메뉴 건너뛰기




Volumn 26, Issue 10, 2019, Pages 2720-2737.e5

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

Author keywords

antibiotics; beige adipocytes; brite adipocytes; brown adipose tissue; butyrate; germ free mice; gut microbiota; hermogenesis; IL 4; macrophage; UCP1; white adipose tissue

Indexed keywords

ANTIBIOTIC AGENT; BUTYRIC ACID; INTERLEUKIN 4; UNCOUPLING PROTEIN 1;

EID: 85061958692     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2019.02.015     Document Type: Article
Times cited : (192)

References (83)
  • 4
    • 84976288773 scopus 로고    scopus 로고
    • Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics
    • Blanton, L.V., Barratt, M.J., Charbonneau, M.R., Ahmed, T., Gordon, J.I., Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics. Science, 352, 2016, 1533.
    • (2016) Science , vol.352 , pp. 1533
    • Blanton, L.V.1    Barratt, M.J.2    Charbonneau, M.R.3    Ahmed, T.4    Gordon, J.I.5
  • 5
    • 84879369738 scopus 로고    scopus 로고
    • Commensal bacteria at the interface of host metabolism and the immune system
    • Brestoff, J.R., Artis, D., Commensal bacteria at the interface of host metabolism and the immune system. Nat. Immunol. 14 (2013), 676–684.
    • (2013) Nat. Immunol. , vol.14 , pp. 676-684
    • Brestoff, J.R.1    Artis, D.2
  • 6
    • 0017886958 scopus 로고
    • Sodium butyrate inhibits histone deacetylation in cultured cells
    • Candido, E.P., Reeves, R., Davie, J.R., Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14 (1978), 105–113.
    • (1978) Cell , vol.14 , pp. 105-113
    • Candido, E.P.1    Reeves, R.2    Davie, J.R.3
  • 7
    • 84863870958 scopus 로고    scopus 로고
    • Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
    • Cani, P.D., Osto, M., Geurts, L., Everard, A., Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes 3 (2012), 279–288.
    • (2012) Gut Microbes , vol.3 , pp. 279-288
    • Cani, P.D.1    Osto, M.2    Geurts, L.3    Everard, A.4
  • 8
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon, B., Nedergaard, J., Brown adipose tissue: function and physiological significance. Physiol. Rev. 84 (2004), 277–359.
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 10
    • 0031128104 scopus 로고    scopus 로고
    • Seasonal variation in the resting metabolic rate of male wood mice Apodemus sylvaticus from two contrasting habitats 15 km apart
    • Corp, N., Gorman, M.L., Speakman, J.R., Seasonal variation in the resting metabolic rate of male wood mice Apodemus sylvaticus from two contrasting habitats 15 km apart. J. Comp. Physiol. B 167 (1997), 229–239.
    • (1997) J. Comp. Physiol. B , vol.167 , pp. 229-239
    • Corp, N.1    Gorman, M.L.2    Speakman, J.R.3
  • 11
    • 84878810790 scopus 로고    scopus 로고
    • Pathways in microbe-induced obesity
    • Cox, L.M., Blaser, M.J., Pathways in microbe-induced obesity. Cell Metab. 17 (2013), 883–894.
    • (2013) Cell Metab. , vol.17 , pp. 883-894
    • Cox, L.M.1    Blaser, M.J.2
  • 13
    • 84883139076 scopus 로고    scopus 로고
    • The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
    • den Besten, G., van Eunen, K., Groen, A.K., Venema, K., Reijngoud, D.J., Bakker, B.M., The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J. Lipid Res. 54 (2013), 2325–2340.
    • (2013) J. Lipid Res. , vol.54 , pp. 2325-2340
    • den Besten, G.1    van Eunen, K.2    Groen, A.K.3    Venema, K.4    Reijngoud, D.J.5    Bakker, B.M.6
  • 14
    • 84944268275 scopus 로고    scopus 로고
    • Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel
    • Dey, N., Wagner, V.E., Blanton, L.V., Cheng, J., Fontana, L., Haque, R., Ahmed, T., Gordon, J.I., Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel. Cell 163 (2015), 95–107.
    • (2015) Cell , vol.163 , pp. 95-107
    • Dey, N.1    Wagner, V.E.2    Blanton, L.V.3    Cheng, J.4    Fontana, L.5    Haque, R.6    Ahmed, T.7    Gordon, J.I.8
  • 16
    • 79955579989 scopus 로고    scopus 로고
    • The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
    • Donohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K., Bultman, S.J., The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 13 (2011), 517–526.
    • (2011) Cell Metab. , vol.13 , pp. 517-526
    • Donohoe, D.R.1    Garge, N.2    Zhang, X.3    Sun, W.4    O'Connell, T.M.5    Bunger, M.K.6    Bultman, S.J.7
  • 21
    • 67649238355 scopus 로고    scopus 로고
    • Butyrate improves insulin sensitivity and increases energy expenditure in mice
    • Gao, Z., Yin, J., Zhang, J., Ward, R.E., Martin, R.J., Lefevre, M., Cefalu, W.T., Ye, J., Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58 (2009), 1509–1517.
    • (2009) Diabetes , vol.58 , pp. 1509-1517
    • Gao, Z.1    Yin, J.2    Zhang, J.3    Ward, R.E.4    Martin, R.J.5    Lefevre, M.6    Cefalu, W.T.7    Ye, J.8
  • 22
    • 85047651751 scopus 로고    scopus 로고
    • How gut microbes are joining the fight against cancer
    • Guglielmi, G., How gut microbes are joining the fight against cancer. Nature 557 (2018), 482–484.
    • (2018) Nature , vol.557 , pp. 482-484
    • Guglielmi, G.1
  • 23
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A., Virbasius, J.V., Puri, V., Czech, M.P., Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9 (2008), 367–377.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 24
    • 84884977637 scopus 로고    scopus 로고
    • Metabolomic analysis of key central carbon metabolism carboxylic acids as their 3-nitrophenylhydrazones by UPLC/ESI-MS
    • Han, J., Gagnon, S., Eckle, T., Borchers, C.H., Metabolomic analysis of key central carbon metabolism carboxylic acids as their 3-nitrophenylhydrazones by UPLC/ESI-MS. Electrophoresis 34 (2013), 2891–2900.
    • (2013) Electrophoresis , vol.34 , pp. 2891-2900
    • Han, J.1    Gagnon, S.2    Eckle, T.3    Borchers, C.H.4
  • 30
    • 85039073107 scopus 로고    scopus 로고
    • UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
    • Ikeda, K., Kang, Q., Yoneshiro, T., Camporez, J.P., Maki, H., Homma, M., Shinoda, K., Chen, Y., Lu, X., Maretich, P., et al. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat. Med. 23 (2017), 1454–1465.
    • (2017) Nat. Med. , vol.23 , pp. 1454-1465
    • Ikeda, K.1    Kang, Q.2    Yoneshiro, T.3    Camporez, J.P.4    Maki, H.5    Homma, M.6    Shinoda, K.7    Chen, Y.8    Lu, X.9    Maretich, P.10
  • 31
    • 85048167446 scopus 로고    scopus 로고
    • Antibiotic drug piperacillin induces neuron cell death through mitochondrial dysfunction and oxidative damage
    • Jiang, S., Li, T., Zhou, X., Qin, W., Wang, Z., Liao, Y., Antibiotic drug piperacillin induces neuron cell death through mitochondrial dysfunction and oxidative damage. Can. J. Physiol. Pharmacol. 96 (2018), 562–568.
    • (2018) Can. J. Physiol. Pharmacol. , vol.96 , pp. 562-568
    • Jiang, S.1    Li, T.2    Zhou, X.3    Qin, W.4    Wang, Z.5    Liao, Y.6
  • 34
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut microbiome and the immune system
    • Kau, A.L., Ahern, P.P., Griffin, N.W., Goodman, A.L., Gordon, J.I., Human nutrition, the gut microbiome and the immune system. Nature 474 (2011), 327–336.
    • (2011) Nature , vol.474 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3    Goodman, A.L.4    Gordon, J.I.5
  • 37
    • 72449186517 scopus 로고    scopus 로고
    • FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
    • Kind, T., Wohlgemuth, G., Lee, D.Y., Lu, Y., Palazoglu, M., Shahbaz, S., Fiehn, O., FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal. Chem. 81 (2009), 10038–10048.
    • (2009) Anal. Chem. , vol.81 , pp. 10038-10048
    • Kind, T.1    Wohlgemuth, G.2    Lee, D.Y.3    Lu, Y.4    Palazoglu, M.5    Shahbaz, S.6    Fiehn, O.7
  • 38
  • 41
    • 84964668099 scopus 로고    scopus 로고
    • Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation
    • Li, F., Wu, R., Cui, X., Zha, L., Yu, L., Shi, H., Xue, B., Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation. J. Biol. Chem. 291 (2016), 4523–4536.
    • (2016) J. Biol. Chem. , vol.291 , pp. 4523-4536
    • Li, F.1    Wu, R.2    Cui, X.3    Zha, L.4    Yu, L.5    Shi, H.6    Xue, B.7
  • 42
    • 85027705172 scopus 로고    scopus 로고
    • Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo
    • Li, L., Li, B., Li, M., Niu, C., Wang, G., Li, T., Król, E., Jin, W., Speakman, J.R., Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo. Mol. Metab. 6 (2017), 1198–1211.
    • (2017) Mol. Metab. , vol.6 , pp. 1198-1211
    • Li, L.1    Li, B.2    Li, M.3    Niu, C.4    Wang, G.5    Li, T.6    Król, E.7    Jin, W.8    Speakman, J.R.9
  • 44
    • 84910139873 scopus 로고    scopus 로고
    • Collateral damage: microbiota-derived metabolites and immune function in the antibiotic era
    • Lopez, C.A., Kingsbury, D.D., Velazquez, E.M., Bäumler, A.J., Collateral damage: microbiota-derived metabolites and immune function in the antibiotic era. Cell Host Microbe 16 (2014), 156–163.
    • (2014) Cell Host Microbe , vol.16 , pp. 156-163
    • Lopez, C.A.1    Kingsbury, D.D.2    Velazquez, E.M.3    Bäumler, A.J.4
  • 45
    • 84960358857 scopus 로고    scopus 로고
    • Antibiotic-treated versus germ-free rodents for microbiota transplantation studies
    • Lundberg, R., Toft, M.F., August, B., Hansen, A.K., Hansen, C.H., Antibiotic-treated versus germ-free rodents for microbiota transplantation studies. Gut Microbes 7 (2016), 68–74.
    • (2016) Gut Microbes , vol.7 , pp. 68-74
    • Lundberg, R.1    Toft, M.F.2    August, B.3    Hansen, A.K.4    Hansen, C.H.5
  • 46
    • 84919786957 scopus 로고    scopus 로고
    • Understanding how commensal obligate anaerobic bacteria regulate immune functions in the large intestine
    • Maier, E., Anderson, R.C., Roy, N.C., Understanding how commensal obligate anaerobic bacteria regulate immune functions in the large intestine. Nutrients 7 (2014), 45–73.
    • (2014) Nutrients , vol.7 , pp. 45-73
    • Maier, E.1    Anderson, R.C.2    Roy, N.C.3
  • 48
  • 51
    • 34547631960 scopus 로고    scopus 로고
    • Unexpected evidence for active brown adipose tissue in adult humans
    • Nedergaard, J., Bengtsson, T., Cannon, B., Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293 (2007), E444–E452.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , pp. E444-E452
    • Nedergaard, J.1    Bengtsson, T.2    Cannon, B.3
  • 53
    • 84937414538 scopus 로고    scopus 로고
    • ANIMAL PHYSIOLOGY. Exceptionally low daily energy expenditure in the bamboo-eating giant panda
    • Nie, Y., Speakman, J.R., Wu, Q., Zhang, C., Hu, Y., Xia, M., Yan, L., Hambly, C., Wang, L., Wei, W., et al. ANIMAL PHYSIOLOGY. Exceptionally low daily energy expenditure in the bamboo-eating giant panda. Science 349 (2015), 171–174.
    • (2015) Science , vol.349 , pp. 171-174
    • Nie, Y.1    Speakman, J.R.2    Wu, Q.3    Zhang, C.4    Hu, Y.5    Xia, M.6    Yan, L.7    Hambly, C.8    Wang, L.9    Wei, W.10
  • 54
    • 85009193567 scopus 로고    scopus 로고
    • Hydroxy-Carboxylic Acid Receptor Actions in Metabolism
    • Offermanns, S., Hydroxy-Carboxylic Acid Receptor Actions in Metabolism. Trends Endocrinol. Metab. 28 (2017), 227–236.
    • (2017) Trends Endocrinol. Metab. , vol.28 , pp. 227-236
    • Offermanns, S.1
  • 59
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell, N.J., Stock, M.J., A role for brown adipose tissue in diet-induced thermogenesis. Nature 281 (1979), 31–35.
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 61
    • 0017864644 scopus 로고
    • The effect of sodium butyrate on histone modification
    • Sealy, L., Chalkley, R., The effect of sodium butyrate on histone modification. Cell 14 (1978), 115–121.
    • (1978) Cell , vol.14 , pp. 115-121
    • Sealy, L.1    Chalkley, R.2
  • 64
    • 0023837943 scopus 로고
    • Regulation of fructose 2,6-bisphosphate levels in cold-acclimated brown adipose tissue of rat
    • Sobrino, F., Gualberto, A., Pintado, E., Regulation of fructose 2,6-bisphosphate levels in cold-acclimated brown adipose tissue of rat. FEBS Lett. 229 (1988), 91–94.
    • (1988) FEBS Lett. , vol.229 , pp. 91-94
    • Sobrino, F.1    Gualberto, A.2    Pintado, E.3
  • 65
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota–masters of host development and physiology
    • Sommer, F., Bäckhed, F., The gut microbiota–masters of host development and physiology. Nat. Rev. Microbiol. 11 (2013), 227–238.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 227-238
    • Sommer, F.1    Bäckhed, F.2
  • 66
    • 0003427964 scopus 로고    scopus 로고
    • Doubly Labelled Water: Theory and Practice
    • Springer
    • Speakman, J., Doubly Labelled Water: Theory and Practice. 1997, Springer.
    • (1997)
    • Speakman, J.1
  • 67
    • 84880669127 scopus 로고    scopus 로고
    • Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints
    • Speakman, J.R., Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints. Annu. Rev. Nutr. 33 (2013), 289–317.
    • (2013) Annu. Rev. Nutr. , vol.33 , pp. 289-317
    • Speakman, J.R.1
  • 70
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli, V., Bäckhed, F., Functional interactions between the gut microbiota and host metabolism. Nature 489 (2012), 242–249.
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 71
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006), 1027–1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 72
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • Turnbaugh, P.J., Bäckhed, F., Fulton, L., Gordon, J.I., Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3 (2008), 213–223.
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Bäckhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 73
    • 84901296354 scopus 로고    scopus 로고
    • The mycobiota: interactions between commensal fungi and the host immune system
    • Underhill, D.M., Iliev, I.D., The mycobiota: interactions between commensal fungi and the host immune system. Nat. Rev. Immunol. 14 (2014), 405–416.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 405-416
    • Underhill, D.M.1    Iliev, I.D.2
  • 74
    • 85018193359 scopus 로고    scopus 로고
    • Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome
    • Ussar, S., Griffin, N.W., Bezy, O., Fujisaka, S., Vienberg, S., Softic, S., Deng, L., Bry, L., Gordon, J.I., Kahn, C.R., Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome. Cell Metab. 22 (2015), 516–530.
    • (2015) Cell Metab. , vol.22 , pp. 516-530
    • Ussar, S.1    Griffin, N.W.2    Bezy, O.3    Fujisaka, S.4    Vienberg, S.5    Softic, S.6    Deng, L.7    Bry, L.8    Gordon, J.I.9    Kahn, C.R.10
  • 76
    • 84897412061 scopus 로고    scopus 로고
    • Role of monocarboxylate transporters in drug delivery to the brain
    • Vijay, N., Morris, M.E., Role of monocarboxylate transporters in drug delivery to the brain. Curr. Pharm. Des. 20 (2014), 1487–1498.
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 1487-1498
    • Vijay, N.1    Morris, M.E.2
  • 79
    • 85035791870 scopus 로고    scopus 로고
    • Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function
    • Yang, J.H., Bhargava, P., McCloskey, D., Mao, N., Palsson, B.O., Collins, J.J., Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function. Cell Host Microbe 22 (2017), 757–765.e3.
    • (2017) Cell Host Microbe , vol.22 , pp. 757-765.e3
    • Yang, J.H.1    Bhargava, P.2    McCloskey, D.3    Mao, N.4    Palsson, B.O.5    Collins, J.J.6
  • 81
    • 85050630484 scopus 로고    scopus 로고
    • Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
    • Zarrinpar, A., Chaix, A., Xu, Z.Z., Chang, M.W., Marotz, C.A., Saghatelian, A., Knight, R., Panda, S., Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat. Commun., 9, 2018, 2872.
    • (2018) Nat. Commun. , vol.9 , pp. 2872
    • Zarrinpar, A.1    Chaix, A.2    Xu, Z.Z.3    Chang, M.W.4    Marotz, C.A.5    Saghatelian, A.6    Knight, R.7    Panda, S.8
  • 82
    • 84882703646 scopus 로고    scopus 로고
    • The gut microbiota and obesity: from correlation to causality
    • Zhao, L., The gut microbiota and obesity: from correlation to causality. Nat. Rev. Microbiol. 11 (2013), 639–647.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 639-647
    • Zhao, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.