Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases

EMBO Journal

Volumn 24, Issue 3, 2005, Pages 464-472

  Lemberg, Marius K ^a   Menendez, Javier ^b   Misik, Angelika ^b   Garcia, Maite ^b   Koth, Christopher M ^b   Freeman, Matthew ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Catalytic dyad; Derlin; Proteolytic processing; Rhomboid; Serine protease

Indexed keywords

ADENOSINE TRIPHOSPHATE; DERLIN; DETERGENT; EPIDERMAL GROWTH FACTOR; GAMMA SECRETASE; MEMBRANE ENZYME; MEMBRANE PROTEIN; MUTANT PROTEIN; PRESENILIN 1; PRESENILIN 2; SERINE PROTEINASE; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG; WATER;

AFFINITY CHROMATOGRAPHY; ANION EXCHANGE CHROMATOGRAPHY; AQUIFEX AEOLICUS; ARTICLE; BACILLUS SUBTILIS; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ESCHERICHIA COLI; HYDROPHOBICITY; IN VITRO STUDY; LIGAND BINDING; LIPID BILAYER; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROVIDENCIA STUARTII; PSEUDOMONAS AERUGINOSA; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; DETERGENTS; HUMANS; MEMBRANE PROTEINS; MEMBRANES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SOLUBILITY;

EID: 14844300797     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600537     Document Type: Article

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