Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors

Journal of Biological Chemistry

Volumn 278, Issue 19, 2003, Pages 16528-16533

  Weihofen, Andreas ^c   Lemberg, Marius K ^c   Friedmann, Elena ^a   Rueeger, Heinrich ^b   Schmitz, Albert ^b   Paganetti, Paolo ^b   Rovelli, Giorgio ^b   Martoglio, Bruno ^a  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CELL MEMBRANES; DISEASE CONTROL;

PATHOGENS; PROTEOLYSIS;

BIOCHEMICAL ENGINEERING;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; KETONE DERIVATIVE; L 658485; L 852646; LY 411575; N [N (3,5 DIFLUOROPHENACETYL)ALANYL]PHENYLGLYCINE TERT BUTYL ESTER; NVP AHW700 NX; PRESENILIN 1; PRESENILIN 2; SIGNAL PEPTIDASE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; WO 9822494; WO 9828268; BACE1 PROTEIN, HUMAN; ENZYME INHIBITOR; PROTEINASE; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NEUROLOGIC DISEASE; PRIORITY JOURNAL; SENILE PLAQUE; TISSUE CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY;

ANIMALIA; HEPATITIS C VIRUS;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; SUBSTRATE SPECIFICITY;

EID: 0037930851     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301372200     Document Type: Article

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