Inhibition of glycosphingolipid biosynthesis reduces secretion of the β-amyloid precursor protein and amyloid β-peptide

Journal of Biological Chemistry

Volumn 280, Issue 30, 2005, Pages 28110-28117

  Tamboli, Irfan Y ^a   Prager, Kai ^a   Barth, Esther ^a   Heneka, Michael ^a   Sandhoff, Konrad ^a   Walter, Jochen ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; CELL CULTURE; CELL MEMBRANES; LIPIDS;

GLYCOSPHINGOLIPIDS; PHARMACOLOGICAL REDUCTION; PROTEOLYTIC PROCESSING; SECRETASES;

ENZYME INHIBITION;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; GLYCOSPHINGOLIPID; GLYCOSYL CERAMIDE SYNTHASE; GLYCOSYLCERAMIDASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; CELL MATURATION; CONTROLLED STUDY; ENDOCYTOSIS; GOLGI COMPLEX; HUMAN; HUMAN CELL; LIPID COMPOSITION; LIPID METABOLISM; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TRANSPORT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BIOLOGICAL TRANSPORT; BIOTINYLATION; BLOTTING, WESTERN; BRAIN; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; ENDOCYTOSIS; GANGLIOSIDES; GLYCOSPHINGOLIPIDS; GOLGI APPARATUS; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; LIPID METABOLISM; MELANOMA, EXPERIMENTAL; MICE; PEPTIDES; RHODAMINES; TIME FACTORS;

EID: 23044510465     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414525200     Document Type: Article

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