A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1

Molecular Cell

Volumn 5, Issue 2, 2000, Pages 197-206

  Mumm, Jeffrey S ^a   Schroeter, Eric H ^a   Saxena, Meera T ^a   Griesemer, Adam ^a   Tian, Xiaolin ^a   Pan, D J ^b   Ray, William J ^a   Kopan, Raphael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; LIGAND; PEPTIDE;

ANIMAL CELL; ARTICLE; BINDING SITE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; POINT MUTATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REGULATORY MECHANISM;

ANIMALIA;

EID: 0033867521     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80416-5     Document Type: Article

References (53)

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4. The SREBP pathway - Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
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8. High efficiency transformation of mammalian cells by plasmid DNA
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14. Alzheimer's disease - In search of gamma-secretase
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24. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
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28. The function and regulation of cut expression on the wing margin of Drosophila - Notch, Wingless and a dominant negative role for Delta and Serrate
29. Regulation of amyloid precursor protein cleavage
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31. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
32. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
33. An essential role for ectodomain shedding in mammalian development
34. Processing of the Notch ligand delta by the metalloprotease kuzbanian
35. Calcium depletion dissociates and activates heterodimeric Notch receptors
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38. Kuz, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
39. Xenopus embryos regulate the nuclear localization of XMyoD
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51. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
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