Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Cell Reports

Volumn 27, Issue 3, 2019, Pages 750-761.e7

  Fachi, José Luís ^a   Felipe, Jaqueline de Souza ^a   Pral, Laís Passariello ^a   da Silva, Bruna Karadi ^a   Corrêa, Renan Oliveira ^a   de Andrade, Mirella Cristiny Pereira ^a   da Fonseca, Denise Morais ^b   Basso, Paulo José ^b   Câmara, Niels Olsen Saraiva ^b   de Sales e Souza, Éricka Lorenna ^c   dos Santos Martins, Flaviano ^c   Guima, Suzana Eiko Sato ^b   Thomas, Andrew Maltez ^b   Setubal, João Carlos ^b,d   Magalhães, Yuli Thamires ^b   Forti, Fábio Luis ^b   Candreva, Thamiris ^a   Rodrigues, Hosana Gomes ^a   de Jesus, Marcelo Bispo ^a   Consonni, Sílvio Roberto ^a   Farias, Alessandro dos Santos ^a   Varga Weisz, Patrick ^e,f   Vinolo, Marco Aurélio Ramirez ^a   more..

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^d VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^e BABRAHAM INSTITUTE   (United Kingdom)

^f UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

colitis; hypoxia; infection; intestinal epithelial cells; microbiota; short chain fatty acids

Indexed keywords

BUTYRIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ANTIINFECTIVE AGENT; BUTYRIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1; INSULIN; TOXIN; TRIACYLGLYCEROL; TRIBUTYRIN; VOLATILE FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; INTESTINE EPITHELIUM CELL; MALE; MICROBIAL COMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; TIGHT JUNCTION; ANIMAL; C57BL MOUSE; CLOSTRIDIOIDES DIFFICILE; COLITIS; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; HUMAN; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; MICROFLORA; ORAL DRUG ADMINISTRATION; PATHOGENICITY; PATHOLOGY; PERMEABILITY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; BUTYRATES; CLOSTRIDIUM DIFFICILE; COLITIS; EPITHELIAL CELLS; FATTY ACIDS, VOLATILE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INSULIN; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MICROBIOTA; PERMEABILITY; TIGHT JUNCTIONS; TOXINS, BIOLOGICAL; TRIGLYCERIDES;

EID: 85063984209     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2019.03.054     Document Type: Article

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