Presenilin-1 and presenilin-2 exhibit distinct yet overlapping γ-secretase activities

Journal of Biological Chemistry

Volumn 278, Issue 25, 2003, Pages 22475-22481

  Lai, Ming Tain ^a   Chen, Elizabeth ^a   Crouthamel, Ming Chih ^a   DiMuzio Mower, Jillian ^a   Xu, Min ^a   Huang, Qian ^a   Price, Eric ^a   Register, R Bruce ^a   Shi, Xiao Ping ^a   Donoviel, Dorit B ^b,c   Bernstein, Alan ^b   Hazuda, Daria ^a   Gardell, Stephen J ^a,d   Li, Yue Ming ^a,e  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

^c LEXICON PHARMACEUTICALS INC   (United States)

^d BAYER CORPORATION   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; CELL MEMBRANES; CHEMICAL ACTIVATION; IMMUNOLOGY;

PROTEIN TRANSCRIPTION;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIBODY; ASPARTIC PROTEINASE; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; IMMUNOBLOTTING; ISOTOPE LABELING; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHOTOACTIVATION; PRIORITY JOURNAL;

AFFINITY LABELS; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLASTOCYST; CELL MEMBRANE; CLONING, MOLECULAR; ENDOPEPTIDASES; ENZYME INHIBITORS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PRESENILIN-1; PRESENILIN-2; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0037590902     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300974200     Document Type: Article

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