Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo

Neurogastroenterology and Motility

Volumn 30, Issue 2, 2018, Pages

  Jennis, M ^a   Cavanaugh, C R ^a   Leo, G C ^b   Mabus, J R ^a   Lenhard, J ^a   Hornby, P J ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Discovery Sciences Janssen Pharmaceutical J and J   (United States)

Author keywords

diet induced obese mice; indole 3 propionic acid; microbiome; T84 cell monolayer; tryptamine; tryptophan

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; BUTYRIC ACID; ENDOTOXIN; GAMMA INTERFERON; GLUCOSE TRANSPORTER 5; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEPROPIONIC ACID; KYNURENIC ACID; KYNURENINASE; KYNURENINE; KYNURENINE 3 MONOOXYGENASE; KYNURENINE AMINOTRANSFERASE; MESSENGER RNA; SEROTONIN; TRYPTAMINE; TRYPTOPHAN; TRYPTOPHAN AMINOTRANSFERASE; TRYPTOPHAN DERIVATIVE; TRYPTOPHAN HYDROXYLASE; TRYPTOPHANASE; TUMOR NECROSIS FACTOR; XANTHURENIC ACID; INDOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; JEJUNUM MUCOSA; LAPAROTOMY; LIPID DIET; MALE; MICROFLORA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROUX-EN-Y GASTRIC BYPASS; T84 CELL LINE; TRANSACTIVATION; TRYPTOPHAN METABOLISM; ANIMAL; C57BL MOUSE; EPITHELIUM CELL; GASTRIC BYPASS SURGERY; INTESTINE FLORA; INTESTINE MUCOSA; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PERMEABILITY;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; EPITHELIAL CELLS; GASTRIC BYPASS; GASTROINTESTINAL MICROBIOME; INDOLES; INTERFERON-GAMMA; INTESTINAL MUCOSA; MALE; MICE, INBRED C57BL; OBESITY; PERMEABILITY; TRYPTOPHAN;

EID: 85027129808     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.13178     Document Type: Article

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