Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

Nature

Volumn 534, Issue 7606, 2016, Pages 213-217

  Perry, Rachel J ^a   Peng, Liang ^a   Barry, Natasha A ^a   Cline, Gary W ^a   Zhang, Dongyan ^a   Cardone, Rebecca L ^a   Petersen, Kitt Falk ^a,b   Kibbey, Richard G ^a   Goodman, Andrew L ^a   Shulman, Gerald I ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; GENTAMICIN; GHRELIN; GLUCAGON LIKE PEPTIDE 1; VANCOMYCIN; ACETIC ACID DERIVATIVE; GLUCOSE; INSULIN;

BRAIN; CELLS AND CELL COMPONENTS; DISEASE TREATMENT; EXPERIMENTAL STUDY; HORMONE; METABOLISM; MICROBIAL COMMUNITY; NERVOUS SYSTEM; OBESITY; PHYSIOLOGICAL RESPONSE; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CHOLINERGIC SYSTEM; CONTROLLED STUDY; GASTRIN BLOOD LEVEL; GLUCAGON BLOOD LEVEL; GLUCOSE STIMULATED INSULIN SECRETION; HYPERPHAGIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTESTINE FLORA; LIPID DIET; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PARASYMPATHETIC TONE; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

RODENTIA;

ACETATES; ANIMALS; BRAIN; DIET, HIGH-FAT; GASTROINTESTINAL MICROBIOME; GHRELIN; GLUCOSE; HYPERPHAGIA; INSULIN; INSULIN-SECRETING CELLS; METABOLIC SYNDROME X; OBESITY; PARASYMPATHETIC NERVOUS SYSTEM; RATS;

EID: 84973667684     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18309     Document Type: Article

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