Presenilin-1, nicastrin, amyloid precursor protein, and γ-secretase activity are co-localized in the lysosomal membrane

Journal of Biological Chemistry

Volumn 278, Issue 29, 2003, Pages 26687-26694

  Pasternak, Stephen H ^a,c   Bagshaw, Richard D ^a,c   Guiral, Marianne ^a   Zhang, Sunqu ^a   Ackerleyll, Cameron A ^b   Pak, Brian J ^e   Callahan, John W ^a,d   Mahuran, Don J ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e CIPHERGEN BIOSYSTEMS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ELECTRON MICROSCOPY; PROTEINS;

PATHOPHYSIOLOGY;

BIOCHEMISTRY;

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN 1; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME LOCALIZATION; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOPRECIPITATION; IN VITRO STUDY; LYSOSOME MEMBRANE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL FRACTIONATION; ENDOPEPTIDASES; ENDOSOMES; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICROSCOPY, IMMUNOELECTRON; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; POLYETHYLENE GLYCOLS; PRESENILIN-1; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0037698096     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304009200     Document Type: Article

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