C terminus of presenilin is required for overproduction of amyloidogenic Aβ342 through stabilization and endoproteolysis of presenilin

Journal of Neuroscience

Volumn 19, Issue 24, 1999, Pages 10627-10634

  Tomita, Taisuke ^a   Takikawa, Rie ^a   Koyama, Akihiko ^a   Morohashi, Yuichi ^a   Takasugi, Nobumasa ^a   Saido, Takaomi C ^b   Maruyama, Kei ^c   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Amyloid peptide; A 42; C terminus; Endoproteolysis; Familial Alzheimer's disease; Presenilin 1; Presenilin 2; Stabilization

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; DEGENERATIVE DISEASE; FAMILIAL DISEASE; GENE MUTATION; MOUSE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0033573477     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-24-10627.1999     Document Type: Article

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