538 (2016).
13. H. Chu et al., Science 352, 1116-1120 (2016).
14. X. C. Morgan et al., Genome Biol. 13, R79 (2012).
15. K. Chen et al., Immunity 35, 997-1009 (2011).
16. H. Xiong et al., Cell 165, 679-689 (2016).
17. A. R. Records, Mol. Plant Microbe Interact. 24, 751-757 (2011).
18. S. Fukuda et al., Nature 469, 543-547 (2011).
19. A. N. Thorburn, L. Macia, C. R. Mackay, Immunity 40, 833-842 (2014).
20. K. Chen et al., J. Immunol. 192, 141.12 (2014).
21. B. H. Kim et al., Nat. Immunol. 17, 481-489 (2016).
22. S. E. Winter, C. A. Lopez, A. J. Bäumler, EMBO Rep. 14, 319-327 (2013).
23. Y. Haberman et al., J. Clin. Invest. 124, 3617-3633 (2014).
24. Y. Taur, E. G. Pamer, Curr. Opin. Infect. Dis. 26, 332-337 (2013).
25. A. Davin-Regli, J. M. Pagès, Front. Microbiol. 6, 392 (2015).
26. S. Mondot et al., Inflamm. Bowel Dis. 17, 185-192 (2011).
27. S. M. Diene et al., Mol. Biol. Evol. 30, 369-383 (2013).
28. J. D. Lewis et al., Cell Host Microbe 18, 489-500 (2015).
29. N. R. Shin, T. W. Whon, J. W. Bae, Trends Biotechnol. 33, 496-503 (2015).
30. H. Tiwana et al., Br. J. Rheumatol. 37, 525-531 (1998).
31. T. Rashid, A. Ebringer, C. Wilson, Int. J. Rheumatol. 2013, 610393 (2013).
32. W. S. Garrett et al., Cell Host Microbe 8, 292-300 (2010).
33. A. Ebringer, T. Rashid, H. Tiwana, C. Wilson, Clin. Rheumatol. 26, 289-297 (2007).