A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b

Nature Cell Biology

Volumn 8, Issue 8, 2006, Pages 894-896

  Fluhrer, Regina ^a   Grammer, Gudula ^a   Israel, Lars ^a   Condron, Margaret M ^b   Haffner, Christof ^a   Friedmann, Elena ^c   Böhland, Claudia ^a   Imhof, Axel ^a   Martoglio, Bruno ^c,d   Teplow, David B ^b   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ETH ZURICH   (Switzerland)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; SIGNAL PEPTIDE PEPTIDASE LIKE PROTEIN 2B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CELL LINE; CYTOSOL; ENDOPEPTIDASES; HUMANS; INTRACELLULAR MEMBRANES; MOLECULAR SEQUENCE DATA; MUTATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR NECROSIS FACTOR-ALPHA; ZEBRAFISH PROTEINS;

EID: 33746608185     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1450     Document Type: Article

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