Mechanisms of disease: New therapeutic strategies for Alzheimer's disease - Targeting APP processing in lipid rafts

Nature Clinical Practice Neurology

Volumn 3, Issue 7, 2007, Pages 374-382

  Cheng, Haipeng ^a   Vetrivel, Kulandaivelu S ^a   Gong, Ping ^a   Meckler, Xavier ^a   Parent, Angèle ^a   Thinakaran, Gopal ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; CHOLESTEROL; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHYL BETA CYCLODEXTRIN; MEVINOLIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CELLULAR DISTRIBUTION; CHOLESTEROL SYNTHESIS; DRUG PENETRATION; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; LIPID RAFT; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; SENILE DEMENTIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; HUMANS; MEMBRANE MICRODOMAINS; PROTEIN TRANSPORT;

EID: 34447273123     PISSN: 1745834X     EISSN: 17458358     Source Type: Journal    
DOI: 10.1038/ncpneuro0549     Document Type: Review

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