Mutations in the transmembrane domain of APP altering γ-secretase specificity

Biochemistry

Volumn 36, Issue 49, 1997, Pages 15396-15403

  Lichtenthaler, Stefan F ^a   Ida, Nobuo ^a   Multhaup, Gerd ^a   Masters, Colin L ^b   Beyreuther, Konrad ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; PHENYLALANINE; PROTEINASE; THREONINE; UNCLASSIFIED DRUG; VALINE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; HYDROPHOBICITY; IMMUNOPRECIPITATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; COS CELLS; ENDOPEPTIDASES; MEMBRANE PROTEINS; POINT MUTATION; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0030720936     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971071m     Document Type: Article

References (32)

1. Allsop, D., Christie, G., Gray, C., Holmes, S., Markwell, R., Owen, D., Smith, L., Wadsworth, H., Ward, R. V., Hartmann, T., Lichtenthaler, S. F., Evin, G., Fuller, S., Tanner, J., Masters, C. L., Beyreuther, K., & Roberts, G. W. (1997) in Alzheimer's Disease: Biology, Diagnosis and Therapeutics (Iqbal, K., Winblad, B., Nishimura, T., Takeda, M., & Wisniewski, H. M., Eds.) pp 717-727, John Wiley & Sons Ltd.
2. Arlt, H., Tauer, R., Feldmann, H., Neupert, W., & Langer, T. (1996) Cell 85, 875-885.
3. Bretscher, M. S., & Munro, S. (1993) Science 261, 1280-1281.
4. Citron, M., Diehl, T. S., Gordon, G., Biere, A. L., Seubert, P., & Selkoe, D. J. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 13170-13175.
5. Dyrks, T., Weidemann, A., Multhaup, G., Salbaum, J. M., Lemaire, H. G., Kang, J., Muller-Hill, B., Masters, C. L., & Beyreuther, K. (1988) EMBO J. 7, 949-957.
6. Dyrks, T., Dyrks, E., Masters, C., & Beyreuther, K. (1992) FEBS Lett. 309, 20-24.
7. Dyrks, T., Dyrks, E., Mönning, U., Urmoneit, B., Turner, J., & Beyreuther, K. (1993) FEBS Lett. 335, 89-93.
8. Evin, G., Beyreuther, K., & Masters, C. L. (1994) Amyloid: Int. J. Exp. Clin. Invest. 1, 263-280.
9. Glenner, G. G., & Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890.
10. Gravina, S. A., Ho, L. B., Eckman, C. B., Long, K. E., Otvos, L., Younkin, L. H., Suzuki, N., & Younkin, S. G. (1995) J. Biol. Chem. 270, 7013-7016.
11. Haass, C., & Selkoe, D. J. (1993) Cell 75, 1039-1042.
12. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., & Teplow, D. B., et al. (1992) Nature 359, 322-325.
13. Haass, C., Hung, A. Y., Schlossmacher, M. G., Teplow, D. B., & Selkoe, D. J. (1993) J. Biol. Chem. 268, 3021-3024.
14. Hartmann, T., Bergsdorf, C., Sandbrink, R., Tienari, P. J., Multhaup, G., Ida, N., Bieger, S., Dyrks, T., Weidemann, A., Masters, C. L., & Beyreuther, K. (1996) J. Biol. Chem. 271, 13208-13214.
15. Higaki, J., Quon, D., Zhong, Z., & Cordell, B. (1995) Neuron 14, 651-659.
16. Ida, N., Hartmann, T., Pantel, J., Schröder, J., Zerfass, R., Förstl, H., Sandbrink, R., Masters, C. L., & Beyreuther, K. (1996) J. Biol. Chem. 271, 22908-22914.
17. Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) Neuron 13, 45-53.
18. Jarrett, J. T., Berger, E. P., & Lansbury, P. T., Jr. (1993) Biochemistry 32, 4693-4697.
19. Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K., & Mueller-Hill, B. (1987) Nature 325, 733-736.
20. Lalowski, M., Golabek, A., Lemere, C. A., Selkoe, D. J., Wisniewski, H. M., Beavis, R. C., Frangione, B., & Wisniewski, T. (1996) J. Biol. Chem. 271, 33623-33631.
21. Leonhard, K., Herrmann, J. M., Stuart, R. A., Mannhaupt, G., Neupert, W., & Langer, T. (1996) EMBO J. 15, 4218-4229.
22. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 4245-4249.
23. Schägger, H., & von Jagow, G. (1987) Anal. Biochem. 166, 368-379.
24. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10, 373-403.
25. Seubert, P., Vigo Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., & Swindlehurst, C., et al. (1992) Nature 359, 325-327.
26. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X. D., McKay, D. M., Tintner, R., & Frangione, B., et al. (1992) Science 258, 126-129.
27. Simons, M., De Strooper, B., Multhaup, G., Tienari, P. J., Dotti, C. G., & Beyreuther, K. (1996) J. Neurosci. 16, 899-908.
28. Suzuki, N., Cheung, T. T., Cai, X. D., Odaka, A., Otvos, L., Jr., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) Science 264, 1336-1340.
29. Tienari, P. J., De Strooper, B., Ikonen, E., Simons, M., Weidemann, A., Czech, C., Hanmann, T., Ida, N., Multhaup, G., Masters, C. L., Van Leuven, F., Beyreuther, K., & Dotti, C. G. (1996) EMBO J. 15, 5218-5229.
30. Tienari, P. J., Ida, N., Ikonen, E., Simons, M., Weidemann, A., Multhaup, G., Masters, C. L., Dotti, C. G., & Beyreuther, K. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 4125-4130.
31. Tischer, E., & Cordell, B. (1996) J. Biol. Chem. 271, 21914-21919.
32. van Poelje, P., & Snell, E. E. (1990) Annu. Rev. Biochem. 59, 29-59.