Alzheimer 100 - Highlights in the history of Alzheimer research

Journal of Neural Transmission

Volumn 113, Issue 11, 2006, Pages 1603-1623

  Jellinger, K A ^a,b  

^a INSTITUTE OF CLINICAL NEUROBIOLOGY   (Austria)

^b NONE   (Austria)

Author keywords

Alzheimer disease; Clinical diagnosis; Dementia; Future perspectives; History of Alzheimer research; Neurobiology

Indexed keywords

ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; CHOLINESTERASE INHIBITOR; ESTROGEN; MEMANTINE; NONSTEROID ANTIINFLAMMATORY AGENT; NOOTROPIC AGENT; VACCINE;

ALZHEIMER DISEASE; CLINICAL ASSESSMENT; DEGENERATIVE DISEASE; DEMENTIA; ELECTRON MICROSCOPY; ESTROGEN THERAPY; HISTOLOGY; HISTORY OF MEDICINE; HUMAN; IMMUNOTHERAPY; MEDICAL RESEARCH; MENINGOENCEPHALITIS; MOLECULAR GENETICS; MORPHOLOGY; NEUROFIBRILLARY TANGLE; NEUROIMAGING; NEUROPATHOLOGY; PATHOGENESIS; PATHOPHYSIOLOGY; PHYSICIAN; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE;

ALZHEIMER DISEASE; BIOMEDICAL RESEARCH; BRAIN; HISTORY, 20TH CENTURY; HUMANS; MEDICAL ILLUSTRATION; PORTRAITS;

EID: 33750510024     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-006-0578-3     Document Type: Review

References (191)

1. PS Aisen 2005 The development of anti-amyloid therapy for Alzheimer's disease: from secretase modulators to polymerisation inhibitors CNS Drugs 19 989 996
2. P Alexopoulos T Grimmer R Perneczky G Domes A Kurz 2006 Progression to dementia in clinical subtypes of mild cognitive impairment Dement Geriatr Cogn Disord 22 27 34
3. C Alf C Bancher T Benke K Berek G Bertha T Bodner A Croy P Dal-Bianco F Fazekas P Fischer G Fruhwürth G Gatterer H Hinterhuber D Imarhiagbe M Krautgartner A Jaksch K Jellinger M Kalousek G Ladurner F Leblhuber A Lechner A Lingg J Marksteiner T Nakajima G Psota M Rainer G Ransmayr F Reisecker E Rumpl R Schmidt T Walch A Walter J Wancata 2004 Konsensus-Statement "Demenz" der Österr. Alzheimer Gesellschaft Mitteilg ÖGN 18 39 46
4. Alf C, Bancher C, Benke K, Berek K, Bodner T, Croy A, Dal-Bianco P, Fischer P, Fruhwürth G, Gatterer G, Grossmann J, Hinterhuber H, Imarhiagbe D, Kapeller P, Krautgartner M, Jaksch A, Jellinger K, Kalousek M, Ladurner G, Leblhuber F, Lechner A, Lingg A, Marksteiner J, Nakajima T, Psota G, Rainer M, Ransmayr G, Reisecker F, Schmidt R, Spatt J, Walch T, Walter A, Wancata J, Winkler A (2006) Konsensusstatement "Demenz" der Österreichischen Alzheimer Gesellschaft - Update 2006 (in press)
5. A Alzheimer 1898 Neuere Arbeiten über die Dementia senilis und die auf atheromatöser Gefässerkrankung basierenden Gehirnkrankheiten Monat Psychiatr Neurol 3 101 115
6. A Alzheimer 1907 Über eine eigenartige Erkrankung der Hirnrinde Allgem Z Psychiatr-Gerich Med 64 146 148
7. A Alzheimer 1911 Über eigenartige Krankheitsfälle des späteren Alters Z Gesamte Neurol Psychiatr 4 356 385
8. Alzheimer Disease & Frontotemporal Dementia Mutation Database (2006) http://www.molgen.ua.ac.be/ADMutations, accessed Sept 6, 2006
9. Alzheimer's Disease Management Council Clinical Consensus Panel (2006) Alzheimer's disease: risk stratification, patient evaluation, and outcome - effective pharmacologic therapy - year 2004 clinical update. Available at: http://www.ahcpub.com, accessed March 28, 2006
10. American Psychiatric Association 1994 Diagnostic and Statistical Manual of Mental Disorders 4 American Psychiatric Association Washington, DC
11. Arshavsky YI (2006) Alzheimer's disease, brain immune privilege and memory: a hypothesis. J Neural Transm Epub ahead of print: DOI: 10.1007/s00702-006-0524-4
12. J Attems KA Jellinger F Lintner 2005 Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy Acta Neuropathol (Berl) 110 222 231
13. L Bäckman S Jones AK Berger EJ Laukka BJ Small 2005 Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis Neuropsychology 19 520 531
14. A Barret 1913 A case of Alzheimer's disease with unusual neurological disturbances J Nerv Ment Dis 40 361 374
15. TG Beach 1987 The history of Alzheimer's disease: three debates J Hist Med Allied Sci 42 327 349
16. DA Bennett DM Holtzman 2005 Immunization therapy for Alzheimer disease? Neurology 64 10 12
17. DA Bennett JA Schneider Z Arvanitakis JF Kelly NT Aggarwal RC Shah RS Wilson 2006 Neuropathology of older persons without cognitive impairment from two community-based studies Neurology 66 1837 1844
18. NC Berchtold CW Cotman 1998 Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s Neurobiol Aging 19 173 189
19. Bick K, Amaducci LA (1987) The early story of Alzheimer's disease: Translation of the Historical Papers by Alois Alzheimer, Oskar Fischer, Francesco Bonfiglio, Emil Kraepelin, and Gaetano Perusini. Liviana Press, Padova
20. KL Bick 1999 The early story of Alzheimer disease RD Terry R Katzman KL Bick S Sisodia Alzheimer Disease 2 Lippincott-Williams & Wilkins Baltimore 1 10
21. Birks J (2006) Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev: CD005593
22. I Blasko G Kemmler W Krampla S Jungwirth I Wichart K Jellinger KH Tragl P Fischer 2005 Plasma amyloid beta protein 42 in non-demented persons aged 75 years: effects of concomitant medication and medial temporal lobe atrophy Neurobiol Aging 26 1135 1143
23. K Blennow MJ de Leon H Zetterberg 2006 Alzheimer's disease Lancet 368 387 403
24. G Blessed BE Tomlinson M Roth 1968 The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects Br J Psychiatry 114 797 811
25. P Blocq G Marinesco 1892 Sur les lésions et la pathogénie de l'épilepsie dite essentielle Sem Med 12 445 446
26. DR Borchelt PC Wong SS Sisodia DL Price 1998 Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis Brain Pathol 8 735 757
27. DM Bowen CB Smith AN Davison 1973 Molecular changes in senile dementia Brain 96 849 856
28. PA Boyle RS Wilson NT Aggarwal Y Tang DA Bennett 2006 Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline Neurology 67 441 445
29. H Braak E Braak 1991 Neuropathological staging of Alzheimer-related changes Acta Neuropathol (Berl) 82 239 259
30. H Braak I Alafuzoff T Arzberger H Kretzschmar K Del Tredici 2006 Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry Acta Neuropathol (Berl) 112 4 389 404
31. EM Castano AE Roher CL Esh TA Kokjohn T Beach 2006 Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects Neurol Res 28 155 163
32. M Citron 2004 Strategies for disease modification in Alzheimer's disease Nat Rev Neurosci 5 677 685
33. CW Cotman WW Poon RA Rissman M Blurton-Jones 2005 The role of caspase cleavage of tau in Alzheimer disease neuropathology J Neuropathol Exp Neurol 64 104 112
34. JT Coyle DL Price MR DeLong 1983 Alzheimer's disease: a disorder of cortical cholinergic innervation Science 219 1184 1190
35. P Cupers J Sautter A Vanvossel 2006 European Union research policy and funding for Alzheimer disease Nat Med 12 774 775
36. P Davies AJF Maloney 1976 Letter to the editor: selective loss of central cholinergic neurons in Alzheimer's disease Lancet II 1403
37. AJ de Craen J Gussekloo B Vrijsen RG Westendorp 2005 Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia Am J Epidemiol 161 114 120
38. A Delacourte JP David N Sergeant L Buee A Wattez P Vermersch F Ghozali C Fallet-Bianco F Pasquier F Lebert H Petit C Di Menza 1999 The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease Neurology 52 1158 1165
39. A Delacourte N Sergeant D Champain A Wattez CA Maurage F Lebert F Pasquier JP David 2002 Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease Neurology 59 398 407
40. A Delacourte 2005 Alzheimer's disease: a true tauopathy fueled by amyloid precursor protein dysfunction I Hanin R Cacabelos A Fisher Recent Progress in Alzheimer's and Parkinson's Diseases Taylor & Francis New York 301 307
41. P Divry 1927 Étude histochemique des plaques séniles J Belg Neur Psychiatr 27 643 657
42. DA Drachman AK Ommaya 1964 Memory and the Hippocampal Complex Arch Neurol 10 411 425
43. C Duyckaerts DW Dickson 2003 Neuropathology of Alzheimer's disease DW Dickson Neurodegeneration The molecular pathology of dementia and movement disorders ISN Neuropath Press Basel 47 65
44. S Engelborghs K De Vreese T Van de Casteele H Vanderstichele B Van Everbroeck P Cras JJ Martin E Vanmechelen PP De Deyn 2006 Evaluation of a CSF-biomarker panel in autopsy-confirmed dementia (Abstr) Eur J Neurol 13 Suppl 2 31
45. I Ferrer M Boada Rovira ML Sanchez Guerra MJ Rey F Costa-Jussa 2004 Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease Brain Pathol 14 11 20
46. CP Ferri M Prince C Brayne H Brodaty L Fratiglioni M Ganguli K Hall K Hasegawa H Hendrie Y Huang A Jorm C Mathers PR Menezes E Rimmer M Scazufca 2005 Global prevalence of dementia: a Delphi consensus study Lancet 366 2112 2117
47. O Fischer 1907 Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmässige Veränderung der Hirnrinde bei seniler Demenz Monat Psychiatr Neurol 22 361 372
48. M Flirski T Sobow 2005 Biochemical markers and risk factors of Alzheimer's disease Curr Alzheimer Res 2 47 64
49. PT Francis AM Palmer M Snape GK Wilcock 1999 The cholinergic hypothesis of Alzheimer's disease: a review of progress J Neurol Neurosurg Psychiatry 66 137 147
50. S Fuller 1912 Alzheimer's disease (senium praecox): The report of a case and review of published cases J Nerv Ment Dis 440-455 536 557
51. JE Galvin KK Powlishta K Wilkins DW [tmp] McKeel Jr C Xiong E Grant M Storandt JC Morris 2005 Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study Arch Neurol 62 758 765
52. D Games M Buttini D Kobayashi D Schenk P Seubert 2006 Mice as models: Transgenic approaches and Alzheimer's disease J Alzheimers Dis 9 133 149
53. SG Gauthier 2005 Alzheimer's disease: the benefits of early treatment Eur J Neurol 12 Suppl 3 11 16
54. N Gellerstedt 1933 Zur Kenntnis der Hirnveränderungen bei der normalen Altersinvolution Upsala Läk-Fören Förh 38 193 408
55. GG Glenner CW Wong 1984 Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochem Biophys Res Commun 120 885 890
56. D Goldgaber 2006 My story: the discovery and mapping to chromosome 21 of the Alzheimer amyloid gene J Alzheimers Dis 9 Suppl 3 349 360
57. MB Graeber S Kosel R Egensperger RB Banati U Muller K Bise P Hoff HJ Moller K Fujisawa P Mehraein 1997 Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis Neurogenetics 1 73 80
58. MB Graeber P Mehraein 1999 Reanalysis of the first case of Alzheimer's disease Eur Arch Psychiatry Clin Neurosci 249 Suppl 3 10 13
59. Graeber MB (2006) Alois Alzheimer (1864-1915). Internet http://www.ibro.info/Pub_Main_Display.asp?Main_Id=34
60. I Grundke-Iqbal K Iqbal M Quinlan YC Tung MS Zaidi HM Wisniewski 1986 Microtubule-associated protein tau. A component of Alzheimer paired helical filaments J Biol Chem 261 6084 6089
61. E Grünthal 1926 Über die Alzheimerische Krankheit: Eine histopathologisch-klinische Studie Z Gesamte Neurol Psychiatr 101 129 157
62. AL Guillozet S Weintraub DC Mash MM Mesulam 2003 Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment Arch Neurol 60 729 736
63. C Haass MG Schlossmacher AY Hung C Vigo-Pelfrey A Mellon BL Ostaszewski I Lieberburg EH Koo D Schenk DB Teplow 1992 Amyloid beta-peptide is produced by cultured cells during normal metabolism Nature 359 322 325
64. H Hampel A Mitchell K Blennow RA Frank S Brettschneider L Weller HJ Moller 2004 Core biological marker candidates of Alzheimer's disease - perspectives for diagnosis, prediction of outcome and reflection of biological activity J Neural Transm 111 247 272
65. L Hansen D Salmon D Galasko E Masliah R Katzman R DeTeresa L Thal MM Pay R Hofstetter M Klauber 1990 The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity Neurology 40 1 8
66. J Hardy 2004 Genetics of Alzheimer's disease and related disorders RW Richter B Zoeller-Richter Current clinical neurology Alzheimer's disease: A Physician's Guide tp Practical Management Humana Press Inc. Totowa, NJ 3 20
67. JA Hardy GA Higgins 1992 Alzheimer's disease: the amyloid cascade hypothesis Science 256 184 185
68. J Hardy K Cullen 2006 Amyloid at the blood vessel wall Nat Med 12 756 757
69. K Herholz D Perani JC Morris 2006 The Dementias: Early Diagnosis and Evaluation Taylor & Francis New York
70. LL Heston AR Mastri 1977 The genetics of Alzheimer's disease: associations with hematologic malignancy and Down's syndrome Arch Gen Psychiatry 34 976 981
71. C Hock U Konietzko JR Streffer J Tracy A Signorell B Muller-Tillmanns U Lemke K Henke E Moritz E Garcia MA Wollmer D Umbricht DJ de Quervain M Hofmann A Maddalena A Papassotiropoulos RM Nitsch 2003 Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease Neuron 38 547 554
72. RJ Hodes 2006 Public funding for Alzheimer disease research in the United States Nat Med 12 770 773
73. BT Hyman GW Van Hoesen AR Damasio CL Barnes 1984 Alzheimer's disease: cell-specific pathology isolates the hippocampal formation Science 225 1168 1170
74. BT Hyman JQ Trojanowski 1997 Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease J Neuropathol Exp Neurol 56 1095 1097
75. BT Hyman JH Growdon 2006 Can the immune system fight Alzheimer disease? Nat Med 12 755 756 discussion 756
76. K Iqbal M Flory S Khatoon H Soininen T Pirttila M Lehtovirta I Alafuzoff K Blennow N Andreasen E Vanmechelen I Grundke-Iqbal 2005 Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers Ann Neurol 58 748 757
77. K Iqbal I Grundke-Iqbal 2006 Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: A personal historical perspective J Alzheimers Dis 9 219 242
78. MC Irizarry 2004 Biomarkers of Alzheimer disease in plasma NeuroRx 1 226 234
79. T Iwatsubo Y Ihara I Kanazawa 2006 Alzheimer disease research in Japan: public funding Nat Med 12 778 779
80. W Jagust A Gitcho F Sun B Kuczynski D Mungas M Haan 2006 Brain imaging evidence of preclinical Alzheimer's disease in normal aging Ann Neurol 59 673 681
81. V Jelic M Kivipelto B Winblad 2006 Clinical trials in mild cognitive impairment: lessons for the future J Neurol Neurosurg Psychiatry 77 429 438
82. Jellinger KA (2003a) Neuropathology of Alzheimer disease and clinical relevance. In: Iqbal K, Winblad B (eds) Alzheimer's disease and related disorders: research advances. Ana Aslan Intl Acad. Aging Bucharest, Romania, pp 153-169
83. KA Jellinger 2003b Plaque-predominant and tangle-predominant variants of Alzheimer's disease DW Dickson Neurodegeneration: the molecular pathology of dementia and movement disorders ISN Neuropath Press Basel 66 68
84. KA Jellinger 2004 Pathology and pathophysiology of vascular cognitive impairment. A critical update Panminerva Med 46 217 226
85. KA Jellinger 2005 Understanding the pathology of vascular cognitive impairment J Neurol Sci 229-230 57 63
86. KA Jellinger 2006a A view on early diagnosis of dementias from neuropathology K Herholz C Morris D Perani The Dementias: early diagnosis and evaluation Taylor & Francis New York 311 428
87. Jellinger KA (2006b) Alzheimer: Meilensteine aus hundert Jahren wissenschaftlicher und klinischer Forschung. AKA, Berlin
88. Jellinger KA (2006c) The enigma of mixed dementia. Alzheimer's & Dementia (in press)
89. GA Jervis SE Soltz 1936 Alzheimer's disease: The so-called juvenile form Am J Psychiatr 93 39 56
90. L Jönssön C Berr 2005 Cost of dementia in Europe Eur J Neurol 12 Suppl 1 50 53
91. M Jucker K Beyreuther C Haass RM Nitsch Y Christen 2006 Alzheimer: 100 years and beyond Springer Berlin Heidelberg New York
92. H Kaduszkiewicz T Zimmermann HP Beck-Bornholdt H van den Bussche 2005 Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials BMJ 331 321 327
93. T Katsuno M Morishima-Kawashima Y Saito H Yamanouchi S Ishiura S Murayama Y Ihara 2005 Independent accumulations of tau and amyloid beta-protein in the human entorhinal cortex Neurology 64 687 692
94. R Katzman 1976 Editorial: The prevalence and malignancy of Alzheimer disease. A major killer Arch Neurol 33 217 218
95. R Katzman K Bick 2000 Alzheimer disease. The changing view Academic Press San Diego
96. ZS Khachaturian 1985 Diagnosis of Alzheimer's disease Arch Neurol 42 1097 1105
97. ZS Khachaturian 2005 Diagnosis of Alzheimer's disease: two decades of progress Alzheimers Dementia 1 93 98
98. ZS Khachaturian 2006 Diagnosis of Alzheimer's disease: two-decades of progress J Alzheimers Dis 9 409 415
99. M Kidd 1963 Paired helical filaments in electron microscopy of Alzheimer's disease Nature 197 192 193
100. M Kidd 2006 The history of the paired helical filaments J Alzheimers Dis 9 71 75
101. S Kins K Beyreuther 2006 Teasing out the tangles Nat Med 12 764 765 discussion 765
102. HH Klünemann W Fronhofer H Wurster W Fischer B Ibach HE Klein 2002 Alzheimer's second patient: Johann F. and his family Ann Neurol 52 520 523
103. WE Klunk H Engler A Nordberg Y Wang G Blomqvist DP Holt M Bergstrom I Savitcheva GF Huang S Estrada B Ausen ML Debnath J Barletta JC Price J Sandell BJ Lopresti A Wall P Koivisto G Antoni CA Mathis B Langstrom 2004 Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B Ann Neurol 55 306 319
104. DS Knopman JE Parisi A Salviati M Floriach-Robert BF Boeve RJ Ivnik GE Smith DW Dickson KA Johnson LE Petersen WC [tmp] McDonald H Braak RC Petersen 2003 Neuropathology of cognitively normal elderly J Neuropathol Exp Neurol 62 1087 1095
105. E Kraepelin 1910 Psychiatrie: ein Lehrbuch für Studierende und Ärzte. II. Band, Klinische Psychiatrie Verlag Johann Ambrosius Barth Leipzig
106. A Kurz J Diehl M Riemenschneider R Perneczky N Lautenschlager 2004 [Mild cognitive disorder. Questions of definition, diagnosis, prognosis and therapy] Nervenarzt 75 6 15
107. JMM Lage 2006 100 years of Alzheimer's disease (1906-2006) J Alzheimers Dis 9 3 Suppl 15 26
108. S Lesne MT Koh L Kotilinek R Kayed CG Glabe A Yang M Gallagher KH Ashe 2006 A specific amyloid-beta protein assembly in the brain impairs memory Nature 440 352 357
109. A Lleo SM Greenberg JH Growdon 2006 Current pharmacotherapy for Alzheimer's disease Annu Rev Med 57 513 533
110. W Malamud K Lowenberg 1929 Alzheimer's disease: a contribution to its etiology and classification Arch Neurol Psychiat 21 805 827
111. A Mandavilli 2006 The amyloid code Nat Med 12 747 751
112. WR Markesbery FA Schmitt RJ Kryscio DG Davis CD Smith DR Wekstein 2006 Neuropathologic substrate of mild cognitive impairment Arch Neurol 63 38 46
113. CL Masters G Simms NA Weinman G Multhaup BL [tmp] McDonald K Beyreuther 1985 Amyloid plaque core protein in Alzheimer disease and Down syndrome Proc Natl Acad Sci USA 82 4245 4249
114. CL Masters K Beyreuther 2006 Pathways to the discovery of the Aβ amyloid of Alzheimer's disease J Alzheimers Dis 9 Suppl 3 155 161
115. K Maurer S Volk H Gerbaldo 1997 Auguste D and Alzheimer's disease Lancet 349 1546 1549
116. K Maurer U Maurer 2003 Alzheimer: The life of a physician and the career of a disease Columbia Univ Press New York
117. U Maurer K Maurer 1999 Auf den Spuren der Auguste D. Alois Alzheimer - Sein Leben und Werk Forschung Frankfurt 4 74 77
118. IG [tmp] McKeith DW Dickson J Lowe M Emre JT O'Brien H Feldman J Cummings JE Duda C Lippa EK Perry D Aarsland H Arai CG Ballard B Boeve DJ Burn D Costa T Del Ser B Dubois D Galasko S Gauthier CG Goetz E Gomez-Tortosa G Halliday LA Hansen J Hardy T Iwatsubo RN Kalaria D Kaufer RA Kenny A Korczyn K Kosaka VM Lee A Lees I Litvan E Londos OL Lopez S Minoshima Y Mizuno JA Molina EB Mukaetova-Ladinska F Pasquier RH Perry JB Schulz JQ Trojanowski M Yamada 2005 Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium Neurology 65 1863 1872
119. G [tmp] McKhann D Drachman M Folstein R Katzman D Price EM Stadlan 1984 Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 939 944
120. McShane R, Areosa Sastre A, Minakaran N (2006) Memantine for dementia. Cochrane Database Syst Rev: CD003154
121. JE Meyer 1961 Alois Alzheimer W Scholz 50 Jahre Neuropathologie in Deutschland (1885-1935) Thieme Stuttgart 67 78
122. MA Mintun GN Larossa YI Sheline CS Dence SY Lee RH Mach WE Klunk CA Mathis ST DeKosky JC Morris 2006 [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease Neurology 67 446 452
123. SS Mirra A Heyman D [tmp] McKeel SM Sumi BJ Crain LM Brownlee FS Vogel JP Hughes G van Belle L Berg 1991 The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease Neurology 41 479 486
124. HJ Möller MB Graeber 1998 The case described by Alois Alzheimer in 1911. Historical and conceptual perspectives based on the clinical record and neurohistological sections Eur Arch Psychiatry Clin Neurosci 248 111 122
125. D Morgan 2006 Immunotherapy for Alzheimer's disease J Alzheimers Dis 9 425 432
126. JH Morris Z Nagy 2004 Alzheimer's disease M Esiri VMY Lee JQ Trojanowski The neuropathology of dementia Cambridge University Press Cambridge 161 206
127. RT Mott DW Dickson JQ Trojanowski V Zhukareva VM Lee M Forman V Van Deerlin JF Ervin DS Wang DE Schmechel CM Hulette 2005 Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias J Neuropathol Exp Neurol 64 420 428
128. C Mount C Downton 2006 Alzheimer disease: progress or profit? Nat Med 12 780 784
129. RE Mrak 2002 The Big Eye in the 21st century: the role of electron microscopy in modern diagnostic neuropathology J Neuropathol Exp Neurol 61 1027 1039
130. SG Mueller MW Weiner LJ Thal RC Petersen CR Jack W Jagust JQ Trojanowski AW Toga L Beckett 2005 Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI) Alzheimer Dementia 1 55 66
131. DG Munoz DW Dickson C Bergeron IR Mackenzie A Delacourte V Zhukareva 2003 The neuropathology and biochemistry of frontotemporal dementia Ann Neurol 54 Suppl 5 S24 S28
132. MA Neumann R Cohn 1953 Incidence of Alzheimer's disease in large mental hospital; relation to senile psychosis and psychosis with cerebral arteriosclerosis AMA Arch Neurol Psychiatry 69 615 636
133. Neundörfer G, Hippius H (2003) Historischer Hintergrund der Alzheimer-Demenz. Alois Alzheimer - sein Name im Kontext der Erkrankung. In: Hampel H, Padberg F, Moeller HJ (eds) Alzheimer-Demenz. Klinische Verläufe, diagnostische Möglichkeiten, moderne Therapiestrategien. Wissenschaftliche Verlagsges. Stuttgart, pp 1-13
134. Newton RD (1948) The identity of Alzheimer's disease and senile dementia and their relationship to senility. J Ment Sci: 225-248
135. JA Nicoll D Wilkinson C Holmes P Steart H Markham RO Weller 2003 Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report Nat Med 9 448 452
136. J O'Brien IG [tmp] McKeith D Ames E Chiu 2006 Dementia with Lewy Bodies and Parkinson's Disease Dementia Taylor & Francis New York
137. JM Orgogozo S Gilman JF Dartigues B Laurent M Puel LC Kirby P Jouanny B Dubois L Eisner S Flitman BF Michel M Boada A Frank C Hock 2003 Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization Neurology 61 46 54
138. S Pantelakis 1954 (A particular type of senile angiopathy of the central nervous system: congophilic angiopathy, topography and frequency.) Monatsschr Psychiatr Neurol 128 219 256
139. EK Perry BE Tomlinson G Blessed K Bergmann PH Gibson RH Perry 1978 Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia Br Med J 2 1457 1459
140. G Perusini 1910 Über klinisch und histologisch eigenartige psychische Erkrankungen des späteren Lebensalters F Nissl A Alzheimer Histologische und histopathologische Arbeiten Fischer Jena
141. RC Petersen 2003 Mild Cognitive Impairment: Aging to Alzheimer's Disease Oxford University Press Oxford
142. RC Petersen RG Thomas M Grundman D Bennett R Doody S Ferris D Galasko S Jin J Kaye A Levey E Pfeiffer M Sano CH van Dyck LJ Thal 2005 Vitamin E and donepezil for the treatment of mild cognitive impairment N Engl J Med 352 2379 2388
143. W Pickett 1904 Senile dementia: a clinical study of two hundred cases with particular regard to types of the disease J Nerv Ment Dis 31 81 88
144. F Portet PJ Ousset PJ Visser GB Frisoni F Nobili P Scheltens B Vellas J Touchon 2006 Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease J Neurol Neurosurg Psychiatry 77 714 718
145. E Redlich 1898 über miliare Sklerosen der hirnrinde bei seniler Atrophie Jahrb Psychiatr Neurol 17 208 216
146. KP Riley DA Snowdon WR Markesbery 2002 Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study Ann Neurol 51 567 577
147. GC Román TK Tatemichi T Erkinjuntti JL Cummings JC Masdeu JH Garcia L Amaducci JM Orgogozo A Brun A Hofman 1993 Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop Neurology 43 250 260
148. WG Rosen RC Mohs KL Davis 1984 A new rating scale for Alzheimer's disease Am J Psychiatry 141 1356 1364
149. AD Roses 2006 On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease J Alzheimers Dis 9 361 366
150. D Rothschild 1937 Pathologic changes in senile psychoses and their psychobiologic significance Am J Psychiatr 93 757 788
151. D Rothschild 1941 Clinical differentiation of senile and ateriosclerotic psychoses Am J Psychiatr 98 324 333
152. M Salkovic-Petrisic F Tribl M Schmidt S Hoyer P Riederer 2006 Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway J Neurochem 96 1005 1015
153. SW Scheff ST DeKosky DA Price 1990 Quantitative assessment of cortical synaptic density in Alzheimer's disease Neurobiol Aging 11 29 37
154. SW Scheff DA Price 2003 Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies Neurobiol Aging 24 1029 1046
155. SW Scheff DA Price 2006 Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus J Alzheimers Dis 9 101 115
156. SW Scheff DA Price FA Schmitt EJ Mufson 2006 Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment Neurobiol Aging 27 1372 1384
157. GD Schellenberg 2006 Early Alzheimer's disease genetics J Alzheimers Dis 9 367 372
158. D Schenk R Barbour W Dunn G Gordon H Grajeda T Guido K Hu J Huang K Johnson-Wood K Khan D Kholodenko M Lee Z Liao I Lieberburg R Motter L Mutter F Soriano G Shopp N Vasquez C Vandevert S Walker M Wogulis T Yednock D Games P Seubert 1999 Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 173 177
159. DJ Selkoe 2006a Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise J Alzheimers Dis 9 163 168
160. DJ Selkoe 2006b The ups and downs of Abeta Nat Med 12 758 759 discussion 759
161. SA Shumaker C Legault SR Rapp L Thal RB Wallace JK Ockene SL Hendrix BN Jones 3rd AR Assaf RD Jackson JM Kotchen S Wassertheil-Smoller J Wactawski-Wende 2003 Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial JAMA 289 2651 2662
162. T Simchowitz 1911 Histologische Studien über die senile Demenz F Nissl A Alzheimer Histologische und histopathologische Arbeiten 4 Fischer Jena 267 444
163. W Spielmeyer 1916 Alzheimers Lebenswerk Z Gesamte Neurol Psychiatr 33 1 44
164. M Storandt EA Grant JP Miller JC Morris 2006 Longitudinal course and neuropathologic outcomes in original vs. revised MCI and in pre-MCI Neurology 67 467 473
165. RD Terry 1963 The fine structure of neurofibrillary tangles in Alzheimer's disease J Neuropathol Exp Neurol 22 629 642
166. RD Terry NK Gonatas M Weiss 1964 Ultrastructural studies in Alzheimer's presenile dementia Am J Pathol 44 269 297
167. RD Terry E Masliah DP Salmon N Butters R DeTeresa R Hill LA Hansen R Katzman 1991 Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment Ann Neurol 30 572 580
168. DR Thal U Rub M Orantes H Braak 2002 Phases of A beta-deposition in the human brain and its relevance for the development of AD Neurology 58 1791 1800
169. LJ Thal K Kantarci EM Reiman WE Klunk MW Weiner H Zetterberg D Galasko D Pratico S Griffin D Schenk E Siemers 2006 The role of biomarkers in clinical trials for Alzheimer disease Alzheimer Dis Assoc Disord 20 6 15
170. The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group 1998 Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease" Neurobiol Aging 19 109 116
171. J Tian J Shi DM Mann 2004 Cerebral amyloid angiopathy and dementia Panminerva Med 46 253 264
172. P Tiraboschi MN Sabbagh LA Hansen DP Salmon A Merdes A Gamst E Masliah M Alford LJ Thal J Corey-Bloom 2004 Alzheimer disease without neocortical neurofibrillary tangles: "a second look" Neurology 62 1141 1147
173. BE Tomlinson G Blessed M Roth 1970 Observations on the brains of demented old people J Neurol Sci 11 205 242
174. JQ Trojanowski D Dickson 2001 Update on the neuropathological diagnosis of frontotemporal dementias J Neuropathol Exp Neurol 60 1123 1126
175. JT Tschanz KA Welsh-Bohmer CG Lyketsos C Corcoran RC Green K Hayden MC Norton PP Zandi L Toone NA West JC Breitner 2006 Conversion to dementia from mild cognitive disorder: the Cache County Study Neurology 67 229 234
176. JH Uyehara-Lock H Petrovich GW Ross KH Masaki DG Davis JM Hardman J Nelson WR Markesbery LR White 2005 A comparison of Braak staging with CERAD criteria for the neuropahtologic assessment of dementia Ann Neurol 58 Suppl 9 S56
177. WM van der Flier P Scheltens 2005 Epidemiology and risk factors of dementia J Neurol Neurosurg Psychiatry 76 Suppl 5 v2 v7
178. M van Oijen A Hofman HD Soares PJ Koudstaal MM Breteler 2006 Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study Lancet Neurol 5 655 660
179. H Vanderstichele G De Meyer N Andreasen V Kostanjevecki A Wallin A Olsson K Blennow E Vanmechelen 2005 Amino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment Clin Chem 51 1650 1660
180. HV Vinters 1987 Cerebral amyloid angiopathy. A critical review Stroke 18 311 324
181. RO Weller A Massey TA Newman M Hutchings YM Kuo AE Roher 1998 Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease Am J Pathol 153 725 733
182. MJ West CH Kawas WF Stewart GL Rudow JC Troncoso 2004 Hippocampal neurons in pre-clinical Alzheimer's disease Neurobiol Aging 25 1205 1212
183. J Wiltfang P Lewczuk P Riederer E Grunblatt C Hock P Scheltens H Hampel H Vanderstichele K Iqbal D Galasko L Lannfelt M Otto H Esselmann AW Henkel J Kornhuber K Blennow 2005 Consensus paper of the WFSBP Task Force on Biological
184. A Wimo L Jonsson B Winblad 2006 An estimate of the worldwide prevalence and direct costs of dementia in 2003 Dement Geriatr Cogn Disord 21 175 181
185. B Winblad A Wimo 2006 The worldwide direct costs and costs of informal care of dementia Alzheimer Dementia 2 Suppl 1 S19
186. HM Wisniewski K Iqbal 1980 Aging of the brain and dementia Trends Neurosci 3 226 228
187. HM Wisniewski A Robe W Zigman W Silverman 1989 Neuropathological diagnosis of Alzheimer disease J Neuropathol Exp Neurol 48 606 609
188. World Health Organization (1993) ICD-10 Classification of mental and behavioural disorders: diagnostic criteria for research. WHO Geneva
189. K Yaffe RC Petersen K Lindquist J Kramer B Miller 2006 Subtype of mild cognitive impairment and progression to dementia and death Dement Geriatr Cogn Disord 22 312 319
190. SK Ziolko LA Weissfeld WE Klunk CA Mathis JA Hoge BJ Lopresti ST Dekosky JC Price 2006 Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease Neuroimage 33 1 94 102
191. BV Zlokovic 2005 Neurovascular mechanisms of Alzheimer's neurodegeneration Trends Neurosci 28 202 208