Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Nature

Volumn 499, Issue 7456, 2013, Pages 97-101

  Yoshimoto, Shin ^a,b   Loo, Tze Mun ^a,b,c   Atarashi, Koji ^b,d   Kanda, Hiroaki ^a   Sato, Seidai ^a,b   Oyadomari, Seiichi ^e   Iwakura, Yoichiro ^c   Oshima, Kenshiro ^f   Morita, Hidetoshi ^g   Hattori, Masahisa ^f   Honda, Kenya ^b,d   Ishikawa, Yuichi ^a   Hara, Eiji ^a,b   Ohtani, Naoko ^a,b  

^a CANCER INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d RIKEN Center for Integrative Medical Sciences   (Japan)

^e UNIVERSITY OF TOKUSHIMA   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g AZABU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCHOLIC ACID; PROTEIN P21; PROTEINASE; VANCOMYCIN;

CANCER; CELL ORGANELLE; DEVELOPMENTAL BIOLOGY; EPIDEMIC; METABOLITE; MICROBIAL ACTIVITY; MOLECULAR ANALYSIS; OBESITY; PHENOTYPE; RODENT; SENESCENCE; TUMOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CANCER GROWTH; CARCINOGENESIS; CELL AGING; CLOSTRIDIUM SORDELLII; CONCENTRATION RESPONSE; DISEASE ASSOCIATION; DNA DAMAGE; INTESTINE FLORA; LIVER CELL; LIVER CELL CARCINOMA; LIVER FIBROSIS; MOUSE; NEWBORN; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; STELLATE CELL;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BILE ACIDS AND SALTS; CARCINOMA, HEPATOCELLULAR; CELL AGING; CELLS, CULTURED; CYTOKINES; DEOXYCHOLIC ACID; DIETARY FATS; DISEASE MODELS, ANIMAL; DNA DAMAGE; FATTY LIVER; GASTROINTESTINAL TRACT; HEPATIC STELLATE CELLS; HUMANS; INTERLEUKIN-1BETA; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; OBESITY; PHENOTYPE; RISK FACTORS;

BACTERIA (MICROORGANISMS); MUS;

EID: 84879888338     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12347     Document Type: Article

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