-
2
-
-
0033817591
-
Remarkable roles of proteolysis on and beyond the cell surface
-
Blobel C. P. (2000) Remarkable roles of proteolysis on and beyond the cell surface. Curr. Opin. Cell Biol. 12, 606-612.
-
(2000)
Curr. Opin. Cell Biol
, vol.12
, pp. 606-612
-
-
Blobel, C.P.1
-
3
-
-
3042848976
-
Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins
-
Brennan K., Gonzalez-Sancho J. M., Castelo-Soccio L. A., Howe L. R. and Brown A. M. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 23, 4873-4884.
-
(2004)
Oncogene
, vol.23
, pp. 4873-4884
-
-
Brennan, K.1
Gonzalez-Sancho, J.M.2
Castelo-Soccio, L.A.3
Howe, L.R.4
Brown, A.M.5
-
4
-
-
0033868818
-
A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
-
Brou C., Logeat F., Gupta N., Bessia C., LeBail O., Doedens J. R., Cumano A., Roux P., Black R. A. and Israel A. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 5, 207-216.
-
(2000)
Mol. Cell
, vol.5
, pp. 207-216
-
-
Brou, C.1
Logeat, F.2
Gupta, N.3
Bessia, C.4
LeBail, O.5
Doedens, J.R.6
Cumano, A.7
Roux, P.8
Black, R.A.9
Israel, A.10
-
5
-
-
0032581370
-
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family
-
Brown S. D., Twells R. C., Hey P. J., Cox R. D., Levy E. R., Soderman A. R., Metzker M. L., Caskey C. T., Todd J. A. and Hess J. F. (1998) Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem. Biophys. Res. Commun. 248, 879-888.
-
(1998)
Biochem. Biophys. Res. Commun
, vol.248
, pp. 879-888
-
-
Brown, S.D.1
Twells, R.C.2
Hey, P.J.3
Cox, R.D.4
Levy, E.R.5
Soderman, A.R.6
Metzker, M.L.7
Caskey, C.T.8
Todd, J.A.9
Hess, J.F.10
-
6
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown M. S., Ye J., Rawson R. B. and Goldstein J. L. (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100, 391-398.
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
7
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X. and Sudhof T. C. (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120.
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
8
-
-
34547136377
-
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein
-
Carey R. M., Balcz B. A., Lopez-Coviella I. and Slack B. E. (2005) Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 6, 30-39.
-
(2005)
BMC Cell Biol
, vol.6
, pp. 30-39
-
-
Carey, R.M.1
Balcz, B.A.2
Lopez-Coviella, I.3
Slack, B.E.4
-
9
-
-
28244440252
-
Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology
-
Caricasole A., Bakker A., Copani A., Nicoletti F., Gaviraghi G. and Terstappen G. C. (2005) Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology. Biosci. Rep. 25, 309-327.
-
(2005)
Biosci. Rep
, vol.25
, pp. 309-327
-
-
Caricasole, A.1
Bakker, A.2
Copani, A.3
Nicoletti, F.4
Gaviraghi, G.5
Terstappen, G.C.6
-
10
-
-
8444223093
-
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
-
Cong F., Schweizer L. and Varmus H. (2004) Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131, 5103-5115.
-
(2004)
Development
, vol.131
, pp. 5103-5115
-
-
Cong, F.1
Schweizer, L.2
Varmus, H.3
-
11
-
-
21444457762
-
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage
-
Cowan J. W., Wang X., Guan R., He K., Jiang J., Baumann G., Black R. A., Wolfe M. S. and Frank S. J. (2005) Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. J. Biol. Chem. 280, 19331-19342.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 19331-19342
-
-
Cowan, J.W.1
Wang, X.2
Guan, R.3
He, K.4
Jiang, J.5
Baumann, G.6
Black, R.A.7
Wolfe, M.S.8
Frank, S.J.9
-
12
-
-
33745886217
-
The canonical Wnt pathway in embryonic axis polarity
-
Croce J. C. and McClay D. R. (2006) The canonical Wnt pathway in embryonic axis polarity. Semin. Cell Dev. Biol.. 17, 168-174.
-
(2006)
Semin. Cell Dev. Biol
, vol.17
, pp. 168-174
-
-
Croce, J.C.1
McClay, D.R.2
-
13
-
-
0026332810
-
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
-
Cunningham B. C., Ultsch M., De Vos A. M., Mulkerrin M. G., Clauser K. R. and Wells J. A. (1991) Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254, 821-825.
-
(1991)
Science
, vol.254
, pp. 821-825
-
-
Cunningham, B.C.1
Ultsch, M.2
De Vos, A.M.3
Mulkerrin, M.G.4
Clauser, K.R.5
Wells, J.A.6
-
14
-
-
0034839287
-
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
-
Cupers P., Orlans I., Craessaerts K., Annaert W. and De Strooper B. (2001) The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J. Neurochem. 78, 1168-1178.
-
(2001)
J. Neurochem
, vol.78
, pp. 1168-1178
-
-
Cupers, P.1
Orlans, I.2
Craessaerts, K.3
Annaert, W.4
De Strooper, B.5
-
15
-
-
28644444440
-
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
-
Davidson G., Wu W., Shen J., Bilic J., Fenger U., Stannek P., Glinka A. and Niehrs C. (2005) Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867-872.
-
(2005)
Nature
, vol.438
, pp. 867-872
-
-
Davidson, G.1
Wu, W.2
Shen, J.3
Bilic, J.4
Fenger, U.5
Stannek, P.6
Glinka, A.7
Niehrs, C.8
-
16
-
-
0036122955
-
Transmodulation of cell surface regulatory molecules via ectodomain shedding
-
Dello Sbarba P. and Rovida E. (2002) Transmodulation of cell surface regulatory molecules via ectodomain shedding. Biol. Chem. 383, 69-83.
-
(2002)
Biol. Chem
, vol.383
, pp. 69-83
-
-
Dello Sbarba, P.1
Rovida, E.2
-
17
-
-
0032079871
-
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C
-
Dethlefsen S. M., Raab G., Moses M. A., Adam R. M., Klagsbrun M. and Freeman M. R. (1998) Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J. Cell Biochem. 69, 143-153.
-
(1998)
J. Cell Biochem
, vol.69
, pp. 143-153
-
-
Dethlefsen, S.M.1
Raab, G.2
Moses, M.A.3
Adam, R.M.4
Klagsbrun, M.5
Freeman, M.R.6
-
18
-
-
2442592973
-
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: Modulation of APLP-1 processing by n-glycosylation
-
Eggert S., Paliga K., Soba P., Evin G., Masters C. L., Weidemann A. and Beyreuther K. (2004) The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. J. Biol. Chem. 279, 18146-18156.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18146-18156
-
-
Eggert, S.1
Paliga, K.2
Soba, P.3
Evin, G.4
Masters, C.L.5
Weidemann, A.6
Beyreuther, K.7
-
19
-
-
0034662929
-
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
-
Farzan M., Schnitzler C. E., Vasilieva N., Leung D. and Choe H. (2000) BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl Acad. Sci. USA 97, 9712-9717.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 9712-9717
-
-
Farzan, M.1
Schnitzler, C.E.2
Vasilieva, N.3
Leung, D.4
Choe, H.5
-
20
-
-
0033798233
-
Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes
-
Figueroa D. J., Hess J. F., Ky B., Brown S. D., Sandig V., Hermanowski-Vosatka A., Twells R. C., Todd J. A. and Austin C. P. (2000) Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. J. Histochem. Cytochem. 48, 1357-1368.
-
(2000)
J. Histochem. Cytochem
, vol.48
, pp. 1357-1368
-
-
Figueroa, D.J.1
Hess, J.F.2
Ky, B.3
Brown, S.D.4
Sandig, V.5
Hermanowski-Vosatka, A.6
Twells, R.C.7
Todd, J.A.8
Austin, C.P.9
-
21
-
-
0037422571
-
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
-
Fujino T., Asaba H., Kang M. J. et al. (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc. Natl Acad. Sci. USA 100, 229-234.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 229-234
-
-
Fujino, T.1
Asaba, H.2
Kang, M.J.3
-
22
-
-
0037064135
-
Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs
-
Gomez-Gaviro M. V., Gonzalez-Alvaro I., Dominguez-Jimenez C., Peschon J., Black R. A., Sanchez-Madrid F. and Diaz-Gonzalez F. (2002) Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J. Biol. Chem. 277, 38212-38221.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 38212-38221
-
-
Gomez-Gaviro, M.V.1
Gonzalez-Alvaro, I.2
Dominguez-Jimenez, C.3
Peschon, J.4
Black, R.A.5
Sanchez-Madrid, F.6
Diaz-Gonzalez, F.7
-
23
-
-
18044386744
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
-
Gong Y., Slee R. B., Fukai N. et al. (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107, 513-523.
-
(2001)
Cell
, vol.107
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
-
24
-
-
0035090635
-
Phorbol ester- and growth factor-induced growth hormone (GH) receptor proteolysis and GH-binding protein shedding: Relationship to GH receptor down-regulation
-
Guan R., Zhang Y., Jiang J., Baumann C. A., Black R. A., Baumann G. and Frank S. J. (2001) Phorbol ester- and growth factor-induced growth hormone (GH) receptor proteolysis and GH-binding protein shedding: relationship to GH receptor down-regulation. Endocrinology 142, 1137-1147.
-
(2001)
Endocrinology
, vol.142
, pp. 1137-1147
-
-
Guan, R.1
Zhang, Y.2
Jiang, J.3
Baumann, C.A.4
Black, R.A.5
Baumann, G.6
Frank, S.J.7
-
25
-
-
0032541395
-
Cloning of a novel member of the low-density lipoprotein receptor family
-
Hey P. J., Twells R. C., Phillips M. S. et al. (1998) Cloning of a novel member of the low-density lipoprotein receptor family. Gene 216, 103-111.
-
(1998)
Gene
, vol.216
, pp. 103-111
-
-
Hey, P.J.1
Twells, R.C.2
Phillips, M.S.3
-
26
-
-
0742287878
-
Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma
-
Hoang B. H., Kubo T., Healey J. H., Sowers R., Mazza B., Yang R., Huvos A. G., Meyers P. A. and Gorlick R. (2004) Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. Int. J. Cancer 109, 106-111.
-
(2004)
Int. J. Cancer
, vol.109
, pp. 106-111
-
-
Hoang, B.H.1
Kubo, T.2
Healey, J.H.3
Sowers, R.4
Mazza, B.5
Yang, R.6
Huvos, A.G.7
Meyers, P.A.8
Gorlick, R.9
-
27
-
-
20444409468
-
Regulation of ApoE receptor proteolysis by ligand binding
-
Hoe H. S. and Rebeck G. W. (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res. Mol. Brain Res. 137, 31-39.
-
(2005)
Brain Res. Mol. Brain Res
, vol.137
, pp. 31-39
-
-
Hoe, H.S.1
Rebeck, G.W.2
-
28
-
-
27744480285
-
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE
-
Jarriault S. and Greenwald I. (2005) Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Dev. Biol. 287, 1-10.
-
(2005)
Dev. Biol
, vol.287
, pp. 1-10
-
-
Jarriault, S.1
Greenwald, I.2
-
29
-
-
0034703063
-
Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins
-
Kawano Y., Okamoto I., Murakami D., Itoh H., Yoshida M., Ueda S. and Saya H. (2000) Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins. J. Biol. Chem. 275, 29628-29635.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 29628-29635
-
-
Kawano, Y.1
Okamoto, I.2
Murakami, D.3
Itoh, H.4
Yoshida, M.5
Ueda, S.6
Saya, H.7
-
30
-
-
0036677928
-
Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: Association with Fe65 and translocation to the nucleus
-
Kinoshita A., Whelan C. M., Smith C. J., Berezovska O. and Hyman B. T. (2002) Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus. J. Neurochem. 82, 839-847.
-
(2002)
J. Neurochem
, vol.82
, pp. 839-847
-
-
Kinoshita, A.1
Whelan, C.M.2
Smith, C.J.3
Berezovska, O.4
Hyman, B.T.5
-
31
-
-
0142103374
-
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65
-
Kinoshita A., Shah T., Tangredi M. M., Strickland D. K. and Hyman B. T. (2003) The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278, 41182-41188.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41182-41188
-
-
Kinoshita, A.1
Shah, T.2
Tangredi, M.M.3
Strickland, D.K.4
Hyman, B.T.5
-
32
-
-
3142512452
-
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
-
Koo E. H. and Kopan R. (2004) Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat. Med. 10(Suppl), S26-33.
-
(2004)
Nat. Med
, vol.10
, Issue.SUPPL.
-
-
Koo, E.H.1
Kopan, R.2
-
33
-
-
0030003538
-
Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
-
Kopan R., Schroeter E. H., Weintraub H. and Nye J. S. (1996) Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl Acad. Sci. USA 93, 1683-1688.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1683-1688
-
-
Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
-
34
-
-
4344624361
-
Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling
-
Landman N. and Kim T. W. (2004) Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling Cytokine Growth Factor Rev. 15, 337-351.
-
(2004)
Cytokine Growth Factor Rev
, vol.15
, pp. 337-351
-
-
Landman, N.1
Kim, T.W.2
-
35
-
-
0141817915
-
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments
-
LaVoie M. J. and Selkoe D. J. (2003) The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J. Biol. Chem. 278, 34427-34437.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 34427-34437
-
-
LaVoie, M.J.1
Selkoe, D.J.2
-
36
-
-
29244474884
-
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
-
Li Y., Chen J., Lu W., McCormick L. M., Wang J. and Bu G. (2005) Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J. Cell Sci. 118, 5305-5314.
-
(2005)
J. Cell Sci
, vol.118
, pp. 5305-5314
-
-
Li, Y.1
Chen, J.2
Lu, W.3
McCormick, L.M.4
Wang, J.5
Bu, G.6
-
37
-
-
25844432119
-
Wnt signalling regulates adult hippocampal neurogenesis
-
Lie D. C., Colamarino S. A., Song H. J. et al. (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature 437, 1370-1375.
-
(2005)
Nature
, vol.437
, pp. 1370-1375
-
-
Lie, D.C.1
Colamarino, S.A.2
Song, H.J.3
-
38
-
-
0034855942
-
Nuclear localization of EGF receptor and its potential new role as a transcription factor
-
Lin S. Y., Makino K., Xia W., Matin A., Wen Y., Kwong K. Y., Bourguignon L. and Hung M. C. (2001) Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat. Cell Biol. 3, 802-808.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 802-808
-
-
Lin, S.Y.1
Makino, K.2
Xia, W.3
Matin, A.4
Wen, Y.5
Kwong, K.Y.6
Bourguignon, L.7
Hung, M.C.8
-
39
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
Logan C. Y. and Nusse R. (2004) The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781-810.
-
(2004)
Annu. Rev. Cell Dev. Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
40
-
-
0345602771
-
Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes
-
Lu D. C., Shaked G. M., Masliah E., Bredesen D. E. and Koo E. H. (2003) Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann. Neurol. 54, 781-789.
-
(2003)
Ann. Neurol
, vol.54
, pp. 781-789
-
-
Lu, D.C.1
Shaked, G.M.2
Masliah, E.3
Bredesen, D.E.4
Koo, E.H.5
-
41
-
-
0037413696
-
Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
-
Mao B. and Niehrs C. (2003) Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 302, 179-183.
-
(2003)
Gene
, vol.302
, pp. 179-183
-
-
Mao, B.1
Niehrs, C.2
-
42
-
-
0035902050
-
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
-
Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A. and Niehrs C. (2001a) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411, 321-325.
-
(2001)
Nature
, vol.411
, pp. 321-325
-
-
Mao, B.1
Wu, W.2
Li, Y.3
Hoppe, D.4
Stannek, P.5
Glinka, A.6
Niehrs, C.7
-
43
-
-
18244427021
-
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
-
Mao J., Wang J., Liu B. et al. (2001b) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7, 801-809.
-
(2001)
Mol. Cell
, vol.7
, pp. 801-809
-
-
Mao, J.1
Wang, J.2
Liu, B.3
-
44
-
-
0037030681
-
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
-
Mao B., Wu W., Davidson G. et al. (2002) Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417, 664-667.
-
(2002)
Nature
, vol.417
, pp. 664-667
-
-
Mao, B.1
Wu, W.2
Davidson, G.3
-
45
-
-
0037166319
-
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain
-
May P., Reddy Y. K. and Herz J. (2002) Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277, 18736-18743.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 18736-18743
-
-
May, P.1
Reddy, Y.K.2
Herz, J.3
-
46
-
-
0038771182
-
RIPped out by presenilin-dependent gamma-secretase
-
Medina M. and Dotti C. G. (2003) RIPped out by presenilin-dependent gamma-secretase. Cell Signal 15, 829-841.
-
(2003)
Cell Signal
, vol.15
, pp. 829-841
-
-
Medina, M.1
Dotti, C.G.2
-
47
-
-
26444510881
-
Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway
-
Mi K. and Johnson G. V. (2005) Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway. J. Cell Biochem. 95, 328-338.
-
(2005)
J. Cell Biochem
, vol.95
, pp. 328-338
-
-
Mi, K.1
Johnson, G.V.2
-
48
-
-
33646166827
-
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
-
Mi K., Dolan P. J. and Johnson G. V. (2006) The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. J. Biol. Chem. 281, 4787-4794.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 4787-4794
-
-
Mi, K.1
Dolan, P.J.2
Johnson, G.V.3
-
49
-
-
0033867521
-
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
-
Mumm J. S., Schroeter E. H., Saxena M. T., Griesemer A., Tian X., Pan D. J., Ray W. J. and Kopan R. (2000) A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol. Cell 5, 197-206.
-
(2000)
Mol. Cell
, vol.5
, pp. 197-206
-
-
Mumm, J.S.1
Schroeter, E.H.2
Saxena, M.T.3
Griesemer, A.4
Tian, X.5
Pan, D.J.6
Ray, W.J.7
Kopan, R.8
-
50
-
-
0035824391
-
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni C. Y., Murphy M. P., Golde T. E. and Carpenter G. (2001) gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294, 2179-2181.
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
51
-
-
33645518840
-
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
-
Petrelli A., Circosta P., Granziero L., Mazzone M., Pisacane A., Fenoglio S., Comoglio P. M. and Giordano S. (2006) Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc. Natl Acad. Sci. USA 103, 5090-5095.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 5090-5095
-
-
Petrelli, A.1
Circosta, P.2
Granziero, L.3
Mazzone, M.4
Pisacane, A.5
Fenoglio, S.6
Comoglio, P.M.7
Giordano, S.8
-
52
-
-
0034727078
-
An LDL-receptor-related protein mediates Wnt signalling in mice
-
Pinson K. I., Brennan J., Monkley S., Avery B. J. and Skarnes W. C. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407, 535-538.
-
(2000)
Nature
, vol.407
, pp. 535-538
-
-
Pinson, K.I.1
Brennan, J.2
Monkley, S.3
Avery, B.J.4
Skarnes, W.C.5
-
54
-
-
0030863621
-
Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma
-
Quinn K. A., Grimsley P. G., Dai Y. P., Tapner M., Chesterman C. N. and Owensby D. A. (1997) Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma. J. Biol. Chem. 272, 23946-23951.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 23946-23951
-
-
Quinn, K.A.1
Grimsley, P.G.2
Dai, Y.P.3
Tapner, M.4
Chesterman, C.N.5
Owensby, D.A.6
-
55
-
-
0038732581
-
Regulated intramembrane proteolysis: From the endoplasmic reticulum to the nucleus
-
Rawson R. B. (2002) Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus. Essays Biochem. 38, 155-168.
-
(2002)
Essays Biochem
, vol.38
, pp. 155-168
-
-
Rawson, R.B.1
-
56
-
-
0242704649
-
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors
-
Schweizer L. and Varmus H. (2003) Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol. 4, 4-14.
-
(2003)
BMC Cell Biol
, vol.4
, pp. 4-14
-
-
Schweizer, L.1
Varmus, H.2
-
57
-
-
0035895927
-
Cleavage and shedding of E-cadherin after induction of apoptosis
-
Steinhusen U., Weiske J., Badock V., Tauber R., Bommert K. and Huber O. (2001) Cleavage and shedding of E-cadherin after induction of apoptosis. J. Biol. Chem. 276, 4972-4980.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 4972-4980
-
-
Steinhusen, U.1
Weiske, J.2
Badock, V.3
Tauber, R.4
Bommert, K.5
Huber, O.6
-
58
-
-
0032524325
-
Nuclear access and action of notch in vivo
-
Struhl G. and Adachi A. (1998) Nuclear access and action of notch in vivo. Cell 93, 649-660.
-
(1998)
Cell
, vol.93
, pp. 649-660
-
-
Struhl, G.1
Adachi, A.2
-
59
-
-
0030967612
-
Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation
-
Subramanian S. V., Fitzgerald M. L. and Bernfield M. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J. Biol. Chem. 272, 14713-14720.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 14713-14720
-
-
Subramanian, S.V.1
Fitzgerald, M.L.2
Bernfield, M.3
-
60
-
-
0034727104
-
LDL-receptor-related proteins in Wnt signal transduction
-
Tamai K., Semenov M., Kato Y., Spokony R., Liu C., Katsuyama Y., Hess F., Saint-Jeannet J. P. and He X. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530-535.
-
(2000)
Nature
, vol.407
, pp. 530-535
-
-
Tamai, K.1
Semenov, M.2
Kato, Y.3
Spokony, R.4
Liu, C.5
Katsuyama, Y.6
Hess, F.7
Saint-Jeannet, J.P.8
He, X.9
-
61
-
-
1642564513
-
A mechanism for Wnt coreceptor activation
-
Tamai K., Zeng X., Liu C., Zhang X., Harada Y., Chang Z. and He X. (2004) A mechanism for Wnt coreceptor activation. Mol. Cell 13, 149-156.
-
(2004)
Mol. Cell
, vol.13
, pp. 149-156
-
-
Tamai, K.1
Zeng, X.2
Liu, C.3
Zhang, X.4
Harada, Y.5
Chang, Z.6
He, X.7
-
63
-
-
0032744527
-
Tau is modified by tissue transglutaminase in situ: Possible functional and metabolic effects of polyamination
-
Tucholski J., Kuret J. and Johnson G. V. (1999) Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination. J. Neurochem. 73, 1871-1880.
-
(1999)
J. Neurochem
, vol.73
, pp. 1871-1880
-
-
Tucholski, J.1
Kuret, J.2
Johnson, G.V.3
-
64
-
-
3242781066
-
Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density
-
Urano T., Shiraki M., Ezura Y. et al. (2004) Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density. J. Bone Miner. Metab. 22, 341-345.
-
(2004)
J. Bone Miner. Metab
, vol.22
, pp. 341-345
-
-
Urano, T.1
Shiraki, M.2
Ezura, Y.3
-
65
-
-
0036777494
-
Intramembrane proteolysis controls diverse signalling pathways throughout evolution
-
Urban S. and Freeman M. (2002) Intramembrane proteolysis controls diverse signalling pathways throughout evolution. Curr. Opin. Genet. Dev. 12, 512-518.
-
(2002)
Curr. Opin. Genet. Dev
, vol.12
, pp. 512-518
-
-
Urban, S.1
Freeman, M.2
-
66
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B. D., Babu-Khan S. et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
-
67
-
-
0035399638
-
Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene
-
Wang Y., Huso D., Cahill H., Ryugo D. and Nathans J. (2001) Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J. Neurosci. 21, 4761-4771.
-
(2001)
J. Neurosci
, vol.21
, pp. 4761-4771
-
-
Wang, Y.1
Huso, D.2
Cahill, H.3
Ryugo, D.4
Nathans, J.5
-
68
-
-
0034727099
-
arrow encodes an LDL-receptor-related protein essential for Wingless signalling
-
Wehrli M., Dougan S. T., Caldwell K., O'Keefe L., Schwartz S., Vaizel-Ohayon D., Schejter E., Tomlinson A. and DiNardo S. (2000) arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407, 527-530.
-
(2000)
Nature
, vol.407
, pp. 527-530
-
-
Wehrli, M.1
Dougan, S.T.2
Caldwell, K.3
O'Keefe, L.4
Schwartz, S.5
Vaizel-Ohayon, D.6
Schejter, E.7
Tomlinson, A.8
DiNardo, S.9
-
69
-
-
0037176727
-
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
-
Weidemann A., Eggert S., Reinhard F. B., Vogel M., Paliga K., Baier G., Masters C. L., Beyreuther K. and Evin G. (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 41, 2825-2835.
-
(2002)
Biochemistry
, vol.41
, pp. 2825-2835
-
-
Weidemann, A.1
Eggert, S.2
Reinhard, F.B.3
Vogel, M.4
Paliga, K.5
Baier, G.6
Masters, C.L.7
Beyreuther, K.8
Evin, G.9
-
70
-
-
0032493859
-
Switching signals on or off by receptor dimerization
-
Weiss A. and Schlessinger J. (1998) Switching signals on or off by receptor dimerization. Cell 94, 277-280.
-
(1998)
Cell
, vol.94
, pp. 277-280
-
-
Weiss, A.1
Schlessinger, J.2
-
71
-
-
33645456502
-
DAPT-induced intracellular accumulations of longer amyloid beta-proteins: Further implications for the mechanism of intramembrane cleavage by gamma-secretase
-
Yagishita S., Morishima-Kawashima M., Tanimura Y., Ishiura S. and Ihara Y. (2006) DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry 45, 3952-3960.
-
(2006)
Biochemistry
, vol.45
, pp. 3952-3960
-
-
Yagishita, S.1
Morishima-Kawashima, M.2
Tanimura, Y.3
Ishiura, S.4
Ihara, Y.5
-
72
-
-
0035823610
-
BACE2 functions as an alternative alpha-secretase in cells
-
Yan R., Munzner J. B., Shuck M. E. and Bienkowski M. J. (2001) BACE2 functions as an alternative alpha-secretase in cells. J. Biol. Chem. 276, 34019-34027.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 34019-34027
-
-
Yan, R.1
Munzner, J.B.2
Shuck, M.E.3
Bienkowski, M.J.4
-
73
-
-
28644439005
-
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
-
Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J. and He X. (2005) A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438, 873-877.
-
(2005)
Nature
, vol.438
, pp. 873-877
-
-
Zeng, X.1
Tamai, K.2
Doble, B.3
Li, S.4
Huang, H.5
Habas, R.6
Okamura, H.7
Woodgett, J.8
He, X.9
-
74
-
-
10944259134
-
Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein
-
Zhao G., Mao G., Tan J., Dong Y., Cui M. Z., Kim S. H. and Xu X. (2004) Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J. Biol. Chem. 279, 50647-50650.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 50647-50650
-
-
Zhao, G.1
Mao, G.2
Tan, J.3
Dong, Y.4
Cui, M.Z.5
Kim, S.H.6
Xu, X.7
-
75
-
-
0034602333
-
Heregulin-dependent trafficking and cleavage of ErbB-4
-
Zhou W. and Carpenter G. (2000) Heregulin-dependent trafficking and cleavage of ErbB-4. J. Biol. Chem. 275, 34737-34743.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 34737-34743
-
-
Zhou, W.1
Carpenter, G.2
-
76
-
-
4444340344
-
Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants
-
Zhou C. J., Pinson K. I. and Pleasure S. J. (2004a) Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants. J. Neurosci. 24, 7632-7639.
-
(2004)
J. Neurosci
, vol.24
, pp. 7632-7639
-
-
Zhou, C.J.1
Pinson, K.I.2
Pleasure, S.J.3
-
77
-
-
0842322748
-
Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities
-
Zhou C. J., Zhao C. and Pleasure S. J. (2004b) Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J. Neurosci. 24, 121-126.
-
(2004)
J. Neurosci
, vol.24
, pp. 121-126
-
-
Zhou, C.J.1
Zhao, C.2
Pleasure, S.J.3
-
78
-
-
33750391166
-
Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway
-
Zhou C. J., Borello U., Rubenstein J. L. and Pleasure S. J. (2006) Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience 142, 1119-1131.
-
(2006)
Neuroscience
, vol.142
, pp. 1119-1131
-
-
Zhou, C.J.1
Borello, U.2
Rubenstein, J.L.3
Pleasure, S.J.4
-
79
-
-
4544339737
-
Linking receptor-mediated endocytosis and cell signaling: Evidence for regulated intramembrane proteolysis of megalin in proximal tubule
-
Zou Z., Chung B., Nguyen T., Mentone S., Thomson B. and Biemesderfer D. (2004) Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule. J. Biol. Chem. 279, 34302-34310.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 34302-34310
-
-
Zou, Z.1
Chung, B.2
Nguyen, T.3
Mentone, S.4
Thomson, B.5
Biemesderfer, D.6
|