Protein sensors for membrane sterols

Cell

Volumn 124, Issue 1, 2006, Pages 35-46

  Goldstein, Joseph L ^a   DeBose Boyd, Russell A ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACETYL COENZYME A SYNTHETASE; CHOLESTEROL; FARNESYL DIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LANOSTEROL; LIPID BINDING PROTEIN; MEMBRANE PROTEIN; MEVALONATE KINASE; MEVALONIC ACID; OXYSTEROL; PHOSPHOMEVALONATE KINASE; PROTEIN INSIG 1; PROTEIN INSIG 2; PROTEIN SCAP; SQUALENE; SQUALENE MONOOXYGENASE; SQUALENE SYNTHASE; STEROL 14ALPHA DEMETHYLASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

BIOSENSOR; CELL MEMBRANE; FEEDBACK SYSTEM; GENETIC TRANSCRIPTION; LIPID TRANSPORT; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; REGULATORY MECHANISM; REVIEW; STEROL SYNTHESIS; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 30344473341     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.12.022     Document Type: Review

References (74)

1. C.M. Adams, J.L. Goldstein, and M.S. Brown Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles Proc. Natl. Acad. Sci. USA 100 2003 10647 10652
2. C.M. Adams, J. Reitz, J.K. DeBrabander, J.D. Feramisco, M.S. Brown, and J.L. Goldstein Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and insigs J. Biol. Chem. 279 2004 52772 52780
3. B. Antonny, and R. Schekman ER export: public transportation by the COPII coach Curr. Opin. Cell Biol. 13 2001 438 443
4. M. Aridor, J. Weissman, S.I. Bannykh, C. Nuoffer, and W.E. Balch Cargo selection by the COPII budding machinery during export from the ER J. Cell Biol. 141 1998 61 70
5. C. Barlowe COPII-dependent transport from the endoplasmic reticulum Curr. Opin. Cell Biol. 14 2002 417 422
6. M.S. Brown, and J.L. Goldstein The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331 340
7. M.S. Brown, and J.L. Goldstein A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc. Natl. Acad. Sci. USA 96 1999 11041 11048
8. M.S. Brown, S.E. Dana, and J.L. Goldstein Cholesteryl ester formation in cultured human fibroblasts: Stimulation by oxygenated sterols J. Biol. Chem. 250 1975 4025 4027
9. A.J. Brown, L. Sun, J.D. Feramisco, M.S. Brown, and J.L. Goldstein Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism Mol. Cell 10 2002 237 245
10. G. Chen, G. Liang, J. Ou, J.L. Goldstein, and M.S. Brown Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver Proc. Natl. Acad. Sci. USA 101 2004 11245 11250
11. P.A. Dawson, N.D. Ridgway, C.A. Slaughter, M.S. Brown, and J.L. Goldstein cDNA cloning and expression of oxysterol binding protein, an oligomer with a potential leucine zipper J. Biol. Chem. 264 1989 16798 16803
12. L.J. Engelking, H. Kuriyama, R.E. Hammer, J.D. Horton, M.S. Brown, J.L. Goldstein, and G. Liang Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis J. Clin. Invest. 113 2004 1168 1175
13. L.J. Engelking, G. Liang, R.E. Hammer, K. Takaishi, H. Kuriyama, B.M. Evers, W.-P. Li, J.D. Horton, J.L. Goldstein, and M.S. Brown Schoenheimer Effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins J. Clin. Invest. 115 2005 2489 2498
14. P.J. Espenshade, D. Cheng, J.L. Goldstein, and M.S. Brown Autocatalytic processing of Site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins J. Biol. Chem. 274 1999 22795 22804
15. P.J. Espenshade, W.-P. Li, and D. Yabe Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER Proc. Natl. Acad. Sci. USA 99 2002 11694 11699
16. S. Fang, M. Ferrone, C. Yang, J.P. Jensen, S. Tiwari, and A.M. Weissman The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum Proc. Natl. Acad. Sci. USA 98 2001 14422 14427
17. J.D. Feramisco, J.L. Goldstein, and M.S. Brown Membrane topology of human insig-1, a protein regulator of lipid synthesis J. Biol. Chem. 279 2004 8487 8496
18. F. Foufelle, and P. Ferre New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c Biochem. J. 366 2002 377 391
19. G. Gil, J.R. Faust, D.J. Chin, J.L. Goldstein, and M.S. Brown Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme Cell 41 1985 249 258
20. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
21. J.L. Goldstein, R.B. Rawson, and M.S. Brown Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis Arch. Biochem. Biophys. 397 2002 139 148
22. Y. Gong, J.N. Lee, P.C.W. Lee, J.L. Goldstein, M.S. Brown, and J. Ye Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake Cell Metab. 3 2006 15 24
23. B.D. Hegarty, A. Bobard, I. Hainault, P. Ferre, P. Bossard, and F. Foufelle Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c Proc. Natl. Acad. Sci. USA 102 2005 791 796
24. J.D. Horton, Y. Bashmakov, I. Shimomura, and H. Shimano Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice Proc. Natl. Acad. Sci. USA 95 1998 5987 5992
25. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
26. J.D. Horton, N.A. Shah, J.A. Warrington, N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein Combined analysis of olignucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes Proc. Natl. Acad. Sci. USA 100 2003 12027 12032
27. X. Hua, A. Nohturfft, J.L. Goldstein, and M.S. Brown Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein (SCAP) Cell 87 1996 415 426
28. X. Hua, J. Sakai, M.S. Brown, and J.L. Goldstein Regulated cleavage of sterol regulatory element binding proteins (SREBPs) requires sequences on both sides of the endoplasmic reticulum membrane J. Biol. Chem. 271 1996 10379 10384
29. E.S. Istvan, M. Palnitkar, S.K. Buchanan, and J. Deisenhofer Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis EMBO J. 19 2000 819 830
30. B.A. Janowski The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP Proc. Natl. Acad. Sci. USA 99 2002 12675 12680
31. J.B. Kim, P. Sarraf, M. Wright, K.M. Yao, E. Mueller, G. Solanes, B.B. Lowell, and B.M. Spiegelman Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J. Clin. Invest. 101 1998 1 9
32. Y. Lange, and T.L. Steck Quantitatnion of the pool of cholesterol associated with acyl-CoA: Cholesterol acyltransferase in human fibroblasts J. Biol. Chem. 272 1997 13103 13108
33. J.N. Lee, and J. Ye Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1 J. Biol. Chem. 279 2004 45257 45265
34. P.C.W. Lee, N. Sever, and R.A. DeBose-Boyd Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2 J. Biol. Chem. 280 2005 25242 25249
35. L. Liscum, J. Finer-Moore, R.M. Stroud, K.L. Luskey, M.S. Brown, and J.L. Goldstein Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum J. Biol. Chem. 260 1985 522 530
36. Luong, A. (2000). Identification of three novel SREBP-activated target genes: acetyl CoA synthetase, 3-β-hydroxysterol dehydrogenase, and CL-6/INSIG1. Ph.D. dissertation. (Dallas: University of Texas Southwestern Medical Center at Dallas), pp. 1-137.
37. J.D. McGarry Glucose-fatty acid interactions in health and disease Am. J. Clin. Nutr. 67 Suppl. 1998 500S 504S
38. B. Meusser, C. Hirsch, E. Jarosch, and T. Sommer ERAD: the long road to destruction Nat. Cell Biol. 7 2005 766 772
39. K.L. Mohn, T.M. Laz, J.-C. Hsu, A.E. Melby, R. Bravo, and R. Taub The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes Mol. Cell. Biol. 11 1991 381 390
40. A. Nohturfft, M.S. Brown, and J.L. Goldstein Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N Proc. Natl. Acad. Sci. USA 95 1998 12848 12853
41. A. Nohturfft, M.S. Brown, and J.L. Goldstein Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain J. Biol. Chem. 273 1998 17243 17250
42. A. Nohturfft, D. Yabe, J.L. Goldstein, M.S. Brown, and P.J. Espenshade Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes Cell 102 2000 315 323
43. V.M. Olkkonen Oxysterol binding protein and its homologues: new regulatory factors involved in lipid metabolism Curr. Opin. Lipidol. 15 2004 321 327
44. Y. Peng, E.J. Schwarz, M.A. Lazar, A. Genin, N.B. Spinner, and R. Taub Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene Genomics 43 1997 278 284
45. C.P. Ponting Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction Biochem. J. 351 2000 527 535
46. A. Radhakrishnan, L.-P. Sun, H.J. Kwon, M.S. Brown, and J.L. Goldstein Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain Mol. Cell 15 2004 259 268
47. T. Ravid, R. Doolman, R. Avner, D. Harats, and J. Roitelman The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase J. Biol. Chem. 275 2000 35840 35847
48. J.J. Repa, and D.J. Mangelsdorf The role of orphan nuclear receptors in the regulation of cholesterol homeostasis Annu. Rev. Cell Dev. Biol. 16 2000 459 481
49. J.J. Repa, G. Liang, J. Ou, Y. Bashmakov, J.-M.A. Lobaccaro, I. Shimomura, B. Shan, M.S. Brown, J.L. Goldstein, and D.J. Mangelsdorf Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Genes Dev. 14 2000 2819 2830
50. N.D. Ridgway, P.A. Dawson, Y.K. Ho, M.S. Brown, and J.L. Goldstein Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding J. Cell Biol. 116 1992 307 319
51. J. Roitelman, E.H. Olender, S. Bar-Nun, W.A. Dunn Jr., and R.D. Simoni Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl Coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum J. Cell Biol. 117 1992 959 973
52. D.W. Russell Oxysterol biosynthetic enzymes Biochim. Biophys. Acta 1529 2000 126 135
53. J. Sakai, A. Nohturfft, D. Cheng, Y.K. Ho, M.S. Brown, and J.L. Goldstein Identification of complexes between the COOH-terminal domains of sterol regulatory element binding proteins (SREBPs) and SREBP cleavage-activating protein (SCAP) J. Biol. Chem. 272 1997 20213 20221
54. M.C. Seabra, E.H. Mules, and A.N. Hume Rab GTPases, intracellular traffic and disease Trends Mol. Med. 8 2002 23 30
55. N. Sever, B.-L. Song, D. Yabe, J.L. Goldstein, M.S. Brown, and R.A. DeBose-Boyd Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol J. Biol. Chem. 278 2003 52479 52490
56. N. Sever, T. Yang, M.S. Brown, J.L. Goldstein, and R.A. DeBose-Boyd Accelerated degradation of HMG CoA reductase mediated by binding of Insig-1 to its sterol-sensing domain Mol. Cell 11 2003 25 33
57. N. Sever, P.C.W. Lee, B.-L. Song, R.B. Rawson, and R.A. DeBose-Boyd Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J. Biol. Chem. 279 2004 43136 43147
58. A.G. Shearer, and R.Y. Hampton Lipid-mediated, reversible misfolding of a sterol-sensing domain protein EMBO J. 24 2005 149 159
59. K. Shimizu, M. Tani, H. Watanabe, Y. Nagamachi, Y. Niinaka, T. Shiroishi, S. Ohwada, A. Raz, and J. Yokota The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein FEBS Lett. 456 1999 295 300
60. I. Shimomura, Y. Bashmakov, S. Ikemoto, J.D. Horton, M.S. Brown, and J.L. Goldstein Insulin selectively increases SREBP-1c mRNA in livers of rats with streptozotocin-induced diabetes Proc. Natl. Acad. Sci. USA 96 1999 13656 13661
61. I. Shimomura, M. Matsuda, R.E. Hammer, Y. Bashmakov, M.S. Brown, and J.L. Goldstein Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Mol. Cell 6 2000 77 86
62. D.G. Skalnik, H. Narita, C. Kent, and R.D. Simoni The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto β-galactosidase J. Biol. Chem. 263 1988 6836 6841
63. B.-L. Song, N.B. Javitt, and R.A. DeBose-Boyd Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Cell Metab. 1 2005 179 189
64. B.-L. Song, N. Sever, and R.A. DeBose-Boyd Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase Mol. Cell 19 2005 829 840
65. L.-P. Sun, L. Li, J.L. Goldstein, and M.S. Brown Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro J. Biol. Chem. 280 2005 26483 26490
66. F. Xu, S.D. Rychnovsky, J.D. Belani, H.H. Hobbs, J.C. Cohen, and R.B. Rawson Dual roles for cholesterol in mammalian cells Proc. Natl. Acad. Sci. USA 102 2005 14551 14556
67. D. Yabe, M.S. Brown, and J.L. Goldstein Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Proc. Natl. Acad. Sci. USA 99 2002 12753 12758
68. D. Yabe, Z.-P. Xia, C.M. Adams, and R.B. Rawson Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols Proc. Natl. Acad. Sci. USA 99 2002 16672 16677
69. D. Yabe, R. Komuro, G. Liang, J.L. Goldstein, and M.S. Brown Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis Proc. Natl. Acad. Sci. USA 100 2003 3155 3160
70. T. Yang, J.L. Goldstein, and M.S. Brown Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP/SREBP exit from endoplasmic reticulum J. Biol. Chem. 275 2000 29881 29886
71. T. Yang, P.J. Espenshade, M.E. Wright, D. Yabe, Y. Gong, R. Aebersold, J.L. Goldstein, and M.S. Brown Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER Cell 110 2002 489 500
72. Y. Ye, Y. Shibata, M. Kikkert, S. van Voorden, E. Wiertz, and T.A. Rapoport Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane Proc. Natl. Acad. Sci. USA 102 2005 14132 14138
73. N.G. Zelenski, R.B. Rawson, M.S. Brown, and J.L. Goldstein Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins J. Biol. Chem. 274 1999 21973 21980
74. X. Zhong, Y. Shen, P. Ballar, A. Apostolou, R. Agami, and S. Fang AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation J. Biol. Chem. 279 2004 45676 45684