Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents

Hepatology

Volumn 52, Issue 4, 2010, Pages 1322-1333

  Yu, Le Xing ^a   Yan, He Xin ^a   Liu, Qiong ^a   Yang, Wen ^a   Wu, Hong Ping ^a   Dong, Wei ^a   Tang, Liang ^a   Lin, Yan ^a   He, Ya Qin ^a   Zou, Shan Shan ^a   Wang, Chao ^a   Zhang, Hui Lu ^a   Cao, Guang Wen ^a   Wu, Meng Chao ^a   Wang, Hong Yang ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; DIETHYLNITROSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NEOMYCIN; POLYMYXIN B; REACTIVE OXYGEN METABOLITE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

ANIMAL; APOPTOSIS; ARTICLE; BLOOD; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; INTESTINE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TUMOR; MALE; MICROBIOLOGY; MOUSE; PATHOLOGY; PHYSIOLOGY; RAT;

ANIMALS; APOPTOSIS; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DIETHYLNITROSAMINE; INTESTINES; LIPOPOLYSACCHARIDES; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MICE; NEOMYCIN; NF-KAPPA B; POLYMYXIN B; RATS; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 4;

MLCS; MLOWN;

EID: 77957948007     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23845     Document Type: Article

References (36)

1. Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6:674-687.
2. Nolan JP, Leibowitz AI. Endotoxins in liver disease. Gastroenterology 1978;75:765-766.
3. Almeida J, Galhenage S, Yu J, Kurtovic J, Riordan SM. Gut flora and bacterial translocation in chronic liver disease. World J Gastroenterol 2006;12:1493-1502.
4. Riordan SM, Williams R. The intestinal flora and bacterial infection in cirrhosis. J Hepatol 2006;45:744-757.
5. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
6. Liu S, Gallo DJ, Green AM, Williams DL, Gong X, Shapiro RA, et al. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun 2002;70:3433-3442.
7. Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, Alarcon WH, et al. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. HEPATOLOGY 2000;31:932-936.
8. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology 2006;130:1886-1900.
9. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995;269(4 Pt 1):G467-G475.
10. Scott MJ, Liu S, Shapiro RA, Vodovotz Y, Billiar TR. Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. HEPATOLOGY 2009;49:1695-1708.
11. Shariff MI, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, Taylor-Robinson SD. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics. Expert Rev Gastroenterol Hepatol 2009;3:353-367.
12. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5: 749-759.
13. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-466.
14. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-990.
15. Morrison DC, Jacobs DM. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry 1976;13:813-818.
16. Sarma DS, Rao PM, Rajalakshmi S. Liver tumour promotion by chemicals: models and mechanisms. Cancer Surv 1986;5:781-798.
17. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. HEPATOLOGY 2006;43(2 Suppl 1):S45-S53.
18. Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A 2008;105: 2415-2420.
19. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ, Brenner DA. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Gastroenterology 2001;120:1251-1262.
20. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, et al. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998;101:802-811.
21. Wong GH, Goeddel DV. Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science 1988;242:941-944.
22. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990;186:407-421.
23. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-241.
24. Gao B, Jeong WI, Tian Z. Liver: An organ with predominant innate immunity. HEPATOLOGY 2008;47:729-736.
25. Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. HEPATOLOGY 2008;48:322-335.
26. Chan CC, Hwang SJ, Lee FY, Wang SS, Chang FY, Li CP, et al. Prognostic value of plasma endotoxin levels in patients with cirrhosis. Scand J Gastroenterol 1997;32:942-946.
27. Such J, Frances R, Munoz C, Zapater P, Casellas JA, Cifuentes A, et al. Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites. HEPATOLOGY 2002;36: 135-141.
28. Rao RK, Seth A, Sheth P. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2004;286(6): G881-G884.
29. Fijen JW, Kobold AC, de BP, Jones CR, van der Werf TS, Tervaert JW, et al. Leukocyte activation and cytokine production during experimental human endotoxemia. Eur J Intern Med 2000;11:89-95.
30. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. HEPATOLOGY 2001;34:101-108.
31. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121-124.
32. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70.
33. Taub R. Hepatoprotection via the IL-6/Stat3 pathway. J Clin Invest 2003;112:978-980.
34. Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002;27:63-68.
35. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, et al. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A 2010;107:844-849.
36. Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-559.