Statins reduce amyloid-β production through inhibition of protein isoprenylation

Journal of Biological Chemistry

Volumn 282, Issue 37, 2007, Pages 26832-26844

  Ostrowski, Stephen M ^a   Wilkinson, Brandy L ^a   Golde, Todd E ^b   Landreth, Gary ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DEGRADATION; DISEASES; ENZYME ACTIVITY; ENZYME INHIBITION;

G-PROTEINS; ISOPRENYLATION; PATHOGENESIS; STATINS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; RAB PROTEIN; RHO FACTOR; SIMVASTATIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS;

AMYLOID BETA-PROTEIN; ANIMALS; BACTERIAL TOXINS; CELL LINE, TUMOR; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; LYSOSOMES; MEVALONIC ACID; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; PROTEIN ISOPRENYLATION; RAB GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SIMVASTATIN;

EID: 34848835187     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702640200     Document Type: Article

References (75)

1. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
2. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
3. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
4. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., Zhao, J., McConlogue, L., and John, V. (1999) Nature 402, 537-540
5. Kim, S. H., Yin, Y. I., Li, Y. M., and Sisodia, S. S. (2004) J. Biol. Chem. 279, 48615-48619
6. Kinoshita, A., Fukumoto, H., Shah, T., Whelan, C. M., Irizarry, M. C., and Hyman, B. T. (2003) J. Cell Sci. 116, 3339-3346
7. Chyung, J. H., Raper, D. M., and Selkoe, D. J. (2005) J. Biol. Chem. 280, 4383-4392
8. Tarassishin, L., Yin, Y. I., Bassit, B., and Li, Y. M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 17050-17055
9. Dugan, J. M., deWit, C., McConlogue, L., and Maltese, W. A. (1995) J. Biol. Chem. 270, 10982-10989
10. McConlogue, L., Castellano, F., deWit, C., Schenk, D., and Maltese, W. A. (1996) J. Biol. Chem. 271, 1343-1348
11. Maltese, W. A., Wilson, S., Tan, Y., Suomensaari, S., Sinha, S., Barbour, R., and McConlogue, L. (2001) J. Biol. Chem. 276, 20267-20279
12. Nobes, C. D., and Hall, A. (1995) Cell 81, 53-62
13. Desire, L., Bourdin, J., Loiseau, N., Peillon, H., Picard, V., De Oliveira, C., Bachelot, F., Leblond, B., Taverne, T., Beausoleil, E., Lacombe, S., Drouin, D., and Schweighoffer, F. (2005) J. Biol. Chem. 280, 37516-37525
14. Zhou, Y., Su, Y., Li, B., Liu, F., Ryder, J. W., Wu, X., Gonzalez-DeWhitt, P. A., Gelfanova, V., Hale, J. E., May, P. C., Paul, S. M., and Ni, B. (2003) Science 302, 1215-1217
15. Endo, A. (1992) J. Lipid Res. 33, 1569-1582
16. Tobert, J. A. (2003) Nat. Rev. Drug Discov. 2, 517-526
17. Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S., and Drachman, D. A. (2000) Lancet 356, 1627-1631
18. Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G. G., and Siegel, G. (2000) Arch. Neurol. 57, 1439-1443
19. Rockwood, K., and Darvesh, S. (2003) Neurol. Res. 25, 601-604
20. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6460-6464
21. Kojro, E., Gimpl, G., Lammich, S., Marz, W., and Fahrenholz, F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5815-5820
22. Burns, M., and Duff, K. (2002) Ann. N. Y. Acad. Sci. 977, 367-375
23. Wahrle, S., Das, P., Nyborg, A. C., McLendon, C., Shoji, M., Kawarabayashi, T., Younkin, L. H., Younkin, S. G., and Golde, T. E. (2002) Neurobiol. Dis. 9, 11-23
24. Cordy, J. M., Hussain, I., Dingwall, C., Hooper, N. M., and Turner, A. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11735-11740
25. Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5856-5861
26. Petanceska, S. S., DeRosa, S., Olm, V., Diaz, N., Sharma, A., Thomas-Bryant, T., Duff, K., Pappolla, M., and Refolo, L. M. (2002) J. Mol. Neurosci. 19, 155-161
27. Stewart, R., White, L. R., Xue, Q. L., and Launer, L. J. (2007) Arch. Neurol. 64, 103-107
28. Wood, W. G., Igbavboa, U., Eckert, G. P., Johnson-Anuna, L. N., and Muller, W. E. (2005) Mol. Neurobiol. 31, 185-192
29. Refolo, L. M., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., Duff, K., and Pappolla, M. A. (2000) Neurobiol. Dis. 7, 321-331
30. Howland, D. S., Trusko, S. P., Savage, M. J., Reaume, A. G., Lang, D. M., Hirsch, J. D., Maeda, N., Siman, R., Greenberg, B. D., Scott, R. W., and Flood, D. G. (1998) J. Biol. Chem. 273, 16576-16582
31. George, A. J., Holsinger, R. M., McLean, C. A., Laughton, K. M., Beyreuther, K., Evin, G., Masters, C. L., and Li, Q. X. (2004) Neurobiol. Dis. 16, 124-132
32. Shie, F. S., Jin, L. W., Cook, D. G., Leverenz, J. B., and LeBoeuf, R. C. (2002) Neuroreport 13, 455-459
33. Liao, J. K., and Laufs, U. (2005) Annu. Rev. Pharmacol. Toxicol. 45, 89-118
34. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
35. Bellosta, S., Ferri, N., Arnaboldi, L., Bernini, F., Paoletti, R., and Corsini, A. (2000) Diabetes Care 23, Suppl. 2, B72-B78
36. Bellosta, S., Ferri, N., Bernini, F., Paoletti, R., and Corsini, A. (2000) Ann. Med. 32, 164-176
37. Takemoto, M., and Liao, J. K. (2001) Arterioscler. Thromb. Vasc. Biol. 21, 1712-1719
38. Youssef, S., Stuve, O., Patarroyo, J. C., Ruiz, P. J., Radosevich, J. L., Hur, E. M., Bravo, M., Mitchell, D. J., Sobel, R. A., Steinman, L., and Zamvil, S. S. (2002) Nature 420, 78-84
39. Zamvil, S. S., and Steinman, L. (2002) Neurology 59, 970-971
40. Kwak, B., Mulhaupt, F., Myit, S., and Mach, F. (2000) Nat. Med. 6, 1399-1402
41. Cordle, A., Koenigsknecht-Talboo, J., Wilkinson, B., Limpert, A., and Landreth, G. (2005) J. Biol. Chem. 280, 34202-34209
42. Overmeyer, J. H., and Maltese, W. A. (1992) J. Biol. Chem. 267, 22686-22692
43. Ivessa, N. E., Gravotta, D., De Lemos-Chiarandini, C., and Kreibich, G. (1997) J. Biol. Chem. 272, 20828-20834
44. Johnson-Anuna, L. N., Eckert, G. P., Keller, J. H., Igbavboa, U., Franke, C., Fechner, T., Schubert-Zsilavecz, M., Karas, M., Muller, W. E., and Wood, W. G. (2005) J. Pharmacol. Exp. Ther. 312, 786-793
45. Murphy, M. P., Uljon, S. N., Fraser, P. E., Fauq, A., Lookingbill, H. A., Findlay, K. A., Smith, T. E., Lewis, P. A., McLendon, D. C., Wang, R., and Golde, T. E. (2000) J. Biol. Chem. 275, 26277-26284
46. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
47. Zhao, X., Bey, E. A., Wientjes, F. B., and Cathcart, M. K. (2002) J. Biol. Chem. 277, 25385-25392
48. Sinensky, M., Beck, L. A., Leonard, S., and Evans, R. (1990) J. Biol. Chem. 265, 19937-19941
49. Cicha, I., Schneiderhan-Marra, N., Yilmaz, A., Garlichs, C. D., and Goppelt-Struebe, M. (2004) Arterioscler. Thromb. Vasc. Biol. 24, 2046-2050
50. Brown, M. S., and Goldstein, J. L. (1980) J. Lipid Res. 21, 505-517
51. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
52. Cole, S. L., Grudzien, A., Manhart, I. O., Kelly, B. L., Oakley, H., and Vassar, R. (2005) J. Biol. Chem. 280, 18755-18770
53. Cordle, A., and Landreth, G. (2005) J. Neurosci. 25, 299-307
54. Rilling, H. C., Bruenger, E., Leining, L. M., Buss, J. E., and Epstein, W. W. (1993) Arch. Biochem. Biophys. 301, 210-215
55. Pedrini, S., Carter, T. L., Prendergast, G., Petanceska, S., Ehrlich, M. E., and Gandy, S. (2005) PLoS Med. 2, e18
56. Voth, D. E., and Ballard, J. D. (2005) Clin. Microbiol. Rev. 18, 247-263
57. Caporaso, G. L., Gandy, S. E., Buxbaum, J. D., and Greengard, P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 2252-2256
58. Tsuzuki, K., Fukatsu, R., Takamaru, Y., Fujii, N., and Takahata, N. (1994) Brain Res. 659, 213-220
59. Knops, J., Lieberburg, I., and Sinha, S. (1992) J. Biol. Chem. 267, 16022-16024
60. Nunan, J., Shearman, M. S., Checler, F., Cappai, R., Evin, G., Beyreuther, K., Masters, C. L., and Small, D. H. (2001) Eur. J. Biochem. 268, 5329-5336
61. Nunan, J., Williamson, N. A., Hill, A. F., Sernee, M. F., Masters, C. L., and Small, D. H. (2003) J. Neurosci. Res. 74, 378-385
62. Ohkuma, S., and Poole, B. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 3327-3331
63. Beck, L. A., Hosick, T. J., and Sinensky, M. (1990) J. Cell Biol. 110, 1489-1499
64. Leonard, S., Beck, L., and Sinensky, M. (1990) J. Biol. Chem. 265, 5157-5160
65. Larijani, B., Hume, A. N., Tarafder, A. K., and Seabra, M. C. (2003) J. Biol. Chem. 278, 46798-46804
66. Zhang, F. L., Kirschmeier, P., Carr, D., James, L., Bond, R. W., Wang, L., Patton, R., Windsor, W. T., Syto, R., Zhang, R., and Bishop, W. R. (1997) J. Biol. Chem. 272, 10232-10239
67. Kim, S. H., Leem, J. Y., Lah, J. J., Slunt, H. H., Levey, A. I., Thinakaran, G., and Sisodia, S. S. (2001) J. Biol. Chem. 276, 43343-43350
68. Khvotchev, M., and Sudhof, T. C. (2004) J. Biol. Chem. 279, 47101-7108
69. Iwata, H., Tomita, T., Maruyama, K., and Iwatsubo, T. (2001) J. Biol. Chem. 276, 21678-21685
70. Kouchi, Z., Kinouchi, T., Sorimachi, H., Ishiura, S., and Suzuki, K. (1998) Eur. J. Biochem. 258, 291-300
71. Sudoh, S., Hua, G., Kawamura, Y., Maruyama, K., Komano, H., and Yanagisawa, K. (2000) Eur. J. Biochem. 267, 2036-2045
72. Aktories, K., and Just, I. (1995) Trends Cell Biol. 5, 441-443
73. Cheng, J., Wang, H., and Guggino, W.B. (2005) J. Biol. Chem. 280, 3731-3739
74. Chiang, S. H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E., and Saltiel, A. R. (2001) Nature 410, 944-948
75. Perez, R. G., Squazzo, S. L., and Koo, E. H. (1996) J. Biol. Chem. 271, 9100-9107