Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

Gut

Volumn 68, Issue 8, 2019, Pages 1504-1515

  Hendrikx, Tim ^a   Duan, Yi ^a,b   Wang, Yanhan ^a,b   Oh, Jee Hwan ^c   Alexander, Laura M ^c   Huang, Wendy ^d   Stärkel, Peter ^e   Ho, Samuel B ^a,b   Gao, Bei ^f   Fiehn, Oliver ^f   Emond, Patrick ^g,h   Sokol, Harry ^i,j,k   Van Pijkeren, Jan Peter ^c   Schnabl, Bernd ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITÉ DE TOURS   (France)

^h UNIVERSITY HOSPITAL OF TOURS   (France)

ⁱ ECOLE NORMALE SUPÉRIEURE   (France)

^j UNIVERSITÉ PARIS SACLAY   (France)

^k ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

more..

Author keywords

ILC; immune response; metabolome; microbiome

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; AROMATIC HYDROCARBON RECEPTOR; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CYTOCHROME P450 2E1; INDOLEACETIC ACID; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 22; MYELOID DIFFERENTIATION FACTOR 88; PANCREATITIS ASSOCIATED PROTEIN; REGENERATING ISLET DERIVED 3GAMMA PROTEIN; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; AHR PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; INDOLEACETIC ACID DERIVATIVE; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; REG3G PROTEIN, MOUSE;

ADH1 GENE; ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; CXCL1 GENE; CXCL2 GENE; CYP2E1 GENE; CYTOKINE PRODUCTION; DYSBIOSIS; EXPERIMENTAL STEATOHEPATITIS; FECES LEVEL; GENE; HEPATITIS; IL22 GENE; LACTOBACILLUS REUTERI; LIVER INJURY; LIVER PROTECTION; LYMPHOID CELL; MOUSE; MYD88 GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REG3B GENE; REG3G GENE; REGULATORY MECHANISM; SUPPLEMENTATION; TLR4 GENE; TRANSGENIC MICROORGANISM; UPREGULATION; ANIMAL; COMPLICATION; DISEASE MODEL; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; INTESTINE FLORA; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; SMALL INTESTINE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DISEASE MODELS, ANIMAL; DYSBIOSIS; ETHANOL; GASTROINTESTINAL MICROBIOME; IMMUNITY, INNATE; INDOLEACETIC ACIDS; INFLAMMATION; INTERLEUKINS; INTESTINE, SMALL; LACTOBACILLUS REUTERI; LIVER DISEASES, ALCOHOLIC; MICE; MICE, KNOCKOUT; PANCREATITIS-ASSOCIATED PROTEINS; RECEPTORS, ARYL HYDROCARBON;

EID: 85056910175     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2018-317232     Document Type: Article

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