Accumulation of succinate controls activation of adipose tissue thermogenesis

Nature

Volumn 560, Issue 7716, 2018, Pages 102-106

  Mills, Evanna L ^a,b   Pierce, Kerry A ^c   Jedrychowski, Mark P ^a,b   Garrity, Ryan ^a   Winther, Sally ^a,b   Vidoni, Sara ^a,b   Yoneshiro, Takeshi ^d   Spinelli, Jessica B ^b   Lu, Gina Z ^a   Kazak, Lawrence ^e   Banks, Alexander S ^f   Haigis, Marcia C ^b   Kajimura, Shingo ^d   Murphy, Michael P ^g   Gygi, Steven P ^b   Clish, Clary B ^c   Chouchani, Edward T ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; UNCOUPLING PROTEIN 1; SUCCINIC ACID; UCP1 PROTEIN, MOUSE;

ADIPOSE TISSUE; ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BROWN ADIPOCYTE; CITRIC ACID CYCLE; COLD EXPOSURE; CONTROLLED STUDY; DIET INDUCED OBESITY; ENZYME ACTIVATION; FEMALE; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; LETTER; LIPID STORAGE; MALE; METABOLOMICS; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATION CONTROL; THERMOGENESIS; ADIPOCYTE; ANIMAL; BROWN ADIPOSE TISSUE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; OBESITY; OXIDATION REDUCTION REACTION; PHYSIOLOGY; WHITE ADIPOSE TISSUE;

MUS;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; FEMALE; MALE; METABOLOMICS; MICE; OBESITY; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; THERMOGENESIS; UNCOUPLING PROTEIN 1;

EID: 85050992801     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0353-2     Document Type: Article

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