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Volumn 135, Issue 3, 2014, Pages 529-540

Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice

Author keywords

Bacteria, inflammation; L. reuteri; Mammary cancer; Probiotics

Indexed keywords

PROBIOTIC AGENT;

EID: 84901014117     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28702     Document Type: Article
Times cited : (114)

References (50)
  • 1
    • 63749101977 scopus 로고    scopus 로고
    • International agency for research on cancer, world health organization. Lyon, Geneva: International Agency for Research on Cancer, WHO Press
    • Boyle P, Levin B,. International agency for research on cancer, world health organization. World cancer report 2008. Lyon, Geneva: International Agency for Research on Cancer, WHO Press, 2008. 510 p.
    • (2008) World Cancer Report 2008 , pp. 510
    • Boyle, P.1    Levin, B.2
  • 2
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R,. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4: 579-91.
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 3
    • 84877263616 scopus 로고    scopus 로고
    • Caloric restriction reverses obesity-induced mammary gland inflammation in mice
    • et al.
    • Bhardwaj P, Du B, Zhou XK, et al. Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer Prev Res (Phila) 2013; 6: 282-9.
    • (2013) Cancer Prev Res (Phila) , vol.6 , pp. 282-289
    • Bhardwaj, P.1    Du, B.2    Zhou, X.K.3
  • 4
    • 79959860165 scopus 로고    scopus 로고
    • A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation
    • et al.
    • Ho VW, Leung K, Hsu A, et al. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res 2011; 71: 4484-93.
    • (2011) Cancer Res , vol.71 , pp. 4484-4493
    • Ho, V.W.1    Leung, K.2    Hsu, A.3
  • 5
    • 77953981792 scopus 로고    scopus 로고
    • Effect of obesity on breast cancer development
    • Cleary MP, Grossmann ME, Ray A,. Effect of obesity on breast cancer development. Vet Pathol 2010; 47: 202-13.
    • (2010) Vet Pathol , vol.47 , pp. 202-213
    • Cleary, M.P.1    Grossmann, M.E.2    Ray, A.3
  • 6
    • 77955551255 scopus 로고    scopus 로고
    • Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis
    • et al.
    • Khalid S, Hwang D, Babichev Y, et al. Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis. Breast Cancer Res Treat 2010; 122: 647-59.
    • (2010) Breast Cancer Res Treat , vol.122 , pp. 647-659
    • Khalid, S.1    Hwang, D.2    Babichev, Y.3
  • 7
    • 79957533706 scopus 로고    scopus 로고
    • Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice
    • et al.
    • Gu JW, Young E, Patterson SG, et al. Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice. Cancer Biol Ther 2011; 11: 910-7.
    • (2011) Cancer Biol Ther , vol.11 , pp. 910-917
    • Gu, J.W.1    Young, E.2    Patterson, S.G.3
  • 8
    • 46349108579 scopus 로고    scopus 로고
    • Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones
    • et al.
    • Nunez NP, Perkins SN, Smith NC, et al. Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer 2008; 60: 534-41.
    • (2008) Nutr Cancer , vol.60 , pp. 534-541
    • Nunez, N.P.1    Perkins, S.N.2    Smith, N.C.3
  • 9
    • 79955862214 scopus 로고    scopus 로고
    • Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland
    • et al.
    • Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila) 2011; 4: 329-46.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 329-346
    • Subbaramaiah, K.1    Howe, L.R.2    Bhardwaj, P.3
  • 10
    • 84867055650 scopus 로고    scopus 로고
    • Diet-induced metabolic change induces estrogen-independent allometric mammary growth
    • et al.
    • Berryhill GE, Gloviczki JM, Trott JF, et al. Diet-induced metabolic change induces estrogen-independent allometric mammary growth. Proc Natl Acad Sci USA 2012; 109: 16294-9.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16294-16299
    • Berryhill, G.E.1    Gloviczki, J.M.2    Trott, J.F.3
  • 11
    • 79955835672 scopus 로고    scopus 로고
    • Inflammatory talk: Linking obesity, NF-kappaB, and aromatase
    • Hursting SD,. Inflammatory talk: linking obesity, NF-kappaB, and aromatase. Cancer Prev Res (Phila) 2011; 4: 285-7.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 285-287
    • Hursting, S.D.1
  • 12
    • 33747481384 scopus 로고    scopus 로고
    • Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    • et al.
    • Rao VP, Poutahidis T, Ge Z, et al. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res 2006; 66: 7395-400.
    • (2006) Cancer Res , vol.66 , pp. 7395-7400
    • Rao, V.P.1    Poutahidis, T.2    Ge, Z.3
  • 13
    • 33847041537 scopus 로고    scopus 로고
    • Breast cancer: Should gastrointestinal bacteria be on our radar screen?
    • et al.
    • Rao VP, Poutahidis T, Fox JG, et al. Breast cancer: should gastrointestinal bacteria be on our radar screen? Cancer Res 2007; 67: 847-50.
    • (2007) Cancer Res , vol.67 , pp. 847-850
    • Rao, V.P.1    Poutahidis, T.2    Fox, J.G.3
  • 14
    • 77449142400 scopus 로고    scopus 로고
    • Unifying roles for regulatory T cells and inflammation in cancer
    • et al.
    • Erdman SE, Rao VP, Olipitz W, et al. Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer 2010; 126: 1651-65.
    • (2010) Int J Cancer , vol.126 , pp. 1651-1665
    • Erdman, S.E.1    Rao, V.P.2    Olipitz, W.3
  • 15
    • 34247499539 scopus 로고    scopus 로고
    • Insights from transgenic mouse models of ERBB2-induced breast cancer
    • et al.
    • Ursini-Siegel J, Schade B, Cardiff RD, et al. Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer 2007; 7: 389-97.
    • (2007) Nat Rev Cancer , vol.7 , pp. 389-397
    • Ursini-Siegel, J.1    Schade, B.2    Cardiff, R.D.3
  • 16
    • 84872608638 scopus 로고    scopus 로고
    • Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer
    • et al.
    • West NR, Kost SE, Martin SD, et al. Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer. Br J Cancer 2013; 108: 155-62.
    • (2013) Br J Cancer , vol.108 , pp. 155-162
    • West, N.R.1    Kost, S.E.2    Martin, S.D.3
  • 17
    • 84872460045 scopus 로고    scopus 로고
    • Probiotic bacteria induce a 'glow of health'
    • et al.
    • Levkovich T, Poutahidis T, Smillie C, et al. Probiotic bacteria induce a 'glow of health'. PLoS One 2013; 8: e53867.
    • (2013) PLoS One , vol.8
    • Levkovich, T.1    Poutahidis, T.2    Smillie, C.3
  • 18
    • 84880011577 scopus 로고    scopus 로고
    • Microbial reprogramming inhibits western diet-associated obesity
    • et al.
    • Poutahidis T, Kleinewietfeld M, Smillie C, et al. Microbial reprogramming inhibits western diet-associated obesity. PLoS One 2013; 8: e68596.
    • (2013) PLoS One , vol.8
    • Poutahidis, T.1    Kleinewietfeld, M.2    Smillie, C.3
  • 19
    • 20444503737 scopus 로고    scopus 로고
    • Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    • et al.
    • Smits HH, Engering A, van der Kleij D, et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 2005; 115: 1260-7.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1260-1267
    • Smits, H.H.1    Engering, A.2    Van Der Kleij, D.3
  • 20
    • 61449199478 scopus 로고    scopus 로고
    • Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice
    • et al.
    • Karimi K, Inman MD, Bienenstock J, et al. Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am J Respir Crit Care Med 2009; 179: 186-93.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 186-193
    • Karimi, K.1    Inman, M.D.2    Bienenstock, J.3
  • 21
    • 84874244550 scopus 로고    scopus 로고
    • Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3(+) regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis
    • et al.
    • Liu Y, Fatheree NY, Dingle BM, et al. Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3(+) regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis. PLoS One 2013; 8: e56547.
    • (2013) PLoS One , vol.8
    • Liu, Y.1    Fatheree, N.Y.2    Dingle, B.M.3
  • 22
    • 0024359973 scopus 로고
    • Consumption of fermented milk products and breast cancer: A case-control study in the Netherlands
    • et al.
    • van't Veer P, Dekker JM, Lamers JW, et al. Consumption of fermented milk products and breast cancer: a case-control study in The Netherlands. Cancer Res 1989; 49: 4020-3.
    • (1989) Cancer Res , vol.49 , pp. 4020-4023
    • Van'T Veer, P.1    Dekker, J.M.2    Lamers, J.W.3
  • 23
    • 84860342259 scopus 로고    scopus 로고
    • Evaluating the links between intake of milk/dairy products and cancer
    • Chagas CE, Rogero MM, Martini LA,. Evaluating the links between intake of milk/dairy products and cancer. Nutr Rev 2012; 70: 294-300.
    • (2012) Nutr Rev , vol.70 , pp. 294-300
    • Chagas, C.E.1    Rogero, M.M.2    Martini, L.A.3
  • 24
    • 35148813459 scopus 로고    scopus 로고
    • The application of probiotics in cancer
    • de Moreno, de LeBlanc A, Matar C, Perdigon G,. The application of probiotics in cancer. Br J Nutr 2007; 98 (Suppl 1): S105-S10.
    • (2007) Br J Nutr , vol.98 , Issue.SUPPL. 1
    • De Moreno1    De Leblanc, A.2    Matar, C.3    Perdigon, G.4
  • 25
    • 35949004479 scopus 로고    scopus 로고
    • Study of immune cells involved in the antitumor effect of kefir in a murine breast cancer model
    • et al.
    • de Moreno, de Leblanc A, Matar C, Farnworth E, et al. Study of immune cells involved in the antitumor effect of kefir in a murine breast cancer model. J Dairy Sci 2007; 90: 1920-8.
    • (2007) J Dairy Sci , vol.90 , pp. 1920-1928
    • De Moreno1    De Leblanc, A.2    Matar, C.3    Farnworth, E.4
  • 26
    • 84878233113 scopus 로고    scopus 로고
    • Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model
    • et al.
    • Maroof H, Hassan ZM, Mobarez AM, et al. Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model. J Clin Immunol 2012; 32: 1353-9.
    • (2012) J Clin Immunol , vol.32 , pp. 1353-1359
    • Maroof, H.1    Hassan, Z.M.2    Mobarez, A.M.3
  • 27
    • 79955718307 scopus 로고    scopus 로고
    • Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features
    • et al.
    • Saulnier DM, Santos F, Roos S, et al. Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features. PLoS One 2011; 6: e18783.
    • (2011) PLoS One , vol.6
    • Saulnier, D.M.1    Santos, F.2    Roos, S.3
  • 28
    • 70349414420 scopus 로고    scopus 로고
    • Survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG in the human gastrointestinal tract with daily consumption of a low-fat probiotic spread
    • et al.
    • Dommels YEM, Kemperman RA, Zebregs YEMP, et al. Survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG in the human gastrointestinal tract with daily consumption of a low-fat probiotic spread. Appl Environ Microbiol 2009; 75: 6198-204.
    • (2009) Appl Environ Microbiol , vol.75 , pp. 6198-6204
    • Dommels, Y.E.M.1    Kemperman, R.A.2    Zebregs, Y.3
  • 29
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S,. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010; 11: 7-13.
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 30
    • 31544451792 scopus 로고    scopus 로고
    • Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice
    • et al.
    • Rao VP, Poutahidis T, Ge Z, et al. Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. Cancer Res 2006; 66: 57-61.
    • (2006) Cancer Res , vol.66 , pp. 57-61
    • Rao, V.P.1    Poutahidis, T.2    Ge, Z.3
  • 31
    • 0141590345 scopus 로고    scopus 로고
    • Persistent mammary hyperplasia in FVB/N mice
    • et al.
    • Nieto AI, Shyamala G, Galvez JJ, et al. Persistent mammary hyperplasia in FVB/N mice. Comp Med 2003; 53: 433-8.
    • (2003) Comp Med , vol.53 , pp. 433-438
    • Nieto, A.I.1    Shyamala, G.2    Galvez, J.J.3
  • 32
    • 84865592614 scopus 로고    scopus 로고
    • Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice
    • et al.
    • Raafat A, Strizzi L, Lashin K, et al. Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice. PLoS One 2012; 7: e43624.
    • (2012) PLoS One , vol.7
    • Raafat, A.1    Strizzi, L.2    Lashin, K.3
  • 34
    • 40349094954 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Balancing immune response: Crosstalk between adaptive and innate immune cells during breast cancer progression
    • DeNardo DG, Coussens LM,. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res 2007; 9: 212.
    • (2007) Breast Cancer Res , vol.9 , pp. 212
    • Denardo, D.G.1    Coussens, L.M.2
  • 35
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM,. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012; 21: 309-22.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 36
    • 79951879290 scopus 로고    scopus 로고
    • Infection, immunoregulation, and cancer
    • 2011.
    • Rook GA, Dalgleish A,. Infection, immunoregulation, and cancer. Immunol Rev 2011; 240: 141-59.
    • Immunol Rev , vol.240 , pp. 141-159
    • Rook, G.A.1    Dalgleish, A.2
  • 37
    • 20144375359 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    • et al.
    • Erdman SE, Sohn JJ, Rao VP, et al. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res 2005; 65: 3998-4004.
    • (2005) Cancer Res , vol.65 , pp. 3998-4004
    • Erdman, S.E.1    Sohn, J.J.2    Rao, V.P.3
  • 38
    • 35648960877 scopus 로고    scopus 로고
    • Is vitamin D deficiency to blame for the asthma epidemic?
    • Litonjua AA, Weiss ST,. Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007; 120: 1031-5.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 1031-1035
    • Litonjua, A.A.1    Weiss, S.T.2
  • 39
    • 9744274548 scopus 로고    scopus 로고
    • Vitamin D and colon carcinogenesis
    • Harris DM, Go VL,. Vitamin D and colon carcinogenesis. J Nutr 2004; 134: 3463S-71S.
    • (2004) J Nutr , vol.134
    • Harris, D.M.1    Go, V.L.2
  • 40
    • 84860864158 scopus 로고    scopus 로고
    • NF-kappaB, stem cells and breast cancer: The links get stronger
    • Shostak K, Chariot A,. NF-kappaB, stem cells and breast cancer: the links get stronger. Breast Cancer Res 2011; 13: 214.
    • (2011) Breast Cancer Res , vol.13 , pp. 214
    • Shostak, K.1    Chariot, A.2
  • 41
    • 33745441050 scopus 로고    scopus 로고
    • C-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer
    • et al.
    • Vleugel MM, Greijer AE, Bos R, et al. c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Hum Pathol 2006; 37: 668-74.
    • (2006) Hum Pathol , vol.37 , pp. 668-674
    • Vleugel, M.M.1    Greijer, A.E.2    Bos, R.3
  • 42
    • 77950891314 scopus 로고    scopus 로고
    • C-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion
    • et al.
    • Jiao X, Katiyar S, Willmarth NE, et al. c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J Biol Chem 2010; 285: 8218-26.
    • (2010) J Biol Chem , vol.285 , pp. 8218-8226
    • Jiao, X.1    Katiyar, S.2    Willmarth, N.E.3
  • 43
    • 78650098891 scopus 로고    scopus 로고
    • C-jun inhibits mammary apoptosis in vivo
    • et al.
    • Katiyar S, Casimiro MC, Dettin L, et al. C-jun inhibits mammary apoptosis in vivo. Mol Biol Cell 2010; 21: 4264-74.
    • (2010) Mol Biol Cell , vol.21 , pp. 4264-4274
    • Katiyar, S.1    Casimiro, M.C.2    Dettin, L.3
  • 44
    • 84894235009 scopus 로고    scopus 로고
    • Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin
    • et al.
    • Poutahidis T, Kearney SM, Levkovich T, et al. Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS One 2013; 8: e78898.
    • (2013) PLoS One , vol.8
    • Poutahidis, T.1    Kearney, S.M.2    Levkovich, T.3
  • 45
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF,. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315: 1650-9.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 46
    • 77950622246 scopus 로고    scopus 로고
    • Oxytocin both increases proliferative response of peripheral blood lymphomonocytes to phytohemagglutinin and reverses immunosuppressive estrogen activity
    • et al.
    • Maccio A, Madeddu C, Chessa P, et al. Oxytocin both increases proliferative response of peripheral blood lymphomonocytes to phytohemagglutinin and reverses immunosuppressive estrogen activity. In Vivo 2010; 24: 157-63.
    • (2010) In Vivo , vol.24 , pp. 157-163
    • Maccio, A.1    Madeddu, C.2    Chessa, P.3
  • 47
    • 0029029665 scopus 로고
    • The potential for oxytocin (OT) to prevent breast cancer: A hypothesis
    • Murrell TG,. The potential for oxytocin (OT) to prevent breast cancer: a hypothesis. Breast Cancer Res Treat 1995; 35: 225-9.
    • (1995) Breast Cancer Res Treat , vol.35 , pp. 225-229
    • Murrell, T.G.1
  • 48
    • 48349133919 scopus 로고    scopus 로고
    • Impact of the neuroendocrine system on thymus and bone marrow function
    • et al.
    • Barnard A, Layton D, Hince M, et al. Impact of the neuroendocrine system on thymus and bone marrow function. Neuroimmunomodulation 2008; 15: 7-18.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 7-18
    • Barnard, A.1    Layton, D.2    Hince, M.3
  • 49
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper LV, Littman DR, Macpherson AJ,. Interactions between the microbiota and the immune system. Science 2012; 336: 1268-73.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 50
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round JL, Mazmanian SK,. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 2010; 107: 12204-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.