Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Nature

Volumn 496, Issue 7444, 2013, Pages 238-242

  Tannahill, G M ^a   Curtis, A M ^a   Adamik, J ^b   Palsson Mcdermott, E M ^a   McGettrick, A F ^a   Goel, G ^c   Frezza, C ^d,e   Bernard, N J ^a   Kelly, B ^a   Foley, N H ^a   Zheng, L ^d   Gardet, A ^f   Tong, Z ^g   Jany, S S ^a   Corr, S C ^a   Haneklaus, M ^a   Caffrey, B E ^a   Pierce, K ^f   Walmsley, S ^h   Beasley, F C ⁱ   Cummins, E ^j   Nizet, V ⁱ   Whyte, M ^h   Taylor, C T ^j   Lin, H ^g   Masters, S L ^k   Gottlieb, E ^d   Kelly, V P ^a   Clish, C ^f   Auron, P E ^b   Xavier, R J ^c,e   O'Neill, L A J ^a   more..

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b DUQUESNE UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^e MEDICAL RESEARCH COUNCIL   (United Kingdom)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g Department of Obstetrics Gynecology   (United States)

^h UNIVERSITY OF SHEFFIELD   (United Kingdom)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j UNIVERSITY COLLEGE DUBLIN   (Ireland)

^k WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; DEOXYGLUCOSE; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; SUCCINIC ACID; TRICARBOXYLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ESTER; IMMUNE RESPONSE; METABOLISM; MICROBIAL ACTIVITY; MITOCHONDRION; POLYSACCHARIDE; SIGNAL; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GLYCOLYSIS; MACROPHAGE; MACROPHAGE ACTIVATION; MITOCHONDRIAL GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN STABILITY; SEPSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; UPREGULATION;

ANIMALS; BONE MARROW CELLS; CITRIC ACID CYCLE; DEOXYGLUCOSE; DOWN-REGULATION; GAMMA-AMINOBUTYRIC ACID; GENES, MITOCHONDRIAL; GLUTAMINE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; SIGNAL TRANSDUCTION; SUCCINIC ACID; UP-REGULATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 84876285741     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11986     Document Type: Article

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