Mechanism of the cleavage specificity of Alzheimer's disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 6, 1999, Pages 3053-3058

  Lichtenthaler, Stefan F ^a   Wang, Rong ^b   Grimm, Heike ^a   Uljon, Sacha N ^b   Masters, Colin L ^c   Beyreuther, Konrad ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MONOCLONAL ANTIBODY; PHENYLALANINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; CELL CULTURE; CELL STRAIN COS1; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; COS CELLS; ENDOPEPTIDASES; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; SUBSTRATE SPECIFICITY;

EID: 0032981558     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.6.3053     Document Type: Article

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