GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Mucosal Immunology

Volumn 11, Issue 3, 2018, Pages 752-762

  Zhao, Ye ^a,b   Chen, Feidi ^b   Wu, Wei ^b,c   Sun, Mingming ^b,c   Bilotta, Anthony J ^b   Yao, Suxia ^b   Xiao, Yi ^b,d   Huang, Xiangsheng ^b   Eaves Pyles, Tonyia D ^b   Golovko, George ^b   Fofanov, Yuriy ^b   D'Souza, Warren ^e   Zhao, Qihong ^f   Liu, Zhanju ^c   Cong, Yingzi ^b  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b University of Texas Medical Branch School of Medicine   (United States)

^c TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^d SICHUAN AGRICULTURAL UNIVERSITY   (China)

^e AMGEN INC   (United States)

^f BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 3; BETA DEFENSIN 4; G PROTEIN COUPLED RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PANCREATITIS ASSOCIATED PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN GPR43; PROTEIN REGIIIGAMMA; SHORT CHAIN FATTY ACID; STAT3 PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA DEFENSIN; FFAR2 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; REG3G PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; VOLATILE FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEEDING; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; METABOLIC REGULATION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; GENETICS; HOMEOSTASIS; INNATE IMMUNITY; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; FATTY ACIDS, VOLATILE; GASTROINTESTINAL MICROBIOME; HOMEOSTASIS; IMMUNITY, INNATE; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PANCREATITIS-ASSOCIATED PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES;

EID: 85048026863     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2017.118     Document Type: Article

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