Roseburia intestinalis-derived flagellin is a negative regulator of intestinal inflammation

Biochemical and Biophysical Research Communications

Volumn 501, Issue 3, 2018, Pages 791-799

  Quan, Yongsheng ^a,b   Song, Kerui ^c   Zhang, Yan ^a   Zhu, Changxin ^a,b   Shen, Zhaohua ^a,b   Wu, Shuai ^a,b   Luo, Weiwei ^a,b   Tan, Bei ^a,b   Yang, Zhenyu ^a   Wang, Xiaoyan ^a,b  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b Hunan Key Laboratory of Nonresolving Inflammation and Cancer   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Flagellin; HIF1A AS2; Inflammatory bowel disease; lncRNA; Roseburia intestinalis

Indexed keywords

FLAGELLIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; LONG UNTRANSLATED RNA; SHORT HAIRPIN RNA; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL FLORA; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ACTIVITY; ENDOTHELIUM CELL; ENTERITIS; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; HIF1A AS2 GENE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ROSEBURIA INTESTINALIS; ULCERATIVE COLITIS; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CACO-2 CELL LINE; CLOSTRIDIALES; GENETICS; HUMAN; IMMUNOLOGY; MALE; MAPK SIGNALING; MICROBIOLOGY;

ANIMALS; CACO-2 CELLS; CLOSTRIDIALES; COLITIS, ULCERATIVE; FLAGELLIN; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; NF-KAPPA B; RNA, LONG NONCODING; TRANSCRIPTOME;

EID: 85047070106     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2018.05.075     Document Type: Article

References (25)

1. Zacharopoulou, E., Gazouli, M., Tzouvala, M., et al. The contribution of long non-coding RNAs in Inflammatory Bowel Diseases. Dig. Liver Dis. 49 (2017), 1067–1072.
2. Fava, V.M., Manry, J., Cobat, A., et al. A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy. PLoS Genet., 13, 2017 e1006637.
3. Edgington-Mitchell, L.E., Long noncoding RNAs: novel links to inflammatory bowel disease?. Am. J. Physiol. Gastrointest. Liver Physiol. 311 (2016), G444–G445.
4. Zhu, C., Song, K., Shen, Z., et al. Roseburia intestinalis inhibits interleukin17 excretion and promotes regulatory T cells differentiation in colitis. Mol. Med. Rep. 17 (2018), 7567–7574.
5. Shen, Z., Zhu, C., Quan, Y., et al. Roseburia intestinalis alleviates experimental colitis pathology by inducing anti-inflammatory responses. J. Gastroenterol. Hepatol., 2018, 10.1111/jgh.14144.
6. Miao, E.A., Andersen-Nissen, E., Warren, S.E., et al. TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin. Immunopathol. 29 (2007), 275–288.
7. Caballero, I., Boyd, J., Alminana, C., et al. Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol. Sci. Rep., 7, 2017, 40981.
8. Kondo, Y., Higa-Nakamine, S., Maeda, N., et al. Stimulation of cell migration by flagellin through the p38 MAP kinase pathway in cultured intestinal epithelial cells. J. Cell. Biochem. 117 (2016), 247–258.
9. Ha, H., Lee, J.H., Kim, H.N., et al. Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. J. Immunol. 180 (2008), 1382–1389.
10. Zeng, H., Wu, H., Sloane, V., et al. Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (2006), G96–G108.
11. Wu, F., Huang, Y., Dong, F., et al. Ulcerative colitis-associated long noncoding RNA, BC012900, regulates intestinal epithelial cell apoptosis. Inflamm. Bowel Dis. 22 (2016), 782–795.
12. Haberman, Y., BenShoshan, M., Di Segni, A., et al. Long ncRNA landscape in the ileum of treatment-naive early-onset Crohn disease. Inflamm. Bowel Dis. 24 (2018), 346–360.
13. Neville, B.A., Forde, B.M., Claesson, M.J., et al. Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli. PLoS One, 7, 2012 e40592.
14. Jiang, C., Xu, M., Kuang, X., et al. Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK/NF-kappaB signaling pathways in human epidermal keratinocytes. Exp. Cell Res. 361 (2017), 46–55.
15. Xu, M., Xie, Y., Jiang, C., et al. Treponema pallidum flagellins elicit proinflammatory cytokines from human monocytes via TLR5 signaling pathway. Immunobiology 222 (2017), 709–718.
16. Kogut, M.H., Genovese, K.J., He, H., et al. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways. Innate Immun. 14 (2008), 213–222.
17. Huang, F.C., Regulation of Salmonella flagellin-induced interleukin-8 in intestinal epithelial cells by muramyl dipeptide. Cell. Immunol. 278 (2012), 1–9.
18. Imada, K., Bacterial flagellar axial structure and its construction. Biophys Rev 10 (2018), 559–570.
19. Zhang, Y., Wang, Y., Li, S., et al. ITRAQ-based quantitative proteomic analysis of processed Euphorbia lathyris L. for reducing the intestinal toxicity. Proteome Sci., 16, 2018, 8.
20. O'Reilly, L.A., Putoczki, T.L., Mielke, L.A., et al. Loss of NF-kappaB1 causes gastric cancer with aberrant inflammation and expression of immune checkpoint regulators in a stat-1-dependent manner. Immunity 48 (2018), 570–583 e8.
21. Hu, Y.W., Kang, C.M., Zhao, J.J., et al. LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1. J. Cell Mol. Med. 22 (2018), 497–510.
22. Ogushi, K., Wada, A., Niidome, T., et al. Salmonella enteritidis FliC (flagella filament protein) induces human beta-defensin-2 mRNA production by Caco-2 cells. J. Biol. Chem. 276 (2001), 30521–30526.
23. Salamone, G.V., Petracca, Y., Fuxman, B.J., et al. Flagellin delays spontaneous human neutrophil apoptosis. Lab. Invest. 90 (2010), 1049–1059.
24. Smaldini, P.L., Stanford, J., Romanin, D.E., et al. Down-regulation of NF-kappaB signaling by Gordonia bronchialis prevents the activation of gut epithelial cells. Innate Immun. 20 (2014), 626–638.
25. Moon, J.Y., Nam, B.H., Kong, H.J., et al. Maximal transcriptional activation of piscine soluble Toll-like receptor 5 by the NF-kappaB subunit p65 and flagellin. Fish Shellfish Immunol. 31 (2011), 881–886.