-
1
-
-
0032720496
-
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
-
(1999)
J. Cell Biol.
, vol.147
, pp. 277-294
-
-
Annaert, W.G.1
Levesque, L.2
Craessaerts, K.3
Dierinck, I.4
Snellings, G.5
Westaway, D.6
George-Hyslop, P.S.7
Cordell, B.8
Fraser, P.9
De Strooper, B.10
-
2
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
4
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
Beyreuther, K.7
Selkoe, D.J.8
Haass, C.9
-
7
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St George Hyslop, P.22
Selkoe, D.J.23
more..
-
8
-
-
0030769092
-
Alzheimer's Abeta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
-
(1997)
Nat. Med.
, vol.3
, pp. 1021-1023
-
-
Cook, D.G.1
Forman, M.S.2
Sung, J.C.3
Leight, S.4
Kolson, D.L.5
Iwatsubo, T.6
Lee, V.M.7
Doms, R.W.8
-
9
-
-
0029812077
-
Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9223-9228
-
-
Cook, D.G.1
Sung, J.C.2
Golde, T.E.3
Felsenstein, K.M.4
Wojczyk, B.S.5
Tanzi, R.E.6
Trojanowski, J.Q.7
Lee, V.M.8
Doms, R.W.9
-
10
-
-
0025283268
-
Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus
-
(1990)
J. Histochem. Cytochem.
, vol.38
, pp. 957-963
-
-
Croul, S.1
Mezitis, S.G.2
Stieber, A.3
Chen, Y.J.4
Gonatas, J.O.5
Goud, B.6
Gonatas, N.K.7
-
11
-
-
0030923412
-
Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment
-
(1997)
J. Neurosci. Res.
, vol.49
, pp. 719-731
-
-
Culvenor, J.G.1
Maher, F.2
Evin, G.3
Malchiodi-Albedi, F.4
Cappai, R.5
Underwood, J.R.6
Davis, J.B.7
Karran, E.H.8
Roberts, G.W.9
Beyreuther, K.10
Masters, C.L.11
-
12
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
13
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
15
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
16
-
-
0032787598
-
Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1263-1269
-
-
Dumanchin, C.1
Czech, C.2
Campion, D.3
Cuif, M.H.4
Poyot, T.5
Martin, C.6
Charbonnier, F.7
Goud, B.8
Pradier, L.9
Frebourg, T.10
-
17
-
-
0031795935
-
Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles
-
(1998)
J. Neurochem
, vol.71
, pp. 2365-2372
-
-
Efthimiopoulos, S.1
Floor, E.2
Georgakopoulos, A.3
Shioi, J.4
Cui, W.5
Yasothornsrikul, S.6
Hook, V.Y.7
Wisniewski, T.8
Buee, L.9
Robakis, N.K.10
-
18
-
-
0033401526
-
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
-
(1999)
Mol. Cell
, vol.4
, pp. 893-902
-
-
Georgakopoulos, A.1
Marambaud, P.2
Efthimiopoulos, S.3
Shioi, J.4
Cui, W.5
Li, H.C.6
Schutte, M.7
Gordon, R.8
Holstein, G.R.9
Martinelli, G.10
Mehta, P.11
Friedrich V.L., Jr.12
Robakis, N.K.13
-
20
-
-
73049155988
-
The isolation of nerve endings from brain: An electron-microscopic study of cell fragments derived by homogenization and centrifugation
-
(1962)
J. Anal.
, vol.96
, pp. 79-87
-
-
Gray, E.1
Whittaker, V.2
-
26
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides
-
(1997)
Nat. Med.
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
Tienari, P.J.4
Ida, N.5
Allsop, D.6
Roberts, G.W.7
Masters, C.L.8
Dotti, C.G.9
Unsicker, K.10
Beyreuther, K.11
-
34
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
(1996)
Nat. Med.
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.W.4
Moir, R.D.5
Merriam, D.E.6
Hollister, R.D.7
Hallmark, O.G.8
Mancini, R.9
Felsenstein, K.M.10
Hyman, B.T.11
Tanzi, R.E.12
Wasco, W.13
-
35
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
41
-
-
15444350008
-
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease
-
(1997)
Ann. Neurol.
, vol.41
, pp. 742-753
-
-
Levey, A.I.1
Heilman, C.J.2
Lah, J.J.3
Nash, N.R.4
Rees, H.D.5
Wakai, M.6
Mirra, S.S.7
Rye, D.B.8
Nochlin, D.9
Bird, T.D.10
Mufson, E.J.11
-
43
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.4
Oshima, J.5
Pettingell, W.6
Yu, C.7
Jondro, P.8
Schmidt, S.9
Wang, K.10
Crowley, A.11
Fu, Y.12
Guenette, S.13
Galas, D.14
Nemens, E.15
Wijsman, E.16
Bird, T.17
Schellenberg, G.18
Tanzi, R.19
-
44
-
-
0029116848
-
Facilitation of 1in-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
45
-
-
0026688633
-
Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions
-
(1992)
J. Cell Biol
, vol.119
, pp. 55-68
-
-
L'Hernault, S.W.1
Arduengo, P.M.2
-
47
-
-
0030671560
-
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12204-12209
-
-
Li, X.1
Greenwald, I.2
-
49
-
-
9444276544
-
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Abeta42(43)
-
(1996)
Ann. Neurol
, vol.40
, pp. 149-156
-
-
Mann, D.M.1
Iwatsubo, T.2
Cairns, N.J.3
Lantos, P.L.4
Nochlin, D.5
Sumi, S.M.6
Bird, T.D.7
Poorkaj, P.8
Hardy, J.9
Hutton, M.10
Prihar, G.11
Crook, R.12
Rossor, M.N.13
Haltia, M.14
-
50
-
-
0031866596
-
Direct association of presenilin-1 with beta-catenin
-
(1998)
FEBS Lett
, vol.433
, pp. 73-77
-
-
Murayama, M.1
Tanaka, S.2
Palacino, J.3
Murayama, O.4
Honda, T.5
Sun, X.6
Yasutake, K.7
Nihonmatsu, N.8
Wolozin, B.9
Takashima, A.10
-
51
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
Kusiak, J.W.4
Tomita, T.5
Iwatsubo, T.6
Qian, X.7
Ginty, D.D.8
Price, D.L.9
Borchelt, D.R.10
Wong, P.C.11
Sisodia, S.S.12
-
55
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
Ostaszewski, B.4
Xia, W.5
Selkoe, D.J.6
Chen, X.7
Stokin, G.B.8
Koo, E.H.9
-
56
-
-
0029554875
-
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene
-
(1995)
NeuroReport
, vol.7
, pp. 297-301
-
-
Perez-Tur, J.1
Froelich, S.2
Prihar, G.3
Crook, R.4
Baker, M.5
Duff, K.6
Wragg, M.7
Busfield, F.8
Lendon, C.9
Clark, R.F.10
-
57
-
-
0030889220
-
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
-
(1997)
Neurobiol. Dis.
, vol.3
, pp. 325-337
-
-
Podlisny, M.B.1
Citron, M.2
Amarante, P.3
Sherrington, R.4
Xia, W.5
Zhang, J.6
Diehl, T.7
Levesque, G.8
Fraser, P.9
Haass, C.10
Koo, E.H.11
Seubert, P.12
St. George-Hyslop, P.13
Tepiow, D.B.14
Selkoe, D.J.15
-
58
-
-
0033579505
-
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36801-36807
-
-
Ray, W.J.1
Yao, M.2
Mumm, J.3
Schroeter, E.H.4
Saftig, P.5
Wolfe, M.6
Selkoe, D.J.7
Kopan, R.8
Goate, A.M.9
-
61
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
62
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
63
-
-
0033529331
-
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7932-7937
-
-
Schwarzman, A.L.1
Singh, N.2
Tsiper, M.3
Gregori, L.4
Dranovsky, A.5
Vitek, M.P.6
Glabe, C.G.7
St George-Hyslop, P.H.8
Goldgaber, D.9
-
64
-
-
12644290265
-
Evidence for phosphorylation and oligomeric assembly of presenilin 1
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5090-5094
-
-
Seeger, M.1
Nordstedt, C.2
Petanceska, S.3
Kovacs, D.M.4
Gouras, G.K.5
Hahne, S.6
Fraser, P.7
Levesque, L.8
Czernik, A.J.9
George-Hyslop, P.S.10
Sisodia, S.S.11
Thinakaran, G.12
Tanzi, R.E.13
Greengard, P.14
Gandy, S.15
-
65
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.2
Liang, Y.3
Rogaeva, E.4
Levesque, G.5
Ikeda, M.6
Chl, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.-F.13
Bruni, A.14
Montesi, M.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Pollnsky, R.24
Wasco, W.25
Silva, H.D.26
Haines, J.27
Pericak-Vance, M.28
Tanzi, R.29
Roses, A.30
Fraser, P.31
Rommens, J.32
George-Hyslop, P.S.33
more..
-
68
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
69
-
-
0030667426
-
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28415-28422
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
Davenport, F.4
Slunt, H.H.5
Price, D.L.6
Borchelt, D.R.7
Sisodia, S.S.8
-
70
-
-
0026702055
-
In AtT20 and HeLa cells brefeldin A induces the fusion of tubular endosomes and changes their distribution and some of their endocytic properties
-
(1992)
J. Cell Biol.
, vol.118
, pp. 813-830
-
-
Tooze, J.1
Hollinshead, M.2
-
72
-
-
0025937289
-
SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 19599-19610
-
-
Wada, I.1
Rindress, D.2
Cameron, P.H.3
Ou, W.J.4
Doherty, J.J.D.5
Louvard, D.6
Bell, A.W.7
Dignard, D.8
Thomas, D.Y.9
Bergeron, J.J.10
-
73
-
-
8044231311
-
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
-
(1996)
Mol. Med.
, vol.2
, pp. 673-691
-
-
Walter, J.1
Capell, A.2
Grunberg, J.3
Pesold, B.4
Schindzielorz, A.5
Prior, R.6
Podlisny, M.B.7
Fraser, P.8
Hyslop, P.S.9
Selkoe, D.J.10
Haass, C.11
-
76
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
Citron, M.4
Podlisny, M.B.5
Teplow, D.B.6
Haass, C.7
Seubert, P.8
Koo, E.H.9
Selkoe, D.J.10
-
79
-
-
0032568821
-
The presenillin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
Levesque, L.6
Rogaeva, E.7
Xu, D.8
Liang, Y.9
Duthie, M.10
St. George-Hyslop, P.H.11
Fraser, P.E.12
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