The mechanism of γ-secretase. Multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

Journal of Biological Chemistry

Volumn 278, Issue 31, 2003, Pages 28968-28975

  Tian, Gaochao ^a   Ghanekar, Smita V ^a   Aharony, David ^a   Shenvi, Ashok B ^a   Jacobs, Robert T ^a   Liu, Xiaodong ^a   Greenberg, Barry D ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; COMPLEXATION; ENZYME KINETICS; REACTION KINETICS;

COMPETITIVE BINDING;

ENZYME INHIBITION;

BENZODIAZEPINE DERIVATIVE; ENZYME INHIBITOR; GAMMA SECRETASE; L 685458; LIGAND; PEPSTATIN METHYL ESTER; RADIOLIGAND; SMALL MOLECULE GAMMA SECRETASE INHIBITOR; SULFONAMIDE; TRANSITION STATE ANALOG; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; PRIORITY JOURNAL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CARBAMATES; CATALYSIS; DIPEPTIDES; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; KINETICS; MATHEMATICS; PEPSTATINS; SOLUBILITY; SULFONAMIDES; TRITIUM;

TRITIUM;

EID: 0042206671     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300905200     Document Type: Article

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