Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

Current Biology

Volumn 11, Issue 16, 2001, Pages 1288-1293

  Riddell, David R ^a   Christie, Gary ^a   Hussain, Ishrut ^a   Dingwall, Colin ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035928732     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00394-3     Document Type: Article

References (32)

1. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
2. Statins and the risk of dementia
3. Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels
4. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
5. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
6. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
7. The role of cholesterol in the biosynthesis of beta-amyloid
8. The use of seldi proteinchip arrays to monitor production of Alzheimer's beta-amyloid in transfected cells
9. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
10. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
11. Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations
12. The role of proteolysis in Alzheimer's disease
13. In search of an enzyme: The beta-secretase of Alzheimer's disease is an aspartic proteinase
14. Proteolytic processing and cell biological functions of the amyloid precursor protein
15. How cells handle cholesterol
16. Functional rafts in cell membranes
17. Structure and function of sphingolipid-and cholesterol-rich membrane rafts
18. Lipid rafts and signal transduction
19. A detergent-insoluble membrane compartment contains A beta in vivo
20. The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells
21. Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins
22. Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells
23. Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane
24. Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains
25. Identification of a novel aspartic protease (Asp 2) as beta-secretase
26. Caveolin-1 associates with TRAF2 to form a complex that is recruited to TNF receptors
27. Maturation and pro-peptide cleavage of beta-secretase
28. ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
29. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein
30. Cholesterol is required for surface transport of influenza virus hemagglutinin
31. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease
32. Peptidyl boronic acids inhibit the degradation of presenilin-1 in presenilin-1 transfected cells