Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Gut

Volumn 64, Issue 11, 2015, Pages 1744-1754

  Chambers, Edward S ^a   Viardot, Alexander ^a,h   Psichas, Arianna ^a   Morrison, Douglas J ^b   Murphy, Kevin G ^a   Zac Varghese, Sagen E K ^a   MacDougall, Kenneth ^c   Preston, Tom ^b   Tedford, Catriona ^c   Finlayson, Graham S ^d   Blundell, John E ^d   Bell, Jimmy D ^a   Thomas, E Louise ^a   Mt Isa, Shahrul ^e   Ashby, Deborah ^e   Gibson, Glen R ^f   Kolida, Sofia ^f   Dhillo, Waljit S ^a   Bloom, Stephen R ^a   Morley, Wayne ^g   Clegg, Stuart ^g   Frost, Gary ^a   more..

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b SCOTTISH UNIVERSITIES ENVIRONMENTAL RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF READING   (United Kingdom)

^g LEATHERHEAD FOOD RESEARCH   (United Kingdom)

^h GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INULIN; LIPID; PEPTIDE YY; PROPIONIC ACID; SHORT CHAIN FATTY ACID; PROPIONIC ACID DERIVATIVE;

ADULT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CALORIC INTAKE; CELL CULTURE; COLON; COLON FLORA; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY FIBER; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; FEMALE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN SECRETION; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TISSUE DISTRIBUTION; WEIGHT GAIN; BODY WEIGHT MAINTENANCE; CYTOLOGY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; MIDDLE AGED; OVERWEIGHT; SECRETION (PROCESS);

ADIPOSITY; APPETITE REGULATION; BODY WEIGHT MAINTENANCE; CELLS, CULTURED; COLON; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MALE; MIDDLE AGED; OVERWEIGHT; PEPTIDE YY; PROPIONATES;

EID: 84945202481     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-307913     Document Type: Article

References (50)

1. Hussain SS, Bloom SR. The regulation of food intake by the gut-brain axis: implications for obesity. Int J Obes (Lond) 2013;37:625-33.
2. Zhao L. The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol 2013;11:639-47.
3. Cani PD. Metabolism in 2013: the gut microbiota manages host metabolism. Nat Rev Endocrinol 2014;10:74-6.
4. Ridaura VK, Faith JJ, Rey FE, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013;341:1241214.
5. Liou AP, Paziuk M, Luevano JM Jr, et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med 2013;5:178ra41.
6. Williamson DF, Kahn HS, Remington PL, et al. The 10-year incidence of overweight and major weight gain in US adults. Arch Intern Med 1990;150:665-72.
7. Mozaffarian D, Hao T, Rimm EB, et al. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med 2011;364:2392-404.
8. Peeters A, Magliano DJ, Backholer K, et al. Changes in the rates of weight and waist circumference gain in Australian adults over time: a longitudinal cohort study. BMJ Open 2014;4:e003667.
9. Heitmann BL, Garby L. Patterns of long-term weight changes in overweight developing Danish men and women aged between 30 and 60 years. Int J Obes Relat Metab Disord 1999;23:1074-8.
10. Zhai F, Wang H, Wang Z, et al. Closing the energy gap to prevent weight gain in China. Obes Rev 2008;9(Suppl 1):107-12.
11. Liu S, Willett WC, Manson JE, et al. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr 2003;78:920-7.
12. Ludwig DS, Pereira MA, Kroenke CH, et al. Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA 1999;282:1539-46.
13. Maskarinec G, Takata Y, Pagano I, et al. Trends and dietary determinants of overweight and obesity in a multiethnic population. Obesity (Silver Spring) 2006;14:717-26.
14. Wanders AJ, van den Borne JJ, de Graaf C, et al. Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials. Obes Rev 2011;12:724-39.
15. Cani PD, Neyrinck AM, Maton N, et al. Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obes Res 2005;13:1000-7.
16. Anastasovska J, Arora T, Sanchez Canon GJ, et al. Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment. Obesity (Silver Spring) 2012;20:1016-23.
17. Cani PD, Joly E, Horsmans Y, et al. Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 2006;60:567-72.
18. Rigaud D, Ryttig KR, Angel LA, et al. Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial. Int J Obes 1990;14:763-9.
19. Howarth NC, Saltzman E, Roberts SB. Dietary fiber and weight regulation. Nutr Rev 2001;59:129-39.
20. Howarth NC, Saltzman E, McCrory MA, et al. Fermentable and nonfermentable fiber supplements did not alter hunger, satiety or body weight in a pilot study of men and women consuming self-selected diets. J Nutr 2003;133:3141-4.
21. Tolhurst G, Heffron H, Lam YS, et al. Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2. Diabetes 2012;61:364-71.
22. Cherbut C, Ferrier L, Roze C, et al. Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. Am J Physiol 1998;275(6 Pt 1):G1415-22.
23. Anini Y, Fu-Cheng X, Cuber JC, et al. Comparison of the postprandial release of peptide YY and proglucagon-derived peptides in the rat. Pflugers Arch 1999;438:299-306.
24. Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature 2006;444:854-9.
25. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003;349:941-8.
26. Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69-72.
27. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-4.
28. Brown AJ, Goldsworthy SM, Barnes AA, et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003;278:11312-19.
29. Le Poul E, Loison C, Struyf S, et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003;278:25481-9.
30. Morrison DJ, Mackay WG, Edwards CA, et al. Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate? Br J Nutr 2006;96:570-7.
31. Cummings JH, Pomare EW, Branch WJ, et al. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987;28:1221-7.
32. Reimann F, Habib AM, Tolhurst G, et al. Glucose sensing in L cells: a primary cell study. Cell Metab 2008;8:532-9.
33. Thomas EL, Parkinson JR, Frost GS, et al. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring) 2012;20:76-87.
34. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, et al. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985;89:1070-7.
35. Kreymann B, Williams G, Ghatei MA, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987;2:1300-4.
36. Flint A, Raben A, Blundell JE, et al. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 2000;24:38-48.
37. Papke LE, Wooldridge JM. Econometric methods for fractional response variables with an application to 401(k) plan participation rates. Journal of Applied Econometrics 1996;11:619-32.
38. Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005;288:E462-8.
39. le Roux CW, Batterham RL, Aylwin SJ, et al. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 2006;147:3-8.
40. Pedersen C, Lefevre S, Peters V, et al. Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study. Appetite 2013;66:44-53.
41. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014;505:559-63.
42. James WP. Treatment of obesity: the constraints on success. Clin Endocrinol Metab 1984;13:635-59.
43. Daubioul C, Rousseau N, Demeure R, et al. Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 2002;132:967-73.
44. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006;444:881-7.
45. Zaibi MS, Stocker CJ, O'Dowd J, et al. Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. FEBS Lett 2010;584:2381-6.
46. Kimura I, Inoue D, Maeda T, et al. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A 2011;108:8030-5.
47. Kimura I, Ozawa K, Inoue D, et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 2013;4:1829.
48. De Vadder F, Kovatcheva-Datchary P, Goncalves D, et al. Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits. Cell 2014;156:84-96.
49. Daud NM, Ismail NA, Thomas EL, et al. The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity (Silver Spring) 2014;22:1430-8.
50. Beylot M. Effects of inulin-type fructans on lipid metabolism in man and in animal models. Br J Nutr 2005;93(Suppl 1):S163-8.