Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

Journal of Biological Chemistry

Volumn 271, Issue 17, 1996, Pages 10379-10384

  Hua, Xianxin ^a   Sakai, Juro ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; ARGININE; BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; TETRAPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SITE DIRECTED MUTAGENESIS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HELIX-LOOP-HELIX MOTIFS; HUMANS; LEUCINE ZIPPERS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 0029878960     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.17.10379     Document Type: Article

References (17)

1. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
2. Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., and Brown, M. S. (1993) Cell 75, 187-197
3. Hua, X., Yokoyama, C., Wu, J., Briggs, M. R., Brown, M. S., Goldstein, J. L., and Wang, X. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11603-11607
4. Sato, R., Yang, J., Wang, X., Evans, M. J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1994) J. Biol. Chem. 269, 17267-17273
5. Lopez, J. M., Bennett, M. K., Sanchez, H. B., Rosenfeld, J. M., and Osborne, T. F. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1049-1053
6. Hua, X., Sakai, J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 29422-29427
7. McKnight, S. L. (1982) Cell 31, 355-365
8. Kozak, M. (1984) Nucleic Acids Res. 12, 857-872
9. Isola, V. J., Eisenberg, R. J., Siebert, G. R., Heilman, C. J., Wilcox, W. C., and Cohen, G. H. (1989) J. Virol. 63, 2325-2334
10. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. V. S. A. 82, 488-492
11. Gil, G., Faust, J. R., Chin, D. J., Goldstein, J. L., and Brown, M. S. (1985) Cell 41, 249-258
12. Bollag, D. M., and Edelstein, S. J. (1991) Protein Methods Wiley-Liss, Inc., New York
13. Yang, J., Sato, E., Goldstein, J. L., and Brown, M. S. (1994) Genes & Dev. 8, 1910-1919
14. Yang, J., Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161
15. Wang, X., Zelenski, N. G., Yang, J., Sakai, J., Brown, M. S., and Goldstein, J. L. (1996) EMBO J. 15, 1012-1020
16. Hua, X., Wu, J., Goldstein, J. L., Brown, M. S., and Hobbs, H. H. (1995) Genomics 25, 667-673
17. Sheng, Z., Otani, H., Brown, M. S., and Goldstein, J. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 935-938