Requirements for Presenilin-dependent cleavage of notch and other transmembrane proteins

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 625-636

  Struhl, Gary ^a   Adachi, Atsuko ^a  

^a The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; LIGAND; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; PRESENILIN 1; PRESENILIN 2;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CHROMOSOME SIZE; EMBRYO; EXTRACELLULAR MATRIX; FEMALE; GENE TARGETING; LIGAND BINDING; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; SEQUENCE ANALYSIS;

EID: 0033639117     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00061-7     Document Type: Article

References (64)

1. Ligand-independent activation of the Sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye
2. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
3. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
4. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
5. Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis
6. Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH
7. Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila
8. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
9. Proteolytic processing and cell biological functions of the amyloid precursor protein
10. Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression
11. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
12. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
13. GAL4 activates transcription in Drosophila
14. Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype
15. LIN-12/Notch signaling: Lessons from worms and flies
16. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans
17. Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells
18. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
19. Identification of a novel aspartic protease (Asp 2) as beta-secretase
20. Signaling downstream of activated mammalian Notch
21. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
22. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
23. Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
24. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
25. Notch signalling and the control of cell fate choices in vertebrates
26. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
27. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
28. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
29. The Notch1 receptor is cleaved constitutively by a furin-like convertase
30. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
31. γ-secretase, evidence for multiple proteolytic activities and influence of membrane position of substrate on generation of amyloid β peptides of varying length
32. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
33. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
34. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
35. Shibire, a neurogenic mutant of Drosophila
36. Processing of the notch ligand delta by the metalloprotease Kuzbanian
37. Calcium depletion dissociates and activates heterodimeric notch receptors
38. Evidence for a physical interaction between Presenilin and Notch
39. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
40. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
41. TOXCAT: A measure of transmembrane helix association in a biological membrane
42. GAL4-VP16 is an unusually potent transcriptional activator
43. Temperature-sensitive periods and autnomy of pleiotropic effects of l(1)N(ts1), a conditional Notch lethal in Drosophila
44. Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
45. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
46. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
47. Requirement for dynamin during Notch signaling in Drosophila neurogenesis
48. Skeletal and CNS defects in Presenilin-1 deficient mice
49. Purification and cloning of amyloid precursor protein beta-secretase from human brain
50. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
51. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
52. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
53. Nuclear access and action of notch in vivo
54. Presenilin is required for activity and nuclear access of Notch in Drosophila
55. Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic
56. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
57. SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
58. Reverse genetic analysis of Caenorhabditis elegans Presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling
59. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
60. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
61. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
62. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
63. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1