β-Amyloid precursor protein: Location of transmembrane domain and specificity of γ-secretase cleavage

Journal of Biological Chemistry

Volumn 271, Issue 36, 1996, Pages 21914-21919

  Tischer, Edmund ^a   Cordell, Barbara ^a  

^a SCIOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DEGENERATIVE DISEASE; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASE SEQUENCE; CELL LINE; ENDOPEPTIDASES; GENE DELETION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0029833865     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.36.21914     Document Type: Article

References (42)

1. Selkoe, D. J. (1994) Annu. Rev. Neurosci. 17, 489-517
2. Cordell, B. (1994) Annu. Rev. Pharmacol. Toxicol 34, 69-89
3. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B., Lieberburg, I, Koo, E., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
4. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., and Younkin, S. G. (1993) Science 258, 126-129
5. Busciglio, J., Gabuzda, D. H., Matsudara, P., and Yankner, B. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2092-2096
6. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, I., and Schenk, D. (1992) Nature 359, 325-327
7. Mullan, M., Crawford, F., Houlden, H., Axelman, K., Lilius, L., Winblad, B., and Lannfelt, L. (1992) Nature Genet. 1, 345-347
8. Citron, M., Vigo-Pelfrey, C., Teplow, D. B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L., and Selkoe, D. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11993-11997
9. Cai, X. D., Golde, T. E., and Younkin, S. G. (1993) Science 259, 514-516
10. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., and Selkoe, D. J. (1992) Nature 360, 672-674
11. Haass, C., Hung, A. Y., Selkoe, D. J., and Teplow, D. B. (1994) J. Biol. Chem. 269, 17741-17748
12. Rumble, B., Retalack, R., Hilbich, C., Simms, G., Multhup, G., Martins, R., Hockey, A., Montgomery, P., Beyreuther, K., and Masters, C. L. (1989) N. Engl. J. Med. 320, 1446-1452
13. Zhong, Z., Quon, D., Higgins, L., Higaki, J., and Cordell, B. (1994) J. Biol. Chem. 269, 12179-12184
14. Quon, D., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., and Cordell, B. (1991) Nature 352, 239-241
15. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, A., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Khan, K., Lee, M., Liebowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Sorlano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B., and Zhao, J. (1995) Nature 373, 523-527
16. Higaki, J., Quon, D., Zhong, Z., and Cordell, B. (1995) Neuron 14, 651-659
17. Martin, B. L., Schrader-Fischer, G., Busciglio, J., Duke, M., Paganetti, P., and Yankner, B. A. (1995) J. Biol. Chem. 270, 26727-26730
18. Haass, C., Lemere, C. A., Capell, A., Citron, M., Seubert, P., Schenk, D., Lannfelt, L., and Selkoe, D. J. (1995) Nature Med. 1, 1291-1296
19. Sisodia, S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6075-6079
20. Zhong, Z., Higaki, J., Murakami, K., Wang, Y., Catalano, R., Quon, D., and Cordell, B. (1994) J. Biol. Chem. 269, 627-632
21. Maruyama, K., Kametani, F., Usami, M., Yamao-Harigaya, W., and Tanaka, K. (1991) Biochem. Biophys. Res. Commun. 179, 1670-1676
22. Sahasrabudhe, S. R., Spruyt, M. A., Muenkel, H. A., Blume, A. J., Vitek, M. P., and Jacobsen, J. S. (1992) J. Biol. Chem. 267, 25602-25608
23. Haass, C., and Selkoe, D. J. (1993) Cell 75, 1039-1042
24. Citron, M., Teplow, D. B., and Selkoe, D. J. (1995) Neuron 14, 661-670
25. Asami-Odaka, A., Ishibashi, Y., Kikuchi, T., Kitada, C., and Suzuki, N. (1995) Biochemistry 34, 10272-10278
26. Roher, A. E., Lowenson, J. D., Clarke, S., Woods, S., Cotter, R. J., Gowing, E., and Ball, M. J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10836-10840
27. Miller, D. L., Papayannopoulos, I. A., Styles, J., Bobin, S. A., Lin, Y. Y., Biemann, K., and Iqbal, K. (1993) .Arch. Biochem. Biophys. 301, 41-52
28. Mori, H., Takio, K., Ogawara, M., and Selkoe, D. J. (1992) J. Biol. Chem. 267, 17082-17086
29. Naslund, J., Schierhorn, A., Hellman, U., Lannfelt, L., Roses, A. D., Tjernberg, L. O., Silberring, J., Gandy, S. E., Winblad, B., Greengard, P., Nordstedt, C., and Terenius, L. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8378-8382
30. Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I., and Schenk, D. B. (1993) J. Neurochem. 61, 1965-1968
31. Blobel, G. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 1496-1500
32. Engelman, D. M., Steitz, T. A., and Goldman, A. (1986) Annu. Rev. Biophys. Biophys. Chem. 15, 321-353
33. Coussens, L., Yang, L., Feng, T. L., Liao, Y. L., Chen, E., Grey, A., McGrath, J., Seeburg, P. H., Libermann, T. A., Schlessinger, J., Francke, U., Levinson, A., and Ullrich, A. (1985) Science 230, 1132-1129
34. Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M., and Hardy, J. (1991) Nature 349, 704-706
35. Murrell, J., Farlow, M., Ghetti, B., and Benson, M. D. (1991) Science 254, 97-99
36. Roth, G. S., Joseph, J. A., and Mason, R. P. (1995) Trends Neurosci. 18, 203-306
37. Ishiura, S., Nishikawa, T., Tsukahara, T., Momoi, T., Ito, H., Suzuki, K., and Sugita, H. (1990) Neurosci. Lett. 115, 329-334
38. Mundy, D. (1994) Biochem. Biophys. Res. Commun. 204, 333-341
39. Ladror, U. S., Snyder, S. W., Wang, G. T., Holzman, T. F., and Krafft, G. A. (1994) J. Biol. Chem. 269, 18422-18428
40. Evin, G., Cappai, R., Li, Q.-X., Culvenor, J. G., Small, D. H., Beyreuther, K., and Masters, C. L. (1995) Biochem. 34, 14185-14192
41. Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., and Muller-Hill, B. (1987) Nature 325, 733-736
42. Bretscher, M. S., and Munro, S. (1993) Science 261, 1280-1281