A presenilin-1-dependent γ-secretase-like protease mediates release of notch intracellular domain

Nature

Volumn 398, Issue 6727, 1999, Pages 518-522

  De Strooper, Bart ^a   Annaert, Wim ^a   Cupers, Philippe ^a   Saftig, Paul ^e   Craessaerts, Katleen ^a   Mumm, Jeffrey S ^b   Schroeter, Eric H ^b   Schrijvers, Vincent ^a   Wolfe, Michael S ^c   Ray, William J ^d   Goate, Alison ^d   Kopan, Raphael ^b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; PRESENILIN 1; PROTEINASE; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL FATE; CONTROLLED STUDY; ENZYME ACTIVITY; MAMMAL CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CYTOPLASM; DNA-BINDING PROTEINS; ENDOPEPTIDASES; FIBROBLASTS; MEMBRANE PROTEINS; MICE; NEURONS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0033535504     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/19083     Document Type: Article

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