Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 10, 2000, Pages 5123-5128

  Ye, Jin ^a   Davé, Utpal P ^a   Grishin, Nick V ^a   Goldstein, Joseph L ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol metabolism; Membrane proteins; Proteolysis

Indexed keywords

ASPARAGINE; CHOLESTEROL; MEMBRANE PROTEIN; PROLINE; PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ARTICLE; CATALYSIS; CHO CELL; CHOLESTEROL METABOLISM; ENZYME ACTIVITY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CELL MEMBRANE; CONSERVED SEQUENCE; CRICETINAE; DIPEPTIDES; DNA-BINDING PROTEINS; ENDOPEPTIDASES; HELIX-LOOP-HELIX MOTIFS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0034625081     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.10.5123     Document Type: Article

References (34)

1. Brown, M. S., Ye, J., Rawson, R. B. & Goldstein, J. L. (2000) Cell 100, 391-398.
2. Brown, M. S. & Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. USA 96, 11041-11048.
3. Hua, X., Nohturfft, A., Goldstein, J. L. & Brown, M. S. (1996) Cell 87, 415-426.
4. Sakai, J., Rawson, R. B., Espenshade, P. J., Cheng, D., Seegmiller, A. C., Goldstein, J. L. & Brown, M. S. (1998) Mol. Cell 2, 505-514.
5. Duncan, E. A., Davé, U. P., Sakai, J., Goldstein, J. L. & Brown, M. S. (1998) J. Biol. Chem. 273, 17801-17809.
6. Brown, M. S. & Goldstein, J. L. (1997) Cell 89, 331-340.
7. Horton, J. D. & Shimomura, I. (1999) Curr. Opin. Lipidol. 10, 143-150.
8. Nohturfft, A., Brown, M. S. & Goldstein, J. L. (1998) Proc. Natl. Acad. Sci. USA 95, 12848-12853.
9. DeBose-Boyd, R. A., Brown, M. S., Li, W.-P., Nohturfft, A., Goldstein, J. L. & Espenshade, P. J. (1999) Cell 99, 703-712.
10. Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T.-Y., Brown, M. S. & Goldstein, J. L. (1997) Mol. Cell 1, 47-57.
11. Rawlings, N. D. & Barrett, A. J. (1995) Methods Enzymol. 248, 183-228.
12. Zelenski, N. G., Rawson, R. B., Brown, M. S. & Goldstein, J. L. (1999) J. Biol. Chem. 274, 21973-21980.
13. Lewis, A. P. & Thomas, P. J. (1999) Protein Sci. 8, 439-442.
14. Rudner, D. Z., Fawcett, P. & Losick, R. (1999) Proc. Natl. Acad. Sci. USA 96, 14765-14770.
15. An, F. Y., Sulavik, M. C. & Clewell, D. B. (1999) J. Bacteriol. 181, 5915-5921.
16. Firth, N., Fink, P. D., Johnson, L. & Skurray, R. A. (1994) J. Bacteriol. 176, 5871-5873.
17. Paetzel, M., Dalbey, R. E. & Strynadka, N. C. J. (1998) Nature (London) 396, 186-190.
18. Hasan, M. T. & Chang, T. Y. (1994) Somatic Cell Mol. Genet. 20, 481-491.
19. Sakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S. & Goldstein, J. L. (1996) Cell 85, 1037-1046.
20. Akusjärvi, G., Svensson, C. & Nygard, O. (1987) Mol. Cell Biol. 7, 549-551.
21. Linstedt, A. D., Mehta, A., Suhan, J., Reggio, H. & Hauri, H.-P. (1997) Mol. Biol. Cell 8, 1073-1087.
22. Rawson, R. B., DeBose-Boyd, R., Goldstein, J. L. & Brown, M. S. (1999) J. Biol. Chem. 274, 28549-28556.
23. Mocchetti, I., Einstein, R. & Brosius, J. (1986) Proc. Natl. Acad. Sci. USA 83, 7221-7225.
24. Rawson, R. B., Cheng, D., Brown, M. S. & Goldstein, J. L. (1998) J. Biol. Chem. 273, 28261-28269.
25. Richardson, J. S. & Richardson, D. C. (1988) Science 240, 1648-1652.
26. Sakai, J., Nohturfft, A., Cheng, D., Ho, Y. K., Brown, M. S. & Goldstein, J. L. (1997) J. Biol. Chem. 272, 20213-20221.
27. von Heijne, G. (1998) Nature (London) 396, 111-113.
28. Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L. & Brown, M. S. (1993) Cell 75, 187-197.
29. Hua, X., Yokoyama, C., Wu, J., Briggs, M. R., Brown, M. S., Goldstein, J. L. & Wang, X. (1993) Proc. Natl. Acad. Sci. USA 90, 11603-11607.
30. Sato, R., Yang, J., Wang, X., Evans, M. J., Ho, Y. K., Goldstein, J. L. & Brown, M. S. (1994) J. Biol. Chem. 269, 17267-17273.
31. Yang, J., Sato, R., Goldstein, J. L. & Brown, M. S. (1994) Gene Dev. 8, 1910-1919.
32. Theopold, U., Ekengren, S. & Hultmark, D. (1996) Proc. Natl. Acad. Sci. USA 93, 1195-1199.
33. Stryer, L. (1995) Biochemistry (Freeman, New York).
34. Bretscher, M. S. & Munro, S. (1993) Science 261, 1280-1281.