TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal γ-secretase-mediated release of the p75 intracellular domain

Journal of Biological Chemistry

Volumn 282, Issue 10, 2007, Pages 7606-7615

  Urra, Soledad ^a,c   Escudero, Claudia A ^a   Ramos, Patricio ^a   Lisbona, Fernanda ^a   Allende, Edgardo ^a   Covarrubias, Paulina ^a   Parraguez, Jose I ^a   Zampieri, Niccolo ^b   Chao, Moses V ^b   Annaert, Wim ^c   Bronfman, Francisca C ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INTRACELLULAR DOMAIN; INTRAMEMBRANE PROTEOLYSIS; NERVE GROWTH FACTOR (NGF); NEUROTROPHINS;

ENZYMES; PROTEOLYSIS; SIGNAL TRANSDUCTION;

NEUROLOGY;

CELL ENZYME; GAMMA SECRETASE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN TYROSINE KINASE A; BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; SECRETASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FRACTIONATION; CELL MIGRATION; CELL STRAIN; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; ENZYME SUBSTRATE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; ENDOCYTOSIS; ENDOSOMES; NERVE GROWTH FACTOR; PC12 CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

EID: 34147179336     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610458200     Document Type: Article

References (87)

1. Gentry, J. J., Barker, P. A., and Carter, B. D. (2004) Prog. Brain Res. 146, 25-39
2. Lu, B., Pang, P. T., and Woo, N. H. (2005) Nat. Rev. Neurosci. 6, 603- 614
3. Chao, M. V., and Lee, F. S. (2004) J. Alzheimers. Dis. 6, S7-S11
4. Chao, M. V., and Hempstead, B. L. (1995) Trends Neurosci. 18, 321-326
5. Bronfman, F. C., and Fainzilber, M. (2004) EMBO Rep. 5, 867-871
6. Roux, P. P., and Barker, P. A. (2002) Prog. Neurobiol. 67, 203-233
7. Tcherpakov, M., Bronfman, F. C., Conticello, S. G., Vaskovsky, A., Levy, Z., Niinobe, M., Yoshikawa, K., Arenas, E., and Fainzilber, M. (2002) J. Biol. Chem. 277, 49101-49104
8. Bronfman, F. C., Tcherpakov, M., Jovin, T. M., and Fainzilber, M. (2003) J. Neurosci. 23, 3209-3220
9. Saxena, S., Howe, C. L., Cosgaya, J. M., Hu, M., Weis, J., and Kruttgen, A. (2004) Mol. Cell Neurosci. 26, 292-307
10. Lalli, G., and Schiavo, G. (2002) J. Cell Biol. 156, 233-239
11. Hibbert, A. P., Kramer, B. M., Miller, F. D., and Kaplan, D. R. (2006) Mol. Cell Neurosci. 32, 387-402
12. Howe, C. L., and Mobley, W. C. (2005) Curr. Opin. Neurobiol. 15, 40-48
13. Kim, D. Y., Ingano, L. A., Carey, B. W., Pettingell, W. H., and Kovacs, D. M. (2005) J. Biol. Chem. 280, 23251-23261
14. Kim, D. Y., Ingano, L. A., and Kovacs, D. M. (2002) J. Biol. Chem. 277, 49976-49981
15. Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H., Okamura, Y., Watanabe, N., Sato, C., Natsugari, H., Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) J. Biol. Chem. 281, 14670-14676
16. Nyborg, A. C., Ladd, T. B., Zwizinski, C. W., Lah, J. J., and Golde, T. E. (2006) Mol. Neurodegener. 1, 3
17. Schulz, J. G., Annaert, W., Vandekerckhove, J., Zimmermann, P., De Strooper, B., and David, G. (2003) J. Biol. Chem. 278, 48651-48657
18. Ni, C. Y., Murphy, M. P., Golde, T. E., and Carpenter, G. (2001) Science 294, 2179-2181
19. Marambaud, P., Wen, P. H., Dutt, A., Shioi, J., Takashima, A., Siman, R., and Robakis, N. K. (2003) Cell 114, 635-645
20. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522
21. Kanning, K. C., Hudson, M., Amieux, P. S., Wiley, J. C., Bothwell, M., and Schecterson, L. C. (2003) J. Neurosci. 23, 5425-5436
22. Jung, K. M., Tan, S., Landman, N., Petrova, K., Murray, S., Lewis, R., Kim, P. K., Kim, D. S., Ryu, S. H., Chao, M. V., and Kim, T. W. (2003) J. Biol. Chem. 278, 42161-42169
23. Allinson, T. M., Parkin, E. T., Turner, A. J., and Hooper, N. M. (2003) J. Neurosci. Res. 74, 342-352
24. Kim, S. H., Yin, Y. I., Li, Y. M., and Sisodia, S. S. (2004) J. Biol. Chem. 279, 48615-48619
25. Pardossi-Piquard, R., Petit, A., Kawarai, T., Sunyach, C., Alves da Costa, C., Vincent, B., Ring, S., D'Adamio, L., Shen, J., Muller, U., St George Hyslop, P., and Checler, F. (2005) Neuron 46, 541-554
26. Hebert, S. S., Serneels, L., Tolia, A., Craessaerts, K., Derks, C., Filippov, M. A., Muller, U., and De Strooper, B. (2006) EMBO Rep. 7, 739-745
27. Annaert, W., and De Strooper, B. (2002) Annu. Rev. Cell Dev. Biol. 18, 25-51
28. Ebinu, J. O., and Yankner, B. A. (2002) Neuron 34, 499-502
29. Selkoe, D., and Kopan, R. (2003) Annu. Rev. Neurosci. 26, 565-597
30. Frade, J. M. (2005) J. Neurosci. 25, 1407-1411
31. Podlesniy, P., Kichev, A., Pedraza, C., Saurat, J., Encinas, M., Perez, B., Ferrer, I., and Espinet, C. (2006) Am. J. Pathol. 169, 119-131
32. Paul, C. E., Vereker, E., Dickson, K. M., and Barker, P. A. (2004) J. Neurosci. 24, 1917-1923
33. Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., and Barker, P. A. (1997) J. Neurosci. 17, 6988-6998
34. Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M. V., and Filbin, M. T. (2005) Neuron 46, 849-855
35. Ahmed, Z., Mazibrada, G., Seabright, R. J., Dent, R. G., Berry, M., and Logan, A. (2006) Faseb. J.
36. Kenchappa, R. S., Zampieri, N., Chao, M. V., Barker, P. A., Teng, H. K., Hempstead, B. L., and Carter, B. D. (2006) Neuron 50, 219-232
37. Gupta-Rossi, N., Six, E., LeBail, O., Logeat, F., Chastagner, P., Olry, A., Israel, A., and Brou, C. (2004) J. Cell Biol. 166, 73-83
38. Cam, J. A., Zerbinatti, C. V., Knisely, J. M., Hecimovic, S., Li, Y., and Bu, G. (2004) J. Biol. Chem. 279, 29639-29646
39. Grbovic, O. M., Mathews, P. M., Jiang, Y., Schmidt, S. D., Dinakar, R., Summers-Terio, N. B., Ceresa, B. P., Nixon, R. A., and Cataldo, A. M. (2003) J. Biol. Chem. 278, 31261-31268
40. Zhang, M., Haapasalo, A., Kim, D. Y., Ingano, L. A., Pettingell, W. H., and Kovacs, D. M. (2006) Faseb J. 20, 1176-1178
41. Spasic, D., Tolia, A., Dillen, K., Baert, V., De Strooper, B., Vrijens, S., and Annaert, W. (2006) J. Biol. Chem. 281, 26569-26577
42. De Strooper, B., Beullens, M., Contreras, B., Levesque, L., Craessaerts, K., Cordell, B., Moechars, D., Bollen, M., Fraser, P., George-Hyslop, P. S., and Van Leuven, F. (1997) J. Biol. Chem. 272, 3590-3598
43. Annaert, W. G., Esselens, C., Baert, V., Boeve, C., Snellings, G., Cupers, P., Craessaerts, K., and De Strooper, B. (2001) Neuron 32, 579-589
44. Zampieri, N., Xu, C. F., Neubert, T. A., and Chao, M. V. (2005) J. Biol. Chem. 280, 14563-14571
45. Grimes, M. L., Zhou, J., Beattie, E. C., Yuen, E. C., Hall, D. E., Valletta, J. S., Topp, K. S., LaVail, J. H., Bunnett, N. W., and Mobley, W. C. (1996) J. Neurosci. 16, 7950-7964
46. Farmery, M. R., Tjernberg, L. O., Pursglove, S. E., Bergman, A., Winblad, B., and Naslund, J. (2003) J. Biol. Chem. 278, 24277-24284
47. Zou, Z., Chung, B., Nguyen, T., Mentone, S., Thomson, B., and Biemesderfer, D. (2004) J. Biol. Chem. 279, 34302-34310
48. Lichtenstein, Y., Desnos, C., Faundez, V., Kelly, R. B., and Clift-O'Grady, L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11223-11228
49. Greene, L. A., and Tischler, A. S. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 2424-2428
50. Barker, P. A., and Shooter, E. M. (1994) Neuron 13, 203-215
51. Faundez, V., Horng, J. T., and Kelly, R. B. (1998) Cell 93, 423-432
52. Loder, M. K., and Melikian, H. E. (2003) J. Biol. Chem. 278, 22168-22174
53. Eichholtz, T., Vossebeld, P., van Overveld, M., and Ploegh, H. (1992) J. Biol. Chem. 267, 22490-22495
54. Seiffert, D., Bradley, J. D., Rominger, C. M., Rominger, D. H., Yang, F., Meredith, J. E., Jr., Wang, Q., Roach, A. H., Thompson, L. A., Spitz, S. M., Higaki, J. N., Prakash, S. R., Combs, A. P., Copeland, R. A., Arneric, S. P., Hartig, P. R., Robertson, D. W., Cordell, B., Stern, A. M., Olson, R. E., and Zaczek, R. (2000) J. Biol. Chem. 275, 34086-34091
55. Huovila, A. P., Turner, A. J., Pelto-Huikko, M., Karkkainen, I., and Ortiz, R. M. (2005) Trends Biochem. Sci. 30, 413-422
56. Kimberly, W. T., Esler, W. P., Ye, W., Ostaszewski, B. L., Gao, J., Diehl, T., Selkoe, D. J., and Wolfe, M. S. (2003) Biochemistry 42, 137-144
57. Berg, M. M., Sternberg, D. W., Parada, L. F., and Chao, M. V. (1992) J. Biol. Chem. 267, 13-16
58. Yoon, S. O., Soltoff, S. P., and Chao, M. V. (1997) J. Biol. Chem. 272, 23231-23238
59. Tarassishin, L., Yin, Y. I., Bassit, B., and Li, Y. M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 17050-17055
60. Lah, J. J., and Levey, A. I. (2000) Mol. Cell Neurosci. 16, 111-126
61. Pasternak, S. H., Callahan, J. W., and Mahuran, D. J. (2004) J. Alzheimers Dis. 6, 53-65
62. Chyung, J. H., Raper, D. M., and Selkoe, D. J. (2005) J. Biol. Chem. 280, 4383-4392
63. Shearman, M. S., Beher, D., Clarke, E. E., Lewis, H. D., Harrison, T., Hunt, P., Nadin, A., Smith, A. L., Stevenson, G., and Castro, J. L. (2000) Biochemistry 39, 8698-8704
64. Blagoveshchenskaya, A. D., Hewitt, E. W., and Cutler, D. F. (1999) J. Cell Biol. 145, 1419-1433
65. Esposito, D., Patel, P., Stephens, R. M., Perez, P., Chao, M. V., Kaplan, D. R., and Hempstead, B. L. (2001) J. Biol. Chem. 276, 32687-32695
66. Weskamp, G., Schlondorff, J., Lum, L., Becherer, J. D., Kim, T. W., Saftig, P., Hartmann, D., Murphy, G., and Blobel, C. P. (2004) J. Biol. Chem. 279, 4241-4249
67. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) J. Biol. Chem. 273, 27765-27767
68. Diaz-Rodriguez, E., Montero, J. C., Esparis-Ogando, A., Yuste, L., and Pandiella, A. (2002) Mol. Biol. Cell 13, 2031-2044
69. Janes, P. W., Saha, N., Barton, W. A., Kolev, M. V., Wimmer-Kleikamp, S. H., Nievergall, E., Blobel, C. P., Himanen, J. P., Lackmann, M., and Nikolov, D. B. (2005) Cell 123, 291-304
70. Georgakopoulos, A., Litterst, C., Ghersi, E., Baki, L., Xu, C., Serban, G., and Robakis, N. K. (2006) EMBO J. 25, 1242-1252
71. Brou, C., Logeat, F., Gupta, N., Bessia, C., LeBail, O., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., and Israel, A. (2000) Mol. Cell 5, 207-216
72. Schlondorff, J., Becherer, J. D., and Blobel, C. P. (2000) Biochem. J. 347, 131-138
73. Kaether, C., Schmitt, S., Willem, M., and Haass, C. (2006) Traffic 7, 408-415
74. Saxena, S., Howe, C. L., Cosgaya, J. M., Steiner, P., Hirling, H., Chan, J. R., Weis, J., and Kruttgen, A. (2005) Mol. Cell Neurosci. 28, 571-587
75. Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., and Simons, K. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 11172-11177
76. Kopan, R., and Ilagan, M. X. (2004) Nat. Rev. Mol. Cell Biol. 5, 499-504
77. Zweifel, L. S., Kuruvilla, R., and Ginty, D. D. (2005) Nat. Rev. Neurosci. 6, 615-625
78. Yano, H., and Chao, M. V. (2004) J. Neurobiol. 58, 244-257
79. Deinhardt, K., Salinas, S., Verastegui, C., Watson, R., Worth, D., Hanrahan, S., Bucci, C., and Schiavo, G. (2006) Neuron 52, 293-305
80. Cavalli, V., Kujala, P., Klumperman, J., and Goldstein, L. S. (2005) J. Cell Biol. 168, 775-787
81. Hanz, S., Perlson, E., Willis, D., Zheng, J. Q., Massarwa, R., Huerta, J. J., Koltzenburg, M., Kohler, M., van-Minnen, J., Twiss, J. L., and Fainzilber, M. (2003) Neuron 40, 1095-1104
82. Cataldo, A. M., Peterhoff, C. M., Troncoso, J. C., Gomez-Isla, T., Hyman, B. T., and Nixon, R. A. (2000) Am. J. Pathol. 157, 277-286
83. Zhang, M., Dwyer, N. K., Love, D. C., Cooney, A., Comly, M., Neufeld, E., Pentchev, P. G., Blanchette-Mackie, E. J., and Hanover, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 4466-4471
84. Pal, A., Severin, F., Lommer, B., Shevchenko, A., and Zerial, M. (2006) J. Cell Biol. 172, 605-618
85. Bronfman, F. C., Moechars, D., and Van Leuven, F. (2000) Neurobiol. Dis. 7, 152-168
86. Tuszynski, M. H., and Blesch, A. (2004) Prog. Brain Res. 146, 441-449
87. Salehi, A., Delcroix, J. D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., Xia, W., Villar, A., Campbell, W. A., Kulnane, L. S., Nixon, R. A., Lamb, B. T., Epstein, C. J., Stokin, G. B., Goldstein, L. S., and Mobley, W. C. (2006) Neuron 51, 29-42