Substrate specificity of γ-secretase and other intramembrane proteases

Cellular and Molecular Life Sciences

Volumn 65, Issue 9, 2008, Pages 1311-1334

  Beel, A J ^a   Sanders, C R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; I CLiP; Intramembrane; Lipid raft; Presenilin; Protease; Proteolysis; Rhomboid; S2P; Secretase; Substrate

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; INTRAMEMBRANE PROTEINASE; PRESENILIN; PROTEINASE; SERINE PROTEINASE;

ALZHEIMER DISEASE; CONFORMATIONAL TRANSITION; GENETIC HETEROGENEITY; IN VIVO STUDY; LIPID RAFT; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SENSITIVITY AND SPECIFICITY;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; MEMBRANE MICRODOMAINS; METALLOPROTEASES; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

EID: 43049163813     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-7462-2     Document Type: Review

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