Molecular regulation of SREBP function: The Insig-SCAP connection and isoform-specific modulation of lipid synthesis

Biochemistry and Cell Biology

Volumn 82, Issue 1, 2004, Pages 201-211

  McPherson, Ruth ^a   Gauthier, Andre ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

Cholesterol synthesis; Insig; Lipid metabolism; SCAP; SREBP

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSYNTHESIS; CHOLESTEROL; FATTY ACIDS; GENES; INSULIN; METABOLISM; PROTEINS;

INSULIN RESISTANCE; MOLECULAR REGULATION; TRANSCRIPTION FACTORS;

LIPIDS;

CHOLESTEROL; FATTY ACID; INSULIN INDUCED GENE 1 PROTEIN; INSULIN INDUCED GENE 2 PROTEIN; ISOPROTEIN; LIPID; PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; ENDOPLASMIC RETICULUM; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HUMAN; LIPID METABOLISM; LIPOGENESIS; LIPOPROTEIN SYNTHESIS; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW;

ANIMALS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEINS; CHOLESTEROL; DNA-BINDING PROTEINS; FATTY ACIDS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPIDS; MEMBRANE PROTEINS; MODELS, ANIMAL; MODELS, BIOLOGICAL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS;

EID: 2342536384     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o03-090     Document Type: Review

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