-
1
-
-
0035870150
-
Characterization of high-affinity binding between gangliosides and amyloid beta-protein
-
Ariga, T., K. Kobayashi, A. Hasegawa, M. Kiso, H. Ishida, and T. Miyatake. 2001. Characterization of high-affinity binding between gangliosides and amyloid beta-protein. Arch. Biochem. Biophys. 388:225-230.
-
(2001)
Arch. Biochem. Biophys.
, vol.388
, pp. 225-230
-
-
Ariga, T.1
Kobayashi, K.2
Hasegawa, A.3
Kiso, M.4
Ishida, H.5
Miyatake, T.6
-
2
-
-
0030928650
-
Lipid binding to amyloid beta-peptide aggregates: Preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids
-
Avdulov, N.A., S.V. Chochina, U. Igbavboa, C.S. Warden, A.V. Vassiliev, and W.G. Wood. 1997. Lipid binding to amyloid beta-peptide aggregates: preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids. J. Neurochem. 69:1746-1752.
-
(1997)
J. Neurochem.
, vol.69
, pp. 1746-1752
-
-
Avdulov, N.A.1
Chochina, S.V.2
Igbavboa, U.3
Warden, C.S.4
Vassiliev, A.V.5
Wood, W.G.6
-
3
-
-
0036500554
-
Conversion of raft associated prion protein to the protease-resisrant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes
-
Baron, G.S., K. Wehrly, D.W. Dorward, B. Chesebro, and B. Caughey. 2002. Conversion of raft associated prion protein to the protease-resisrant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J. 21:1031-1040.
-
(2002)
EMBO J.
, vol.21
, pp. 1031-1040
-
-
Baron, G.S.1
Wehrly, K.2
Dorward, D.W.3
Chesebro, B.4
Caughey, B.5
-
4
-
-
0035815635
-
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
-
Benjannet, S., A. Elagoz, L. Wickham, M. Mamarbachi, J.S. Munzer, A. Basak, C. Lazure, J.A. Cromlish, S. Sisodia, F. Checler, et al. 2001. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem. 276:10879-10887.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10879-10887
-
-
Benjannet, S.1
Elagoz, A.2
Wickham, L.3
Mamarbachi, M.4
Munzer, J.S.5
Basak, A.6
Lazure, C.7
Cromlish, J.A.8
Sisodia, S.9
Checler, F.10
-
5
-
-
0029932417
-
Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties
-
Bouillot, C., A. Prochiantz, G. Rougon, and B. Allinquant. 1996. Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties. J. Biol. Chem. 271:7640-7644.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7640-7644
-
-
Bouillot, C.1
Prochiantz, A.2
Rougon, G.3
Allinquant, B.4
-
6
-
-
0031558768
-
Structure of detergent-resistant membrane domains: Does phase separation occur in biological membranes?
-
Brown, D.A., and E. London. 1997. Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? Biochem. Biophys. Res. Commun. 240:1-7.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.240
, pp. 1-7
-
-
Brown, D.A.1
London, E.2
-
7
-
-
14444272986
-
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum, J.D., K.N. Liu, Y. Luo, J.L. Slack, K.L. Stocking, J.J. Peschon, R.S. Johnson, B.J. Castner, D.P. Cerretti, and R.A. Black. 1998. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273:27765-27767.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
Peschon, J.J.6
Johnson, R.S.7
Castner, B.J.8
Cerretti, D.P.9
Black, R.A.10
-
8
-
-
0037085453
-
Apical sorting of beta-secretase limits amyloid beta-peptide production
-
Capell, A., L. Meyn, R. Fluhrer, D.B. Teplow, J. Walter, and C. Haass. 2002. Apical sorting of beta-secretase limits amyloid beta-peptide production. J. Biol. Chem. 277:5637-5643.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5637-5643
-
-
Capell, A.1
Meyn, L.2
Fluhrer, R.3
Teplow, D.B.4
Walter, J.5
Haass, C.6
-
9
-
-
0023711798
-
Calcium phosphate-mediated gene transfer: A highly efficient transfection system for stably transforming cells with plasmid DNA
-
Chen, C.A., and H. Okayama. 1988. Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques. 6:632-638.
-
(1988)
Biotechniques
, vol.6
, pp. 632-638
-
-
Chen, C.A.1
Okayama, H.2
-
10
-
-
0035028703
-
Floating the raft hypothesis: The roles of lipid rafts in B cell antigen receptor function
-
Cheng, P.C., A. Cherukuri, M. Dykstra, S. Malapati, T. Sproul, M.R. Chen, and S.K. Pierce. 2001. Floating the raft hypothesis: the roles of lipid rafts in B cell antigen receptor function. Semin. Immunol. 13:107-114.
-
(2001)
Semin. Immunol.
, vol.13
, pp. 107-114
-
-
Cheng, P.C.1
Cherukuri, A.2
Dykstra, M.3
Malapati, S.4
Sproul, T.5
Chen, M.R.6
Pierce, S.K.7
-
11
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder, E.H., A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, A.D. Roses, J.L. Haines, and M.A. Pericak-Vance. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:921-923.
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
12
-
-
0028036513
-
Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
-
Damke, H., T. Baba, D.E. Warnock, and S.L. Schmid. 1994. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J. Cell Biol. 127:915-934.
-
(1994)
J. Cell Biol.
, vol.127
, pp. 915-934
-
-
Damke, H.1
Baba, T.2
Warnock, D.E.3
Schmid, S.L.4
-
13
-
-
0035192073
-
Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing
-
Daugherty, B.L., and S.A. Green. 2001. Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing. Traffic. 2:908-916.
-
(2001)
Traffic
, vol.2
, pp. 908-916
-
-
Daugherty, B.L.1
Green, S.A.2
-
14
-
-
0034049944
-
Proteolytic processing and cell biological functions of the amyloid precursor protein
-
De Strooper, B., and W. Annaert. 2000. Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci. 113:1857-1870.
-
(2000)
J. Cell Sci.
, vol.113
, pp. 1857-1870
-
-
De Strooper, B.1
Annaert, W.2
-
15
-
-
0036293424
-
Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas
-
Ehehalt, R., B. Michel, D. De Pietri Tonelli, D. Zacchetti, K. Simons, and P. Keller. 2002. Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas. Biochem. Biophys. Res. Commun. 293:30-37.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 30-37
-
-
Ehehalt, R.1
Michel, B.2
De Pietri Tonelli, D.3
Zacchetti, D.4
Simons, K.5
Keller, P.6
-
16
-
-
0035943345
-
A portrait of Alzheimer secretases - New features and familiar faces
-
Esler, W.P., and M.S. Wolfe. 2001. A portrait of Alzheimer secretases - new features and familiar faces. Science. 293:1449-1454.
-
(2001)
Science
, vol.293
, pp. 1449-1454
-
-
Esler, W.P.1
Wolfe, M.S.2
-
17
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
-
Fassbender, K., M. Simons, C. Bergmann, M. Stroick, D. Lutjohann, P. Keller, H. Runz, S. Kuhl, T. Bertsch, K. von Bergmann, et al. 2001. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad Sci. USA. 98:5856-5861.
-
(2001)
Proc. Natl. Acad Sci. USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
Stroick, M.4
Lutjohann, D.5
Keller, P.6
Runz, H.7
Kuhl, S.8
Bertsch, T.9
Von Bergmann, K.10
-
18
-
-
0027257099
-
Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells
-
Fiedler, K., T. Kobayashi, T.V. Kurzchalia, and K. Simons. 1993. Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. Biochemistry. 32:6365-6373.
-
(1993)
Biochemistry
, vol.32
, pp. 6365-6373
-
-
Fiedler, K.1
Kobayashi, T.2
Kurzchalia, T.V.3
Simons, K.4
-
19
-
-
0034632034
-
Evidence that dynamin-2 functions as a signal-transducing GTPase
-
Fish, K.N., S.L. Schmid, and H. Damke. 2000. Evidence that dynamin-2 functions as a signal-transducing GTPase. J. Cell Biol. 150:145-154.
-
(2000)
J. Cell Biol.
, vol.150
, pp. 145-154
-
-
Fish, K.N.1
Schmid, S.L.2
Damke, H.3
-
20
-
-
0026735070
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
-
Haass, C., E.H. Koo, A. Mellon, A.Y. Hung, and D.J. Selkoe. 1992. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357:500-503.
-
(1992)
Nature
, vol.357
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
21
-
-
0031750335
-
Lipid domain structure of the plasma membrane revealed by patching of membrane components
-
Harder, T., P. Scheiffele, P. Verkade, and K. Simons. 1998. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141:929-942.
-
(1998)
J. Cell Biol.
, vol.141
, pp. 929-942
-
-
Harder, T.1
Scheiffele, P.2
Verkade, P.3
Simons, K.4
-
22
-
-
0032478271
-
A simplified system for generating recombinant adenoviruses
-
He, T.C., S. Zhou, L.T. da Costa, J. Yu, K.W. Kinzler, and B. Vogelstein. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA. 95:2509-2514.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2509-2514
-
-
He, T.C.1
Zhou, S.2
Da Costa, L.T.3
Yu, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
23
-
-
0032489879
-
Dynamin-mediated internalization ofcaveolae
-
Henley, J.R., E.W. Krueger, B.J. Oswald, and M.A. McNiven. 1998. Dynamin-mediated internalization ofcaveolae. J. Cell Biol. 141:85-99.
-
(1998)
J. Cell Biol.
, vol.141
, pp. 85-99
-
-
Henley, J.R.1
Krueger, E.W.2
Oswald, B.J.3
McNiven, M.A.4
-
24
-
-
17344377424
-
A novel rab5 GDP/GTP exchange factor complexed to rabaptin-5 links nucleotide exchange to effector recruitment and function
-
Horiuchi, H., R. Lippe, H.M. McBride, M. Rubino, P. Woodman, H. Stenmark, V. Rybin, M. Wilm, K. Ashman, M. Mann, and M. Zerial. 1997. A novel rab5 GDP/GTP exchange factor complexed to rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 90:1149-1159.
-
(1997)
Cell
, vol.90
, pp. 1149-1159
-
-
Horiuchi, H.1
Lippe, R.2
McBride, H.M.3
Rubino, M.4
Woodman, P.5
Stenmark, H.6
Rybin, V.7
Wilm, M.8
Ashman, K.9
Mann, M.10
Zerial, M.11
-
25
-
-
0034721842
-
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
-
Huse, J.T., D.S. Pijak, G.J. Leslie, V.M. Lee, and R.W. Doms. 2000. Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J. Biol. Chem. 275:33729-33737.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.4
Doms, R.W.5
-
26
-
-
0032727709
-
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
-
Janes, P.W., S.C. Ley, and A.I. Magee. 1999. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147:447-461.
-
(1999)
J. Cell Biol.
, vol.147
, pp. 447-461
-
-
Janes, P.W.1
Ley, S.C.2
Magee, A.I.3
-
27
-
-
0033998793
-
The role of lipid rafts in T cell antigen receptor (TCR) signalling
-
Janes, P.W., S.C. Ley, A.I. Magee, and P.S. Kabouridis. 2000. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin. Immunol. 12:23-34.
-
(2000)
Semin. Immunol.
, vol.12
, pp. 23-34
-
-
Janes, P.W.1
Ley, S.C.2
Magee, A.I.3
Kabouridis, P.S.4
-
28
-
-
0034638746
-
Statins and the risk of dementia
-
Jick, H., G.L. Zornberg, S.S. Jick, S. Seshadri, and D.A. Drachman. 2000. Statins and the risk of dementia. Lancet. 356:1627-1631.
-
(2000)
Lancet
, vol.356
, pp. 1627-1631
-
-
Jick, H.1
Zornberg, G.L.2
Jick, S.S.3
Seshadri, S.4
Drachman, D.A.5
-
29
-
-
0035816709
-
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid
-
Kakio, A., S.I. Nishimoto, K. Yanagisawa, Y. Kozutsumi, and K. Matsuzaki. 2001. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid. J. Biol. Chem. 276: 24985-24990.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24985-24990
-
-
Kakio, A.1
Nishimoto, S.I.2
Yanagisawa, K.3
Kozutsumi, Y.4
Matsuzaki, K.5
-
30
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
-
Kamal, A., A. Almenar-Queralt, J.F. LeBlanc, E.A. Roberts, and L.S. Goldstein. 2001. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 414:643-648.
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.5
-
31
-
-
0035897938
-
Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study
-
Kivipelto, M., E.L. Helkala, M.P. Laakso, T. Hanninen, M. Hallikainen, K. Alhainen, H. Soininen, J. Tuomilehto, and A. Nissinen. 2001. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ. 322:1447-1451.
-
(2001)
BMJ
, vol.322
, pp. 1447-1451
-
-
Kivipelto, M.1
Helkala, E.L.2
Laakso, M.P.3
Hanninen, T.4
Hallikainen, M.5
Alhainen, K.6
Soininen, H.7
Tuomilehto, J.8
Nissinen, A.9
-
32
-
-
0037013148
-
Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor
-
Klopfenstein, D.R., M. Tomishige, N. Stuurman, and R.D. Vale. 2002. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell. 109:347-358.
-
(2002)
Cell
, vol.109
, pp. 347-358
-
-
Klopfenstein, D.R.1
Tomishige, M.2
Stuurman, N.3
Vale, R.D.4
-
33
-
-
0033569653
-
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
-
Koike, H., S. Tomioka, H. Sorimachi, T.C. Saido, K. Maruyama, A. Okuyama, A. Fujisawa-Sehara, S. Ohno, K. Suzuki, and S. Ishiura. 1999. Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem. J. 343:371-375.
-
(1999)
Biochem. J.
, vol.343
, pp. 371-375
-
-
Koike, H.1
Tomioka, S.2
Sorimachi, H.3
Saido, T.C.4
Maruyama, K.5
Okuyama, A.6
Fujisawa-Sehara, A.7
Ohno, S.8
Suzuki, K.9
Ishiura, S.10
-
34
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-ecretase ADAM 10
-
Kojro, E., G. Gimpl, S. Lammich, W. Marz, and F. Fahrenholz. 2001. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-ecretase ADAM 10. Proc. Natl. Acad. Sci. USA. 98:5815-5820.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
Gimpl, G.2
Lammich, S.3
Marz, W.4
Fahrenholz, F.5
-
35
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo, E.H., and S.L. Squazzo. 1994. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J. Biol. Chem. 269:17386-17389.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
36
-
-
0032573572
-
Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels
-
Kuo, Y.M., M.R. Emmerling, C.L. Bisgaier, A.D. Essenburg, H.C. Lampert, D. Drumm, and A.E. Roher. 1998. Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels. Biochem. Biophys. Res. Commun. 252:711-715.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.252
, pp. 711-715
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Bisgaier, C.L.3
Essenburg, A.D.4
Lampert, H.C.5
Drumm, D.6
Roher, A.E.7
-
37
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
38
-
-
0033616716
-
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
Lammich, S., E. Kojro, R. Postina, S. Gilbert, R. Pfeiffer, M. Jasionowski, C. Haass, and F. Fahrenholz. 1999. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl Acad. Sci. USA. 96:3922-3927.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
Gilbert, S.4
Pfeiffer, R.5
Jasionowski, M.6
Haass, C.7
Fahrenholz, F.8
-
39
-
-
0034051162
-
Membrane rafts and signaling by the multichain immune recognition receptors
-
Langlet, C., A.M. Bernard, P. Drevot, and H.T. He. 2000. Membrane rafts and signaling by the multichain immune recognition receptors. Curr. Opin. Immunol. 12:250-255.
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 250-255
-
-
Langlet, C.1
Bernard, A.M.2
Drevot, P.3
He, H.T.4
-
40
-
-
0034676451
-
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
-
Lanzetti, L., V. Rybin, M.G. Malabarba, S. Christoforidis, G. Scita, M. Zerial, and P.P. Di Fiore. 2000. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature. 408:374-377.
-
(2000)
Nature
, vol.408
, pp. 374-377
-
-
Lanzetti, L.1
Rybin, V.2
Malabarba, M.G.3
Christoforidis, S.4
Scita, G.5
Zerial, M.6
Di Fiore, P.P.7
-
41
-
-
0031746979
-
A detergent-insoluble membrane compartment contains A beta in vivo
-
Lee, S.J., U. Liyanage, P.E. Bickel, W. Xia, P.T. Lansbury, Jr., and K.S. Kosik. 1998. A detergent-insoluble membrane compartment contains A beta in vivo. Nat. Med. 4:730-734.
-
(1998)
Nat. Med.
, vol.4
, pp. 730-734
-
-
Lee, S.J.1
Liyanage, U.2
Bickel, P.E.3
Xia, W.4
Lansbury P.T., Jr.5
Kosik, K.S.6
-
42
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li, Y.M., M. Xu, M.T. Lai, Q. Huang, J.L. Castro, J. DiMuzio-Mower, T. Harrison, C. Lellis, A. Nadin, J.G. Neduvelil, et al. 2000. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 405:689-694.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelil, J.G.10
-
43
-
-
0033591230
-
Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture
-
Mizuno, T., M. Nakata, H. Naiki, M. Michikawa, R. Wang, C. Haass, and K. Yanagisawa. 1999. Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture. J. Biol. Chem. 274:15110-15114.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15110-15114
-
-
Mizuno, T.1
Nakata, M.2
Naiki, H.3
Michikawa, M.4
Wang, R.5
Haass, C.6
Yanagisawa, K.7
-
44
-
-
0033609449
-
Cleavage of Alzheimer's amyloid precursot protein by alpha-secretase occurs at the surface of neuronal cells
-
Parvathy, S., I. Hussain, E.H. Karran, A.J. Turner, and N.M. Hooper. 1999. Cleavage of Alzheimer's amyloid precursot protein by alpha-secretase occurs at the surface of neuronal cells. Biochemistry. 38:9728-9734.
-
(1999)
Biochemistry
, vol.38
, pp. 9728-9734
-
-
Parvathy, S.1
Hussain, I.2
Karran, E.H.3
Turner, A.J.4
Hooper, N.M.5
-
45
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
-
Perez, R.G., S. Soriano, J.D. Hayes, B. Ostaszewski, W. Xia, D.J. Selkoe, X. Chen, G.B. Stokin, and E.H. Koo. 1999. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J. Biol. Chem. 274:18851-18856.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
Ostaszewski, B.4
Xia, W.5
Selkoe, D.J.6
Chen, X.7
Stokin, G.B.8
Koo, E.H.9
-
46
-
-
0034611005
-
Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
-
Pralle, A., P. Keller, E.L. Florin, K. Simons, and J.K. Horber. 2000. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J. Cell Biol. 148:997-1008.
-
(2000)
J. Cell Biol.
, vol.148
, pp. 997-1008
-
-
Pralle, A.1
Keller, P.2
Florin, E.L.3
Simons, K.4
Horber, J.K.5
-
47
-
-
0035067187
-
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
-
Prior, I.A., A. Harding, J. Yan, J. Sluimer, R.G. Parton, and J.F. Hancock. 2001. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3:368-375.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 368-375
-
-
Prior, I.A.1
Harding, A.2
Yan, J.3
Sluimer, J.4
Parton, R.G.5
Hancock, J.F.6
-
48
-
-
0034795651
-
Acyl-coenzyme A: Cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
-
Puglielli, L., G. Konopka, E. Pack-Chung, L.A. Ingano, O. Berezovska, B.T. Hyman, T.Y. Chang, R.E. Tanzi, and D.M. Kovacs. 2001. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat. Cell Biol. 3:905-912.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 905-912
-
-
Puglielli, L.1
Konopka, G.2
Pack-Chung, E.3
Ingano, L.A.4
Berezovska, O.5
Hyman, B.T.6
Chang, T.Y.7
Tanzi, R.E.8
Kovacs, D.M.9
-
49
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Refolo, L.M., B. Malester, J. LaFrancois, T. Bryant-Thomas, R. Wang, G.S. Tint, K. Sambamurti, K. Duff, and M.A. Pappolla. 2000. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7:321-331.
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 321-331
-
-
Refolo, L.M.1
Malester, B.2
LaFrancois, J.3
Bryant-Thomas, T.4
Wang, R.5
Tint, G.S.6
Sambamurti, K.7
Duff, K.8
Pappolla, M.A.9
-
50
-
-
0035928732
-
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
-
Riddell, D.R., G. Christie, I. Hussain, and C. Dingwall. 2001. Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr. Biol. 11:1288-1293.
-
(2001)
Curr. Biol.
, vol.11
, pp. 1288-1293
-
-
Riddell, D.R.1
Christie, G.2
Hussain, I.3
Dingwall, C.4
-
51
-
-
0032931988
-
Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
-
Rodal, S.K., G. Skretting, O. Garred, F. Vilhardt, B. van Deurs, and K. Sandvig. 1999. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol. Biol. Cell. 10:961-974.
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 961-974
-
-
Rodal, S.K.1
Skretting, G.2
Garred, O.3
Vilhardt, F.4
Van Deurs, B.5
Sandvig, K.6
-
52
-
-
0033145517
-
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
-
Roy, S., R. Luetterforst, A. Harding, A. Apolloni, M. Etheridge, E. Stang, B. Rolls, J.F. Hancock, and R.G. Parton. 1999. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat. Cell Biol. 1:98-105.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 98-105
-
-
Roy, S.1
Luetterforst, R.2
Harding, A.3
Apolloni, A.4
Etheridge, M.5
Stang, E.6
Rolls, B.7
Hancock, J.F.8
Parton, R.G.9
-
53
-
-
0035823495
-
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
-
Scheuermann, S., B. Hambsch, L. Hesse, J. Stumm, C. Schmidt, D. Beher, T.A. Bayer, K. Beyreuther, and G. Multhaup. 2001. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J. Biol. Chem. 276:33923-33929.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33923-33929
-
-
Scheuermann, S.1
Hambsch, B.2
Hesse, L.3
Stumm, J.4
Schmidt, C.5
Beher, D.6
Bayer, T.A.7
Beyreuther, K.8
Multhaup, G.9
-
54
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe, D.J. 2001. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:741-766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
56
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons, M., P. Keller, B. De Strooper, K. Beyreuther, C.G. Dorti, and K. Simons. 1998. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA. 95:6460-6464.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
Beyreuther, K.4
Dorti, C.G.5
Simons, K.6
-
57
-
-
0035949755
-
Cholesterol and Alzheimer's disease: Is there a link?
-
Simons, M., P. Keller, J. Dichgans, and J.B. Schulz. 2001. Cholesterol and Alzheimer's disease: is there a link? Neurology. 57:1089-1093.
-
(2001)
Neurology
, vol.57
, pp. 1089-1093
-
-
Simons, M.1
Keller, P.2
Dichgans, J.3
Schulz, J.B.4
-
58
-
-
0028177562
-
Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
-
Sparks, D.L., S.W. Scheff, J.C. Hunsaker, III, H. Liu, T. Landers, and D.R. Gross. 1994. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 126:88-94.
-
(1994)
Exp. Neurol.
, vol.126
, pp. 88-94
-
-
Sparks, D.L.1
Scheff, S.W.2
Hunsaker J.C. III3
Liu, H.4
Landers, T.5
Gross, D.R.6
-
59
-
-
0033214070
-
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
-
Steiner, H., K. Duff, A. Capell, H. Romig, M.G. Grim, S. Lincoln, J. Hardy, X. Yu, M. Picciano, K. Fechteler, et al. 1999. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J. Biol. Chem. 274:28669-28673.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28669-28673
-
-
Steiner, H.1
Duff, K.2
Capell, A.3
Romig, H.4
Grim, M.G.5
Lincoln, S.6
Hardy, J.7
Yu, X.8
Picciano, M.9
Fechteler, K.10
-
60
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter, W.J., A.M. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G.S. Salvesen, and A.D. Roses. 1993. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1977-1981.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
Roses, A.D.7
-
61
-
-
0033625038
-
GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival
-
Tansey, M.G., R.H. Baloh, J. Milbrandt, and E.M. Johnson, Jr. 2000. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron. 25:611-623.
-
(2000)
Neuron.
, vol.25
, pp. 611-623
-
-
Tansey, M.G.1
Baloh, R.H.2
Milbrandt, J.3
Johnson E.M., Jr.4
-
62
-
-
0028966735
-
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform
-
Taraboulos, A., M. Scott, A. Semenov, D. Avrahami, L. Laszlo, S.B. Prusiner, and D. Avraham. 1995. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J. Cell Biol. 129:121-132.
-
(1995)
J. Cell Biol.
, vol.129
, pp. 121-132
-
-
Taraboulos, A.1
Scott, M.2
Semenov, A.3
Avrahami, D.4
Laszlo, L.5
Prusiner, S.B.6
Avraham, D.7
-
63
-
-
0036180950
-
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol- rich membrane microdomains
-
Wahrle, S., P. Das, A.C. Nyborg, C. McLendon, M. Shoji, T. Kawarabayashi, L.H. Younkin, S.G. Younkin, and T.E. Golde. 2002. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol- rich membrane microdomains. Neurobiol. Dis. 9:11-23.
-
(2002)
Neurobiol. Dis.
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
Das, P.2
Nyborg, A.C.3
McLendon, C.4
Shoji, M.5
Kawarabayashi, T.6
Younkin, L.H.7
Younkin, S.G.8
Golde, T.E.9
-
64
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
Weihofen, A., K. Binns, M.K. Lemberg, K. Ashman, and B. Martoglio. 2002. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science. 296:2215-2218.
-
(2002)
Science
, vol.296
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.K.3
Ashman, K.4
Martoglio, B.5
-
65
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin, B., W. Kellman, P. Ruosseau, G.G. Celesia, and G. Siegel. 2000. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57:1439-1443.
-
(2000)
Arch. Neurol.
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
66
-
-
0031957080
-
GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain
-
Yanagisawa, K., and Y. Ihara. 1998. GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain. Neurobiol. Aging. 19:S65-S67.
-
(1998)
Neurobiol. Aging
, vol.19
-
-
Yanagisawa, K.1
Ihara, Y.2
-
67
-
-
0028885854
-
GM1 ganglioside-bound amyloid beta-protein (A beta): A possible form of preamyloid in Alzheimer's disease
-
Yanagisawa, K., A. Odaka, N. Suzuki, and Y. Ihara. 1995. GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. Nat. Med. 1:1062-1066.
-
(1995)
Nat. Med.
, vol.1
, pp. 1062-1066
-
-
Yanagisawa, K.1
Odaka, A.2
Suzuki, N.3
Ihara, Y.4
|