Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Cell Metabolism

Volumn 22, Issue 6, 2015, Pages 983-996

  Singh, Vishal ^a   Chassaing, Benoit ^b   Zhang, Limin ^a,c   San Yeoh, Beng ^a   Xiao, Xia ^a   Kumar, Manish ^a   Baker, Mark T ^b   Cai, Jingwei ^a   Walker, Rachel ^a   Borkowski, Kamil ^a   Harvatine, Kevin J ^a   Singh, Nagendra ^d   Shearer, Gregory C ^a   Ntambi, James M ^e   Joe, Bina ^f   Patterson, Andrew D ^a   Gewirtz, Andrew T ^b   Vijay Kumar, Matam ^a,g  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d AUGUSTA UNIVERSITY   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f MEDICAL COLLEGE OF OHIO   (United States)

^g PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

gut bacteria; hepatic neutral lipids; low grade inflammation; metabolic diseases; monounsaturated fatty acids; short chain fatty acids; Toll like receptor 5

Indexed keywords

ACETYL COENZYME A ACETYLTRANSFERASE; ACETYL COENZYME A ACETYLTRANSFERASE 2; ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE 1; CXCL1 CHEMOKINE; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 2; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; INSULIN; INTERLEUKIN 1BETA; LINOLEOYL COENZYME A DESATURASE; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITRIC OXIDE SYNTHASE; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOLIPID; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TOLL LIKE RECEPTOR 5; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; SCD1 PROTEIN, MOUSE; VOLATILE FATTY ACID;

ABDOMINAL OBESITY; ANAEROBIC FERMENTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; BODY WEIGHT; CALORIC RESTRICTION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL ESTERIFICATION; COLITIS; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FATTY ACID ANALYSIS; FATTY ACID SYNTHESIS; FATTY LIVER; FEMALE; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTESTINE FLORA; LIPID COMPOSITION; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RISK FACTOR; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; SPLENOMEGALY; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANIMAL; BLOOD; CHEMISTRY; DEFICIENCY; FECES; GENETICS; INTESTINE; KNOCKOUT MOUSE; LIVER; METABOLISM; MICROBIOLOGY; MICROFLORA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY;

ANIMALS; BODY WEIGHT; CALORIC RESTRICTION; DIET, HIGH-FAT; FATTY ACIDS, VOLATILE; FECES; FEMALE; INSULIN RESISTANCE; INTESTINES; LIPOGENESIS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC SYNDROME X; MICE; MICE, KNOCKOUT; MICROBIOTA; OLEIC ACID; STEAROYL-COA DESATURASE; TOLL-LIKE RECEPTOR 5; UP-REGULATION;

EID: 84951733419     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.09.028     Document Type: Article

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