Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Science

Volumn 352, Issue 6289, 2016, Pages 1116-1120

  Chu, Hiutung ^a   Khosravi, Arya ^a   Kusumawardhani, Indah P ^a   Kwon, Alice H K ^a   Vasconcelos, Anilton C ^b   Cunha, Larissa D ^c   Mayer, Anne E ^d   Shen, Yue ^a   Wu, Wei Li ^a   Kambal, Amal ^d   Targan, Stephan R ^e   Xavier, Ramnik J ^f   Ernst, Peter B ^b   Green, Douglas R ^c   McGovern, Dermot P B ^e   Virgin, Herbert W ^d   Mazmanian, Sarkis K ^a  

^a California Institute of Technology HHMI   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CEDARS SINAI MEDICAL CENTER   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATG16L1 PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; CASPASE RECRUITMENT DOMAIN PROTEIN 15; UNCLASSIFIED DRUG; ATG16L1 PROTEIN, HUMAN; CARRIER PROTEIN; NOD2 PROTEIN, HUMAN;

BACTERIUM; CELLS AND CELL COMPONENTS; COMMENSAL; DISEASE; ETIOLOGY; GENETIC ANALYSIS; GENOME; IMMUNE SYSTEM; MEMBRANE; PATHOGENICITY; SECRETION;

ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; MEMBRANE VESICLE; MICROFLORA; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; OUTER MEMBRANE; OUTER MEMBRANE VESICLE; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYMBIOSIS; ADULT; AGED; ANIMAL; BACTEROIDES FRAGILIS; C57BL MOUSE; EXOSOME; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN GENOME; IMMUNOLOGY; INTESTINE FLORA; INTESTINE MUCOSA; MALE; MICROBIOLOGY; MIDDLE AGED;

BACTEROIDES FRAGILIS;

ADULT; AGED; ANIMALS; AUTOPHAGY; BACTEROIDES FRAGILIS; CARRIER PROTEINS; DENDRITIC CELLS; EXTRACELLULAR VESICLES; FEMALE; GASTROINTESTINAL MICROBIOME; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, GENETIC; T-LYMPHOCYTES, REGULATORY;

EID: 84966293351     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad9948     Document Type: Article

References (41)

1. D. A. Peterson, D. N. Frank, N. R. Pace, J. I. Gordon, Cell Host Microbe 3, 417-427 (2008).
2. D. A. Hill, D. Artis, Annu. Rev. Immunol. 28, 623-667 (2010).
3. K. Honda, D. R. Littman, Annu. Rev. Immunol. 30, 759-795 (2012).
4. E. M. Brown, M. Sadarangani, B. B. Finlay, Nat. Immunol. 14, 660-667 (2013).
5. Y. Belkaid, T. W. Hand, Cell 157, 121-141 (2014).
6. L. V. Hooper, D. R. Littman, A. J. Macpherson, Science 336, 1268-1273 (2012).
7. S. R. Brant, Inflamm. Bowel Dis. 17, 1-5 (2011).
8. M. Orholm et al., Scand. J. Gastroenterol. 35, 1075-1081 (2000).
9. J. Halfvarson, L. Bodin, C. Tysk, E. Lindberg, G. Järnerot, Gastroenterology 124, 1767-1773 (2003).
10. C. Tysk, E. Lindberg, G. Järnerot, B. Flodérus-Myrhed, Gut 29, 990-996 (1988).
11. L. Jostins et al., Nature 491, 119-124 (2012).
12. M. Wlodarska, A. D. Kostic, R. J. Xavier, Cell Host Microbe 17, 577-591 (2015).
13. J. Hampe et al., Nat. Genet. 39, 207-211 (2007).
14. J. D. Rioux et al., Nat. Genet. 39, 596-604 (2007).
15. M. Parkes et al., Nat. Genet. 39, 830-832 (2007).
16. A. Gardet, R. J. Xavier, Curr. Opin. Immunol. 24, 522-529 (2012).
17. J. P. Hugot et al., Nature 411, 599-603 (2001).
18. Y. Ogura et al., Nature 411, 603-606 (2001).
19. K.S.Kobayashiet al., Science 307, 731-734 (2005).
20. L. H. Travassos et al., Nat. Immunol. 11, 55-62 (2010).
21. R. Cooney et al., Nat. Med. 16, 90-97 (2010).
22. A. Murthy et al., Nature 506, 456-462 (2014).
23. K. G. Lassen et al., Proc. Natl. Acad. Sci. U.S.A. 111, 7741-7746 (2014).
24. T. Saitoh et al., Nature 456, 264-268 (2008).
25. K. Cadwell et al., Cell 141, 1135-1145 (2010).
26. V. M. Hubbard-Lucey et al., Immunity 41, 579-591 (2014).
27. S. Park et al., Cell Host Microbe 19, 91-101 (2016).
28. Q. Lu et al., Cell Host Microbe 19, 102-113 (2016).
29. J. M. Kimmey et al., Nature 528, 565-569 (2015).
30. S. K. Mazmanian, J. L. Round, D. L. Kasper, Nature 453, 620-625 (2008).
31. J. L. Round, S. K. Mazmanian, Proc. Natl. Acad. Sci. U.S.A. 107, 12204-12209 (2010).
32. S. E. Allan et al., Immunol. Rev. 223, 391-421 (2008).
33. Y. Shen et al., Cell Host Microbe 12, 509-520 (2012).
34. J. Wei et al., Nat. Immunol. 17, 277-285 (2016).
35. A. M. Kabat et al., eLife 5, e12444 (2016).
36. J. Martinez et al., Nat. Cell Biol. 17, 893-906 (2015).
37. J. L. Round et al., Science 332, 974-977 (2011).
38. M. A. Sanjuan et al., Nature 450, 1253-1257 (2007).
39. Wellcome Trust Case Control Consortium, Nature 447, 661-678 (2007).
40. C. D. Packey, R. B. Sartor, Curr. Opin. Infect. Dis. 22, 292-301 (2009).
41. N. A. Molodecky et al., Gastroenterology 142, 46-54.e42, quiz e30 (2012).