Longer forms of amyloid β protein: Implications for the mechanism of intramembrane cleavage by γ-secretase

Journal of Neuroscience

Volumn 25, Issue 2, 2005, Pages 436-445

  Qi Takahara, Yue ^a   Morishima Kawashima, Maho ^a   Tanimura, Yu ^a   Dolios, Georgia ^b   Hirotani, Naoko ^c   Horikoshi, Yuko ^d   Kametani, Fuyuki ^e   Maeda, Masahiro ^d   Saido, Takaomi C ^c   Wang, Rong ^b   Ihara, Yasuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d Immuno Biological Laboratories Co Ltd   (Japan)

^e TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

secretase; Alzheimer's disease; Amyloid protein; APP; Intramembrane cleavage; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MONOCLONAL ANTIBODY; N [N (3,5 DIFLUOROPHENACETYL)ALANYL] S PHENYLGLYCINE TERTBUTYLESTER; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN LEVEL; CELL LEVEL; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; MASS SPECTROMETRY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CELL LINE; CRICETINAE; CRICETULUS; DIPEPTIDES; ENDOPEPTIDASES; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SUBCELLULAR FRACTIONS;

EID: 19944430034     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1575-04.2005     Document Type: Article

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