The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase

Journal of Neuroscience

Volumn 26, Issue 14, 2006, Pages 3821-3828

  Yamasaki, Aya ^a   Eimer, Stefan ^a   Okochi, Masayasu ^b   Smialowska, Agata ^a,c   Kaether, Christoph ^a   Baumeister, Ralf ^a,c   Haass, Christian ^a   Steiner, Harald ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

secretase; Alzheimer's disease; Amyloid peptide; Notch; Presenilin; SPE 4

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN; SPERMATOGENESIS DEFECTIVE 4 PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BAY REGION BINDING SITE; CAENORHABDITIS ELEGANS; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATALYSIS; CELLS, CULTURED; ENDOPEPTIDASES; ENZYME ACTIVATION; FIBROBLASTS; MEMBRANE PROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; PRESENILIN-1; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33645559774     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5354-05.2006     Document Type: Article

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